Article
Medicine, General & Internal
Shreekant Tiwari, Monalisah Nanda, Swetalona Pattanaik, Ganiga Channaiah Shivakumar, Bukanakere Sangappa Sunila, Marco Cicciu, Giuseppe Minervini
Summary: The study aimed to investigate the impact of dermatophytosis and dermatomycoses, which are fungal infections affecting the superficial keratinized layer of the skin, nails, and hair. It was found that these infections are more prevalent in India's hot, muggy, tropical climate. The study also discovered that non-dermatophytic moulds play a significant role in the development of superficial mycoses in addition to dermatophytes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Ashutosh Singh, Prerna Singh, Jacques F. Meis, Anuradha Chowdhary
Summary: Olorofim demonstrates potent in vitro activity against drug-resistant dermatophytes and opportunistic moulds, with exceptions in Alternaria alternata. When compared to other systemic antifungal drugs, Olorofim exhibits lower activity against Penicillium and Talaromyces species. Particularly, Olorofim shows strong activity against Trichophyton isolates, including those resistant to terbinafine and azoles.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Patricia Cerqueira, Ana Cunha, Cristina Almeida-Aguiar
Summary: Propolis, a natural compound with antimicrobial properties, has been found to have potential activities in antioxidant, anti-tumor, anti-inflammatory, hepatoprotective, and immunomodulatory effects. It shows strong inhibitory effects against fungi causing skin diseases and can be used as an alternative skin treatment.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Emanuel Pereira Silva, Marcelo Antonio Nobrega da Rocha, Risley Nikael Medeiros Silva, Juliana Moura-Mendes, Gabriela Ribeiro de Sousa, Jailton de Souza-Ferrari, Jose Maria Barbosa-Filho, Edeltrudes de Oliveira Lima, Fillipe de Oliveira Pereira
Summary: This study evaluated the antifungal and antibiofilm activity of RIP3 against different dermatophyte strains. The results showed that RIP3 can inhibit fungal growth, biofilm formation, and sulfite secretion.
Article
Pharmacology & Pharmacy
Sebastian Gnat, Dominik Lagowski, Mariusz Dylag, Grzegorz Jozwiak, Aleksandra Troscianczyk, Aneta Nowakiewicz
Summary: This study evaluated the antifungal activity of ebselen and diphenyl diselenide against Trichophyton mentagrophytes clinical isolates and found that they exhibit high antifungal activity. However, the observed synergistic effects in combination therapy with antifungal drugs were weak.
Article
Chemistry, Medicinal
Siham Benanane, Nawel Cheikh, Nour El-houda Bendhina, Didier Villemin, Ahcene Boumendjel
Summary: The aim of this study was to synthesize a novel class of compounds containing a coumarin structure, either iminocoumarins or characterized by the presence of a pyridone ring fused within the iminocoumarin scaffold. The targeted compounds were successfully synthesized through a short method utilizing microwave activation. The antifungal activity of the synthesized compounds was evaluated, and one of them showed activity comparable to the widely used reference drug, amphotericin B. The ease and conditions of synthesis suggest a high potential for diversity-oriented synthesis, making it valuable in the field of drug discovery.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ying-Hui He, Xiao-Fei Shang, Hai-Xin Li, An-Ping Li, Chen Tang, Bao-Qi Zhang, Zhi-Jun Zhang, Rui Wang, Yue Ma, Sha-Sha Du, Yong-Mei Hu, Tian-Lin Wu, Wen-Bin Zhao, Cheng-Jie Yang, Ying-Qian Liu
Summary: The study evaluated the antifungal activities of Cnidium monnieri fruit extracts and isolated compounds, particularly focusing on 4-methoxycoumarin. The research found that 4-methoxycoumarin exhibited strong and broad-spectrum antifungal activity against plant pathogenic fungi, showing potential for use in preventing potato black scurf in a concentration-dependent manner.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Polymer Science
Andra-Cristina Humelnicu, Petrisor Samoila, Corneliu Cojocaru, Raluca Dumitriu, Andra-Cristina Bostanaru, Mihai Mares, Valeria Harabagiu, Bogdan C. Simionescu
Summary: This paper investigates new approaches to chitosan-based antifungal therapeutic formulations. By using gel-like formulations and controlling the composition, the study achieved effective inhibition and controlled release of fungi.
Article
Pharmacology & Pharmacy
Caroline B. Costa-Orlandi, Niura M. Bila, Jean Lucas C. Bonatti, Carolina O. Vaso, Mariana B. Santos, Carlos R. Polaquini, Mariana M. Santoni M. Biasioli, Rondinelli D. Herculano, Luis O. Regasini, Ana Marisa Fusco-Almeida, Maria Jose S. Mendes-Giannini
Summary: The ability of dermatophytes to form biofilms and resist antifungal drugs has led to treatment recurrence. In this study, the susceptibility and mechanism of action of nonyl 3,4-dihydroxybenzoate (nonyl) on planktonic cells and biofilms of T. rubrum and T. mentagrophytes were evaluated. The results showed that nonyl effectively damaged the biofilms, while synthetic drugs had little effect and even promoted the development of resistant structures. Confocal and transmission electron microscopy revealed a reduction in biofilm thickness and disruption of the plasma membrane. These findings support the potential of nonyl as a promising antifungal compound.
Article
Infectious Diseases
Paulo H. F. Carmo, Gustavo J. C. Freitas, Joao C. M. Dornelas, Bruna C. T. Almeida, Ludmila M. Baltazar, Gabriella F. Ferreira, Nalu T. A. Peres, Daniel A. Santos
Summary: Amorolfine and ciclopirox olamine exhibit antifungal activity in onychomycosis through the production of oxidative and nitrosative radicals, leading to cell damage and fungal death.
Article
Pharmacology & Pharmacy
M. -Y. Ren, Y. -J. Shi, Y. Ding, W. Lu, S. -S. Fan, X. -H. Tao
Summary: Superficial fungal infections (SFIs) have diverse causes, complex pathogenesis, and geographical variation in patient symptoms. Conventional management of SFIs can lead to complications and clinical difficulties, while drug-resistant fungi and low penetration of antifungal drugs in hard tissues are emerging concerns. Nanotechnology offers potential opportunities for effective treatment of SFIs through new dosing forms, chemical modification of traditional drugs, and pharmacokinetic improvement. This study reviewed the direct use of nanoparticles and their use as carriers in SFIs, discussing their future medicinal applications.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
M. -Y. Ren, Y. -J. Shi, Y. Ding, W. Lu, S. -S. Fan, X. -H. Tao
Summary: Superficial fungal infections (SFIs) have diverse etiologies, complex pathogenesis, and geographical differences in patient symptoms. Conventional management of SFIs has complications and clinical difficulties, and the low penetration of antifungal drugs in hard tissues and drug-resistant fungi are emerging concerns. Nanotechnology provides potential opportunities for the effective treatment of SFIs through new dosing forms, chemical modification of drugs, and pharmacokinetic improvement. This study reviews the direct use of nanoparticles and their use as carriers in SFIs, discussing their future medicinal applications.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Dermatology
Bharti Sharma, Skarma Nonzom
Summary: Superficial mycoses of skin, nails, and hair caused by dermatophytes, non-dermatophyte moulds, yeasts, and yeast-like fungi are common fungal infections. These infections, prevalent in warm, humid, and poor hygienic conditions, impact the quality of life of infected individuals.
Article
Microbiology
Anne-Laure Bidaud, Patrick Schwarz, Anuradha Chowdhary, Eric Dannaoui
Summary: A combination of terbinafine with itraconazole was found to have synergistic effects against both terbinafine-susceptible and terbinafine-resistant isolates of Trichophyton spp. from India.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Andrea Lombardi, Margherita Campo, Pamela Vignolini, Marco Papalini, Mirco Pizzetti, Roberta Bernini
Summary: This study characterized phenolic-rich extracts from olive, chestnut, pomegranate, and grape residues through HPLC-MS-DAD analysis. The results showed that these extracts exhibited significant growth inhibition against fungi, especially pathogenic dermatophytes. These extracts have potential applications as antifungal agents in the agri-food and biomedical fields.
Article
Materials Science, Multidisciplinary
M. A. Dominguez-Crespo, L. Gerardo Zepeda-Vallejo, A. M. Torres-Huerta, S. B. Brachetti-Sibaja, D. Palma-Ramirez, A. E. Rodriguez-Salazar, D. E. Ontiveros-De La Torre
METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE
(2020)
Article
Biochemical Research Methods
Elvia Becerra-Martinez, Yesenia Pacheco-Hernandez, Edmundo Lozoya-Gloria, Martha G. Betancourt-Jimenez, Diego Hidalgo-Martinez, Luis G. Zepeda-Vallejo, Nemesio Villa-Ruano
PHYTOCHEMICAL ANALYSIS
(2020)
Review
Chemistry, Physical
Javier Cervantes-Gonzalez, David A. Vosburg, Salma E. Mora-Rodriguez, Miguel A. Vazquez, L. Gerardo Zepeda, Clarisa Villegas Gomez, Selene Lagunas-Rivera
Article
Food Science & Technology
Rodolfo Velasquez-Valle, Nemesio Villa-Ruano, Diego Hidalgo-Martinez, L. Gerardo Zepeda-Vallejo, Nury Perez-Hernandez, Cesar A. Reyes-Lopez, Eric Reyes-Cervantes, Diana L. Medina-Melchor, Elvia Becerra-Martinez
FOOD RESEARCH INTERNATIONAL
(2020)
Article
Dermatology
Ignacio Mejia-Calvo, Leonardo E. Lopez-Juarez, Said Vazquez-Leyva, Carlos A. Lopez-Morales, Daniel Montoya-Escutia, Pamela G. Merlos Rivera, Jose Enrique Herbert-Pucheta, Luis Gerardo Zepeda-Vallejo, Marco Velasco-Velazquez, Lenin Pavon, Sonia M. Perez-Tapia, Emilio Medina-Rivero
Summary: A liquid formulation containing collagen hydrolyzed was developed and evaluated using advanced technology to define its quality attributes. The product effectively reduced wrinkles on the forehead, with long-lasting effects, and was gentle and non-irritating for sensitive skin.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Gabriela Aguilar-Hernandez, Luis Gerardo Zepeda-Vallejo, Maria de Lourdes Garcia-Magana, Maria de los Angeles Vivar-Vera, Alejandro Perez-Larios, Manuel Giron-Perez, Ana Velia Coria-Tellez, Cristian Rodriguez-Aguayo, Efigenia Montalvo-Gonzalez
APPLIED SCIENCES-BASEL
(2020)
Article
Food Science & Technology
Moises Ramirez-Meraz, Reinaldo Mendez-Aguilar, Diego Hidalgo-Martinez, Nemesio Villa-Ruano, L. Gerardo Zepeda-Vallejo, Fernando Vallejo-Contreras, Claudia J. Hernandez-Guerrero, Elvia Becerra-Martinez
FOOD RESEARCH INTERNATIONAL
(2020)
Article
Food Science & Technology
Nemesio Villa-Ruano, Alberto Rosas-Bautista, Enrique Rico-Arzate, Yair Cruz-Narvaez, L. Gerardo Zepeda-Vallejo, Liliana Lalaleo, Diego Hidalgo-Martinez, Elvia Becerra-Martinez
LWT-FOOD SCIENCE AND TECHNOLOGY
(2020)
Article
Chemistry, Analytical
Jose Enrique Herbert-Pucheta, Carlos A. Lopez-Morales, Emilio Medina-Rivero, Sergio Estrada-Parra, Sonia Mayra Perez-Tapia, L. Gerardo Zepeda-Vallejo
Summary: The research developed non-invasive NMR schemes to validate the quality and consistency of human DLE drugs, accurately identifying and quantifying peptide content using NMR technology, demonstrating the feasibility of the technique as a routine analysis of drugs.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Physical
Sergio Andres Torres-Perez, Luis Vallejo-Castillo, Said Vazquez-Leyva, Luis Gerardo Zepeda-Vallejo, Jose Enrique Herbert-Pucheta, Childerick Severac, Etienne Dague, Sonia Mayra Perez-Tapia, Eva Ramon-Gallegos
Summary: The newly developed One-Step Poly(amidoamine) (OS-PAMAM) dendrimers show promise in drug delivery and as therapeutic agents in the biomedical field. Physicochemical characteristics of OS-PAMAM were compared with commercial PAMAM-G6, revealing similarities and advantages such as lower molecular weight and faster, cost-effective synthesis methods for potential industry and research applications in biomedicine.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Agronomy
Diana Laura Medina-Melchor, Diego Helman Zapata-Sarmiento, Elvia Becerra-Martinez, Mario Rodriguez-Monroy, L. Gerardo Zepeda Vallejo, Gabriela Sepulveda-Jimenez
Summary: Infection with Stemphylium vesicarium reduces energy production processes in onion plants while promoting the successful growth of the pathogen by increasing the concentration of certain metabolites.
EUROPEAN JOURNAL OF PLANT PATHOLOGY
(2022)
Article
Food Science & Technology
Claudia J. Hernandez-Guerrero, Nemesio Villa-Ruano, L. Gerardo Zepeda-Vallejo, Alma D. Hernandez-Fuentes, Karla Ramirez-Estrada, Sergio Zamudio-Lucero, Diego Hidalgo-Martinez, Elvia Becerra-Martinez
Summary: This study utilized 1H NMR metabolomics profiling to analyze different cultivars of Phaseolus vulgaris seeds and leaves, finding a similar metabolomics fingerprint with a variety of metabolites, higher concentrations of free amino acids in seeds, and more abundant organic acids in leaves. FN seeds and FPe leaves were highlighted for best nutritional properties, with high protein, flavonoids, amino acids, and nucleosides content.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Ixchell Y. Sedillo-Torres, alvaro O. Hernandez-Rangel, Yolanda Gomez-y-Gomez, Daniel Cortes-Avalos, Blanca Estela Garcia-Perez, Juan C. Villalobos-Rocha, Cesar H. Hernandez-Rodriguez, Luis Gerardo Zepeda-Vallejo, Paulina Estrada-de los Santos, Maria Elena Vargas-Diaz, Jose Antonio Ibarra
Summary: An organic extract of Hibiscus sabdariffa L. containing hibiscus acid was found to inhibit motility and reduce the secretion of virulence factors in Salmonella enterica serovars Typhi and Typhimurium. The compound was not toxic to eukaryotic cells and could reduce the invasion of Salmonella Typhimurium in epithelial cells. Initial studies suggested that the mode of action of hibiscus acid might involve the disruption of membrane proton balance.
Article
Chemistry, Analytical
Julio C. Ontiveros-Rodriguez, Jose Serrano-Contreras, Jose Roberto Villagomez-Ibarra, Hugo A. Garcia-Gutierrez, L. Gerardo Zepeda-Vallejo
Summary: Mexican gordolobo is an important medicinal plant in Mexico, and its chemical profiling was characterized using a semi-targeted H-1 NMR-based chemometric method. The study identified chemical markers that can aid in the correct identification of Mexican gordolobo.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Mabel M. Montenegro-Sustaita, Hugo A. Jimenez-Vazquez, Elena Vargas-Diaz, J. Enrique Herbert-Pucheta, L. Gerardo Zepeda-Vallejo
Summary: A series of decalin and hydrindane derivatives were synthesized through a cascade reaction of cyclohexanone/cyclopentanone enolates and methyl acrylate. The stereochemistry of the products was determined using NMR and X-ray crystallography, and confirmed by computational analysis and simulation of NMR spectra. This synthetic method is simple and practical, and allows for the generation of structurally diverse decalin and hydrindane derivatives.
