Article
Infectious Diseases
Xueqi Chen, Yinping Shi, Yiman Li, Shan Su, Peng Wang, Shujuan Sun
Summary: This study demonstrates that the combination of lonidamine and fluconazole exerts synergistic antifungal effects against resistant Candida albicans by inhibiting hyphal growth and activating metacaspase, but not by affecting cellular ROS levels or drug transporters.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Article
Microbiology
Ying Gong, Shulin Yin, Shujuan Sun, Min Li
Summary: Chelerythrine combined with fluconazole exhibits a strong synergistic effect against fluconazole-resistant Candida albicans and its biofilm, and can reverse drug resistance.
FUTURE MICROBIOLOGY
(2022)
Article
Microbiology
J. D. Sobel
Summary: A review of vaginal isolates of Candida albicans obtained from a university vaginitis referral clinic over a 10-year period revealed an increase in fluconazole resistance, which has been associated with treatment choice. Factors contributing to azole resistance in Candida albicans vaginal infection are discussed.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Angela Maione, Marianna Imparato, Annalisa Buonanno, Federica Carraturo, Antonetta Schettino, Maria Teresa Schettino, Marilena Galdiero, Elisabetta de Alteriis, Marco Guida, Emilia Galdiero
Summary: Candida albicans is a common microorganism in the human microbiota that can cause vulvovaginal infections. The development of drug resistance in C. albicans isolates is a complication that requires new therapeutic strategies. The study found that phenyllactic acid (PLA) has strong antifungal and antivirulence activities against C. albicans, including reducing biofilm formation and affecting gene expression. PLA shows promise as a novel and safe antifungal agent for the treatment of vulvovaginal candidiasis.
Article
Infectious Diseases
Ghada El-Saeed Mashaly, Mayada Sabry Zeid
Summary: This study investigated the relationship between genotype, virulence factors and fluconazole tolerance among Candida albicans isolates from pediatric patients. The results showed that genotype A was the most prevalent, and biofilm formation and enzyme production were important virulence determinants in pediatric infections. Fluconazole tolerance was significantly correlated with biofilm formation and proteinase production.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Chemistry, Medicinal
Xueqi Chen, Jiyong Wu, Lei Sun, Jing Nie, Shan Su, Shujuan Sun
Summary: The study revealed that BEH alone or in combination with FLC exhibited potent antifungal activity against C. albicans, possibly through increasing intracellular calcium concentration, activating metacaspase activity to reduce virulence, and anti-biofilms, but not related to drug efflux.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Microbiology
Petr Jaros, Maria Vrublevskaya, Kristyna Lokocova, Jana Michailidu, Irena Kolouchova, Katerina Demnerova
Summary: The use of antibiotics and antifungals to control infections caused by pathogenic microorganisms is currently ineffective due to emerging resistance. Boswellia serrata extract containing boswellic acids has shown promising antifungal activity against Candida species.
Article
Immunology
Yasmine H. Tartor, Gamal A. Elmowalid, Mohamed N. Hassan, Asmaa Shaker, Dalia F. Ashour, Taisir Saber
Summary: This study investigated the inhibition of Candida albicans biofilms and the interactions between biofilms and phagocytes in the presence of essential oils, biological and chemical agents, or fluconazole. The results showed that cinnamon oil, sodium dodecyl sulfate (SDS), and cetyltrimethylammonium bromide (CTAB) were the most effective inhibitors of C. albicans biofilms, while fluconazole was ineffective. Additionally, it was found that phagocytes could rapidly engulf C. albicans cells in biofilms treated with cinnamon oil, Enterococcus faecalis cell-free supernatant (CFS), or SDS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Jiadi Shen, Ming Ma, Wei Duan, Yun Huang, Banruo Shi, Qiaochu Wu, Xin Wei
Summary: This study aimed to investigate the effects of an activator and an inhibitor of autophagy on the susceptibility of C. albicans biofilms to antifungal agents and the related mechanisms. It was found that the autophagic activity of C. albicans biofilms was closely related to their susceptibility to antifungal agents.
Article
Microbiology
Liu-Yan Su, Guang-Hui Ni, Yi-Chuan Liao, Liu-Qing Su, Jun Li, Jia-Sheng Li, Gao-Xiong Rao, Rui-Rui Wang
Summary: The study demonstrated that the combination of TA and FLC exhibited strong synergistic antifungal activity against drug-resistant C. albicans, inhibiting gene expression and reducing infectivity and resistance.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Amir Arastehfar, Melika Laal Kargar, Shahla Roudbar Mohammadi, Maryam Roudbary, Nayereh Ghods, Ladan Haghighi, Farnaz Daneshnia, Mahin Tavakoli, Jalal Jafarzadeh, Mohammad Taghi Hedayati, Huiwei Wang, Wenjie Fang, Agostinho Carvalho, Macit Ilkit, David S. Perlin, Cornelia Lass-Floerl
Summary: RVVC is a common fungal infection that may be caused by dysbiosis and other factors. FLZR and FLZT phenotypes were found to contribute to fluconazole therapeutic failure, with Iran having a heavy burden of RVVC. Research on RVVC remains limited.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Najla A. Alshaikh, Kahkashan Perveen
Summary: This study provides experimental evidence that thyme essential oil (TEO) has antifungal activity against fluconazole-resistant clinical isolates of C. albicans. TEO successfully inhibits the growth, germ tube formation, and budding of fungal pathogens at low doses, showing potential as an alternative to fluconazole for drug-resistant strains.
Article
Electrochemistry
Kayode Olaifa, Jasmina Nikodinovic-Runic, Biljana Glisic, Francesco Boschetto, Elia Marin, Francesco Segreto, Enrico Marsili
Summary: Candida albicans is a common fungal pathogen, and analyzing biofilms and assessing antifungal therapy quickly is a critical challenge in clinical practice. This study demonstrates the use of electrochemical methods to evaluate the activity of antifungal compounds on C. albicans biofilms, indicating the suitability of electrochemical testing for assessing antifungal drugs.
ELECTROCHIMICA ACTA
(2021)
Article
Microbiology
Jack D. Sobel, Robert Akins
Summary: Antifungal drug susceptibility tests (AST) are increasingly needed for women with refractory or recurrent Candida vaginitis due to fluconazole resistance. It is proposed that the AST be performed at pH 4.5 instead of the recommended pH 7.0, as testing at only pH 7.0 is likely to miss a significant number of clinically relevant azole-resistant C. albicans vaginal isolates.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jakub Suchodolski, Anna Krasowska
Summary: Fructose elevates fluconazole resistance in Candida albicans by activating Mdr1p and inducing higher levels of Cdr1p.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Gunderao H. Kathwate, Ravikumar B. Shinde, S. Mohan Karuppayil
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
(2015)
Article
Microbiology
Jayant S. Raut, Ravikumar B. Shinde, Mohan S. Karuppayil
AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH
(2012)
Article
Biotechnology & Applied Microbiology
Jayant S. Raut, Ravikumar B. Shinde, Nitin M. Chauhan, S. Mohan Karuppayil
Article
Infectious Diseases
Ravikumar Bapurao Shinde, Jayant Shankar Raut, Nitin Mahendra Chauhan, Sankunny Mohan Karuppayil
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2013)
Article
Microbiology
Nitin M. Chauhan, Ravikumar B. Shinde, S. Mohan Karuppayil
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Ravikumar B. Shinde, Sandeep B. Rajput, Jayant S. Raut, S. Mohan Karuppayil
JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Jayant Shankar Raut, Ravikumar Bapurao Shinde, Nitin Mahendra Chauhan, Sankunny Mohan Karuppayil
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2014)
Article
Microbiology
Ravikumar B. Shinde, Nitin M. Chauhan, Jayant S. Raut, Sankunny M. Karuppayil
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2012)
Article
Integrative & Complementary Medicine
Sandeep B. Rajput, Ravikumar B. Shinde, Madhushree M. Routh, Sankunny M. Karuppayil
Article
Biochemistry & Molecular Biology
Kunie Yoshinaga-Sakurai, Ravikumar Shinde, Myosotys Rodriguez, Barry P. Rosen, Nazira El-Hage
ACS CHEMICAL NEUROSCIENCE
(2020)
Review
Biotechnology & Applied Microbiology
Ravikumar B. Shinde, Murugan Veerapandian, Ajeet Kaushik, Pandiaraj Manickam
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Gunderao Hanumantrao Kathwate, Ravikumar Bapurao Shinde, S. Mohan Karuppayil
Summary: Experimental results indicate that non-antifungal drugs have the potential to become new antifungal agents, helping to overcome the resistance of Candida infections to antibiotic treatment.
JOURNAL OF ANTIBIOTICS
(2021)
Review
Chemistry, Analytical
Pandiaraj Manickam, Siva Ananth Mariappan, Sindhu Monica Murugesan, Shekhar Hansda, Ajeet Kaushik, Ravikumar Shinde, S. P. Thipperudraswamy
Summary: Artificial intelligence (AI) is a modern approach in computer science that develops intelligent and efficient devices through programs and algorithms. The Internet of Medical Things (IoMT) combines network-linked biomedical devices and software applications as a next-generation bio-analytical tool. This review discusses the importance of AI in enhancing the capabilities of IoMT and point-of-care devices in healthcare, as well as its role and challenges in advanced biomedical applications.
