Article
Allergy
Cosby A. Stone, Jason A. Trubiano, Elizabeth J. Phillips
Summary: This study found that cross-reactivity of cephalosporins is based on shared R1 groupings, and increasing time since the original reaction and having a penicillin allergy label (PAL) with unknown cephalosporin tolerance predicted a lower likelihood of positive skin testing.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Heena Mehta, Carolyn Jack, Catherine Maari, Etienne Saint-Cyr Proulx, Robert Bissonnette, Francisco Ramirez-Valle, Marika Sarfati
Summary: The potential benefit of inducing delayed-type hypersensitivity (DTH) reaction in healthy volunteers as experimental models to study skin inflammatory disorders was reported. This study investigated the immunophenotype of skin T cells and their modulation by oral drugs in a local DTH reaction.
Article
Biochemistry & Molecular Biology
Svitlana Skoroplyas, Ondrej Vasicek, Michaela Chorvatova, Petra Dad'ova, Katerina Lehka, Lukas Kubala
Summary: Pseurotin D has the potential to inhibit DTH reaction through inhibiting the activation and differentiation of both T cells and B cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Oncology
Ines Roger, Paula Montero, Martin Perez-Leal, Javier Milara, Julio Cortijo
Summary: The clinical practice faces the problem of delayed-type hypersensitivity (DTH) caused by various drugs, especially in antineoplastic treatments. DTH reactions can range from mild self-limiting maculopapular eruptions to severe Stevens-Johnson Syndrome, resulting in worsened patient quality of life. Apart from impacting patients, these reactions also lead to economic losses due to drug withdrawal and high hospitalization costs. However, there is currently no standard in vitro or in vivo method to evaluate the sensitizing potential of drugs in preclinical studies. This review aims to comprehensively evaluate in vitro and in vivo methods for detecting DTH and testing antineoplastic hypersensitivity reactions caused by different antineoplastic families.
Article
Immunology
Yvelise Barrios, Andres Franco, Inmaculada Sanchez-Machin, Paloma Poza-Guedes, Ruperto Gonzalez-Perez, Victor Matheu
Summary: Specific spike DTH test shows high concordance with anti-RBD-IgG in identifying COVID-19 patients and has a high specificity in non-sick individuals. It provides more stable results over time compared to specific anti-RBD-IgG testing.
CLINICAL IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Ines Roger, Paula Montero, Antonio Garcia, Javier Milara, Pilar Ribera, Jose Alejandro Perez-Fidalgo, Julio Cortijo
Summary: Delayed-type hypersensitivity (DTH) is a common reaction caused by various drugs, especially antineoplastic drugs, which may affect patients' quality of life. However, there is currently a lack of standardized methods for evaluating the sensitizing potential of drugs in the preclinical phase. This study aimed to adapt in vitro techniques to predict the sensitizing potential of antineoplastic agents and discovered that inhibition of the VEGFR1 pathway may be a potential trigger of DTH.
Article
Immunology
Yvelise Barrios, Andres Franco, Inmaculada Sanchez-Machin, Paloma Poza-Guedes, Ruperto Gonzalez-Perez, Victor Matheu
Summary: The study assessed the specific antibody and T cell immune response in vaccinated individuals using classic ELISA and DTH skin test. Results showed that most individuals exhibited positive immune responses post-vaccination. This method has potential applications in large-scale vaccine studies.
Article
Allergy
Carina M. Woodruff, Nina Botto
Summary: Confirming drug imputability is crucial in managing cutaneous adverse drug reactions (CADR). Patch testing, although widely used, shows significant variability in test positivity among different drugs and types of reactions. It may be worthwhile in certain common CADRs, but its utility is limited and not recommended in complex cases.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Allergy
Ji-Hyang Lee, Chan Sun Park, Min Ju Pyo, A. Ryang Lee, Eunyong Shin, Young-Sang Yoo, Woo-Jung Song, Tae-Bum Kim, You-Sook Cho, Hyouk-Soo Kwon
Summary: This study compared the diagnostic value of intradermal tests (IDTs) and the ImmunoCAP test for cefaclor-induced immediate-type hypersensitivity. The results showed that regardless of the severity of the hypersensitivity reaction, IDT was more sensitive than ImmunoCAP for diagnosing cefaclor allergy. Therefore, a combination of IDT and ImmunoCAP is recommended for the diagnosis of cefaclor hypersensitivity.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Dermatology
Jidapa Triwatcharikorn, Natthiya Pholmoo, Narumol Ratanasutiranont, Pawinee Rerknimitr, Jettanong Klaewsongkram
Summary: Drug-induced immune complex-mediated vasculitis is primarily diagnosed based on medical history, clinical setting, and laboratory evidence. Skin test with delayed reading can play a potential role in diagnosing some instances of immune complex-mediated hypersensitivity reactions.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Chemistry, Medicinal
Katarzyna Nazimek, Eugenio Bustos-Moran, Noelia Blas-Rus, Bernadeta Nowak, Justyna Toton-Zuranska, Michal T. Seweryn, Pawel Wolkow, Olga Woznicka, Rafal Szatanek, Maciej Siedlar, Philip W. Askenase, Francisco Sanchez-Madrid, Krzysztof Bryniarski
Summary: This study demonstrates that suppressor T cell-derived EVs carrying miRNA-150 can antigen-specifically downregulate mouse delayed-type hypersensitivity. Pre-incubation with antigen-specific antibodies enhances the inhibitory effect of macrophage-released EVs on effector T cells. The specific binding of EVs to MHC class II-expressing EVs promotes their aggregation and significantly increases their suppressive activity in vivo, potentially offering therapeutic benefits.
Article
Immunology
Alycia P. Fratzke, Anthony E. Gregory, Erin J. van Schaik, James E. Samuel
Summary: Q-VAX (R), a vaccine for Q fever, provides long-term protection but can cause reactions in sensitized individuals, limiting its use outside Australia. Studying different mouse strains revealed that the reactions to C. burnetii whole cell vaccine are consistent with a Th1 delayed-type hypersensitivity response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Juliette Caron, Sahara Graf, Christine Delebarre-Sauvage
Summary: Among patients with immediate hypersensitivity reactions to iodinated contrast media, the rate of confirmed allergic patients by positive skin tests was 8.1%. Despite negative skin test results, 12.5% of re-exposed patients experienced recurrent hypersensitivity reactions. Additional investigations on pure intradermal tests to contrast media and development of drug provocation tests could provide a safety net for detecting recurrent reactors. Agreement among allergists is necessary to standardize practices.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Review
Allergy
Feng Xu, Hongting Zhang, Hao Xiao, Juan Meng
Summary: This case report highlights a delayed-type IV allergic reaction to furazolidone in a patient receiving treatment for H.pylori infection. Clinicians should be aware of the potential for hypersensitivity to furazolidone.
CONTACT DERMATITIS
(2023)
Article
Dermatology
Joseph Han, Scott Stratman, Jade N. Young, Dina Poplausky, Shayan Owji, Yen Luu, Yeriel Estrada, Joel Correa da Rosa, James G. Krueger, Nicholas Gulati
Summary: Diphencyprone (DPCP) causes a delayed-type hypersensitivity reaction when applied topically, and is used clinically for various conditions. In this study, proteomic analysis of healthy volunteers showed upregulation of immune cell activation, tissue remodeling, antineoplastic markers, and Th1 axis markers following DPCP application. Negative regulators of immune function were also upregulated, which may explain the therapeutic benefits in autoimmune conditions. The study also revealed a transient Th2 response followed by Th1 polarization. Overall, DPCP induces a complex and evolving immunological response.
JOURNAL OF DERMATOLOGY
(2023)