Article
Microbiology
Emerenziana Ottaviano, Giovanna Baron, Laura Fumagalli, Jessica Leite, Elisa Adele Colombo, Angelica Artasensi, Giancarlo Aldini, Elisa Borghi
Summary: The study demonstrated the efficacy of urinary cranberry metabolites VAL and 4-HBA in inhibiting Candida adhesion and biofilm formation in vitro. These metabolites interfered with yeast adhesion by modulating key gene expression, leading to a significant reduction in biofilm biomass and metabolic activity. The findings suggest that VAL and 4-HBA could be potential targets for drug development in preventing genitourinary Candida infections.
Article
Food Science & Technology
Quan Lin, Yanxin Li, Maokun Sheng, Jiaman Xu, Xiaoyan Xu, Jintae Lee, Yulong Tan
Summary: In recent years, there has been an increasing trend in Candida contamination caused by Candida mastitis, which has a significant impact on the hygienic quality of raw milk and dairy products. The biofilm produced by Candida albicans plays a critical role in fungal infection by protecting the fungus from host defense and drug attacks. Therefore, finding effective means to reduce the biofilm and drug resistance of Candida albicans has become an urgent problem. This study investigated the anti-biofilm effect of berberine-loaded chitosan nanoparticles on Candida albicans and explored the antifungal mechanism of released berberine.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Immunology
Maral Gharaghani, Ali Rezaei-Matehkolaei, Amir Kamal Hardani, Ali Zarei Mahmoudabadi
Summary: The presence of Candida species in urine is often due to colonization in the bladder, urinary catheter, and perineum. Various virulence factors of Candida albicans contribute to its pathogenicity. Genotyping, extracellular enzymes, phenotype switching, and biofilm formation can help in identifying and understanding Candida isolates.
MICROBIAL PATHOGENESIS
(2021)
Article
Microbiology
Eunsoo Do, Max Cravener, Manning Y. Huang, Gemma May, C. Joel McManus, Aaron P. Mitchell
Summary: In this study, natural variation in the fungal pathogen Candida albicans was investigated to understand the gene regulatory control of biofilm formation, an important aspect of its virulence. Collaboration between the transcription factors Efg1 and Wor1 was found to drive natural variation in biofilm formation and gene expression. These findings highlight the importance of studying natural isolates to uncover unexpected features of gene function.
Article
Biochemistry & Molecular Biology
Lana Glerieide Silva Garcia, Maria Gleiciane da Rocha, Laysa Rocha Lima, Arcelina Pacheco Cunha, Jonathas Sales de Oliveira, Ana Raquel Colares de Andrade, Nagila Maria Pontes Silva Ricardo, Waldemiro Aquino Pereira-Neto, Jose Julio Costa Sidrim, Marcos Fabio Gadelha Rocha, Rodrigo Silveira Vieira, Raimunda Samia Nogueira Brilhante
Summary: The study aimed to produce and characterize chitosan microparticles loaded with essential oils, evaluate their anti-Candida activity, and assess essential oil release profile. The results showed that these microparticles have promising antibiofilm activity against Candida.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biophysics
Florian Weber, Louise Morais Dornelas-Figueira, Nora Hafiane, Daria Zaytseva-Zotova, Alejandro Barrantes, Fernanda Cristina Petersen, Hanna Tiainen
Summary: Oral biofilms can cause infections and diseases, and the role of fungi is often overlooked in research. Plant-derived polyphenolic coatings may be effective in resisting microbial growth and adhesion, but further research is needed.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Microbiology
Sabi Pokhrel, Nawarat Boonmee, Orawan Tulyaprawat, Sujiraphong Pharkjaksu, Iyarit Thaipisutikul, Phoom Chairatana, Popchai Ngamskulrungroj, Chalermchai Mitrpant
Summary: Biofilm formation is an important virulence factor for the pathogenesis of Candida albicans. This study used the zebrafish model to evaluate the in vivo virulence of strains with different biofilm formation strengths. The results showed that stronger biofilm formation was associated with shorter survival time in zebrafish and higher up-regulation of biofilm-associated genes.
Article
Microbiology
Petr Jaros, Maria Vrublevskaya, Kristyna Lokocova, Jana Michailidu, Irena Kolouchova, Katerina Demnerova
Summary: The use of antibiotics and antifungals to control infections caused by pathogenic microorganisms is currently ineffective due to emerging resistance. Boswellia serrata extract containing boswellic acids has shown promising antifungal activity against Candida species.
Article
Food Science & Technology
Peng-Wei Wei, Chao-Rong Song, Xu Wang, Ming Chen, Yong-Xin Yang, Cong Wang, Zu-Quan Hu, Hong-Mei Liu, Bing Wang
Summary: This study synthesized a housefly larval antimicrobial peptide, Phormicin C-NS, and found that it exhibited anti-C. albicans activity. Transcriptomic analysis revealed the mechanism by which Phormicin C-NS inhibited C. albicans. The peptide was able to inhibit bud-to-hyphal transition and biofilm formation, and reduce C. albicans propagation in pasteurized milk. Therefore, Phormicin C-NS has potential as a new preservative in the milk industry.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Dermatology
Debora Casagrande Pierantoni, Laura Corte, Arturo Casadevall, Vincent Robert, Gianluigi Cardinali, Carlo Tascini
Summary: This study aimed to investigate the thermal tolerance of biofilms formed by three medically relevant fungal species. The results showed that Candida sessile cells have a strain-specific response to different temperatures, with attachment and growth mechanisms showing different outputs at high temperatures. The strain-dependent response observed may be essential for the success of infection, attachment, and growth of these fungal species, especially in the context of increasing environmental temperatures and excessive domestic heating.
Article
Immunology
Marion Girardot, Marion Millot, Guillaume Hamion, Jeanne-Louise Billard, Camille Juin, G. M. A. Ndong Ntoutoume, Vincent Sol, Lengo Mambu, Christine Imbert
Summary: Lichens, with their symbiotic nature of fungi and algae, produce unique polyphenolic compounds that show potential anti-biofilm activity against Candida albicans. Among these compounds, evernic acid stands out as an effective inhibitor of biofilm formation and maturation, showing low toxicity and no hemolytic activity at active concentrations.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Lingbing Zeng, Yongcheng Huang, Junjun Tan, Jun Peng, Niya Hu, Qiong Liu, YanLi Cao, Yuping Zhang, Junzhu Chen, Xiaotian Huang
Summary: This study investigates the role of the cytochrome b-c1 complex subunit 7 gene (QCR7) in the virulence of Candida albicans. Defective QCR7 reduces inflammation cell recruitment and attenuates the virulence of C. albicans infection. It also affects the use of multiple carbon sources and causes mitochondrial dysfunction. Furthermore, overexpression of cell-surface-associated genes can restore the defective virulence and carbon-source utilization of the QCR7 knockout strain.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
P. Gupta, V. Pruthi, K. M. Poluri
Summary: The study demonstrates that Eucalyptol has anti-biofilm activity against Candida strains, affecting biochemical components and enzyme activity. Additionally, Eucalyptol influences cell cycle, mitochondrial membrane potential, ROS generation, and transcriptional expression of selected genes.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Infectious Diseases
Ghada El-Saeed Mashaly, Mayada Sabry Zeid
Summary: This study investigated the relationship between genotype, virulence factors and fluconazole tolerance among Candida albicans isolates from pediatric patients. The results showed that genotype A was the most prevalent, and biofilm formation and enzyme production were important virulence determinants in pediatric infections. Fluconazole tolerance was significantly correlated with biofilm formation and proteinase production.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Yu Wang, Zejun Pei, Zaixiang Lou, Hongxin Wang
Summary: The study demonstrated the inhibitory and eradicating effects of cordycepin on Candida albicans biofilms, reducing their metabolic activity and damaging the biofilm structure. Furthermore, cordycepin showed low acute toxicity in mice, suggesting its safety as a potential antifungal agent.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Biochemistry & Molecular Biology
Mohd Adnan, Saleha Anwar, Debarati DasGupta, Mitesh Patel, Abdelbaset Mohamed Elasbali, Hassan H. Alhassan, Alaa Shafie, Arif Jamal Siddiqui, Fevzi Bardakci, Mejdi Snoussi, Md. Imtaiyaz Hassan
Summary: In this study, the alkaloid Harmaline (HAR) was investigated for its potential as a MARK4 inhibitor. Molecular docking and fluorescence binding studies showed a strong binding affinity between HAR and MARK4, and HAR significantly inhibited the kinase activity of MARK4. Structural investigations revealed that HAR binds to the active site pocket of MARK4 and forms multiple non-covalent interactions with biologically important residues. These findings suggest that HAR could be a potential therapeutic agent for MARK4-related diseases, including Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Arif Jamal Siddiqui, Mitesh Patel, Mohd Adnan, Sadaf Jahan, Juhi Saxena, Mohammed Merae Alshahrani, Abdelmushin Abdelgadir, Fevzi Bardakci, Manojkumar Sachidanandan, Riadh Badraoui, Mejdi Snoussi, Allal Ouhtit
Summary: The objective of this study was to synthesize bacteriocin-derived silver nanoparticles (Bac10307-AgNPs) from Lactobacillus acidophilus (L. acidophilus) to enhance the bioactivity of bacteriocins and overcome their commercial limitations. The synthesized Bac10307-AgNPs showed strong antibacterial activity, promising antioxidant activity, and cytotoxicity against human liver cancer cells.
Article
Biochemistry & Molecular Biology
Mejdi Snoussi, Ramzi Hadj Lajimi, Riadh Badraoui, Mousa Al-Reshidi, Mohammad A. A. Abdulhakeem, Mitesh Patel, Arif Jamal Siddiqui, Mohd Adnan, Karim Hosni, Vincenzo De Feo, Flavio Polito, Adel Kadri, Emira Noumi
Summary: This study investigated the chemical composition and medicinal properties of Ducrosia flabellifolia Boiss., a rare desert plant species. The major compounds in the volatile oil were identified as decanal and dodecanal, while the methanolic extract contained phenolic compounds. The extract showed antimicrobial and antioxidant activities, and exhibited anticancer activity against various cancer cell lines. Computational analysis revealed strong binding affinities between the identified compounds and certain proteins. These findings highlight the ethnopharmacological properties of D. flabellifolia and its potential applications in medicine.
Article
Infectious Diseases
Mohd Adnan, Arif Jamal Siddiqui, Emira Noumi, Sami Hannachi, Syed Amir Ashraf, Amir Mahgoub Awadelkareem, Mejdi Snoussi, Riadh Badraoui, Fevzi Bardakci, Manojkumar Sachidanandan, Mirav Patel, Mitesh Patel
Summary: This study used a network pharmacology approach to investigate the anti-listeriosis properties of biosurfactants and their mechanisms of action. It identified certain biosurfactants with potential therapeutic effects against L. monocytogenes infection and explored their pharmacological mechanisms, providing a foundation for further research and development.
Article
Biology
Emira Noumi, Iqrar Ahmad, Nouha Bouali, Harun Patel, Siwar Ghannay, Ayshah Aysh ALrashidi, Mohammad A. A. Abdulhakeem, Mitesh Patel, Ozgur Ceylan, Riadh Badraoui, Afnan Elayyan Mousa Elayyan, Mohd Adnan, Adel Kadri, Mejdi Snoussi
Summary: In this study, the phytochemical composition, antimicrobial, antioxidant, anti-quorum sensing, and anticancer activities of Thymus musilii methanolic extract were investigated. The results showed that the extract exhibited high antifungal and antibacterial activity, as well as strong antioxidant properties. The in silico docking study suggested that the constituent compounds of T. musilii may have potential antimicrobial, antioxidant, and anticancer activities.
Article
Biology
Nouha Bouali, Walid Sabri Hamadou, Riadh Badraoui, Ramzi Hadj Lajimi, Assia Hamdi, Mousa Alreshidi, Mohd Adnan, Zohra Soua, Arif Jamal Siddiqui, Emira Noumi, Mejdi Snoussi
Summary: Cancer is a leading cause of death globally, and attention is shifting towards natural products like honey for the development of new cancer therapies. This study evaluated the phytochemical profiling, antioxidant properties, drug-likeness, and anticancer activity of Ziziphus honey (ZH) from Saudi Arabia. The results showed that ZH contains various compounds with antioxidant and anticancer effects, making it a potential source for bioactive compounds.
Article
Polymer Science
Mohd Adnan, Arif Jamal Siddiqui, Syed Amir Ashraf, Mejdi Snoussi, Riadh Badraoui, Angum M. M. Ibrahim, Mousa Alreshidi, Manojkumar Sachidanandan, Mitesh Patel
Summary: In recent years, there has been an increasing interest in bio-based degradable plastics as a substitute for synthetic plastics. Polyhyroxybutyrate (PHB), a macromolecule produced by bacteria, has fast degradation properties, making it a potential alternative for biodegradable plastics. This study isolated PHB-producing bacteria from soil samples collected from a solid waste landfill site in Saudi Arabia. Bacillus flexus was found to accumulate the highest amount of PHB among all the isolated bacteria. The production of PHB using agro-residues as carbon sources was evaluated, and the optimal conditions for PHB synthesis were determined using response surface methodology (RSM). This research demonstrates that B. flexus has the potential to produce industrial-scale quantities of PHB from agricultural wastes, providing a solution to the environmental concerns associated with synthetic plastics.
Article
Environmental Sciences
Arif Jamal Siddiqui, Nisha Kumari, Mohd Adnan, Sanjeev Kumar, Abdelmushin Abdelgadir, Juhi Saxena, Riadh Badraoui, Mejdi Snoussi, Puja Khare, Ritu Singh
Summary: In this study, a magnetic nanocomposite based on biochar, nanoscale zerovalent iron, and chitosan was fabricated for the removal of aspirin and carbamazepine. The nanocomposite was characterized and optimized using a response surface methodology. Under optimized conditions, the maximum removal efficiency of aspirin was observed to be 97.8%, while for carbamazepine, it was 89.32%. The isotherm models, kinetics models, and thermodynamic parameters confirmed the effectiveness and feasibility of the nanocomposite.
Article
Chemistry, Multidisciplinary
Khouloud Hchicha, Elena Cambiotti, Hmed Ben-Nasr, Daniel Chappard, Matti Haukka, Loredana Latterini, Salem Elkahoui, Arif J. Siddiqui, Mejdi Snoussi, Mohd Adnan, Houcine Naili, Riadh Badraoui
Summary: A sulfate-bridged copper complex with high thermal stability and therapeutic properties against skeletal metastases in breast cancer cells was synthesized. The structure analysis revealed a 1D chain-like structure interconnected by covalent sulfate linkages and a 2D network formed through hydrogen bonding. Optical studies demonstrated a hypsochromic effect in the absorption and photoluminescence spectra of the compound.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Correction
Chemistry, Multidisciplinary
Manel Ben Hammouda, Iqrar Ahmad, Assia Hamdi, Amal Dbeibia, Harun Patel, Nouha Bouali, Walid Sabri Hamadou, Karim Hosni, Siwar Ghannay, Fahad Alminderej, Emira Noumi, Mejdi Snoussi, Kaiss Aouadi, Adel Kadri
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Emira Noumi, Iqrar Ahmad, Mohd Adnan, Harun Patel, Abderrahmen Merghni, Najla Haddaji, Nouha Bouali, Khulood Fahad Alabbosh, Adel Kadri, Lucia Caputo, Flavio Polito, Mejdi Snoussi, Vincenzo De Feo
Summary: Star anise, also known as Illicium verum, has various uses including culinary and religious purposes. This study aimed to analyze the chemical composition and antibacterial properties of the essential oil obtained from Illicium verum. The results showed that the essential oil had significant antibacterial effects against various bacterial strains and inhibited biofilm formation.
Article
Biotechnology & Applied Microbiology
Yazeed Albulaihed, Mohd Adnan, Arshad Jamal, Mejdi Snoussi, Kartik Patel, Mitesh Patel
Summary: This study aimed to isolate bacteria capable of producing laccase enzymes and optimize laccase production using response surface methodology (RSM) and the one variable at a time approach. The identified bacterium, Stenotrophomonas maltophilia, was able to produce three times more laccase than the unoptimized medium. The laccase exhibited efficient dye decolorization capabilities and enzymatic detoxification of the dye metabolites.
BIORESOURCES AND BIOPROCESSING
(2023)
Article
Agricultural Engineering
Ibtissem Chakroun, Zied Bouraoui, Takwa Ayachi, Karim Hosni, Hamadi Guerbej, Mejdi Snoussi, Jamel Jebali, Tahar Gharred
Summary: This study investigated the phytochemical composition and bioactivities of polar and non-polar extracts from Tunisian Thomson Navel orange peels. The extracts exhibited promising antioxidant, antimicrobial, and cytotoxic effects, making them potential sources for developing natural agents.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
