Journal
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Volume 754, Issue 1-2, Pages 63-70Publisher
ELSEVIER
DOI: 10.1016/j.mrgentox.2013.04.008
Keywords
Low benzene exposure; Genotoxicity; Protein carbonyl; 3-Nitrotyrosine; Vitamin C
Funding
- CNPq/Universal [479613/2009-5, 484096/2011-7]
- FAPERGS [1017503 PqG 06/2010]
- CAPES
- CNPq
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We evaluated genotoxic effects of exposure to low levels of benzene, a class I human carcinogen, among gasoline station attendants (GSA). Oxidative stress and the protective effects of antioxidants on DNA damage were also analyzed. Although exposures were below ACGIH (American Conference of Governmental Industrial Hygienists) limits, the GSA group presented higher DNA damage indices and micronucleus frequencies, increased oxidative protein damage, and decreased antioxidant capacity relative to the control group. Duration of benzene exposure was correlated with DNA and protein damage. The biomarkers evaluated in this work may provide early signals of damage in subjects occupationally exposed to benzene. (C) 2013 Elsevier B.V. All rights reserved.
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