Article
Geriatrics & Gerontology
Teresa Juarez-Cedillo, Nancy Martinez-Rodriguez, Gilberto Vargas-Alarcon, Enrique Juarez-Cedillo, Antonio Valle-Medina, Osvaldo Garrido-Acosta, Alfredo Ramirez
Summary: Neuroinflammation plays an important role in certain types of dementia. This study found that gene-gene interaction models can be used to identify populations susceptible to dementia.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Mengni Wang, Chang Peng, Hongjuan Chang, Mengying Yu, Fajuan Rong, Yizhen Yu
Summary: This study reveals the interaction between SIRT1 gene and childhood maltreatment on aggressive behavior among Chinese adolescents. The minor allele of SIRT1 rs4746720 shows a protective effect on reducing aggression risk when combined with childhood maltreatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Genetics & Heredity
Ayatun Nesa, Md. Mostafijur Rahman, Md Tahminur Rahman, Yearul Kabir
Summary: This study aimed to investigate the association of NAT2, GSTT1, and GSTM1 gene polymorphisms with prostate cancer risk in the Bangladeshi population. The results showed a higher frequency of mutant NAT2*5A, NAT2*6A, and NAT2*7A in prostate cancer cases compared to controls. The presence of NAT2 slow genotypes, GSTT1 genotype, and GSTM1 genotype significantly increased the risk of prostate cancer.
Article
Physiology
Yijun Wang, Qiongling Yang, Lingzhen Zheng
Summary: The aim of this study was to investigate the association between oxidative stress, programmed cell death, smoking, and the GSTM1 gene in the risk of lung carcinogenesis. The results of a two-step Mendelian randomization analysis revealed evidence of association between the exposure and mediators with the resulting outcome. Smoking was found to interfere with the GSTM1 gene, leading to programmed cell death in the lungs and ultimately causing lung carcinogenesis. The study highlighted the significance of oxidative stress, programmed cell death, and the GSTM1 gene in the development of lung cancer.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gordana Nedic Erjavec, Mirko Grubor, Maja Zivkovic, Nada Bozina, Marina Sagud, Matea Nikolac Perkovic, Alma Mihaljevic-Peles, Nela Pivac, Dubravka Svob Strac
Summary: Antipsychotic-induced parkinsonism is the most common extrapyramidal side effect caused by the blockage of dopamine receptors. This study found significant associations between HTR6 gene polymorphism and tremor and rigidity induced by haloperidol. Additionally, a combined effect of HTR6 T and SLC6A3 9R alleles on AIP was observed.
Article
Biochemistry & Molecular Biology
Jianming Fang, Fazhuang Fang, Jianxin Huang, Xiaodong Zhang, Hongjuan Wang
Summary: This study explores the relationship between GSTMI and GSTT1 gene polymorphisms and gallbladder cancer and finds that the deletion frequency of these two genes significantly reduces after treatment. Therefore, conducting gene testing before surgical treatment of gallbladder cancer can improve treatment effect.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Review
Genetics & Heredity
Jing Ye, Yi-Yang Mu, Jiong Wang, Xiao-Feng He
Summary: This study investigated the association between GSTM1 and GSTT1 null genotypes and the risk of cervical or ovarian cancer. The overall analysis showed that GSTM1 null genotype was associated with increased risk of cervical cancer, while GSTT1 null genotype was not significantly associated with cervical cancer. For ovarian cancer, GSTM1 null genotype was associated with increased risk in East Asia, and GSTT1 null genotype was associated with increased risk in South America. However, the confidence of these associations was low.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Leticia Madureira Pacholak, Rodrigo Kern, Stefania Tagliari de Oliveira, Leia Carolina Lucio, Marla Karine Amarante, Roberta Losi Guembarovski, Maria Angelica Ehara Watanabe, Carolina Panis
Summary: The study found that polymorphisms in GSTM1 and GSTT1 genes were not associated with breast cancer susceptibility, and did not have a significant impact on GSH levels in patients. Further research is needed to understand the relationship between these polymorphisms and breast cancer.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Nutrition & Dietetics
Somayeh Hosseinpour-Niazi, Bahar Bakhshi, Asiyeh-Sadat Zahedi, Mahdi Akbarzadeh, Maryam S. Daneshpour, Parvin Mirmiran, Fereidoun Azizi
Summary: The study found that high nut consumption may be associated with a reduced risk of MetS in individuals with certain TCF7L2 gene variants (rs7903146 and rs12255372), and weight change may modify this association.
NUTRITION & METABOLISM
(2021)
Review
Genetics & Heredity
Yan Zhao, Di Wang, Cheng-Yu Zhang, Yan-Ju Liu, Xiao-Hui Wang, Meng-Ying Shi, Wei Wang, Xu-Liang Shen, Xiao-Feng He
Summary: This study found that GSTM1, GSTT1, and GSTP1 IIe105Val polymorphisms are associated with leukemia risk, but the combined effects are not significant. A significant increase in leukemia risk was observed only for the GSTT1 null genotype in Asians.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Ruo-Xi Chen, Meng-Di Dai, Qing-Zhao Zhang, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Xin-Jie Zhu, Zhong-Fei Wu, Zheng-Dong Zhang, Lei Cheng
Summary: This study explored the genetic association of allergic rhinitis (AR) with single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway. It found that genetic polymorphisms in TLR2 and CD14, as well as gene-gene interactions, were associated with susceptibility to AR in this Han Chinese population. However, the results regarding gene-environment interactions were limited.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Medicine, General & Internal
Yunchao Ou, Xiaoli Jiang, Huiwen Guan
Summary: The study found a significant association between the FokI rs2228570 polymorphism and the risk of atopic dermatitis, while no significant associations were found for TaqI, BsmI, and ApalI polymorphisms. Certain haplotypes were found to significantly increase the risk of AD. The effects of rs2228570 were more evident in certain subgroups, and the C allele of rs2228570 decreased relative mRNA expression.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Kuo Liu, Yunyi Xie, Qian Zhao, Wenjuan Peng, Chunyue Guo, Jie Zhang, Ling Zhang
Summary: This study found that SNPs and haplotypes in AGER and IL6R genes, as well as the interaction between rs184003 and rs4845625, were significantly associated with diabetic IHD.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Federica Ghelli, Valeria Bellisario, Giulia Squillacioti, Marco Panizzolo, Alfredo Santovito, Roberto Bono
Summary: This study investigated alterations in oxidative and inflammatory status among hospital workers, finding significantly higher levels of 15-F-2t-IsoP, MDA, and TNF-alpha in those exposed to formaldehyde. The air formaldehyde levels were positively correlated with oxidative and inflammatory markers.
Article
Orthopedics
Jun Li, Zebing Liu, Yanxia Ren, Han Shao, Siyuan Li
Summary: This study found that LRP5-rs2306862 and LRP6-rs2302685 gene polymorphisms and gene-gene and gene-age interactions may increase the risk of abnormal bone mass in postmenopausal women. However, there was no significant association between any of the SNPs and menopausal years and ABM susceptibility.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Environmental Sciences
Radek Indra, Petr Pompach, Katarina Vavrova, Katefina Jaklova, Zbynek Heger, Vojtech Adam, Tomag Eckschlager, Katefina Kopeacova, Volker Manfred Arlt, Marie Stiborova
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2020)
Article
Genetics & Heredity
Thomas R. Downs, Volker M. Arlt, Brenda C. Barnett, Ryan Posgai, Stefan Pfuhler
Summary: The metabolites of 2-AAF are more efficiently detected in the skin comet assay than the RSMN assay, and after multiple exposures and enzyme induction, 2-AAF-induced DNA damage can be detected in the APC-modified comet assay.
Article
Chemistry, Medicinal
Alena Dedikova, Frantisek Barta, Vaclav Martinek, Kevin Kotalik, Sarka Duskova, Jaroslav Mraz, Volker Manfred Arlt, Marie Stiborova, Petr Hodek
CHEMICAL RESEARCH IN TOXICOLOGY
(2020)
Article
Toxicology
Mustafa Abbass, Yuzhi Chen, Volker M. Arlt, Stephen R. Sturzenbaum
Summary: The study found that exposure to high concentrations of BaP significantly impacted life cycle endpoints of C. elegans, such as reduced reproductive output and shortened lifespan, despite the absence of the classical CYP1A1 bioactivation pathway. DNA damage increased dose-dependently, but no bulky DNA adducts were observed. Transcriptomic analysis identified changes in gene expression related to xenobiotic metabolism, suggesting the involvement of parallel pathways in BaP metabolism in C. elegans.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Food Science & Technology
Lisa Holzl-Armstrong, Sarah Moody, Jill E. Kucab, Edwin P. Zwart, Medjda Bellamri, Mirjam Luijten, Robert J. Turesky, Michael R. Stratton, Volker M. Arlt, David H. Phillips
Summary: The metabolite of PhIP, N-OH-PhIP, induces G:C base pair transversions in the human TP53 gene, with a high frequency of G > T/C > A transversions. The mutational signature of N-OH-PhIP-treated clones shows similarity to signatures found in human tumors, indicating a potential link between PhIP exposure and cancer development.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Genetics & Heredity
Lisa Holzl-Armstrong, Andrea Naevisdal, Julie A. Cox, Alexandra S. Long, Nikolai L. Chepelev, David H. Phillips, Paul A. White, Volker M. Arlt
Summary: The study assessed three human carcinogens and their proximate metabolites to aid in the validation of the FE1 cell mutagenicity assay. Results showed varying levels of mutagenicity for different compounds, with the most potent being N-OH-PhIP -S9. Gene expression analysis revealed the role of key CYP isozymes in metabolizing the compounds. The FE1 cell mutagenicity assay has the potential to be used alongside other traditional in vitro mutagenicity assays.
Article
Environmental Sciences
Lisa Holzl-Armstrong, Jill E. Kucab, Edwin P. Zwart, Mirjam Luijten, David H. Phillips, Volker M. Arlt
Summary: TP53 gene harbors somatic mutations in human tumors, with bladder cancer showing unique mutation distribution. Using human TP53 knock-in mouse embryo fibroblasts (HUFs) as a model, it was found that treatment with N-OH-4-ABP induced mutations in TP53 gene.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2021)
Article
Environmental Sciences
Michael N. Moore, Susanna Sforzini, Aldo Viarengo, Audrey Barranger, Yann Aminot, James W. Readman, Andrei N. Khlobystov, Volker M. Arlt, Mohamed Banni, Awadhesh N. Jha
Summary: The hypothesis that C-60 fullerene nanoparticles exert an antagonistic interactive effect on the toxicity of benzo[a]pyrene was supported by this investigation. The combination treatment of C-60 and BaP was found to reduce cellular damage caused by BaP alone, and the scavenging property of C-60 against reactive oxygen species was identified as a key factor in reducing oxidative damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Efrain Rios-Sanchez, Alberto Gonzalez-Zamora, Maria Eugenia Gonsebatt Bonaparte, Elizabeth Meza Mata, Maria Fernanda Gonzalez-Delgado, Alejandra Zamago Amaro, Rebeca Perez-Morales
Summary: Nitrates, naturally occurring in soil and water, have detrimental effects on human health due to the excessive use of fertilizers increasing their groundwater presence. Subchronic exposure to sodium nitrate in female rats resulted in leukocytosis, histological changes in liver and thyroid tissues, and upregulation of genes involved in thyroid hormone synthesis without affecting hormone levels, indicating a stable thyroid hormone status.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Genetics & Heredity
Angela L. Caipa Garcia, Volker M. Arlt, David H. Phillips
Summary: Advances in three-dimensional cell culture technology have allowed the development of organoids, which have proven useful for studying organ development, disease, toxicology, and drug screening. Organoids derived from pluripotent stem cells have greater complexity compared to those derived from adult stem cells. These organoids have been beneficial for pre-clinical testing of personalized treatments and in developing large toxicity and efficacy screens. They have also shown promise in environmental and genetic toxicology studies, providing responses similar to those observed in primary tissues and in vivo models.
Article
Environmental Sciences
Edgar Garcia-Torres, Rebeca Perez-Morales, Alberto Gonzalez-Zamora, Esperanza Yasmin Calleros-Rincon
Summary: This study evaluated the relationship between chronic exposure to nitrates and thyroid function in rural zone families. The results showed a negative correlation between methemoglobin and thyroid hormones, as well as a high frequency of subclinical hypothyroidism in the population under study, which may be related to the consumption of nitrate-contaminated water.
Article
Biochemistry & Molecular Biology
Angela L. Caipa L. Garcia, Jill E. E. Kucab, Halh Al-Serori, Rebekah S. S. Beck, Franziska Fischer, Matthias Hufnagel, Andrea Hartwig, Andrew Floeder, Silvia Balbo, Hayley Francies, Mathew Garnett, Meritxell Huch, Jarno Drost, Matthias Zilbauer, Volker M. M. Arlt, David H. H. Phillips
Summary: Human organoids derived from different tissues have the ability to metabolize the environmental carcinogen benzo[a]pyrene. The response and metabolite formation of the organoids varied between tissue types. This study demonstrates the potential of organoids for studying environmental carcinogenesis and genetic toxicology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Diana Dennys Gandarilla-Esparza, Esperanza Yasmin Calleros-Rincon, Hortensia Moreno Macias, Maria Fernanda Gonzalez-Delgado, Gonzalo Garcia Vargas, Jaime Duarte Sustaita, Alberto Gonzalez-Zamora, Efrain Rios-Sanchez, Rebeca Perez-Morales
Summary: This study found that chronic exposure to nitrates in drinking water can lead to metabolic and hormonal alterations as well as genotoxic damage in women.
GENETICS AND MOLECULAR BIOLOGY
(2021)