Article
Environmental Sciences
Raphael B. de Souza, Cleiton Pereira de Souza, Jose Roberto Guimaraes
Summary: This study evaluated the phytotoxicity and genotoxicity of Eprinomectin, a veterinary drug widely used in the agricultural sector. The results showed that Eprinomectin affected root development and germination speed, as well as induced chromosomal aberrations and micronuclei. Therefore, the release of Eprinomectin into the environment should be minimized.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Onisan Emilian, Sarac Ioan, Petrescu Irina, Pascalau Raul, Ciulca Adriana, Camen Dorin, Stroia Ciprian
Summary: Salt stress causes cytotoxicity, disrupting the vacuolization process and mitotic division, leading to inhibited plant growth. The experiment evaluated the effects of different NaCl concentrations on sunflower seeds, showing that salt stress increases vacuolization, decreases mitotic index, and increases chromosomal aberrations.
APPLIED SCIENCES-BASEL
(2023)
Article
Oncology
Kavya Prasad, Mathew Bloomfield, Hagai Levi, Kristina Keuper, Sara Bernhard, Nicolaas C. Baudoin, Gil Leor, Yonatan Eliezer, Maybelline Giam, Cheng Kit Wong, Giulia Rancati, Zuzana Storchova, Daniela Cimini, Uri Ben-David
Summary: The interactions between whole-genome duplication and aneuploidy are crucial for tumor evolution, emphasizing the importance of considering genome status in the analysis and modeling of cancer aneuploidy.
Article
Biochemistry & Molecular Biology
Yu-Syuan Luo, Tai-Ying Long, Su-Yin Chiang, Kuen-Yuh Wu
Summary: This study investigated the toxicokinetics of AA, GA2, and GA3-GSH in Sprague Dawley rats, showing rapid formation, elimination, and linear kinetics of these conjugates. The values of AA-and GA-GSHs represent direct detoxification of AA and GA in vivo, providing insights into sex and inter-species differences in AA detoxification.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Obstetrics & Gynecology
Seo-Jin Park, Ji-You Min, Jeom-Soon Kang, Byung-Guk Yang, Seung-Yong Hwang, Sung-Hee Han
Summary: This study investigated the demographic data and karyotypes of 19,000 couples who experienced recurrent spontaneous abortion (RSA). The results showed that 4.44% of the couples had chromosomal aberrations, with females being more likely to have them. The mean age of individuals with chromosomal aberrations was younger, and there were significant correlations between sex and age distribution and the subtypes of chromosomal aberrations.
FERTILITY AND STERILITY
(2022)
Article
Environmental Sciences
Anithadevi Kenday Sivaram, Panneerselvan Logeshwaran, Aravind Surapaneni, Kalpit Shah, Nicholas Crosbie, Zoe Rogers, Elliot Lee, Kartik Venkatraman, Kurunthachalam Kannan, Ravi Naidu, Mallavarapu Megharaj
Summary: The study found that PFOS has significant cytotoxic and genotoxic effects on Allium cepa root meristem cells. As the concentration increases, cell division decreases and chromosomal aberrations increase. This is the first study to investigate the cyto-genotoxic potential of PFOS in higher plants.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Review
Rheumatology
Amihood Singer, Julia Grinshpun-Cohen, Lena Sagi-Dain
Summary: The study revealed that there is an increased risk of fetal chromosomal aberrations in fetuses of colchicine-treated patients, but the absolute risk is relatively low. This information should be taken into consideration when contemplating invasive testing in such pregnancies.
Article
Environmental Sciences
Anna Lovinskaya, Saule Kolumbayeva, Mariya Suvorova
Summary: This study investigates the genotoxic potential in rivers and lakes of the Almaty agglomeration, Kazakhstan, and finds that the surface water contamination poses a threat to both organisms and human populations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Demography
Zhanbol B. Sabirov, Sharbanu B. Battakova, Maral B. Otarbayeva, Manara A. Mukasheva, Kispayev Tokhtar, Zhumagaliyeva Z. Zharkyn, Aliya B. Yeshmagambetova, Zhunusov Serik
Summary: The study examines the chromosomal mutations in residents living in the Aral Sea disaster zone, specifically focusing on the combined impact of a chemical mutagen (nickel) and bacterial microflora on the level of chromosomal aberrations. Various methods, including cell cultivation and determination of chromosomal aberrations, were used to analyze the samples. The results show that increased levels of the chemical agent in the blood lead to a higher frequency of chromosomal aberrations due to the damage caused to the cells and contamination by microflora. The study highlights the link between chemical exposure, membrane damage, and increased chromosomal mutations.
BIODEMOGRAPHY AND SOCIAL BIOLOGY
(2023)
Article
Engineering, Environmental
Sakthi Thesai Annadurai, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Rajakumar Sundaram, Mohankumar Periyasamy, Manikandan Rajendran, Ayyasamy Pudukadu Munusamy, Leticia Paiva Matos, Guilherme Malafaia
Summary: The present study focuses on the use of dead fungal mycelium as novel adsorbents for defluorination, and the results showed that the isolated fungus Aspergillus niger exhibited high fluoride adsorption capacity. The biosorption behavior followed pseudo-second-order kinetics and the Langmuir isotherm. Additionally, the study also found genotoxic effects of fluoride water contamination on biota through chromosome analysis. Therefore, the research has both theoretical and practical significance in the management of environmental pollution.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Medicine, Research & Experimental
Onat Kadioglu, Mohamed E. M. Saeed, Nuha Mahmoud, Shaymaa Azawi, Kristin Mrasek, Thomas Liehr, Thomas Efferth
Summary: The study characterized U87.MG Delta EGFR glioblastoma cells with constitutively active EGFR and identified novel drug resistance mechanisms related to the expression of mutation-activated EGFR. The cells showed numerous chromosomal aberrations and gene overexpression, including well-known drug resistance genes and novel ones. These findings may have important implications for future treatment strategies.
Article
Food Science & Technology
Sirajudheen Anwar, Siddique Akber Ansari, Abdulwahab Alamri, Abdulhakeem Alamri, Aali Alqarni, Saleh Alghamdi, Mohamed E. Wagih, Akbar Ahmad, Kannan R. R. Rengasamy
Summary: Camel Urine (CU) is composed of components with antitumor properties and therapeutic benefits. While being cytotoxic, CU does not induce clastogenic effects, and possesses anticlastogenic properties, making it a potential drug target for further research on metabolites profiling and molecular mechanisms.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Obstetrics & Gynecology
Lena Sagi-Dain, Amihood Singer, Reeval Segel, Racheli Berger, Bibi Kanengisser-Pines, Idit Maya
Summary: The study found that the residual risk of clinically significant chromosomal microarray analysis results in pregnancies with fetuses with congenital heart defects following normal noninvasive prenatal screening was higher than those in pregnancies with normal ultrasound. The detection rate of noninvasive prenatal screening varied depending on the type of congenital heart defect, with higher risks in certain subtypes. It is important for obstetricians and genetic counselors to consider this information when deciding on diagnostic testing options.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Genetics & Heredity
Paul Dremsek, Thomas Schwarz, Beatrix Weil, Alina Malashka, Franco Laccone, Juergen Neesen
Summary: Optical genome mapping has emerged as a promising method for detecting large-scale structural variants in human genomes, but further research is needed to understand its applications and limitations.
Article
Environmental Sciences
M. Alaguprathana, M. Poonkothai, Mysoon M. Al-Ansari, Latifah Al-Humaid, Woong Kim
Summary: This study assessed the cytogenotoxic effect of untreated and methyl orange treated on Allium cepa roots. It was found that roots exposed to treated dye solution had higher root growth, root length, and mitotic index, while roots exposed to untreated dye solution showed higher mitotic inhibition and chromosomal abnormalities. The research can be used as a biomarker to detect the genotoxic effects of textile dyes on biota.
ENVIRONMENTAL RESEARCH
(2022)
Article
Microbiology
Mafalda N. S. Miranda, Marta Pingarilho, Victor Pimentel, Maria do Rosario O. Martins, Rolf Kaiser, Carole Seguin-Devaux, Roger Paredes, Maurizio Zazzi, Francesca Incardona, Ana B. Abecasis
Summary: This study describes the patterns of transmitted and acquired drug resistance in HIV-1 infected patients in Europe and compares the patterns between late presenters and non-late presenters. The overall prevalence of transmitted drug resistance and acquired drug resistance showed a decreasing trend, with slightly lower transmitted drug resistance in late presenters and slightly higher acquired drug resistance in late presenters.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Mafalda N. S. Miranda, Marta Pingarilho, Victor Pimentel, Andrea Torneri, Sofia G. Seabra, Pieter J. K. Libin, Ana B. Abecasis
Summary: Emerging infectious diseases pose a significant threat to public health, and understanding the determinants and countermeasures of past pandemics is crucial for future preparedness.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Sara Raimondi, Sara Gandini, Gibran Horemheb Rubio Quintanares, Ana Abecasis, Pier Luigi Lopalco, Oriana D'Ecclesiis, Susanna Chiocca, Elisa Tomezzoli, Ilaria Cutica, Davide Mazzoni, Nuno Amparo, Marta Pingarilho, Daniela Carmagnola, Claudia Dallavia, Gianvincenzo Zuccotti, Chiara Ronchini, Federica Bellerba, Felix Dewald, Rolf Kaiser, Francesca Incardona
Summary: This study aims to determine whether the Lolli-Methode (LM) is useful in supporting schools reopening and reducing clusters and attack rates of SARS-CoV-2. The study will enroll 440 classes from two countries, with samples collected and tested using PCR techniques. An observational study will also be conducted to evaluate the effectiveness of preventive measures and psychological issues in students and teachers.
BMC INFECTIOUS DISEASES
(2023)
Article
Immunology
Adolfo de Salazar, Laura Vinuela, Ana Fuentes, Elisa Teyssou, Charlotte Charpentier, Sidonie Lambert-Niclot, Esther Serrano-Conde, Marta Pingarilho, Lavinia Fabeni, Anne De Monte, Karl Stefic, Carlo Federico Perno, Antonio Aguilera, Iker Falces, Rafael Delgado, Sandra Fernandes, Isabel Diogo, Perpetua Gomes, Dimitrios Paraskevis, Maria-Mercedes Santoro, Francesca Ceccherini-Silberstein, Anne-Genevieve Marcelin, Federico Garcia
Summary: The prevalence of transmitted drug resistance to INSTIs and NRTIs and clinically relevant resistance was evaluated in newly diagnosed HIV patients naive to ART in Europe. The results showed low prevalence rates of INSTI-SDRMs (0.30%), NRTI-SDRMs (5.77%), INSTI-CRR (2.33%), and first-line NRTI-CRR (1.74-2.29%) during 2018-2021.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Food Science & Technology
Iris Guerreiro, Bojana Vidovic, Joao G. Costa, Marta Martins, Sandra Ferreira, Nuno G. Oliveira, Nuno Saraiva, Ana S. Fernandes
Summary: This study evaluated the impact of erucin on renal cancer cell biology and found that erucin can decrease cell viability, induce cell cycle arrest, alter cell morphology and adhesion, as well as affect microtubule polymerization. These results provide new insights into dietary approaches for renal cancer chemoprevention.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yan Zhou, Jose Russo, Jose Rueff, Marcelo A. M. Pires, Guilherme Bezerra de Castro
Summary: Population study reveals that Xavante Indians have distinct genetic compositions and extremely low risk of breast cancer, providing new insights for breast cancer research.
SCIENTIFIC REPORTS
(2023)
Correction
Infectious Diseases
Sara Raimondi, Sara Gandini, Gibran Horemheb Rubio Quintanares, Ana Abecasis, Pier Luigi Lopalco, Oriana D'Ecclesiis, Susanna Chiocca, Elisa Tomezzoli, Ilaria Cutica, Davide Mazzoni, Nuno Amparo, Marta Pingarilho, Daniela Carmagnola, Claudia Dellavia, Gianvincenzo Zuccotti, Chiara Ronchini, Federica Bellerba, Felix Dewald, Rolf Kaiser, Francesca Incardona
BMC INFECTIOUS DISEASES
(2023)
Article
Genetics & Heredity
Rui Barata, Marc Fila, Fabienne Dalla-Vale, Roberto Bogarin, Paula Nunes, Jose Ramalho, Jose Rueff, Joaquim Calado
Summary: This study aims to validate the identified variants of Familiar Renal Glucosuria (FRG) according to the ACMG-AMP 2015 criteria. The variants evaluated include 16 novel alleles, all of which are rare or absent from population databases and mostly missense changes. According to the ACMG-AMP standards, only 74% of the variants were classified as likely pathogenic or pathogenic. The lack of related patient descriptions and testing of additional affected family members prevented conclusive determination of pathogenicity for variants classified as variants of unknown significance (VUS), highlighting the importance of family testing and variant reporting. Finally, the cryo-EM structure analysis improved the pathogenicity score by identifying critical/functional protein domains.
Article
Oncology
Rita Adubeiro Lourenco, Miguel Lanca, Octavia Monteiro Gil, Joana Cardoso, Teresa Lourenco, Jose B. Pereira-Leal, Antonio Sebastiao Rodrigues, Jose Rueff, Susana Nunes Silva
Summary: Genetic testing using NGS has led to the identification of various genetic variants, including VUS. Functional assays are necessary to determine the biological effect of these VUS. In this study, a VUS in the BRCA1 gene was found in two women at risk for breast cancer, and functional assays showed that this VUS is likely benign.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Nanoscience & Nanotechnology
Joao Conde, Robert Langer, Jose Rueff
Summary: Since the early 1990s, the combination of genetics and nanomedicine has become a game changer in the medical field, offering promising advancements in treating diseases such as cancer and infectious or genetic diseases. The key to this revolution lies in the evolving world of messenger RNA and its 'cues'.
NATURE NANOTECHNOLOGY
(2023)
Article
Food Science & Technology
Joana Moura, Cintia Ferreira-Pego, Ana Sofia Fernandes
Summary: This study investigated the preferences, safety perceptions, and usage practices of Portuguese consumers regarding Food Contact Materials (FCM) used for cooking and food storage. Results showed that safety was the most important factor when choosing cookware materials, although the criteria varied with age. Most respondents recognized the risk of food contamination through cookware. Stainless steel and glass were considered the safest materials for cooking, and glass and plastic were the most commonly used for food storage. Older individuals had better maintenance practices and knowledge about handling cookware. There was a general lack of knowledge about FCM symbols. This study highlights the need to provide reliable information to the public regarding cookware, promoting health literacy and reducing exposure to food contact chemicals.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Neurosciences
Bruno Costa Gomes, Nuno Peixinho, Rita Pisco, Marta Gromicho, Ana Catarina Pronto-Laborinho, Jose Rueff, Mamede de Carvalho, Antonio Sebastiao Rodrigues
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that causes muscle control loss, muscle atrophy, and death. This study aimed to assess the differential expression of plasma miRNAs in ALS patients and control populations. Although no specific miRNA signature for ALS diagnosis was identified, miR-7-2-3p, miR-26a-1-3p, miR-224-5p, and miR-206 were found to be potential candidates for understanding the pathophysiology of ALS.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Virology
Leonid Joaquim, Mafalda N. S. Miranda, Victor Pimentel, Maria do Rosario Oliveira Martins, Tacilta Nhampossa, Ana Abecasis, Marta Pingarilho
Summary: This study analyzed the retention in clinical care and virological response of HIV-1 patients receiving ART at the Maputo Military Hospital (MMH). The results showed that age, unemployment, CD4 count, and hemoglobin levels were associated with patient loss to follow-up and virological failure.
Article
Biochemistry & Molecular Biology
Francisco Esteves, Cristina M. M. Almeida, Sofia Silva, Ines Saldanha, Philippe Urban, Jose Rueff, Denis Pompon, Gilles Truan, Michel Kranendonk
Summary: A unique cytochrome P450 (CYP) oxidoreductase (CPR) is important for maintaining the activities of human microsomal CYPs. The conformation of the CPR protein influences electron transfers and complex formation with CYPs. Mutations in the hinge region and FD domain of CPR can modulate CYP activities and regiospecificity of reactions in a substrate-dependent manner.
Editorial Material
Food Science & Technology
Ana S. Fernandes, Cintia Ferreira-Pego, Joao G. Costa
