Article
Toxicology
Xiaowei Wang, Dan Guan, Dafei Wang, Hanting Liu, Yanling Wu, Weida Gong, Mulong Du, Haiyan Chu, Jing Qian, Zhengdong Zhang
Summary: The study revealed the crucial regulatory role of m(6)A modification genes in gastric cancer (GC) development, with the SNP rs9906944 C > T in IGF2BP1 significantly associated with a decreased risk of GC. Higher expression of IGF2BP1 was linked to poorer overall survival in GC patients.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Infectious Diseases
Eugenia Lo, Gianluca Russo, Kareen Pestana, Daniel Kepple, Beka Raya Abagero, Ghyslaine Bruna Djeunang Dongho, Karthigayan Gunalan, Louis H. Miller, Muzamil Mahdi Abdel Hamid, Delenasaw Yewhalaw, Giacomo Maria Paganotti
Summary: Plasmodium vivax malaria was previously thought to be rare in Africans lacking the Duffy blood group antigen, but recent studies show that it can infect Duffy-negative individuals. The prevalence and genetic features of P. vivax vary across African regions, with higher infection rates and lower parasite densities in Duffy-negative populations. Sharing similar DBP haplotypes, Duffy-negative and Duffy-positive populations do not show monophyletic patterns, indicating the need for standardized diagnostic approaches and resources for vivax malaria in Africa.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Toxicology
Hanting Liu, Jingjing Gu, Yu Jin, Qi Yuan, Gaoxiang Ma, Mulong Du, Yuqiu Ge, Chao Qin, Qiang Lv, Guangbo Fu, Meilin Wang, Haiyan Chu, Lin Yuan, Zhengdong Zhang
Summary: The study investigated the association between genetic variants in m(6)A-switches and bladder cancer risk, identifying a significant effect of a specific SNP in the SOD2 gene on reducing bladder cancer risk. It was also found that SOD2 may regulate its expression through an m(6)A-hnRNP C dependent mechanism, playing a crucial role in suppressing bladder cancer cell growth and invasion.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Andres Lizasoain, Daiana Mir, Matias Salvo, Viviana Bortagaray, Gisela Masachessi, Adrian Farias, Nelida Rodriguez-Osorio, Silvia Nates, Matias Victoria, Rodney Colina
Summary: This study assessed the diversity of enteroviruses through Illumina next-generation sequencing of VP1-amplicons obtained by RT-PCR directly applied to viral concentrates of 84 wastewater samples collected in Uruguay. Fifty out of the 84 samples were positive for enteroviruses, with 27 different types detected. The results revealed the circulation of EV-A71 sub-genogroup C2 in both Uruguay and Argentina since at least 2011-2012, as well as the emergence of a C1-like variant in Argentina.
Editorial Material
Immunology
Lavanya Sivapalan, Valsamo Anagnostou
Summary: The study challenges previous associations between germline HLA genotypes and immunotherapy outcomes, indicating that germline HLA genotypes and diversity alone are not independent biomarkers of anti-PD1 clinical efficacy.
Article
Genetics & Heredity
Xi Wang, Zheng Guo, Huanhuan Zhu, Junyi Xin, Lin Yuan, Chao Qin, Meilin Wang, Zhengdong Zhang, Yunyan Wang, Haiyan Chu
Summary: The study suggests that the rs978416 G>A SNP in RBFOX3 may be associated with bladder cancer predisposition in the Chinese population and could potentially serve as a novel biomarker for bladder cancer risk. The protective effect of rs978416 was more significant in the subgroup of low grade and non-muscle invasive bladder cancer. Additionally, RBFOX3 mRNA expression was found to be decreased in bladder tumor tissues.
Article
Rheumatology
Yiming Luo, Marcela A. Ferrada, Keith A. Sikora, Cameron Rankin, Hugh D. Alessi, Daniel L. Kastner, Zuoming Deng, Mengqi Zhang, Peter A. Merkel, Virginia B. Kraus, Andrew S. Allen, Peter C. Grayson
Summary: This study suggests that rare variants in the DCBLD2 gene may play a role in the development of RP. These findings should be further validated in a larger sample and supported by functional experiments.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Oncology
Jason J. Liu, Immaculata De Vivo, Chun-Ying Wu, Edward Giovannucci
Summary: This study found that childhood and adolescent cancer survivors have a higher risk of subsequent urogenital and kidney cancers, with females being more susceptible. Females also have a higher risk of specific reproductive system cancers.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Toxicology
Zhichao Han, Jingjing Gu, Junyi Xin, Hanting Liu, Yanling Wu, Mulong Du, Haiyan Chu, Yadong Liu, Zhengdong Zhang
Summary: This study investigated the association between genetic variants in the choline metabolism pathway and bladder cancer susceptibility. The results showed that the C allele of rs6810830 in ENPP6 was a significant protective allele for bladder cancer. Additionally, the study found that the expression of ENPP6 was decreased in bladder tumors and high expression was associated with worse overall survival in bladder cancer patients.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Microbiology
Tanya Kumar, MacKenzie Bryant, Kalen Cantrell, Se Jin Song, Daniel McDonald, Helena M. M. Tubb, Sawyer Farmer, Emily S. S. Lukacz, Linda Brubaker, Rob Knight
Summary: The urogenital microbiome is an important yet understudied human microbiome niche, and urine has been found to contain microorganisms that can affect health. It is crucial to study urine sample storage conditions for scientific rigor and reproducibility.
Article
Biochemistry & Molecular Biology
Dongjo Ban, Stephen N. Housley, John F. McDonald
Summary: The study aims to comprehensively examine the nucleotide and chromosomal variation associated with the onset and progression of serous ovarian cancer. Computational and statistical methods were used to analyze the exome sequence profiles of genetic variants in 432 ovarian cancer patient samples. The results show that genetic variation is a significant contributor to ovarian cancer and can be used as a predictor of tumor aggressiveness and resistance to chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Angela N. Giaquinto, Hyuna Sung, Kimberly D. Miller, Joan L. Kramer, Lisa A. Newman, Adair Minihan, Ahmedin Jemal, Rebecca L. Siegel
Summary: This article provides an update on female breast cancer statistics in the United States, including data on incidence, mortality, survival, and mammography screening. It shows that breast cancer incidence rates have increased over the past few decades, driven by localized-stage and hormone receptor-positive disease. However, breast cancer mortality rates have been steadily declining since 1989, although at a slower pace in recent years. Despite lower incidence rates, there remains a racial disparity in breast cancer mortality, with higher rates among Black women compared to White women.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Oncology
Anouk E. Hentschel, Rianne van den Helder, Nienke E. van Trommel, Annina P. van Splunter, Robert A. A. van Boerdonk, Mignon D. J. M. van Gent, Jakko A. Nieuwenhuijzen, Renske D. M. Steenbergen
Summary: The study demonstrated that tumor DNA in the urine of urogenital cancer patients can originate not only from shedding of the local tumor, but also from transrenal excretion of circulating tumor DNA. This supports the potential of urine as a diagnostic tool for cancer detection. The results provide evidence that urine as a liquid biopsy for urogenital cancers relies on both local shedding of tumor cells and cell fragments, as well as transrenal excretion of tumor DNA into the urine.
Editorial Material
Biochemistry & Molecular Biology
Claudio Azat
Summary: Emerging infectious diseases (EIDs) pose a threat to biodiversity and human health, with genetic variability of pathogens causing different impacts at the population level. Global spread of pathogens is facilitated by globalization of transport, such as air travel rapidly spreading pathogens like SARS-CoV-2. Understanding the genetic diversity of pathogens is crucial in developing timely mitigation strategies.
MOLECULAR ECOLOGY RESOURCES
(2021)
Article
Toxicology
Yujuan Zhang, Guoquan Tao, Ping Liu, Kai Lu, Zhichao Han, Hanting Liu, Mulong Du, Meilin Wang, Haiyan Chu, Zhengdong Zhang
Summary: The study revealed that genetic variants in NuRD complex subunits encoding genes are associated with gastric cancer risk, with an increase in the number of favorable alleles of specific SNPs linked to lower risk. Specific SNPs in GATAD2A were significantly correlated with mRNA expression levels, and patients with higher expression levels of GATAD2A or CHD4 mRNA had more advantageous overall survival.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
C. F. M. Menck, R. S. Galhardo, A. Quinet
Summary: Studies have shown that xeroderma pigmentosum variant (XP-V) patients have mutations in the POLH gene, resulting in a high frequency of skin tumors. However, it is paradoxical that the translesion synthesis DNA polymerase eta (Pol η) in these patients can actually suppress mutations, and the mechanism behind this is still unclear. Recent evidence suggests that cyclobutane pyrimidine dimers (CPDs) play an instructional role for Pol η, enabling accurate replication of these lesions, and the mutagenic effects induced by UV radiation are caused by the deamination of C-containing CPDs. This process leads to C>T transitions, which are the most common mutations in skin cancers. The delayed replication in XP-V cells amplifies the deamination of C in CPDs and increases the burden of C>T mutations through the activity of backup TLS polymerases.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
(2024)
