Article
Pediatrics
Luigi Gagliardi, Franca Rusconi, Brian Reichman, Mark Adams, Neena Modi, Liisa Lehtonen, Satoshi Kusuda, Maximo Vento, Brian A. Darlow, Dirk Bassler, Tetsuya Isayama, Mikael Norman, Stellan Hakansson, Shoo K. Lee, Kei Lui, Junmin Yang, Prakeshkumar Shah
Summary: Research shows that in extremely preterm twins, girls have lower risks than boys, and opposite-sex twins have lower risks than same-sex twins.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)
Article
Public, Environmental & Occupational Health
Maja Popovic, Valentina Fiano, Elena Isaevska, Chiara Moccia, Morena Trevisan, Franca Rusconi, Laura De Marco, Silvia Polidoro, Franco Merletti, Costanza Pizzi, Lorenzo Richiardi
Summary: The study found a moderate positive association between DNA methylation age and chronological age, but weak evidence of associations between infant saliva epigenetic age acceleration and parental socio-economic position and pregnancy outcomes.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Environmental Sciences
Dolores Catelan, Annibale Biggeri, Francesca Russo, Dario Gregori, Gisella Pitter, Filippo Da Re, Tony Fletcher, Cristina Canova
Summary: A study was conducted in the Veneto Region's Red Zone to assess COVID-19 mortality rates, revealing a higher risk possibly linked to PFAS exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biology
Tihana Maric, Ana Katusic Bojanac, Ana Matijevic, Marcello Ceppi, Marco Bruzzone, Evangelini Evgeni, Tea Petrovic, Iwona Wojcik, Irena Trbojevic-Akmacic, Gordan Lauc, Davor Jezek, Aleksandra Fucic
Summary: The study showed that DNA integrity and seminal plasma N-glycans are closely associated with pathological sperm parameters. Specific N-glycans are also correlated with sperm chromatin maturity and have potential implications in future fertility research and clinical diagnostics.
Article
Pediatrics
Franca Rusconi, Enrico Lombardi, Elena Spada, Sonia Brescianini, Martina Culasso, Francesca Di Toro, Antonella Frassanito, Lorenzo Richiardi, Luca Ronfani, Ileana Stella, Luigi Gagliardi
Summary: The study found that children who had wheezing and lower respiratory tract infections during infancy had reduced lung function in school age, whereas those with lower respiratory tract infections only did not show the same impact.
PEDIATRIC PULMONOLOGY
(2022)
Article
Environmental Sciences
Giorgia Stoppa, Carolina Mensi, Lucia Fazzo, Giada Minelli, Valerio Manno, Dario Consonni, Annibale Biggeri, Dolores Catelan
Summary: This study uses Bayesian models to explore the geographical ecological association between ovarian cancer and malignant mesothelioma, and finds evidence of a shared risk factor between the two diseases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Marco Peluso, Armelle Munnia, Valentina Russo, Andrea Galli, Valeria Pala, Yvonne T. van der Schouw, Matthias B. Schulze, Elisabete Weiderpass, Rosario Tumino, Calogero Saieva, Amiano Exezarreta Pilar, Dagfinn Aune, Alicia K. Heath, Elom Aglago, Antonio Agudo, Salvatore Panico, Kristina Elin Nielsen Petersen, Anne Tjonneland, Lluis Cirera, Miguel Rodriguez-Barranco, Verena Katzke, Rudolf Kaaks, Fulvio Ricceri, Lorenzo Milani, Paolo Vineis, Carlotta Sacerdote
Summary: This study found a correlation between the consumption of cruciferous vegetables and the frequency of bulky DNA damage. Higher intake of cruciferous vegetables was associated with a reduction in DNA damage, particularly in former smokers. Therefore, increasing the consumption of cruciferous vegetables may have potential cancer prevention benefits.
Article
Obstetrics & Gynecology
Franca Rusconi, Monia Puglia, Martina Pacifici, Sonia Brescianini, Luigi Gagliardi, Anna Maria Nannavecchia, Pietro Buono, Sara Cantoira, Sara Farchi, Michele Gobbato, Edda Pellegrini, Enrica Perrone, Riccardo Pertile, Elisa Eleonora Tavormina, Laura Visona Dalla Pozza, Francesca Zambri
Summary: There was a decrease in the rate of preterm birth in Italy after the introduction of COVID-19 restriction measures, without an increase in stillbirths.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Oncology
Valentina Russo, Eleonora Lallo, Armelle Munnia, Miriana Spedicato, Luca Messerini, Romina D'Aurizio, Elia Giuseppe Ceroni, Giulia Brunelli, Antonio Galvano, Antonio Russo, Ida Landini, Stefania Nobili, Marcello Ceppi, Marco Bruzzone, Fabio Cianchi, Fabio Staderini, Mario Roselli, Silvia Riondino, Patrizia Ferroni, Fiorella Guadagni, Enrico Mini, Marco Peluso
Summary: Metastatic colorectal cancer (mCRC) has a high incidence and mortality rate. Innovative biomarkers have been developed for predicting treatment response. By analyzing specific narrative publications, this study examines the ability of learning methods to build predictive models for mCRC patients, either for chemotherapy alone or combined with targeted therapy. The results show promising outcomes in predicting treatment response or toxic side-effects. Radiomics and molecular biomarkers are able to accurately identify responders and non-responders in the majority of patients.
Article
Immunology
Vieri Lastrucci, Monia Puglia, Martina Pacifici, Primo Buscemi, Michela Sica, Giorgia Alderotti, Gilda Belli, Elettra Berti, Franca Rusconi, Fabio Voller
Summary: Premature and small-for-gestational-age infants have a higher susceptibility to vaccine-preventable diseases and exhibit delayed vaccination. Tailored public health programs are needed to improve vaccination timeliness in these high-risk groups.
Article
Biochemistry & Molecular Biology
Armelle Munnia, Valentina Bollati, Valentina Russo, Luca Ferrari, Marcello Ceppi, Marco Bruzzone, Stefano Dugheri, Giulio Arcangeli, Franco Merlo, Marco Peluso
Summary: Studies have shown that air pollution, including surface-level ozone (O-3), has a significant impact on the risk of chronic diseases. This study examined the association between traffic-related pollutants and DNA methylation alterations and bulky DNA adducts, two biomarkers of carcinogen exposure and cancer risk. The results revealed that air pollution exposure led to a reduction in global DNA methylation and an increase in DNA adducts. Regression models also indicated a correlation between higher levels of certain pollutants and changes in DNA methylation. Overall, these findings emphasize the importance of developing strategies to reduce traffic-related air pollution and its impact on molecular alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Pediatrics
Valentina Agnese Ferraro, Amelia Licari, Alessandro Volpini, Grazia Fenu, Maria Francesca Patria, Manuela Seminara, Elena Spada, Franca Rusconi
PEDIATRIC PULMONOLOGY
(2023)
Article
Oncology
Dolores Catelan, Annibale Biggeri, Lauro Bucchi, Valerio Manno, Marilena Pappagallo, Giorgia Stoppa, Francesco Grippo, Luisa Frova, Federica Zamagni, Roberta Crialesi, Giada Minelli
Summary: The study analyzed the mortality risk of lung cancer in Italy from 1995 to 2016, focusing on the spatial-temporal evolution by sex and province of residence. It found that the peak mortality of lung cancer among males occurred in the 1920-1929 cohort, followed by a decline. Among females, a peak was observed in the 1955-1964 cohort, with a downward trend thereafter. The risk of lung cancer has shifted to the southwest of Italy, raising concerns.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Environmental Sciences
Mahara Valverde, Adriana Granados, Mirta Milic, Marcello Ceppi, Leticia Sollano, Stefano Bonassi, Emilio Rojas
Summary: DNA damage in newborn children's cord blood cells from Mexico City is correlated with the DNA damage in their mothers, as well as the environmental exposure and complications during pregnancy. Mothers living in the southern part of the city have double DNA damage compared to those living in the northern part. This study highlights the importance of antioxidants during pregnancy and the role of the placental barrier in protecting newborns from DNA-damaging effects of pollution.