Article
Medicine, General & Internal
Marta Morawska, Jadwiga Dwilewicz-Trojaczek, Tomasz Stompor, Piotr Ligocki, Marek Stopinski, Michal Sutkowski, Norbert Grzasko, Anna Kordecka, Mariusz Kordecki, Artur Jurczyszyn, Dominik Dytfeld, Tomasz Wrobel, Krzysztof Jamroziak, Agnieszka Druzd-Sitek, Adam Walter-Croneck, Krzysztof Giannopoulos
Summary: This study developed a 3-step screening protocol for monoclonal gammopathies and multiple myeloma, which proved to be efficient in diagnosis. The protocol can help standardize the understanding of clinical manifestation and diagnostic methods among primary care physicians.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Dickran Kazandjian, Elizabeth Hill, Alexander Dew, Candis Morrison, Joseph Roswarski, Neha Korde, Michael Emanuel, Ani Petrosyan, Manisha Bhutani, Katherine R. Calvo, Alina Dulau-Florea, Mary Kwok, Min-Jung Lee, Sunmin Lee, Liza Lindenberg, Sham Mailankody, Elisabet Manasanch, Irina Maric, Esther Mena, Nisha Patel, Nishant Tageja, Jane B. Trepel, Baris Turkbey, Hao-Wei Wang, Weixin Wang, Constance Yuan, Yong Zhang, Raul Braylan, Peter Choyke, Maryalice Stetler-Stevenson, Seth M. Steinberg, William D. Figg, Mark Roschewski, Ola Landgren
Summary: Treatment with novel triplet regimens such as KRd and lenalidomide maintenance therapy for high-risk smoldering myeloma may significantly delay the progression to symptomatic multiple myeloma, altering the natural history of the disease. Further randomized clinical trials are needed to confirm the favorable benefit-to-risk profile observed in this phase 2 trial.
Article
Clinical Neurology
Pannathat Soontrapa, Jennifer A. Tracy, Wilson I. Gonsalves, Teerin Liewluck
Summary: A case of monoclonal gammopathy-associated myopathy (MGAM) was reported in a patient with POEMS syndrome. This condition, along with other subtypes of MGAM, is treatable and should be recognized for proper diagnosis and treatment.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Hematology
Carolina Schinke, Alexandra M. Poos, Michael Bauer, Lukas John, Sarah Johnson, Shayu Deshpande, Luis Carrillo, Daisy Alapat, Leo Rasche, Sharmilan Thanendrarajan, Maurizio Zangari, Samer Al Hadidi, Frits van Rhee, Faith Davies, Marc S. Raab, Gareth Morgan, Niels Weinhold
Summary: This study used single-cell RNA sequencing to analyze bone marrow cells at different stages of multiple myeloma (MM) and found changes in immune cell populations during disease progression. These changes included a decrease in memory and naive CD4 T cells, an increase in CD8+ effector T cells and T-regulatory cells, as well as an enrichment of nonclonal memory B cells and CD14, CD16 monocytes. These findings provide important information for understanding the immune changes in MM and for patient stratification and early therapeutic intervention.
Article
Oncology
Laura Duran-Lozano, Gudmar Thorleifsson, Aitzkoa Lopez de Lapuente Portilla, Abhishek Niroula, Molly Went, Malte Thodberg, Maroulio Pertesi, Ram Ajore, Caterina Cafaro, Pall I. Olason, Lilja Stefansdottir, G. Bragi Walters, Gisli H. Halldorsson, Ingemar Turesson, Martin F. Kaiser, Niels Weinhold, Niels Abildgaard, Niels Frost Andersen, Ulf-Henrik Mellqvist, Anders Waage, Annette Juul-Vangsted, Unnur Thorsteinsdottir, Markus Hansson, Richard Houlston, Thorunn Rafnar, Kari Stefansson, Bjorn Nilsson
Summary: A new MM risk variant at SOHLH2 on chromosome 13q13.3 was identified in a genome-wide association study involving 5,320 cases and 422,289 controls from Nordic populations. This variant influences transcriptional activity in plasma cells and represents a novel insight into MM susceptibility.
BLOOD CANCER JOURNAL
(2021)
Article
Medicine, Research & Experimental
Xuanli Tang, Feng Wan, Jin Yu, Xiaohong Li, Ruchun Yang, Bin Zhu
Summary: The study found that the clinicopathological characteristics of patients with MGRS were between those of MM and MGUS. Treatment for MGRS and MM was more intensive, with overall low mortality rates. MGUS and renal monoIg alone exhibited milder clinicopathological features compared to MGRS and MM, with focus on primary renal diseases in treatment.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Nabin Simkhada, Prakash Adhikari, Nisha Baral, Bishal Dhakal, Krish Mahat
Summary: Multiple myeloma is a clonal proliferation of plasma cells in the bone marrow, more common in elderly adults and presenting with symptoms such as bone pain and fatigue. Peripheral neuropathy is an atypical presentation. The association between vasculitic neuropathy and MM remains understudied, with no strong evidence suggesting a clear link between the two conditions.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Federico Canzian, Chiara Piredda, Angelica Macauda, Daria Zawirska, Niels Frost Andersen, Arnon Nagler, Jan Maciej Zaucha, Grzegorz Mazur, Charles Dumontet, Marzena Watek, Krzysztof Jamroziak, Juan Sainz, Judit Varkonyi, Aleksandra Butrym, Katia Beider, Niels Abildgaard, Fabienne Lesueur, Marek Dudzinski, Annette Juul Vangsted, Matteo Pelosini, Edyta Subocz, Mario Petrini, Gabriele Buda, Malgorzata Razny, Federica Gemignani, Herlander Marques, Enrico Orciuolo, Katalin Kadar, Artur Jurczyszyn, Agnieszka Druzd-Sitek, Ulla Vogel, Vibeke Andersen, Rui Manuel Reis, Anna Suska, Herve Avet-Loiseau, Marcin Kruszewski, Waldemar Tomczak, Marcin Rymko, Stephane Minvielle, Daniele Campa
Summary: Multiple myeloma (MM) risk has a strong genetic background, with 23 risk loci identified through genome-wide association studies (GWAS). Combining SNPs into a polygenic risk score (PRS) showed significant associations with MM risk, providing a first step towards using genetics for risk stratification in the general population.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Oncology
Rosalinda Termini, David Zihala, Evangelos Terpos, Albert Perez-Montana, Tomas Jelinek, Marc Raab, Niels Weinhold, Elias K. Mai, Anna Luise Grab, Jill Corre, Francois Vergez, Antonio Sacco, Marco Chiarini, Viviana Giustini, Alessandra Tucci, Sara Rodriguez, Cristina Moreno, Cristina Perez, Catarina Maia, Esperanza Martin-Sanchez, Camilla Guerrero, Cirino Botta, Juan-Jose Garces, Aitziber Lopez, Luis-Esteban Tamariz-Amador, Felipe Prosper, Joan Bargay, Maria-Elena Cabezudo, Enrique M. Ocio, Roman Hajek, Joaquin Martinez-Lopez, Fernando Solano, Rebeca Iglesias, Artur Paiva, Catarina Geraldes, Helena Vitoria, Clara Gomez, Felipe De Arriba, Heinz Ludwig, Antoni Garcia-Guinon, Maria Casanova, Adrian Alegre, Valentin Cabanas, Maialen Sirvent, Albert Oriol, Javier de la Rubia, Jose-Angel Hernandez-Rivas, Luis Palomera, Maria Sarasa, Pablo Rios, Noemi Puig, Maria-Victoria Mateos, Juan Flores-Montero, Alberto Orfao, Hartmut Goldschmidt, Herve Avet-Loiseau, Aldo M. Roccaro, Jesus F. San-Miguel, Bruno Paiva
Summary: This study suggests that measuring circulating tumor cells (CTCs) in peripheral blood is more accurate than bone marrow plasma cells (BM PCs) for assessing tumor burden in smoldering multiple myeloma (SMM). Combining the 20/2/0.015 model with an immune risk score based on specific immune cell percentages allows for better risk stratification of SMM patients.
CLINICAL CANCER RESEARCH
(2022)
Article
Clinical Neurology
Benjamin Bardel, Valerie Molinier-Frenkel, Fabien Le Bras, Samar S. Ayache, Tarik Nordine, Jean-Pascal Lefaucheur, Violaine Plante-Bordeneuve
Summary: This study highlights the wide spectrum of IgM-related neuropathies in patients with IgM monoclonal gammopathy, including MGUS, anti-MAG antibody positive neuropathy, neurolymphomatosis, AL amyloid neuropathy, and Neuropathy of Uncertain Relationship with the IgM (NURIM). Prognosis varies considerably among these different subtypes, emphasizing the need for further studies to better understand and classify these patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Eleanor S. Marsh, Stephen Keddie, Fern Terris-Prestholt, Shirley D'Sa, Michael P. Lunn
Summary: Misdiagnosis in POEMS syndrome leads to diagnostic delay, disease progression, and significant healthcare costs. Introducing mandatory VEGF testing for patients with acquired demyelinating neuropathy is a cost-effective strategy, allowing for early POEMS diagnosis and timely disease-directed therapy.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Oncology
Romanos Sklavenitis-Pistofidis, Michelle P. Aranha, Robert A. Redd, Joanna Baginska, Nicholas J. Haradhvala, Margaret Hallisey, Ankit K. Dutta, Alexandra Savell, Shohreh Varmeh, Daniel Heilpern-Mallory, Sylvia Ujwary, Oksana Zavidij, Francois Aguet, Nang K. Su, Elizabeth D. Lightbody, Mark Bustoros, Sabrin Tahnri, Tarek H. Mouhieddine, Ting Wu, Lea Flechon, Shankara Anand, Jacalyn M. Rosenblatt, Jeffrey Zonder, James J. Vredenburgh, Adam Boruchov, Manisha Bhutani, Saad Z. Usmani, Jeffrey Matous, Andrew J. Yee, Andrzej Jakubowiak, Jacob Laubach, Salomon Manier, Omar Nadeem, Paul Richardson, Ashraf Z. Badros, Maria-Victoria Mateos, Lorenzo Trippa, Gad Getz, Irene M. Ghobrial
Summary: This study found that early treatment with EloLenDex is safe and effective for high-risk SMM patients, and provides a comprehensive characterization of alterations in immune cell composition and TCR repertoire diversity in patients. The study also revealed that the similarity of a patient's immune cell composition to that of healthy donors may have prognostic relevance at diagnosis and after treatment.
Article
Ophthalmology
Jesus Guerrero-Becerril, Itamar Vigderovich-Cielak, Yvette Neme-Yunes, Alejandro Navas Perez, Arturo Ramirez Miranda, Juan Carlos Zenteno-Ruiz, Ricardo Terrazas-Marin, Enrique O. Graue-Hernandez
Summary: This study aimed to report a unique clinical presentation of paraproteinemic keratopathy after myopic LASIK, which led to the diagnosis of gammopathy of undetermined significance. The patient presented with bilateral branching opacities limited to the optical zone of the LASIK procedure. Systemic workup revealed abnormal levels of IgG and lambda-free light chain. After chemotherapy, the patient's visual acuity improved. This is the first reported case of paraproteinemic keratopathy after LASIK.
Article
Clinical Neurology
Pitcha Chompoopong, Bayan Almarwani, Bashar Katirji
Summary: Peripheral neuropathy is observed in 15% of patients with IgA monoclonal gammopathy, indicating a potential risk of malignant transformation. Neurologists play a crucial role in identifying underlying plasma cell disorders. Failure to investigate for hematologic malignancy and AL amyloidosis may lead to significant delays in treatment and fatal outcomes.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Hua Huang, Shen-Xian Qian
Summary: Lichen myxedematosus (LM) combined with monoclonal gammopathy of undetermined significance (MGUS) can be diagnosed as scleromyxedema. However, we report a case of generalized papules combined with MGUS that was eventually diagnosed as atypical or intermediate forms of LM because it only involved the skin and the pathological type was not consistent with scleromyxedema. There have been few reports on atypical or intermediate forms of LM, making the course of the disease unpredictable.
FRONTIERS IN MEDICINE
(2023)