Journal
MUSCLE & NERVE
Volume 47, Issue 4, Pages 477-482Publisher
WILEY
DOI: 10.1002/mus.23688
Keywords
cell culture; experimental model; in vitro; in vivo; skeletal muscle cell
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Cell cultures have been used extensively by many scientists in recent decades to study various cell and tissue mechanisms. The use of cell cultures has many advantages over use of in vivo experimental models, but there are also limitations. As skeletal musclederived cell cultures become more commonly utilized in studies of muscle regeneration processes the question of their relevance in experimentation is highlighted with regard to in vivo experimental models. This article reviews studies that have been performed simultaneously in in vivo and in vitro experiments on skeletal muscle and assesses the correlation of results. Although they seem to correlate, no such studies on humans have been performed so far. Muscle Nerve, 2013
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