Article
Clinical Neurology
Han-ding Mao, Xin Li, Shu-yuan Liu, Ling Xing, Jin-bao Zhao, Zhi-jun Tan, Hai-long Sun, Qing Song
Summary: Exertional rhabdomyolysis (ER) frequently occurs during prolonged intense exercise in hot conditions, posing a health threat to military personnel. This study identified risk factors for ER, including shorter length of service, higher BMI, lack of physical exercise, previous heat injury, and protective factors such as frequent fruit consumption and proper hydration habits. Preventative measures include gradual training adaptation for recruits, proper fluid intake before exercise, increased fruit consumption, and adequate potassium supplementation.
Review
Urology & Nephrology
Mirna Aleckovic-Halilovic, Mirha Pjanic, Enisa Mesic, Joshua Storrar, Alexander Woywodt
Summary: Rhabdomyolysis is a common cause of acute kidney injury, often seen in elderly and frail patients but also caused by a variety of other factors. Its history dates back to antiquity, with links to poisoning and armed conflict in the 20th century.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Satoru Mitsuboshi, Kazumasa Kotake
Summary: This study analyzed the FAERS database and conducted a systematic review/meta-analysis of randomized controlled trials to investigate the association between febuxostat and muscle injury. The results suggest that febuxostat does not increase the risk of muscle injury.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Sport Sciences
Zidong Li, Zachary J. McKenna, Matthew R. Kuennen, Flavio de Castro Magalhaes, Christine M. Mermier, Fabiano T. Amorim
Summary: Exertional heat stroke is a life-threatening condition that mainly affects athletes, military personnel, firefighters, and occupational workers. It can be caused by prolonged and strenuous physical activities in high heat conditions, with exercise-induced muscle damage being a potential predisposing factor for EHS and AKI. Understanding this relationship may help to minimize the risks of EHS and AKI for individuals engaging in physical work in hot environments.
Article
Medicine, Research & Experimental
Chien-Ming Chao, Lin-Yu Wang, Chien-Cheng Huang, Wei-Ting Chang, Ling-Yu Tang, Mao-Tsun Lin, Chang Ching-Ping
Summary: Using a survival male rat model of acute exertional heat stroke (EHS), this study investigated the effects of EHS on myocardium structure and function. It was found that EHS caused skeletal muscle and myocardial damage, with myocardial damage lasting for at least 14 days post-EHS. This study is significant as it provides key findings on the pathophysiology and risk factors of EHS, as well as highlighting the need for further research.
Article
Orthopedics
Michelle Meyer, Sneha Sundaram, Ingeborg Schafhalter-Zoppoth
Summary: This report illustrates a case of exercise-induced rhabdomyolysis in a 31-year-old female after a CrossFit workout, resulting in hospitalization and IV fluid administration. Rhabdomyolysis can be triggered by high-intensity exercises like CrossFit, sometimes with symptoms that may be underestimated and underreported.
CLINICAL JOURNAL OF SPORT MEDICINE
(2021)
Article
Geriatrics & Gerontology
Sixiao He, Ru Li, Yanmei Peng, Ziqing Wang, Junhao Huang, Hongen Meng, Junxia Min, Fudi Wang, Qiang Ma
Summary: This study demonstrates the important role of ACSL4 in mediating ferroptosis activation in the development of RM following EHS. Inhibition of ACSL4 improves muscle cell death caused by EHS, thereby ameliorating RM development and suggesting a novel therapeutic strategy to limit skeletal muscle cell death and prevent RM after EHS.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Urology & Nephrology
Conglin Wang, Baojun Yu, Ronglin Chen, Lei Su, Ming Wu, Zhifeng Liu
Summary: Patients with rhabdomyolysis (RM) following exertional heatstroke (EHS) often experience coagulation dysfunction and acute kidney injury (AKI). D-dimer is associated with AKI in these patients, serving as an independent risk factor for the development of AKI in RM patients.
Article
Medicine, General & Internal
Prakash Adhikari, Adithya Hari, Laurent Morel, Yolin Bueno
Summary: Multiple studies have reported the metabolic benefits of high-intensity exercise programs like CrossFit, but improper structured pattern could lead to adverse outcomes like rhabdomyolysis. This case report demonstrates a possible preventable rhabdomyolysis that developed secondary to undue participation in CrossFit exercise.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Andy K. H. Lim, Ajinkya Bhonsle, Karen Zhang, Joy Hong, Kuo L. C. Huang, Joseph Nim
Summary: This study found an association between hyponatremia and the severity of rhabdomyolysis, even after adjusting for confounders. The study also found that patients with psychotic and alcohol use disorders were more likely to develop hyponatremia and rhabdomyolysis compared to the general population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Primary Health Care
Barry P. Boden, David J. Isaacs, Anwar E. Ahmed, Scott A. Anderson
Summary: Over the past 20 years, there has been an increasing trend in the number of patients presenting to emergency departments in the US with exertional rhabdomyolysis (ER). Young males and African Americans are at the highest risk for ER, with a higher incidence rate compared to females and white patients. The majority of ER cases require hospitalization for treatment.
PHYSICIAN AND SPORTSMEDICINE
(2022)
Article
Medicine, General & Internal
Shih-Wei Lai, Kuan-Fu Liao, Yu-Hung Kuo, Cheng-Li Lin, Chiu-Shong Liu, Bing-Fang Hwang, Yen-Jen Lai
Summary: The study in Taiwan found that the incidence of herpes zoster was higher during the months of May to October with high ambient temperature and strong ultraviolet radiation. For every 1 degree Celsius increase in ambient temperature per month, the incidence rate of herpes zoster increased by 0.072 per 10,000 persons per month. Similarly, for every 1 MJ m(-2) increase in monthly ultraviolet radiation, the incidence rate of herpes zoster increased by 0.313 per 10,000 persons per month. There is a significant association between ambient temperature, ultraviolet radiation, and the development of herpes zoster.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Oncology
Ming Wu, Conglin Wang, Li Zhong, Zhifeng Liu
Summary: This study suggests that serum myoglobin is a better predictor of AKI and 90-day mortality than serum creatine kinase in patients with RM after exertional heatstroke.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Multidisciplinary Sciences
Sungmin Kim, Kun-Bo Park, Hyun Woo Kim, Jong Eun Kim, Hoon Park
Summary: This study aimed to evaluate the degree of leg length discrepancy (LLD) in patients treated with in situ fixation with screws for slipped capital femoral epiphysis (SCFE) and identify the risk factors for LLD development. The study found that LLD and articulotrochanteric distance difference (ATDD) were significantly higher in patients with moderate slips compared to those with mild slips. The degree of slip angle was only associated with the degree of LLD. Younger age and a larger degree of slip angle were associated with the degree of LLD in moderate slips. Age at surgery did not affect LLD, and there were no factors related to the degree of LLD in mild slip. Monitoring for LLD may be necessary only for patients with moderate slip who undergo in situ screw fixation.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Andreia Carneiro, Janaina Macedo-da-Silva, Veronica Feijoli Santiago, Gilberto Santos de Oliveira, Thiago Guimaraes, Clarissa Ferolla Mendonca, Jessica Lais de Oliveira Branquinho, Cintia Verdan Lucena, Juliana Osorio, Eduardo Pernambuco, Josino Costa Moreira, Joao Bosco Pesquero, Marcos Dias Pereira, Giuseppe Palmisano
Summary: This study analyzed the blood and urine samples of marine soldiers during a special training program, and identified changes in proteins related to immune system and cell adhesion after strenuous physical exercise. The study also found associations between genetic polymorphisms and protein abundance, as well as identified six proteins as potential markers for early non-invasive diagnosis of ERM.
JOURNAL OF PROTEOMICS
(2022)
Article
Clinical Neurology
Mohamed Kazamel, Eric J. Sorenson, Kathleen M. McEvoy, Lyell K. Jones, Andrea N. Leep-Hunderfund, Michelle L. Mauermann, Margherita Milone
Article
Clinical Neurology
Bruce Sigsbee, Christopher T. Bever, Lyell K. Jones
Editorial Material
Clinical Neurology
Lyell K. Jones, Marc R. Nuwer
Article
Clinical Neurology
Pushpa Narayanaswami, Thomas Geisbush, Lyell Jones, Michael Weiss, Tahseen Mozaffar, Gary Gronseth, Seward B. Rutkove
Editorial Material
Clinical Neurology
Eugene L. Scharf, Lyell K. Jones
Article
Clinical Neurology
Bruce Sigsbee, James N. Goldenberg, Christopher T. Bever, Becky Schierman, Lyell K. Jones
Article
Clinical Neurology
Pushpa Narayanaswami, Millie Suk, Lyell K. Jones
Article
Clinical Neurology
Alexander L. Cohen, Lyell K. Jones, Joseph E. Parisi, James P. Klaas
Article
Clinical Neurology
Lyell K. Jones, Scott D. Z. Eggers, David J. Capobianco, Christopher J. Boes
Review
Clinical Neurology
Lyell K. Jones
SEMINARS IN NEUROLOGY
(2018)
Editorial Material
Clinical Neurology
Lyell K. Jones, Anup D. Patel
Article
Clinical Neurology
Christine M. Baca, Sarah Benish, Aleksandar Videnovic, Karen Lundgren, Brandon Magliocco, Becky Schierman, Laura Palmer, Lyell K. Jones
Editorial Material
Clinical Neurology
Lyell K. Jones
Article
Clinical Neurology
Michael W. Ruff, Anthony Fine, Ay Mandrekar, Cindy Sweeney, Lyell K. Jones, James P. Klaas
Article
Clinical Neurology
A. S. Zubair, C. Hunt, J. Watson, A. Nelson, L. K. Jones
AMERICAN JOURNAL OF NEURORADIOLOGY
(2017)