Article
Medicine, Research & Experimental
Paulina Maria Reyes-Mata, Argelia Esperanza Rojas-Mayorquin, Lucrecia Carrera-Quintanar, Celia Gonzalez-Castillo, Mario Alberto Mireles-Ramirez, Jose de Jesus Guerrero-Garcia, Daniel Ortuno-Sahagun
Summary: This study aimed to investigate the serum levels of Pleiotrophin (PTN) in patients with Multiple Sclerosis (MS). The results showed that PTN serum levels were significantly higher in RRMS patients compared to the healthy control group, and were associated with sex, body mass index (BMI), and IFN-beta treatment.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Immunology
Tatiana Koudriavtseva, Svetlana Lorenzano, Maria Cellerino, Mauro Truglio, Marco Fiorelli, Caterina Lapucci, Giovanna D'Agosto, Laura Conti, Annunziata Stefanile, Silvana Zannino, Maria Maddalena Filippi, Antonio Cortese, Carlo Piantadosi, Marta Maschio, Andrea Maialetti, Edvina Galie, Marco Salvetti, Matilde Inglese
Summary: The objective of this observational study was to identify the most specific pro-coagulative/vascular factors for multiple sclerosis pathogenesis and to correlate them with brain hemodynamic abnormalities. The results showed that tissue-factor was one of the key variables in differentiating multiple sclerosis from controls and relapse from remission.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Eva Feodora Romahn, Tun Wiltgen, Matthias Bussas, Lilian Aly, Rebecca Wicklein, Christina Noll, Achim Berthele, Vera Dehmelt, Christian Mardin, Claus Zimmer, Thomas Korn, Bernhard Hemmer, Jan S. Kirschke, Mark Muehlau, Benjamin Knier
Summary: Optical coherence tomography angiography can assess retinal vessel structures in patients with multiple sclerosis. The thinning and loss of retinal vessels are associated with brain atrophy and disability in multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Martin Valis, Zbysek Pavelek, Michal Novotny, Blanka Klimova, Jana Sarlakova, Simona Haluskova, Marek Peterka, Ivana Stetkarova, Pavel Stourac, Jan Mares, Pavel Hradilek, Radek Ampapa, Marta Vachova, Eva Recmanova, Eva Meluzinova
Summary: This study analyzed the characteristics and treatment of pediatric patients with multiple sclerosis. The results showed that these patients usually start disease-modifying drug treatment at the age of 15.89, with moderate and mild relapses being common. Moreover, the first-choice treatment is similar to that of adult patients, but low efficacy or lack of tolerance may lead to treatment discontinuation in children.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Daniel Merlo, Jim Stankovich, Claire Bai, Tomas Kalincik, Chao Zhu, Melissa Gresle, Jeannette Lechner-Scott, Trevor Kilpatrick, Michael Barnett, Bruce Taylor, David Darby, Helmut Butzkueven, Anneke Van der Walt
Summary: This study utilized a computerized cognitive battery and latent class mixed models to identify discrete longitudinal reaction time trajectories in patients with relapsing-remitting multiple sclerosis. The findings indicate that a group of participants showed slowing reaction times and were more likely to experience 6-month confirmed disability progression.
Article
Clinical Neurology
Zhizheng Zhuo, Yongmei Li, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Jinli Ding, Decai Tian, Xinli Wang, Jinhui Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li, Haiqing Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Xuemei Han, Sven Haller, Frederik Barkhof, Fudong Shi, Yaou Liu
Summary: Three MRI subtypes of RRMS were identified with distinct clinical and imaging features and different prognoses. The subtypes showed variations in cognitive impairment and conversion rate to SPMS.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Tomas Kalincik, Ibrahima Diouf, Sifat Sharmin, Charles Malpas, Tim Spelman, Dana Horakova, Eva Kubala Havrdova, Maria Trojano, Guillermo Izquierdo, Alessandra Lugaresi, Alexandre Prat, Marc Girard, Pierre Duquette, Pierre Grammond, Vilija Jokubaitis, Anneke Van der Walt, Francois Grand'Maison, Patrizia Sola, Diana Ferraro, Vahid Shaygannejad, Raed Alroughani, Raymond Hupperts, Murat Terzi, Cavit Boz, Jeannette Lechner-Scott, Eugenio Pucci, Vincent Van Pesch, Franco Granella, Roberto Bergamaschi, Daniele Spitaleri, Mark Slee, Steve Vucic, Radek Ampapa, Pamela McCombe, Cristina Ramo-Tello, Julie Prevost, Javier Olascoaga, Edgardo Cristiano, Michael Barnett, Maria Laura Saladino, Jose Luis Sanchez-Menoyo, Suzanne Hodgkinson, Csilla Rozsa, Stella Hughes, Fraser Moore, Cameron Shaw, Ernest Butler, Olga Skibina, Orla Gray, Allan Kermode, Tunde Csepany, Bhim Singhal, Neil Shuey, Imre Piroska, Bruce Taylor, Magdolna Simo, Carmen-Adella Sirbu, Attila Sas, Helmut Butzkueven
Summary: The study demonstrates that continued treatment with MS immunotherapies significantly reduces disability accrual, risk of needing a walking aid, and frequency of relapses over a 15-year period.
Article
Clinical Neurology
Josephine Wauschkuhn, Gilberto Solorza Buenrostro, Lilian Aly, Susanna Asseyer, Rebecca Wicklein, Julia Maria Hartberger, Klemens Ruprecht, Mark Muehlau, Tanja Schmitz-Huebsch, Claudia Chien, Achim Berthele, Alexander U. U. Brandt, Thomas Korn, Friedemann Paul, Bernhard Hemmer, Hanna G. G. Zimmermann, Benjamin Knier
Summary: Thinning of retinal combined ganglion cell and inner plexiform layer (GCIP) as measured by OCT is common in patients with multiple sclerosis. This study aimed to investigate whether a single retinal OCT analysis allows prediction of future disease activity after a first demyelinating event. The results showed that GCIP thickness measurement provides information for early risk stratification and progression of multiple sclerosis after the initial manifestation.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Oliver Neuhaus, Wolfgang Koehler, Florian Then Bergh, Wolfgang Kristoferitsch, Juergen Faiss, Thorsten Rosenkranz, Dirk Reske, Robert Patejdl, Hans-Peter Hartung, Uwe K. Zettl
Summary: This study aimed to investigate the correlation between clinical, neuropsychological, and immunological parameters in RRMS patients with fatigue before and during treatment with GA. After 12 months of treatment, 13 patients showed improvement in all three fatigue assessment scales, while 5 patients deteriorated and 7 patients showed inconsistent effects. Fatigue and overall quality of life improved, but no clear correlation between clinical and molecular effects of GA was found in RRMS patients with fatigue.
Article
Genetics & Heredity
Vicente Navarro-Lopez, Maria Angeles Mendez-Miralles, Rosa Vela-Yebra, Ana Fries-Ramos, Pedro Sanchez-Pellicer, Beatriz Ruzafa-Costas, Eva Nunez-Delegido, Humberto Gomez-Gomez, Sara Chumillas-Lidon, Jose A. Pico-Monllor, Laura Navarro-Moratalla
Summary: This study analyzed the gut microbiota of patients with RRMS and found differences compared to a healthy control group. Analysis of the microbiota components revealed the potential of certain genera as predictive factors for RRMS prognosis and diagnosis.
Article
Clinical Neurology
Pavle Repovic, Derrick Robertson, Kiren Kresa-Reahl, Stanley L. Cohan, Ray Su, Robin Avila, Irene Koulinska, Jason P. Mendoza
Summary: This study found that dimethyl fumarate may be an effective treatment option for relapsing multiple sclerosis patients who experience suboptimal response to glatiramer acetate. In both first switch and early MS switch patients, most patients showed significant improvement in relapse rates and symptoms after 12 months of DMF treatment.
NEUROLOGY AND THERAPY
(2021)
Article
Clinical Neurology
Seraj Makkawi, Ammar Aljabri, Ghassan Bin Lajdam, Ammar Albakistani, Abdulrahman Aljohani, Suhail Labban, Razaz Felemban
Summary: This study identified the relationship between seasonal variation and relapse rate in RRMS patients in Jeddah, Saudi Arabia, and found that the relapse rate was higher during the winter and correlated with low vitamin D levels. However, relapses are likely multifactorial, and more population-based studies are needed to understand the role of environmental variables in MS exacerbation.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Xingwei Fang, Yaxin Lu, Yongmei Fu, Zifeng Liu, Allan G. Kermode, Wei Qiu, Li Ling, Chunxin Liu
Summary: This study investigated the association between routine cerebrospinal fluid (CSF) findings, especially CSF chloride, at the time of the first lumbar puncture and the relapse risk and disability progression of relapsing-remitting multiple sclerosis (RRMS). The study found that elevated CSF chloride levels were associated with a higher risk of MS relapse.
Article
Radiology, Nuclear Medicine & Medical Imaging
James G. Harper, Elizabeth N. York, Rozanna Meijboom, Agniete Kampaite, Michael J. Thrippleton, Patrick K. A. Kearns, Maria del C. Valdes Hernandez, Siddharthan Chandran, Adam D. Waldman
Summary: This study aimed to quantify brain microstructural changes in recently diagnosed relapsing-remitting multiple sclerosis (RRMS) patients using T-1 measures, and determine their associations with clinical disability. The results showed that T-1 is sensitive to brain microstructural changes in early RRMS, and prolonged T-1 in lesions and subtle changes in normal-appearing white matter and gray matter structures are associated with disability.
EUROPEAN RADIOLOGY
(2023)
Article
Neuroimaging
Amy Romanello, Stephan Krohn, Nina Von Schwanenflug, Claudia Chien, Judith Bellmann-Strobl, Klemens Ruprecht, Friedemann Paul, Carsten Finke
Summary: This study aimed to investigate brain network organization in early multiple sclerosis (MS) patients and its relationship with clinical disability status and multi-domain clinical outcomes. The results showed widespread spatiotemporal pattern of altered connectivity in patients with mild to moderate disability. Furthermore, symptom severity in different clinical outcome domains was positively associated with disability scores.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Alberto Calvi, Margareta A. Clarke, Ferran Prados, Declan Chard, Olga Ciccarelli, Manel Alberich, Deborah Pareto, Marta Rodriguez Barranco, Jaume Sastre-Garriga, Carmen Tur, Alex Rovira, Frederik Barkhof
Summary: This study found that chronic active lesions in magnetic resonance imaging (MRI), known as slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs), are associated with greater clinical progression in multiple sclerosis (MS) patients. SELs are more numerous than PRLs in MS patients.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Enric Monreal, Jose Ignacio Fernandez-Velasco, Maria Isabel Garcia-Sanchez, Susana Sainz de la Maza, Sara Llufriu, Roberto Alvarez-Lafuente, Bonaventura Casanova, Manuel Comabella, Lluis Ramio-Torrenta, Jose Enrique Martinez-Rodriguez, Luis Brieva, Albert Saiz, Sara Eichau, Jose Maria Cabrera-Maqueda, Noelia Villarrubia, Mercedes Espino, Francisco Perez-Miralles, Xavier Montalban, Mar Tintore, Ana Quiroga-Varela, Maria Inmaculada Dominguez-Mozo, Fernando Rodriguez-Jorge, Juan Luis Chico-Garcia, Daniel Lourido, Jose Carlos Alvarez-Cermeno, Jaime Masjuan, Lucienne Costa-Frossard, Luisa Maria Villar
Summary: This multicenter cohort study found that high serum neurofilament light chain (sNfL) values obtained within the first year of disease were associated with long-term disability worsening in patients with multiple sclerosis (MS), suggesting that sNfL level measurement may help identify optimal candidates for highly effective disease-modifying treatments.
Article
Clinical Neurology
Marta Renom, Ingrid Galan, Xavier Vidal, Mireia Aldevert, Gemma Curto, Patricia Feliu, Itziar Garcia, Lorena Gonzalo, Xavier Sibera, Elisenda Anglada, Roger Meza, Montserrat Garcia, Victor Najas, Neus Mongay-Ochoa, Maria Jesus Arevalo, Angela Vidal-Jordana, Mar Tintore, Helena Bascunana, Xavier Montalban, Rosa Terre, Jaume Sastre-Garriga
Summary: The aim of this study was to translate and validate the Dysphagia in Multiple Sclerosis Questionnaire (DYMUS) in Spanish. The questionnaire was filled out by 100 patients with multiple sclerosis, and the results showed that the DYMUS scale is not sufficiently useful to detect dysphagia in this population. However, it can be helpful as a screening tool when combined with other measures.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Miguel-Angel Robles-Sanchez, Montse Moharra, Cristina Bosch-Farre, Maria Jose Hernandez-Leal, Xavier Montalban, Jaume Sastre-Garriga, Lluis Ramio-Torrenta, Carme Bertran-Noguer
Summary: This qualitative study aimed to identify the key elements from the perspective of patients with relapsing-remitting multiple sclerosis (MS) to create a patient decision aid in the Spanish sociocultural context. The study found that patients have needs in information access, knowledge of available treatment options, and their decision-making role. These findings provide valuable information for designing and developing a patient decision aid to improve understanding and facilitate shared decision making between nurses and patients.
JOURNAL OF NEUROSCIENCE NURSING
(2023)
Correction
Clinical Neurology
Sachi A. Patil, Binu Joseph, Paula Tagliani, Jaume Sastre-Garriga, Xavier Montalban, Angela Vidal-Jordana, Steven L. Galetta, Laura J. Balcer, Rachel C. Kenney
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Alvaro Cobo-Calvo, Carmen Tur, Susana Otero-Romero, Pere Carbonell-Mirabent, Mariano Ruiz, Agustin Pappolla, Javier Villacieros Alvarez, Angela Vidal-Jordana, Georgina Arrambide, Joaquin Castillo, Ingrid Galan, Marta Rodriguez Barranco, Luciana Soledad Midaglia, Carlos Nos, Breogan Rodriguez Acevedo, Ana Zabalza de Torres, Neus Mongay, Jordi Rio, Manuel Comabella, Cristina Auger, Jaume Sastre-Garriga, Alex Rovira, Mar Tintore, Xavier Montalban
Summary: This study aimed to evaluate the impact of early treatment on the long-term disability risk of patients with a first demyelinating event, including MR scores. The results showed that early treatment can reduce disability risk and improve clinical outcomes.
Article
Health Care Sciences & Services
Jennifer S. Graves, Marcin Elantkowski, Yan-Ping Zhang, Frank Dondelinger, Florian Lipsmeier, Corrado Bernasconi, Xavier Montalban, Luciana Midaglia, Michael Lindemann
Summary: The Pinching Test serves as a remote tool to assess upper extremity function in MS patients and can complement standard clinical evaluations.
JMIR FORMATIVE RESEARCH
(2023)
Article
Neuroimaging
Llucia Coll, Deborah Pareto, Pere Carbonell-Mirabent, Alvaro Cobo-Calvo, Georgina Arrambide, Angela Vidal-Jordana, Manuel Comabella, Joaquin Castillo, Breogan Rodriguez-Acevedo, Ana Zabalza, Ingrid Galan, Luciana Midaglia, Carlos Nos, Annalaura Salerno, Cristina Auger, Manel Alberich, Jordi Rio, Jaume Sastre-Garriga, Arnau Oliver, Xavier Montalban, Alex Rovira, Mar Tintore, Xavier Llado, Carmen Tur
Summary: The application of convolutional neural networks (CNNs) to MRI data is a promising approach for accurate prediction of neurological conditions. The study of CNN-derived attention maps can uncover key disease mechanisms.
NEUROIMAGE-CLINICAL
(2023)
Review
Clinical Neurology
Oscar Fernandez, Xavier Montalban, Eduardo Aguera, Yolanda Aladro, Ana Alonso, Rafael Arroyo, Luis Brieva, Carmen Calles, Lucienne Costa-Frossard, Sara Eichau, Jose M. Garcia-Dominguez, Miguel A. Hernandez, Lamberto Landete, Miguel Llaneza, Sara Llufriu, Jose E. Meca-Lallana, Virginia Meca-Lallana, Neus Mongay-Ochoa, Ester Moral, Celia Oreja-Guevara, Lluis Ramio i Torrenta, Nieves Tellez, Lucia Romero-Pinel, Alfredo Rodriguez-Antiguedad
Summary: This article summarizes the latest developments in multiple sclerosis discussed at the 15th edition of the Post-ECTRIMS Meeting, including therapeutic strategies, definition of therapeutic failure, personalized treatment and precision medicine. It also presents the results from studies on oral cladribine and evobrutinib presented at ECTRIMS 2022.
REVISTA DE NEUROLOGIA
(2023)
Meeting Abstract
Clinical Neurology
L. Airas, M. Williams, T. Chitnis, S. Saini, M. Hide, G. Sussman, J. Nakahara, R. Bermel, T. Dorner, B. Loop, M. Ziehn, R. Willi, B. Kieseier, I. Nikolaev, S. Haemmerle, A. Zharkov, R. Siegel, B. Cenni, H. Wiendl, M. Maurer, A. Gimenez-Arnau, X. Montalban
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Meeting Abstract
Clinical Neurology
A. Bar-Or, A. H. Cross, A. Cunningham, Y. Hyvert, A. Seitzinger, E. E. Drouin, N. Alexandri, D. Tomic, X. Montalban
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Meeting Abstract
Clinical Neurology
Heinz Wiendl, Nicola De Stefano, Frederik Barkhof, Xavier Montalban, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Klaus Schmierer, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Elina Jarvinen, Anita Chudecka, Lidia Gardner
Meeting Abstract
Clinical Neurology
A. Bar-Or, A. H. Cross, A. Cunningham, Y. Hyvert, A. Seitzinger, E. E. Drouin, N. Alexandri, D. Tomic, X. Montalban
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Clinical Neurology
J. Kuhle, L. Kappos, X. Montalban, P. Benkert, Y. Li, K. Thangavelu, Y. Hyvert, D. Tomic
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Clinical Neurology
D. Langdon, B. Brochet, E. K. Havrdova, J. Lechner-Scott, X. Montalban, F. Patti, F. Piehl, K. Selmaj, A. Solari, N. Alexandri, A. Nolting, A. Lehn, A. Smyk
MULTIPLE SCLEROSIS JOURNAL
(2023)
