4.3 Article

Impact of neurological impairment, depression, cognitive function and coping on quality of life of people with multiple sclerosis: A relative importance analysis

Journal

MULTIPLE SCLEROSIS JOURNAL
Volume 21, Issue 11, Pages 1468-1472

Publisher

SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458514562439

Keywords

Cognitive function; coping; depression; Expanded Disability Status Scale; multiple sclerosis; predictive model; relative importance; relative weight; quality of life measures

Funding

  1. Ministry of Education, Culture and Sport of Spain

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Background: Determining the relative importance of factors that predict quality of life (QoL) in people with multiple sclerosis (MS) must be addressed through multiple regression metrics, e.g. relative weights, which are designed to solve colinearity problems. Objective: We aimed to compare disease variables, Expanded Disability Status Scale (EDSS), depressive symptomatology (BDI-FS), cognitive performance and coping in predicting MS patients' QoL, using relative weights. Methods: We assessed 97 patients with MS, using the Functional Assessment of MS (FAMS) as the criterion. Results: EDSS predicted global and physical QoL domains, whereas BDI-FS predicted general contentment and global QoL. Conclusion: EDSS and BDI-FS are relevant determinants of QoL in people with MS.

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