Article
Obstetrics & Gynecology
Chloe Arthuis, Juliette LeGoff, Marion Olivier, Anne-Sophie Coutin, Nathalie Banaskiewicz, Philippe Gillard, Guillaume Legendre, Norbert Winer
Summary: Most women (70.7%) reported a good experience after childbirth, with vaginal delivery and satisfactory management being the main factors contributing to a positive experience. Epidural analgesia increased the feeling of failure, while receiving information and consenting to procedures improved the overall experience.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Environmental Sciences
Kokeb Tesfamariam, Alemayehu Argaw, Giles T. Hanley-Cook, Seifu H. Gebreyesus, Patrick Kolsteren, Tefera Belachew, Mario Van de Velde, Sarah De Saeger, Marthe De Boevre, Carl Lachat
Summary: This study aimed to assess biomarkers of multiple mycotoxin exposure during pregnancy in rural Ethiopia and their associations with adverse birth outcomes. The findings indicated an extensive presence of multiple mycotoxin exposure among pregnant women, but no statistically significant associations were found with adverse birth outcomes.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Health Care Sciences & Services
Sabine Striebich, Elke Mattern, Theresa Oganowski, Rainhild Schafers, Gertrud Ayerle
Summary: The article discusses the methodological and organizational challenges of conducting multicenter trials in maternity wards, as well as the strategies for addressing these challenges, with a focus on the project-related and process-oriented challenges faced by hospital staff.
BMC MEDICAL RESEARCH METHODOLOGY
(2021)
Review
Endocrinology & Metabolism
Manuel S. Vidal, Ryan C. V. Lintao, Mary Elise L. Severino, Ourlad Alzeus G. Tantengco, Ramkumar Menon
Summary: Survivors of preterm birth face various disabilities, and addressing the rates of low birth weight, neonatal and maternal morbidities and mortalities is crucial. Research has provided theories on risk factors and clinical manifestations, but there is a lack of biomarkers for early diagnosis. To overcome current limitations, an integrated approach studying the network interaction between different tissues and organs is needed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Kristen H. Kjerulff, Laura B. Attanasio, Jennifer Vanderlaan, Kristin K. Sznajder
Summary: This study found that primiparous women who labor at home until their contractions become regular and <= 5-minutes apart are more likely to have active labor on hospital admission and less likely to receive oxytocin augmentation, epidural analgesia, and cesarean birth.
Article
Endocrinology & Metabolism
Kamil Biringer, Stefan Sivak, Jana Sivakova, Robert Ruzinak, Martina Martinikova, Ema Kantorova, Zuzana Biringerova, Erik Kudela, Egon Kurca
Summary: This study evaluated pregnancy-related issues in patients with multiple sclerosis (MS) and highlighted the importance of close cooperation among patients, gynaecologists, and neurologists. Vaginal delivery is not primarily contraindicated, and indications for cesarean section should be considered individually based on personal factors.
NEUROENDOCRINOLOGY LETTERS
(2021)
Article
Obstetrics & Gynecology
Johanne Augusta Horn Welle-Strand, Christian Tappert, Torbjorn Moe Eggebo
Summary: The study found no significant differences in rates of intrapartum cesarean section, postpartum hemorrhage, and anal sphincter ruptures between induced and spontaneous breech deliveries. However, neonates born from induced labor had slightly lower median pH in the umbilical artery compared to those from spontaneous labor, and there was an increased incidence of metabolic acidosis in induced labor.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Environmental Sciences
Wanrong Wang, Siqi Mu, Weizhen Yan, Naiyu Ke, Han Cheng, Rui Ding
Summary: Adverse pregnancy outcomes (APOs), including preterm birth, low birth weight, small for gestational age, stillbirth, and change in birthweight, are significantly associated with maternal exposure to PM2.5 during pregnancy, according to this meta-analysis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Obstetrics & Gynecology
Abirami Kirubarajan, Jackie Tsang, Susan Dong, Jeanette Hui, Padmaja Sreeram, Zuhal Mohmand, Shannon Leung, Alessandra Ceccacci, Mara Sobel
Summary: This systematic review highlights the urgent need for improved care and attention for individuals who experience pregnancy and childbirth in correctional facilities, including issues such as mental health challenges, dehumanization of prenatal care and delivery, lack of privacy and support.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Multidisciplinary Sciences
Samson Gebremedhin, Tilahun Bekele
Summary: In sub-Saharan Africa, pregnant women on average gain inadequate weight (6.6 kg) over pregnancy, with the most significant weight gain occurring in the second and third trimesters. Women with higher education and from wealthier households tend to have higher gestational weight gain. Recent data does not show significant improvements in gestational weight gain in sub-Saharan Africa.
Article
Public, Environmental & Occupational Health
Ya-Hui Chang, Yu-Wen Chien, Chiung-Hsin Chang, Ping-Ling Chen, Tsung-Hsueh Lu, I-Lin Hsu, Chung-Yi Li
Summary: This study investigated the association between maternal exposure to motor vehicle crashes during pregnancy and the risk of adverse neonatal outcomes. The results showed that offspring exposed to maternal MVCs during pregnancy had a higher risk of birth defects, especially in the early stages of pregnancy. Further research is needed to understand the underlying mechanisms linking maternal exposure to MVCs and birth defects.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Anders Husby, Jan Wohlfahrt, Mads Melbye
Summary: A woman's reproductive history is associated with her risk of ovarian cancer. This study found that the protective effect against ovarian cancer is mainly driven by the first three pregnancies, and not the duration of pregnancy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Obstetrics & Gynecology
Parivash Ahmadpour, Sanaz Moosavi, Sakineh Mohammad-Alizadeh-Charandabi, Shayesteh Jahanfar, Mojgan Mirghafourvand
Summary: This study investigated the effect of birth plan on maternal and neonatal outcomes. The results showed that a birth plan can improve childbirth experiences, increase perceived support and control in labor, reduce fear of delivery, alleviate psychological symptoms of depression and PTSD, and increase the frequency of vaginal delivery.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Jessica Alana Hoffmann, Kathleen Gruendler, Dagmar- Ulrike Richter, Johannes Stubert
Summary: This study evaluates the performance of CCL2 and CXCL10 as biomarkers for predicting spontaneous preterm birth in high-risk women. The results suggest that high CXCL10 serum levels are associated with a higher risk of preterm birth before 34 weeks, while low CCL2 serum levels are associated with a higher risk of preterm birth within seven days. Additionally, the CXCL10/CCL2 ratio shows the best predictive performance for preterm birth.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Clinical Neurology
Juan Pablo Cuello, Maria Luisa Martinez Gines, Jose Manuel Garcia Dominguez, Amalia Tejeda-Velarde, Alberto Lozano Ros, Yolanda Higueras, Ariana Meldana Rivera, Haydee Goicochea Briceno, Santiago Garcia-Tizon, Juan De Leon-Luis, Silvia Medina Heras, Jose Ignacio Fernandez Velasco, Silvia Perez-Perez, Maria Angel Garcia-Martinez, Beatriz Pardo-Rodriguez, Maria Inmaculada Dominguez-Mozo, Estefania Garcia-Calvo, Hector Estevez, Jose Luis Luque-Garcia, Luisa Maria Villar, Roberto Alvarez-Lafuente
Summary: Short-chain fatty acids (SCFAs) can have pro- or anti-inflammatory properties, but their relationship with multiple sclerosis (MS) relapses during pregnancy remains unknown. This study found that low propionate/acetate ratio values during the first trimester of gestation identified MS patients at risk of relapses during pregnancy and the postpartum period. Increases in acetate levels were observed in all MS patients during pregnancy and postpartum, but propionate and butyrate values were higher in nonrelapsing patients and remained similar to healthy pregnant women in relapsing patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Jonathan Roux, Elaine Kingwell, Feng Zhu, Helen Tremlett, Emmanuelle Leray
Summary: The study applied multi-channel sequence analysis (MCSA) to identify care consumption patterns of persons with multiple sclerosis in British Columbia, Canada, revealing disparities between different care consumption clusters and associations based on demographics and clinical features both in incident and prevalent cases.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
A. Dessa Sadovnick, Irene M. Yee, Maria Criscuoli, Gabriele C. DeLuca
Summary: The study evaluated the impact of temporal increase of female to male sex ratio on the familial risk for individuals with multiple sclerosis. Genetic sharing and environmental factors were found to both play important roles in determining familial risk. An increase in MS risk due to environmental factors was observed over time, particularly for sisters/brothers of female probands.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Huah Shin Ng, Feng Zhu, Elaine Kingwell, Yinshan Zhao, Shenzhen Yao, Okechukwu Ekuma, Lawrence W. Svenson, Charity Evans, John D. Fisk, Ruth Ann Marrie, Helen Tremlett
Summary: The study found a beneficial relationship between DMD exposure and hospitalizations, but generally no substantial differences in physician visits.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Ali Mirza, Feng Zhu, Natalie Knox, Jessica D. Forbes, Gary Van Domselaar, Charles N. Bernstein, Morag Graham, Ruth Ann Marrie, Janace Hart, E. Ann Yeh, Douglas L. Arnold, Amit Bar-Or, Julia O'Mahony, Yinshan Zhao, William Hsiao, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett
Summary: In this study, we found differences in the functional potential and taxonomy of the gut microbiome between individuals with pediatric-onset MS and controls, including a higher prevalence of methane-producing pathways from Archaea and depletion of lactate fermentation pathways. DMD exposure was associated with enrichment of butyrate-producing enzymes. These findings suggest a disturbed gut microbiome in individuals with MS.
Article
Immunology
Huah Shin Ng, Jonas Graf, Feng Zhu, Elaine Kingwell, Orhan Aktas, Philipp Albrecht, Hans-Peter Hartung, Sven G. Meuth, Charity Evans, John D. Fisk, Ruth Ann Marrie, Yinshan Zhao, Helen Tremlett
Summary: This study examined the relationship between age, disease-modifying drug (DMD) exposure, and health service use in a population of multiple sclerosis (MS) patients. The results showed that the use of any DMDs in patients under the age of 55 was associated with a lower risk of hospitalization, while this association was not significant in patients aged 55 and above.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Helen Tremlett, Kassandra L. Munger, Naila Makhani
Summary: Growing evidence suggests the existence of a clinically symptomatic prodromal phase in multiple sclerosis (MS), which could have significant implications for prevention, early recognition and treatment, as well as improved disease prognosis. However, the understanding of the prodromal phase in MS is still limited, and further research is needed to identify biomarkers and address related challenges.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Geoffrey Liang, Feng Zhu, Ali Mirza, Amit Bar-Or, Charles N. Bernstein, Christine Bonner, Jessica D. Forbes, Morag Graham, Janace Hart, Natalie C. Knox, Ruth Ann Marrie, Julia O'Mahony, Gary Van Domselaar, E. Ann Yeh, Yinshan Zhao, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett
Summary: This study examined the changes in gut microbiota composition across repeated samples in paediatric-onset multiple sclerosis (MS) and monophasic-acquired demyelinating syndromes (monoADS). The results showed stability in microbiota composition between different stool samples, suggesting that single stool sample procurement is a reasonable first approach.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Anibal Chertcoff, Huah Shin Ng, Fong Zhu, Yinshan Zhao, Helen Tremlett
Summary: This study estimated the prevalence of polypharmacy in individuals with multiple sclerosis (MS) and compared the characteristics of those with and without polypharmacy. The results showed that more than one in four MS patients met the criteria for polypharmacy. The likelihood of polypharmacy was higher in women, older individuals, those with multiple comorbidities, and lower socioeconomic status.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Floriane Calocer, Huah Shin Ng, Feng Zhu, Yinshan Zhao, Olivier Dejardin, Emmanuelle Leray, Gilles Defer, Charity Evans, John D. Fisk, Ruth Ann Marrie, Helen Tremlett
Summary: The study found that lower socioeconomic status is associated with a higher mortality risk in persons with multiple sclerosis (PwMS).
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Dessa Sadovnick, Maria Criscuoli, Irene Yee, Robert Carruthers, Alice Schabas, Virginia Devonshire, Penelope Smyth
Summary: This study found that women with multiple sclerosis (MS) do not have a higher risk of first-trimester miscarriages compared to the general population.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Fardowsa L. A. Yusuf, Ayesha Asaf, Ruth Ann Marrie, Ping Li, Kyla McKay, Yinshan Zhao, Feng Zhu, Colleen Maxwell, Helen Tremlett
Summary: Canada has one of the highest rates of paediatric-onset multiple sclerosis (PoMS) globally, and the prevalence, but not incidence, has increased over time. Allocation of resources to support the growing youth population with MS should be a priority.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Meeting Abstract
Clinical Neurology
F. La Yusuf, A. Asaf, P. Li, K. A. Mckay, Y. Zhao, F. Zhu, H. Tremlett, R. A. Marrie, C. Maxwell
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Bridget LaMonica Ostrem, Annika Anderson, Sarah Conway, Brian C. Healy, Jiwon Oh, Dina Jacobs, Ruth Dobson, Edith Larmon Graham, A. Dessa Sadovnick, Vanessa Zimmerman, Yanqing Liu, Riley Bove, Maria Houtchens
Summary: Moderately to severely disabled women with MS have a lower risk of relapse during pregnancy, but a significant increase postpartum. Women with higher preconception EDSS have a greater risk of relapses and disability worsening postpartum.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2022)
Meeting Abstract
Clinical Neurology
X. Zhou, M. Horton, K. Mccauley, L. Krupp, J. Tillema, M. P. Gorman, L. Benson, J. Ness, B. Weinstock-Guttman, A. T. Waldman, J. Hart, T. Casper, S. Lynch, H. Tremlett, E. Waubant
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
J. Graf, H. Ng, F. Zhu, E. Kingwell, O. Aktas, P. Albrecht, H. Hartung, S. Meuth, C. Evans, J. D. Fisk, R. Marrie, Y. Zhao, H. Tremlett
MULTIPLE SCLEROSIS JOURNAL
(2022)
