Article
Health Care Sciences & Services
Feng Liu, Zhenxiang Zhang, Beilei Lin, Zhiguang Ping, Yongxia Mei
Summary: The study translated and cross-culturally adapted the RTW-SE questionnaire into Chinese, and examined its psychometric properties among young and middle-aged stroke survivors using Rasch model analysis, confirming its appropriate reliability and validity for measuring self-efficacy to return to work.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Article
Medicine, General & Internal
Fabio Zaina, Irene Ferrario, Antonio Caronni, Stefano Scarano, Sabrina Donzelli, Stefano Negrini
Summary: Idiopathic scoliosis is a common condition in adults that can affect their physical and mental health. The Scoliosis Research Society-22 Questionnaire (SRS-22) and the Italian Spine Youth Quality of Life (ISYQOL) international questionnaire are both used to assess health-related quality of life in scoliosis patients. This study compared the validity of ISYQOL and SRS-22 in adults with scoliosis, and found that both questionnaires were comparable in measuring disease burden.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Anne F. Klassen, Emiel L. W. G. van Haren, Tert C. van Alphen, Stefan Cano, Karen M. Cross, Anne-Margreet van Dishoeck, Kenneth L. Fan, Maarten Michael Hoogbergen, Dennis Orgill, Lotte Poulsen, Jens Ahm Sorensen, Lee Squitieri, Elena Tsangaris, Dalibor Vasilic, Andrea L. Pusic
Summary: The WOUND-Q is a patient-reported outcome measurement tool for chronic wounds, developed through patient interviews and expert input on wound characteristics, quality of life, care experience, and wound treatment. The tool has been translated into Danish and Dutch and validated through an international field-test study, demonstrating reliability and validity in measuring outcomes from the perspective of patients with any type of wound.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Clinical Neurology
Samira Zarrabi-Ajami, Hadi Zamanian, Mohammadali Amini-Tehrani, Zahra Farhadidanaloo, Razieh Janati Razavi, Azam Abbasi, Saeideh Darbandi, Pegah Chenari
Summary: This study conducted a cross-cultural validation of the short quality of life scale (SQoL) for multiple sclerosis (MS) patients in the Persian language. The scale's original structure had an acceptable model fit, but a slightly modified structure also had a sound fit and meaningful dimensions. The Persian version of the scale (P-SQoL) showed good reliability and validity. Further cross-cultural investigations are recommended to confirm these findings.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Gerontology
Joelle H. Fong, Yongjoon Youn
Summary: This study examined the stability over time of activities of daily living (ADL) items in three different countries and found that dressing and bathing were relatively more difficult for older adults in all study populations. The results support the use of ADL scales as screening tools and interventions to reduce dependency in bathing and dressing can help improve independent functioning for community-dwelling older adults.
Article
Environmental Sciences
Anne Mari Steigen, Hanne Soberg Finbraten, Annette Lovheim Kleppang
Summary: The aim of this study was to assess the psychometric properties of the five-item version of the General Self-Efficacy Scale (GSES) among adolescents aged 13 to 19 using Rasch analysis. The results showed that the five-item version of the GSES was found to be unidimensional and had acceptable reliability, although the targeting could have been better. All items had ordered thresholds, indicating that the response categories worked well. Therefore, the five-item version of the GSES has potential for measuring self-efficacy in a general population of adolescents.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychology, Multidisciplinary
Fatemeh Asl-Dehghan, Simin Hosseinian, Abbas Abdollahi
Summary: The aim of this study was to examine the psychometric properties of the Persian version of the Psychologists and Counselors Self-Efficacy Scale (PCES). The results showed that the scale had acceptable validity and reliability, making it suitable for use in supervision and employment of counselors and psychologists.
CURRENT PSYCHOLOGY
(2023)
Article
Rheumatology
Mwidimi Ndosi, Celia Almeida, Jill Dawson, Emma Dures, Rosemary Greenwood, Alison Bromhead, Catherine Guly, Steve Stern, Catherine Hill, Sarah Mackie, Joanna C. Robson
Summary: The study aimed to determine the final scale structure and measurement properties of the GCA patient reported outcome (GCA-PRO) in assessing the impact of GCA on health-related quality of life (HRQoL). It found that the final GCA-PRO is a 30-item, four-domain scale with robust evidence of validity and reliability in measuring HRQoL in people with GCA.
Article
Clinical Neurology
Carolyn A. Young, Roger Mills, David Rog, Basil Sharrack, Tahir Majeed, Cris S. Constantinescu, Seema Kalra, Timothy Harrower, Helen Santander, Gillian Courtald, Helen L. Ford, John Woolmore, Alan Tennant
Summary: The study found that 91.2% of multiple sclerosis patients' quality of life can be explained by fatigue, disability, and self-efficacy, with age having an insignificant effect.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Rehabilitation
Temima Greenberg, Rotem Soll, Mark Dolev, Alon Kalron
Summary: This study aimed to evaluate the test-retest reproducibility and convergent validity of the sitting-rising test in people with multiple sclerosis. The results showed a strong correlation between the SRT and other functional tests, supporting its validity and reproducibility in this population.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Anna He, Tim Spelman, Ali Manouchehrinia, Olga Ciccarelli, Jan Hillert, Kyla McKay
Summary: Timing of disease-modifying therapy affects clinical symptoms and physical health in patients with multiple sclerosis, but does not affect overall quality of life.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Jing Chen, Ibrahima Diouf, Bruce Taylor, Tomas Kalincik, Ingrid van der Mei
Summary: In a large prospective cohort study, natalizumab showed superior outcomes over time in terms of patient-reported health and employment outcomes compared to other DMTs. These findings could impact treatment selection and cost-effectiveness analyses in clinical practice.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Education, Scientific Disciplines
Johan Renes, Cees P. M. van der Vleuten, Carlos F. Collares
Summary: This study compares a novel multimodal test format called Proxy-CBA with the traditional MCQ-CBA and finds that Proxy-CBA has higher reliability and validity, while maintaining similar cognitive load, suggesting its utility as an alternative assessment format.
Article
Health Care Sciences & Services
Hadeel R. Bakhsh, Nouf S. Aldajani, Bodor Bin Sheeha, Monira I. Aldhahi, Atheer A. Alsomali, Ghada K. Alhamrani, Rahaf Z. Alamri, Rehab Alhasani
Summary: This study translated and validated the Arabic version of the PROMIS General Life Satisfaction Short Form (GLS SF5a) in the general population of Saudi Arabia. The findings confirmed the satisfactory psychometric properties of the Arabic version, indicating its usefulness as a tool for measuring general life satisfaction. Further research is needed to explore its responsiveness and feasibility in clinical settings.
Article
Psychology, Clinical
Jamie L. Tingey, Thomas R. Valentine, Anna L. Kratz, Jacob A. Bentley, Dawn M. Ehde, Kevin N. Alschuler
Summary: This study aims to improve our understanding of self-efficacy in individuals newly diagnosed with MS by examining self-efficacy trajectories and identifying patient characteristics associated with trajectories in the first year following diagnosis. The study found that self-efficacy remains relatively stable in the first year following a MS diagnosis, but high symptom severity is associated with decreased self-efficacy at 12-months postdiagnosis. Clinical characteristics, such as MS diagnosis and disability level, also appear to influence the course of self-efficacy in this postdiagnosis year. Timely interventions can enhance self-efficacy and improve specific clinical characteristics, promoting healthy self-management of MS.
REHABILITATION PSYCHOLOGY
(2023)
Article
Clinical Neurology
Carolyn Young, Susana Pinto, Julian Grosskreutz, Orla Hardiman, Lora L. Clawson, Merit E. Cudkowicz, Jinsy A. Andrews
Summary: The roundtable meeting discussed respiratory support in ALS patients, highlighting the potential of orally administered medication in delaying the introduction of NIV or enhancing its benefits. Furthermore, attention was given to the impact of the COVID-19 pandemic on the usual assessment and management practices for respiratory difficulties in ALS patients.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2022)
Article
Clinical Neurology
Carolyn A. Young, Roger Mills, Dawn Langdon, Basil Sharrack, Tahir Majeed, Seema Kalra, David Footitt, David Rog, Tim Harrower, Richard Nicholas, John Woolmore, John Thorpe, C. Oliver Hanemann, Helen Ford, David Paling, Cathy Ellis, Jackie Palace, Cris Constantinescu, Alan Tennant
Summary: This study aimed to determine the distribution of self-efficacy in people with Multiple Sclerosis (pwMS) and identify distinct self-efficacy trajectories. The results revealed four different trajectories, each associated with different health status indicators. Baseline self-efficacy levels were found to be predictive of individuals' trajectories.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Health Care Sciences & Services
Hikari Ando, Rosanna Cousins, Carolyn A. Young
Summary: This study investigated factors influencing quality of life in people with multiple sclerosis (pwMS), revealing four key factors: restricted enjoyment, disrupted future, challenged self-perception, and well-being of significant others. Differences in quality of life impact were found across different subtypes of MS, attributed to varying illness trajectories. It is important for clinicians to understand and address the unique challenges faced by pwMS based on their subtype.
QUALITY OF LIFE RESEARCH
(2022)
Article
Clinical Neurology
Carolyn Young, John Ealing, Christopher McDermott, Tim Williams, Ammar Al-Chalabi, Tahir Majeed, Rhys Roberts, Roger Mills, Alan Tennant
Summary: The study found that dyspnea in ALS patients influences quality of life and depression largely through indirect effects, primarily via anxiety and fatigue, while disability plays a dominant role in the model.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2022)
Article
Clinical Neurology
Maria Grazia Celani, Francesco Nonino, Kathryn Mahan, Massimiliano Orso, Ben Ridley, Elisa Baldin, Angelo Antonio Bignamini, Roberto D'Amico, Teresa Anna Cantisani, Cinzia Colombo, Fary Khan, Sascha Koepke, Joanna Laurson-Doube, Catherine Schvarz, Carolyn A. Young, Guy Peryer, Paolo Rosati, Graziella Filippini
Summary: Collaborating with stakeholders, research on multiple sclerosis revealed high priority questions such as the use of MRI in predicting disability worsening, benefits and harms of different drugs for PwMS, and the impact of multidisciplinary care on health outcomes. The survey results provide guidance for future research and reducing research waste.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Carolyn A. Young, John Ealing, Christopher J. McDermott, Tim L. Williams, Ammar Al-Chalabi, Tahir Majeed, Kevin Talbot, Timothy Harrower, Christina Faull, Andrea Malaspina, Joe Annadale, Roger J. Mills, Alan Tennant
Summary: The aim of this study was to investigate whether the WHODAS 2.0 can provide interval level measurement of disability in ALS, allowing parametric analyses. The results showed that the WHODAS 2.0 can be used as a brief patient reported outcome measure to assess disability in ALS and can be used for surveillance of at risk populations.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Rubika Balendra, Ashley R. Jones, Ahmad Al Khleifat, Theresa Chiwera, Paul Wicks, Carolyn A. Young, Pamela J. Shaw, Martin R. Turner, P. Nigel Leigh, Ammar Al-Chalabi
Summary: ALS is a clinically heterogeneous disease and the King's clinical staging system has been proposed to aid in patient care, research, trial design and health economic analyses. This study validates the King's clinical staging system in four patient groups located in different regions and countries, demonstrating consistent results.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
C. A. Young, J. Ealing, C. J. McDermott, T. L. Williams, A. Al-Chalabi, T. Majeed, K. Talbot, T. Harrower, C. Faull, A. Malaspina, J. Annadale, R. J. Mills, A. Tennant
Summary: This study reveals that the prevalence of depression in ALS patients is close to a quarter, with most patients belonging to a single trajectory group. Estimates based on screening for current depressive symptoms underestimate the actual prevalence of depression.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Psychology, Clinical
I. Rothman, A. Tennant, R. J. Mills, C. A. Young
Summary: This study aimed to explore the relationship between health locus of control and clinical and psychosocial factors associated with multiple sclerosis (MS). The findings showed that health locus of control was significantly associated with clinical variables and age, but not gender or educational level. Believing that health is controlled mainly by chance was found to be most beneficial for quality of life in MS.
JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS
(2023)
Article
Clinical Neurology
Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, Floriana De Angelis, Anisha Doshi, Sarah Wright, Madiha C. Shatila, Marios C. Yiannakas, Fatima Chowdhury, Jon Stutters, Antonio Ricciardi, Ferran Prados, David MacManus, Marie Braisher, James Blackstone, Olga Ciccarelli, Claudia A. M. Gandini Wheeler-Kingshott, Frederik Barkhof, Jeremy Chataway
Summary: This study aimed to investigate the cross-sectional relationships between excess modifiable cardiovascular risk (CVR) and whole and regional brain atrophy as well as disability in patients with secondary progressive multiple sclerosis (SPMS). The results showed that prematurely achieved CVR was associated with smaller brain volumes and poorer working memory performance in SPMS patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Mojtaba Dehghan, Parisa Sharifi, Jafar Hasani, Carolyn A. Young, Dawn Langdon
Summary: The present study aimed to investigate the impact of self-efficacy and emotion regulation difficulties on distress and quality of life in multiple sclerosis (MS) patients, as well as comparing different types of MS (RRMS, PPMS, and SPMS) in terms of self-efficacy, emotion regulation difficulties, distress, and quality of life. The findings revealed that self-efficacy had a negative impact on emotion regulation difficulties and distress, while having a positive impact on quality of life. Emotion regulation difficulties had a negative impact on quality of life and a positive impact on distress. Moreover, the indirect effect of self-efficacy on distress and quality of life through emotion regulation difficulties was significant. Additionally, significant differences were found between RRMS and SPMS in terms of self-efficacy and distress.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Health Care Sciences & Services
Carolyn J. Young, David Rog, Basil Sharrack, Cris Constantinescu, Seema Kalra, Tim Harrower, Dawn Langdon, Alan J. Tennant, Roger Mills
Summary: The reliable measurement of disability in MS using WHODAS 2.0 would be beneficial for clinical and research purposes.
QUALITY OF LIFE RESEARCH
(2023)
Article
Medicine, Research & Experimental
Rebecca Gould, Charlotte K. Rawlinson, Ben Thompson, Kirsty Weeks, Rebecca Gossage-Worrall, Hannah A. Cantrill, Marc Serfaty, Christopher Graham, Lance H. McCracken, David White, Robert Howard, Matt Bursnall, Mike Bradburn, Ammar Al-Chalabi, Richard Orrell, Suresh Chhetri, Rupert Noad, Aleksandar Radunovic, Tim J. Williams, Carolyn J. Young, David Dick, Vanessa Lawrence, Laura Goldstein, Tracey Young, John Ealing, Hamish McLeod, Nicola Williams, Helen Weatherly, Richard Cave, Theresa Chiwera, Francesco Pagnini, Cindy Cooper, Pamela Shaw, Christopher McDermott, COMMEND Collaboration Group
Summary: This study examined the feasibility and acceptability of Acceptance and Commitment Therapy (ACT) for improving the psychological health of people living with Motor Neuron Disease (MND). The results showed that ACT may have some positive effects on the psychological health of the participants, but further research with a larger sample size is needed for confirmation.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Clinical Neurology
Carolyn A. Young, David J. Rog, Radu Tanasescu, Seema Kalra, Dawn Langdon, Alan Tennant, Roger J. Mills
Summary: This study examined the properties of the MS Vision Questionnaire (MSVQ-7) in a large multiple sclerosis (MS) population. The results showed that visual problems were reported by 80% of MS patients and varied over time. The MSVQ-7 questionnaire demonstrated good psychometric properties and strong associations with anxiety, depression, and stigma. This highlights the importance of regular monitoring of visual problems in MS patients for their psychological well-being.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Carolyn A. Young, David J. Rog, Basil Sharrack, Radu Tanasescu, Seema Kalra, Timothy Harrower, Alan Tennant, Roger J. Mills
Summary: In patients with relapsing-remitting multiple sclerosis, factors such as smoking, comorbidities, disease-modifying therapy, and patient-reported outcome measures can influence the risk of relapse, along with age.
NEUROLOGICAL SCIENCES
(2023)
