Article
Immunology
Chen Du, Pei Zeng, Jin-Rui Han, Tian-Xiang Zhang, Dongmei Jia, Fu-Dong Shi, Chao Zhang
Summary: The study showed that tocilizumab in combination with high-dose methylprednisolone was effective in reducing disability and relapse risk in patients with acute myelitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica and its spectrum is a relapsing demyelinating disorder of the central nervous system, encompassing six syndromes and associated with aquaporin-4 autoantibodies. Effective treatment is able to prevent relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica, previously known as Devic's disease, is a relapsing demyelinating disorder of the central nervous system that encompasses six syndromes and is associated with aquaporin-4 autoantibodies. Effective treatment is crucial in preventing relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Ren Wei, Xiaolu Xu, Yunyun Duan, Ningnannan Zhang, Jie Sun, Haiqing Li, Yuxin Li, Yongmei Li, Chun Zeng, Xuemei Han, Fuqing Zhou, Muhua Huang, Runzhi Li, Zhizheng Zhuo, Frederik Barkhof, James H. Cole, Yaou Liu
Summary: This study evaluated the clinical significance of deep learning-derived brain age prediction in NMOSD and RRMS. The results showed that both NMOSD and RRMS patients had a significantly higher brain age gap compared to healthy controls. The brain age gap was associated with baseline disability score, advanced brain volume loss, and disease duration. Additionally, the brain age gap predicted the worsening of disability status in both NMOSD and RRMS patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Silvia Messina, Romina Mariano, Ruth Geraldes, Su-Hyun Kim, Chanjira Satukijcha, Domizia Vecchio, Yi Yi Chua, James Taylor, Naveen George, Ana Cavey, Alejandro Rubio Diaz, Sandra Reeve, Rosie Everett, Gabriele De Luca, Maria Isabel Leite, Ho Jin Kim, Jacqueline Palace
Summary: Smoking is associated with worse disability in NMOSD-AQP4-Ab and MS patients, mainly through poor recovery rather than increased risk of relapses. Additionally, MS patients who smoke have a significantly higher risk of reaching EDSS 6 and SPMS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Immunology
Xiaoya Chen, Yuling Peng, Qiao Zheng, Dan Luo, Yongliang Han, Qi Luo, Qiyuan Zhu, Tianyou Luo, Yongmei Li
Summary: The study investigated the differences in fiber connections between RRMS and NMOSD patients and their correlation with brain tissue volume and structural and functional network parameters. The results showed that RRMS patients had decreased fiber numbers, especially in middle- and long-range connections, as well as increased fiber numbers in short-range connections compared to NMOSD patients and healthy controls. The FA of three fibers was significantly reduced in both RRMS and NMOSD, with RRMS showing greater reduction. The fiber numbers of short- and long-range connections in RRMS correlated with brain tissue atrophy and structural network parameters. There was no worsening of fiber damage in the short-term follow-up of both diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Juan Zhang, Mei-Jiao Chen, Gui-Xian Zhao, Hong-Fu Li, Lei Wu, Yong-Feng Xu, Yajin Liao, Zengqiang Yuan, Zhi-Ying Wu
Summary: The study explored the association between PRRC2A variants and susceptibility to NMOSD and MS in the Han Chinese population. Certain PRRC2A variants were found to alter susceptibility to AQP4(+)NMOSD and MS, with specific genotypes increasing the risk. Additionally, haplotypes and gene expression levels associated with these variants were identified, suggesting potential implications for personalized therapeutic approaches in these disease entities.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Eun Bin Cho, Se Young Jung, Jin-Hyung Jung, Yohwan Yeo, Hee Jin Kim, Kyungdo Han, Dong Wook Shin, Ju-Hong Min
Summary: A population-based study in South Korea found that patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) have an increased risk of developing dementia, with MS patients having a higher risk compared to NMOSD patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Romina Mariano, Silvia Messina, Adriana Roca-Fernandez, Maria Leite, Yazhuo Kong, Jacqueline A. Palace
Summary: Spinal cord involvement is a key feature of multiple sclerosis, neuromyelitis optica with AQP4 antibodies, and MOG-antibody disease. Quantitative spinal cord MRI was used in a cross-sectional study to differentiate these conditions, showing significant damage in AQP4-antibody disease and multiple sclerosis, while MOG-antibody disease had a predominant central grey matter component. The study also found that relapsing MOG-antibody disease is a more severe phenotype and applied various analyses to discriminate between different diseases.
Article
Clinical Neurology
Negar Molazadeh, Tetsuya Akaishi, Gauruv Bose, Shuhei Nishiyama, Tanuja Chitnis, Michael Levy
Summary: Relapse-independent changes in the EDSS, CDW, and MRI activity are not common in AQP4+NMOSD and MOGAD, especially when compared with MS. Our study supports the importance of preventing relapses in AQP4+NMOSD and MOGAD and suggests different pathologic mechanisms of relapse-free neurological damage between MS and AQP4+NMOSD/MOGAD.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Burak Arslan, Gokce Ayhan Arslan, Asli Tuncer, Rana Karabudak, Aylin Sepici Dincel
Summary: This pilot study evaluated dynamic thiol-disulfide homeostasis as an oxidative stress parameter in neuroimmunological diseases, finding a significant relationship between clinical features and thiol homeostasis. Serum biomarkers of thiol homeostasis differed from CSF levels, indicating a potential role in monitoring disease activity.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Laura Clarke, Simon Arnett, Wajih Bukhari, Elham Khalilidehkordi, Sofia Jimenez Sanchez, Cullen O'Gorman, Jing Sun, Kerri M. Prain, Mark Woodhall, Roger Silvestrini, Christine S. Bundell, David A. Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J. Brew, Wallace Brownlee, Helmut Butzkueven, William M. Carroll, Cella Chen, Alan Coulthard, Russell C. Dale, Chandi Das, Marzena J. Fabis-Pedrini, David Gillis, Simon Hawke, Robert Heard, Andrew P. D. Henderson, Saman Heshmat, Suzanne Hodgkinson, Trevor J. Kilpatrick, John King, Christopher Kneebone, Andrew J. Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard A. L. Macdonell, Deborah F. Mason, Pamela A. McCombe, Jennifer Pereira, John D. Pollard, Sudarshini Ramanathan, Stephen W. Reddel, Cameron P. Shaw, Judith M. Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C. Wong, Eppie M. Yiu, Michael H. Barnett, Allan G. K. Kermode, Mark P. Marriott, John D. E. Parratt, Mark Slee, Bruce Taylor, Ernest Willoughby, Fabienne Brilot, Angela Vincent, Patrick Waters, Simon A. Broadley
Summary: Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS with overlapping clinical and MRI features, but distinguishing them can be achieved with the use of MRI features and machine learning models.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Wei Lin, Chung-Hsing Chou, Fu-Chi Yang, Chia-Kuang Tsai, Yu-Kai Lin, Yueh-Feng Sung
Summary: A patient previously diagnosed with RRMS experienced fatal rebound syndrome after cessation of fingolimod treatment. Fingolimod withdrawal syndrome, although more commonly seen in patients with MS, can also occur in other patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jinhua Tang, Xiaopeng Zeng, Jun Yang, Lei Zhang, Hang Li, Rui Chen, Shi Tang, Yetao Luo, Xinyue Qin, Jinzhou Feng
Summary: This study explores the expression patterns of RGMa in NMOSD and its correlation with the clinical features of the disease. The results suggest that RGMa may serve as a potential biomarker for predicting the severity, disability, and clinical features of NMOSD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Yara D. Fragoso, Sidney Gomes, Marcus Vinicius M. Goncalves, Euldes Mendes Junior, Bianca Etelvina S. de Oliveira, Cristiane Franklin Rocha, Gutemberg A. Cruz dos Santos, Carlos Bernardo Tauil, Raquel Vassao Araujo, Jean Pierre S. Peron
Summary: This article reports on nine patients (eight with MS and one with NMOSD) who experienced a disease relapse shortly after receiving their first dose of AZD1222 vaccine against COVID-19. These patients had been stable for six years on average, with no disease activity and unchanged medication. Within a median of 13 days (range 7 to 25 days) after vaccination, they developed new relapses with increased disability and new lesions on magnetic resonance imaging. Although this association may be rare, it suggests a potential adverse event of AZD1222.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Xiaobo Sun, Wei Qiu, Jingqi Wang, Shisi Wang, Yuge Wang, Xiaonan Zhong, Chunxin Liu, Chunping Cui, Hai Hong, Hui Yang, Xiao-Jing Li, Zhengqi Lu, Xueqiang Hu, Allan G. Kermode, Lisheng Peng
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2020)
Article
Clinical Neurology
Xiaonan Zhong, Chen Chen, Xiaobo Sun, Jingqi Wang, Rui Li, Yanyu Chang, Ping Fan, Yuge Wang, Yunting Wu, Lisheng Peng, Zhengqi Lu, Wei Qiu
Summary: The study found that the HLA-DQB1*05:02 allele is significantly associated with NMOSD in Chinese patients, while the Haplotype HLA-DQB1*05:02-DRB1*15:01 and loss-of-function mutations in NOP16 play important roles in disease susceptibility. The IgG1-G390R variant is also commonly found in NMOSD patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Immunology
Cong Li, Jingqi Wang, Xiaobo Sun, Rui Li, Yanyu Chang, Yuge Wang, Xiaonan Zhong, Allan G. Kermode, Zhifeng Mao, Wei Qiu
Summary: The study found that immunosuppression treatment was less frequently used in children with NMOSD compared to adults, and patients who had been using medication for a long period still need to be cautious of relapses after drug withdrawal.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Behavioral Sciences
Chunxin Liu, Hui Xiao, Xiayin Zhang, Yipeng Zhao, Rui Li, Xiaonan Zhong, Yuge Wang, Yaqing Shu, Yanyu Chang, Jingqi Wang, Caixia Li, Haotian Lin, Wei Qiu
Summary: OCT angiography revealed distinct structural and microvascular retinal changes in MS and AQP4-IgG-seropositive NMOSD. The combination of structural and microvascular parameters showed promising diagnostic capabilities for discriminating between NMOSD and MS.
BRAIN AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Wenjing Luo, Yashuang Chen, Shanshan Mao, Jianing Jin, Chunxin Liu, Xiaonan Zhong, Xiaobo Sun, Allan G. Kermode, Wei Qiu
Summary: The study showed that sNfL levels are beneficial for identifying recent relapses and seizures, and indicate that adult and pediatric MOGAD patients had similar sNfL levels.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Immunology
Xiaoyu Ma, Chen Chen, Ling Fang, Xiaonan Zhong, Yanyu Chang, Rui Li, Yuge Wang, Xueqiang Hu, Wei Qiu, Yaqing Shu
Summary: Patients with anti-NMDARE showed decreased serum CD40 and increased CD40L concentrations. Both CD40 and CD40L levels were elevated in the acute stage and reduced during remission. Serum CD40L levels were positively correlated with serum CD40 levels, indicating a potential role of the CD40/CD40L signaling pathway in the pathogenesis of anti-NMDARE.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Immunology
Xi Cheng, Luyao Zhou, Zhibin Li, Shishi Shen, Yipeng Zhao, Chunxin Liu, Xiaonan Zhong, Yanyu Chang, Allan G. Kermode, Wei Qiu
Summary: In this study, the role of Tfh cells in NMOSD recurrence and the regulation mechanism of serum CXCL13 levels and bile acid GUDCA were investigated. The results revealed that the frequency of circulating Tfh cells was lower in patients with ARR<1, serum CXCL13 levels were downregulated, and the level of bile acid GUDCA was positively correlated with CXCL13. Additionally, the frequency of Tfh precursor cells in the spleen decreased after GUDCA intervention.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Clinical Neurology
Xiaodong Chen, Chunxin Liu, Xiaonan Zhong, Yuge Wang, Wei Qiu
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Yuge Wang, Xiaonan Zhong, Honghao Wang, Yu Peng, Fudong Shi, Dongmei Jia, Huan Yang, Qiuming Zeng, Chao Quan, Jingzi ZhangBao, Michael Lee, Jun Qi, Xiaoxiang Chen, Wei Qiu
Summary: This study assessed the safety and efficacy of batoclimab in patients with NMOSD acute attacks. The results showed that batoclimab had a beneficial neurological effect and was well-tolerated by the patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Yanyu Chang, Luyao Zhou, Xiaonan Zhong, Ziyan Shi, Xiaobo Sun, Yuge Wang, Rui Li, Youming Long, Hongyu Zhou, Chao Quan, Allan G. Kermode, Qingfen Yu, Wei Qiu
Summary: This study investigated the clinical characteristics and genetic background of familial neuromyelitis optica spectrum disorder (NMOSD) in China. Familial NMOSD patients had more severe symptoms compared to sporadic cases. The USP18 gene was found to be associated with the pathogenesis of NMOSD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Fuhua Peng, Hongda She, Yuge Wang, Li Xu, Yilong Shan, Yanyu Chang, Xiaonan Zhong, Rui Li, Wei Qiu, Yaqing Shu, Sha Tan
Summary: This pilot study found that abnormal tryptophan metabolism occurs in NMOSD patients and kynurenine might be a potential target for the treatment of AQP4-IgG-positive NMOSD patients.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Health Care Sciences & Services
Xiaonan Zhong, Yina Wang, Wenjing Luo, Xiaoyu Ma, Xiaobo Sun, Boxiong Jiang, Wei Qiu
Summary: MOG-Abs are pathogenic antibodies targeting a protein exclusively expressed in the central nervous system, while MOG-IgG is considered as a demyelinating disease-associated autoantibody in humans. The CBAs method is recommended for identifying MOG-Abs, but its reliability can be influenced by various factors.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Clinical Neurology
Jing Zhou, Yaxin Lu, Shishi Shen, Ling Fang, Chen Chen, Xia Wang, Cong Li, Zifeng Liu, Hongyu Zhou, Chao Quan, Wei Qiu, Xiaonan Zhong
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Xiaodong Chen, Jing Zhou, Rui Li, Bingjun Zhang, Yuge Wang, Xiaonan Zhong, Yaqing Shu, Yanyu Chang, Wei Qiu
Summary: This study investigated the clinical characteristics, disease course, treatment, and prognosis of patients with limited form of neuromyelitis optica spectrum disorders (LF-NMOSD) at disease onset. The results showed that some patients eventually developed definite NMOSD, particularly those with isolated/mixed area postrema syndrome (APS) at onset. Immunosuppressive therapy was found to reduce the rates of clinical relapse and residual functional disability.
JOURNAL OF CLINICAL NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Lisheng Peng, Xiaonan Zhong, Xiaobo Sun, Ziyan Shi, Yuge Wang, Yu Yang, Yanyu Chang, Chen Chen, Jingqi Wang, Xueqiang Hu, Allan G. Kermode, Hongyu Zhou, Zhengqi Lu, Wei Qiu
MULTIPLE SCLEROSIS JOURNAL
(2020)