Trends in annualized relapse rates in relapsing–remitting multiple sclerosis and consequences for clinical trial design

Good Practices for Adaptive Clinical Trials in Pharmaceutical Product Development

(2012) Brenda Gaydos et al.   DRUG INFORMATION JOURNAL

Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies with an Application to Multiple Sclerosis

(2012) Tim Friede et al.   DRUG INFORMATION JOURNAL

Aspects of Modernizing Drug Development Using Clinical Scenario Planning and Evaluation

(2012) Norbert Benda et al.   DRUG INFORMATION JOURNAL

The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability

(2010) Antonio Scalfari et al.   BRAIN

Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial

(2010) G. C. Ebers et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Blinded Sample Size Reestimation with Negative Binomial Counts in Superiority and Non-inferiority Trials

(2010) T. Friede et al.   METHODS OF INFORMATION IN MEDICINE

Assessing changes in relapse rates in multiple sclerosis

(2010) Seidu Inusah et al.   Multiple Sclerosis Journal

A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis

(2010) Jeremy Chataway et al.   Multiple Sclerosis Journal

A Placebo-Controlled Trial of Oral Cladribine for Relapsing Multiple Sclerosis

(2010) Gavin Giovannoni et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Magnetic resonance imaging as a potential surrogate for relapses in multiple sclerosis: A meta-analytic approach

(2009) Maria Pia Sormani et al.   ANNALS OF NEUROLOGY

Statistical methods for the analysis of relapse data in MS clinical trials

(2009) Y.C. Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Two-stage design of clinical trials involving recurrent events

(2009) Richard J. Cook et al.   STATISTICS IN MEDICINE

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) Ludwig Kappos et al.   LANCET

Ethics of placebo-controlled clinical trials in multiple sclerosis: A reassessment

(2008) C. H. Polman et al.   NEUROLOGY