Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 17, Issue 12, Pages 1405-1411Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458511425366
Keywords
clinical trials; multiple sclerosis; prevention; treatment; vitamin D
Categories
Funding
- National Institute of Neurological Disorders and Stroke [NS046635]
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Observational studies suggest that adequate vitamin D nutrition may reduce the risk of MS and affect the course of the disease. Inherent limitations in these studies, however, preclude a causal interpretation. Randomized controlled clinical trials are the next step to addressing whether vitamin D prevents MS or can favorably affect the course and progression of MS. Here we briefly review the current literature on vitamin D and MS, both as a risk factor and potential treatment for MS with a focus on the issues and challenges in designing prevention and treatment clinical trials.
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