Article
Clinical Neurology
Damiano Mistri, Laura Cacciaguerra, Paola Valsasina, Elisabetta Pagani, Massimo Filippi, Maria A. Rocca
Summary: This study compared cognitive performance between primary progressive and secondary progressive multiple sclerosis (MS) patients, and investigated the structural and functional magnetic resonance imaging (MRI) correlates of their cognitive functions. The results showed that primary progressive and secondary progressive MS had similar cognitive scores in all domains, and cognitive dysfunction was associated with distinct patterns of brain structural abnormalities and involvement of different white matter tracts.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sam Harding-Forrester, Izanne Roos, Ai-Lan Nguyen, Charles B. Malpas, Ibrahima Diouf, Nahid Moradi, Sifat Sharmin, Guillermo Izquierdo, Sara Eichau, Francesco Patti, Dana Horakova, Eva Kubala Havrdova, Alexandre Prat, Marc Girard, Pierre Duquette, Francois Grand Maison, Marco Onofrj, Alessandra Lugaresi, Pierre Grammond, Serkan Ozakbas, Maria Pia Amato, Oliver Gerlach, Patrizia Sola, Diana Ferraro, Katherine Buzzard, Olga Skibina, Jeannette Lechner-Scott, Raed Alroughani, Cavit Boz, Vincent Van Pesch, Elisabetta Cartechini, Murat Terzi, Davide Maimone, Cristina Ramo-Tello, Bassem Yamout, Samia Joseph Khoury, Daniele La Spitaleri, Maria Jose Sa, Yolanda Blanco, Franco Granella, Mark Slee, Ernest Butler, Youssef Sidhom, Riadh Gouider, Roberto Bergamaschi, Rana Karabudak, Radek Ampapa, Jose Luis Sanchez-Menoyo, Julie Prevost, Tamara Castillo-Trivino, Pamela A. McCombe, Richard Macdonell, Guy Laureys, Liesbeth Van Hijfte, Jiwon Oh, Ayse Altintas, Koen de Gans, Recai Turkoglu, Anneke van der Walt, Helmut Butzkueven, Steve Vucic, Michael Barnett, Edgardo Cristiano, Suzanne Hodgkinson, Gerardo Iuliano, Ludwig Kappos, Jens Kuhle, Vahid Shaygannejad, Aysun Soysal, Bianca Weinstock-Guttman, Bart Van Wijmeersch, Tomas Kalincik
Summary: This study compared primary and secondary progressive multiple sclerosis (PPMS, SPMS), and found that SPMS has later onset of the progressive phase and slower disability accrual, but higher baseline disability.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah Schlaeger, Suprosanna Shit, Paul Eichinger, Marco Hamann, Roland Opfer, Julia Krueger, Michael Dieckmeyer, Simon Schoen, Mark Muehlau, Claus Zimmer, Jan S. Kirschke, Benedikt Wiestler, Dennis M. Hedderich
Summary: This study trained a convolutional neural network to segment contrast-enhancing lesions in brain magnetic resonance imaging of patients with multiple sclerosis. The AI tool performed similarly to human readers in clinical data and may be helpful as a second reader in neuroradiological assessment.
INSIGHTS INTO IMAGING
(2023)
Article
Clinical Neurology
Carmen Alcala Vicente, Laura Lacruz, Francisco Gascon, Sara Carratala, Carlos Quintanilla-Bordas, Maria T. Sanz, Maria Carcelen-Gadea, Javier Mallada, Joan Carreres, Laura Gabaldon Torres, Jose Andres Dominguez, Emmanuel Canizares, Sara Gil-Perotin, Laura Cubas, Raquel Gasque Rubio, Jessica Castillo-Villalba, Francisco Carlos Perez-Miralles, Bonaventura Casanova
Summary: The presence of OCMB and SC-T2 lesions may independently predict the conversion to SPMS.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Daniela Noa Zohar, David Magalashvili, Sapir Dreyer-Alster, Chen Hoffmann, Gil Harari, Mark Dolev, Anat Achiron
Summary: This study aimed to identify the clinical characteristics of secondary progressive multiple sclerosis (SPMS) patients with high radiological disease activity (RDA). By evaluating the occurrence of RDA in SPMS patients followed at the Sheba Multiple Sclerosis Center between 2015 and 2020, patients were subdivided into RDA and non-RDA groups, and demographic variables and disease-related data were compared. The results showed that RDA unrelated to clinical symptomatology was more frequent in young SPMS patients.
EUROPEAN NEUROLOGY
(2023)
Article
Clinical Neurology
Winston Dzau, Sifat Sharmin, Francesco Patti, Guillermo Izquierdo, Sara Eichau, Alexandre Prat, Marc Girard, Pierre Duquette, Marco Onofrj, Alessandra Lugaresi, Serkan Ozakbas, Oliver Gerlach, Cavit Boz, Pierre Grammond, Murat Terzi, Maria Pia Amato, Daniele La Spitaleri, Cristina Ramo-Tello, Davide Maimone, Elisabetta Cartechini, Katherine Buzzard, Olga Skibina, Anneke van der Walt, Helmut Butzkueven, Gerardo Iuliano, Aysun Soysal, Tomas Kalincik
Summary: This study investigated the association between early progression independent of relapse activity (PIRA) and relapse-associated worsening (RAW) with the onset and disability accumulation of secondary progressive multiple sclerosis (SPMS). It found that early PIRA and RAW were associated with increased risk of SPMS, but not with the rate of disability progression during SPMS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Ben J. E. Raveney, Wakiro Sato, Daiki Takewaki, Chenyang Zhang, Tomomi Kanazawa, Youwei Lin, Tomoko Okamoto, Manabu Araki, Yukio Kimura, Noriko Sato, Terunori Sano, Yuko Saito, Shinji Oki, Takashi Yamamura
Summary: This study identified a subset of cytotoxic CD4(+) T cells expressing Eomes, known as Eomes(+) Th cells, that are crucially involved in the pathogenesis of secondary progressive MS (SPMS). Eomes levels could act as a biomarker to predict disease worsening in SPMS patients with over 80% accuracy. These findings have significant implications for SPMS biomarkers and potential therapeutic targets.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Clinical Neurology
Sarah B. Simmons, Daniel Ontaneda
Summary: The etiology of progressive accumulation of neurologic disability in persons with multiple sclerosis (MS) remains poorly understood, and chronic active lesions may play a key role in disease progression.
Article
Clinical Neurology
Paolo Preziosa, Elisabetta Pagani, Raffaello Bonacchi, Laura Cacciaguerra, Andrea Falini, Maria A. Rocca, Massimo Filippi
Summary: This study characterized microstructural abnormalities in multiple sclerosis (MS) cortex using neurite orientation dispersion and density imaging (NODDI). Results showed significant neurite loss in MS normal-appearing (NA) cortex and further neurite density reduction in cortical lesions (CLs), indicating a simplification of neurite complexity. NODDI is relevant for investigating the heterogeneous pathology of the MS cortex in vivo.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Ralf Gold, Daniela Piani-Meier, Ludwig Kappos, Amit Bar-Or, Patrick Vermersch, Gavin Giovannoni, Robert J. Fox, Douglas L. Arnold, Ralph H. B. Benedict, Iris-Katharina Penner, Nicolas Rouyrre, Ajay Kilaru, Goril Karlsson, Shannon Ritter, Frank Dahlke, Thomas Hach, Bruce A. C. Cree
Summary: The study found that siponimod reduced the risk of disability progression and had positive effects on cognition and MRI outcomes in patients with active secondary progressive multiple sclerosis.
JOURNAL OF NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ariane de Panafieu, Augustin Lecler, Adrien Goujon, Sidney Krystal, Antoine Gueguen, Jean-Claude Sadik, Julien Savatovsky, Loic Duron
Summary: This study compared the differences in detecting enhancing lesions between 3D TSE T1-WI and 3D GRE T1-WI in patients with multiple sclerosis (MS). The results showed that 3D TSE T1-WI detected more enhancing lesions and had higher contrast ratio and contrast-to-noise ratio. Therefore, 3D TSE T1-WI should be used in MS patients requiring contrast-enhanced examination.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Clinical Neurology
Sina C. Rosenkranz, Lilija Gutmann, Arzu Ceylan Has Silemek, Michael Dorr, Vivien Haussler, Margareta Lupke, Andrea Monch, Stefanie Reinhardt, Jens Kuhle, Penelope Tilsley, Christoph Heesen, Manuel A. Friese, Alexander Brandt, Friedemann Paul, Hanna Zimmermann, Jan-Patrick Stellmann
Summary: In this study, the long-term changes in visual function, retinal neurodegeneration, and serum NfL levels were assessed in PPMS patients. It was found that visual function remains stable until a certain turning point, while retinal nerve fiber layer thickness gradually decreases. Serum NfL levels remained stable and were not associated with structural or functional impairment in the visual system.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Eva M. Strijbis, Eline Coerver, Jop Mostert, Zoe L. E. van Kempen, Joep Killestein, Jacynthe Comtois, Pavle Repovic, James D. Bowen, Gary Cutter, Marcus Koch
Summary: This study investigates the association between age and inflammatory disease activity in relapsing-remitting multiple sclerosis (RRMS) using patient-level data from randomized controlled trials (RCTs) of natalizumab treatment. The results show that older age is associated with lower prevalence and degree of focal inflammatory disease activity in treated and untreated RRMS patients. These findings provide important insights for the design of RCTs and the decision-making process of immunomodulatory treatment in RRMS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Asta Theodorsdottir, Pia Veldt Larsen, Helle Hvilsted Nielsen, Zsolt Illes, Mads Henrik Ravnborg
Summary: In patients with secondary progressive MS (SPMS), the Multiple Sclerosis Impairment Scale (MSIS) correlated with functional motor tests. MSIS had stronger correlations with atrophy of central nervous system areas and may be more sensitive in assessing cerebellar and sensory function compared to the Expanded Disability Status Scale (EDSS).
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Clinical Neurology
Marcus W. Koch, Jop Mostert, Pavle Repovic, James D. Bowen, Bernard Uitdehaag, Gary Cutter
Summary: The study compared the frequency of progression and improvement events in SPMS trials using data from the placebo arms of two large RCTs. The EDSS showed the highest rates of improvement over time, with the smallest difference between progression and improvement rates, followed by the T25FW and 9HPT. The findings suggest random variation and measurement error in all investigated outcome measures, with the T25FW and 9HPT showing less than the more established outcome measure EDSS.
Article
Clinical Neurology
Anna-Marie Bueno, Ana-Luiza Sayao, Masoud Yousefi, Virginia Devonshire, Anthony Traboulsee, Helen Tremlett
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2015)
Article
Clinical Neurology
Ellen Lu, Feng Zhu, Yinshan Zhao, Mia van der Kop, Anne Synnes, Leanne Dahlgren, A. Dessa Sadovnick, Anthony Traboulsee, Helen Tremlett
Article
Genetics & Heredity
Stephanie Skinner, Colleen Guimond, Rachel Butler, Emily Dwosh, Anthony L. Traboulsee, A. Dessa Sadovnick
JOURNAL OF GENETIC COUNSELING
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Youngjin Yoo, Thomas Prasloski, Irene Vavasour, Alexander MacKay, Anthony L. Traboulsee, David K. B. Li, Roger C. Tam
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2015)
Article
Statistics & Probability
Yinshan Zhao, David K. B. Li, A. John Petkau, Andrew Riddehough, Anthony Traboulsee
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2014)
Article
Medicine, General & Internal
Anthony L. Traboulsee, Katherine B. Knox, Lindsay Machan, Yinshan Zhao, Irene Yee, Alexander Rauscher, Darren Klass, Peter Szkup, Robert Otani, David Kopriva, Shanti Lala, David K. Li, Dessa Sadovnick
Letter
Clinical Neurology
Cecily Q. Bernales, Jay P. Ross, Joshua D. Lee, Yinshan Zhao, A. Dessa Sadovnick, Anthony L. Traboulsee, Carles Vilarino-Gueell
MULTIPLE SCLEROSIS JOURNAL
(2014)
Article
Clinical Neurology
H. Kang, L. M. Metz, A. L. Traboulsee, M. Eliasziw, G. J. Zhao, Y. Cheng, Y. Zhao, D. K. B. Li
MULTIPLE SCLEROSIS JOURNAL
(2014)
Editorial Material
Clinical Neurology
Anthony Traboulsee, Katrina McMullen
MULTIPLE SCLEROSIS JOURNAL
(2014)
Article
Clinical Neurology
E. Lu, F. Zhu, Y. Zhao, M. van der Kop, A. D. Sadovnick, A. Synnes, L. Dahlgren, A. Traboulsee, H. Tremlett
MULTIPLE SCLEROSIS JOURNAL
(2014)
Article
Clinical Neurology
Jing Dong, Yinshan Zhao, A. John Petkau, David K. B. Li, Andrew Riddehough, Anthony Traboulsee
MULTIPLE SCLEROSIS JOURNAL
(2015)
Article
Genetics & Heredity
Anthony L. Traboulsee, Cecily Q. Bernales, Jay P. Ross, Joshua D. Lee, A. Dessa Sadovnick, Carles Vilarino-Gueell
Article
Clinical Neurology
C. Wang, R. C. Tam, E. Mackie, D. K. B. Li, A. L. Traboulsee