Review
Clinical Neurology
M. Puthenparampil, P. Perini, R. Bergamaschi, M. Capobianco, M. Filippi, P. Gallo
Summary: Italy is considered a high-risk country for multiple sclerosis (MS), with the incidence and prevalence gradually increasing over the past years. Research suggests that environmental factors may better explain this trend than genetic heterogeneity.
JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Hui Lu, Peng-Fei Wu, Deng-Lei Ma, Wan Zhang, Meichen Sun
Summary: Genetically predicted circulating levels of FGF23 are causally associated with the risk of Multiple Sclerosis (MS), while other growth factors such as GDF15, IGF1, IGFBP3 and VEGF do not have causal effects. Further research is needed to confirm FGF23 as a genetically valid target for MS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Marijne Vandebergh, Nicolas Degryse, Benedicte Dubois, An Goris
Summary: Multiple sclerosis (MS) is a complex disease involving genetic variants and environmental factors, including obesity, vitamin D deficiency, Epstein-Barr virus infection, and smoking. Leveraging genetics through the Mendelian randomization paradigm helps inform prevention strategies for MS by studying the impact of environmental factors on susceptibility. This approach draws parallels with observational studies and randomized controlled trials, highlighting the challenges and opportunities for future research in this area.
JOURNAL OF NEUROLOGY
(2022)
Review
Public, Environmental & Occupational Health
Bruno Kusznir Vitturi, Alfredo Montecucco, Alborz Rahmani, Guglielmo Dini, Paolo Durando
Summary: This study conducted the first systematic review with meta-analysis to investigate the occupational risk factors of Multiple Sclerosis. It found that agricultural workers, offshore workers, hairdressers, individuals exposed to toxic fumes from oil wells, low-frequency magnetic fields, and pesticides had an increased likelihood of being diagnosed with MS, which could potentially influence public policies and calls for future research in this area.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Vladeta Ajdacic-Gross, Nina Steinemann, Gabor Horvath, Stephanie Rodgers, Marco Kaufmann, Yanhua Xu, Christian P. Kamm, Jurg Kesselring, Zina-Mary Manjaly, Chiara Zecca, Pasquale Calabrese, Milo A. Puhan, Viktor von Wyl
Summary: By studying the clustering of MS onset symptoms, different symptom patterns were identified, along with their associations with potential risk factors and comorbid diseases. These findings provide new insights into the heterogeneity of MS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Malthe Faurschou Wandall-Holm, Mathias Due Buron, Tine Iskov Kopp, Karsten Thielen, Finn Sellebjerg, Melinda Magyari
Summary: Initiating treatment early reduces the risk of disability pension in patients with RRMS. This finding highlights the importance of early diagnosis and treatment on a patient-centered, socioeconomic disability milestone.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Torbjorn Akerstedt, Tomas Olsson, Lars Alfredsson, Anna Karin Hedstroem
Summary: Insufficient sleep and low sleep quality may increase the risk of developing multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Benjamin M. Jacobs, Pooja Tank, Jonathan P. Bestwick, Alastair J. Noyce, Charles R. Marshall, Rohini Mathur, Gavin Giovannoni, Ruth Dobson
Summary: This study aimed to determine whether modifiable risk factors for multiple sclerosis have similar effects across diverse ethnic backgrounds. The study found that established modifiable risk factors such as smoking, obesity, infectious mononucleosis, low vitamin D levels, and head injury were consistently associated with multiple sclerosis in the Black and South Asian cohorts.
JOURNAL OF NEUROLOGY
(2023)
Article
Rehabilitation
Aaron P. Turner, Anne Arewasikporn, Eric J. Hawkins, Pradeep Suri, Stephen P. Burns, Steve L. Leipertz, Jodie K. Haselkorn
Summary: This study aimed to characterize patterns of prescription opioid use in individuals with multiple sclerosis (MS) and identify risk factors associated with chronic use. The results showed a decline in chronic opioid use over the study period, but it remains common among a substantial minority of MS patients. Prior chronic opioid use, history of pain condition, post-traumatic stress disorder, and rural residence were associated with a greater risk of chronic prescription opioid use.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Clinical Neurology
Filipe Cortes-Figueiredo, Nete Munk Nielsen, Egon Stenager, Friedemann Paul, Jesper Hallas, Kasper Bruun Kristensen
Summary: The use of systemic retinoids was not found to be associated with a reduced incidence of MS compared to the use of non-retinoid acne drugs in this study. The results showed no significant association between the use of systemic retinoids and MS incidence when compared to the use of non-retinoid acne drugs.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Soonwook Kwon, Se Young Jung, Kyung-do Han, Jin Hyung Jung, Yohwan Yeo, Eun Bin Cho, Jong Hyeon Ahn, Dong Wook Shin, Ju-Hong Min
Summary: This study found that patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) have an increased risk of developing Parkinson's disease (PD), especially in MS patients. Sex, age, diabetes, hypertension, and dyslipidemia did not significantly affect the risk of PD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Luke Hone, Benjamin M. Jacobs, Charles Marshall, Gavin Giovannoni, Alastair Noyce, Ruth Dobson
Summary: Using longitudinal Mendelian randomisation, this study provides evidence that genetically determined higher body mass index (BMI) during early life is associated with increased risk of multiple sclerosis (MS), possibly driven by shared genetic architecture with later-life BMI.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Ruth Leadbetter, Michael MacAskill, Daniell J. Myall, Bruce Taylor, Purwa Joshi, Deborah F. Mason
Summary: A long-term study on multiple sclerosis patients in New Zealand found that their median survival age is 7.2 years lower than the general population and they have twice the mortality risk. The survival gap is greater for those with an early age of onset and progressive-onset disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Katharine Elizabeth Harding, Gillian Ingram, Emma Clare Tallantyre, Fady Joseph, Mark Wardle, Trevor P. Pickersgill, Mark D. Willis, Valentina Tomassini, Owen Rhys Pearson, Neil P. Robertson
Summary: This study provides a detailed contemporary model of disability outcomes in a representative population-based MS cohort. The results support a trend of increasing time to disability milestones compared with historical reference populations, and document disability variation with the use of transitional matrices. This study has important implications for patient counseling, clinical trial design, and assessment of therapeutic interventions.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Benedetta Angeloni, Rachele Bigi, Gianmarco Bellucci, Rosella Mechelli, Chiara Ballerini, Carmela Romano, Emanuele Morena, Giulia Pellicciari, Roberta Renie, Virginia Rinaldi, Maria Chiara Buscarinu, Silvia Romano, Giovanni Ristori, Marco Salvetti
Summary: Multiple sclerosis is a complex autoimmune disease that is more prevalent in women. Gender differences play a critical role in disease onset, progression, and prognosis, highlighting the necessity of understanding the mechanisms behind these differences for developing personalized therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)