Article
Rehabilitation
Elianne E. A. van Egmond, Dennis A. M. van Gorp, Peter J. Jongen, Jac J. L. van der Klink, Michiel F. Reneman, Edo P. J. Arnoldus, Ernesto A. C. Beenakker, Jeroen J. J. van Eijk, Stephan T. F. M. Frequin, Oliver H. H. Gerlach, Gerald J. D. Hengstman, Johan W. B. Moll, Wim I. M. Verhagen, Huub A. M. Middelkoop, Leo H. Visser, Karin van der Hiele
Summary: In people with MS, both cognitive and physical impact of fatigue are positively related to presenteeism, while symptoms of depression and cognitive impact of fatigue are positively related to absenteeism.
DISABILITY AND REHABILITATION
(2022)
Review
Rehabilitation
Areum Han
Summary: This study examined the effects of mindfulness-and acceptance-based interventions (MABIs) on reducing symptoms in individuals with multiple sclerosis (MS). The results showed significant effects of MABIs in reducing symptoms of depression, anxiety, stress, and pain, but a moderate effect on fatigue symptoms. Future high-quality studies with follow-up evaluations are needed to further support these findings and explore intervention features that enhance and sustain effects.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Review
Clinical Neurology
Wan-Yu Hsu, Chia-Hsiung Cheng, Theodore P. Zanto, Adam Gazzaley, Riley M. Bove
Summary: The study suggests that transcranial direct current stimulation (tDCS) has positive effects on cognition, mood disturbance, pain, and fatigue in people with multiple sclerosis (PwMS), although the impact on cognition and fatigue varies depending on the specific assessment used.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychology, Multidisciplinary
Madia M. M. Biasi, Alessia Manni, Ilaria Pepe, Chiara Abbatantuono, Daphne Gasparre, Pietro Iaffaldano, Marta Simone, Maria F. F. De Caro, Maria Trojano, Paolo Taurisano, Damiano Paolicelli
Summary: This study examined the correlations between information processing speed and physical fatigue in a cohort of Italian multiple sclerosis patients. The results showed significant correlations between information processing speed and both physical fatigue and depression. The mediation analyses revealed that depression mediated the impact of physical fatigue on cognitive performance.
Review
Clinical Neurology
Joanna Tarasiuk, Katarzyna Kapica-Topczewska, Agata Czarnowska, Monika Chorazy, Jan Kochanowicz, Alina Kulakowska
Summary: Fatigue and depression are common symptoms in patients with multiple sclerosis (MS). Primary fatigue and depression in MS are caused by inflammatory, oxidative/nitrosative, and neurodegenerative processes. Secondary fatigue and depression may be caused by emotional factors, sleep disorders, pain, coexisting diseases, and medication use.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Samar S. Ayache, Benjamin Bardel, Jean-Pascal Lefaucheur, Moussa A. Chalah
Summary: Fatigue, affective manifestations, cognitive deficits, and pain are common and debilitating symptoms in patients with multiple sclerosis (MS), which may have a complex pathophysiology and challenging management. Neurofeedback (NFB) could potentially improve outcomes by modulating brain activity in specific electroencephalographic bands, but further research is needed to explore its utility. Different NFB protocols and comprehensive evaluation may help optimize interventions for specific symptoms and potentially combine with other approaches to enhance management of MS symptoms.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Anna Gil-Sanchez, Marc Canudes, Petya Valcheva, Lara Nogueras, Cristina Gonzalez-Mingot, Jose Vicente Hervas, Silvia Peralta, Maria Solana, Luis Brieva
Summary: This observational case series study explored the effects of Vortioxetine on patients with multiple sclerosis (MS) and depression. The results showed that Vortioxetine was effective in reducing depression symptoms and improving anxiety, vitality, and mental health. However, it did not improve cognition or fatigue.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Clinical Neurology
Thomas R. Valentine, Kevin N. Alschuler, Dawn M. Ehde, Anna L. Kratz
Summary: The study found that pain, fatigue, depression, and anxiety are common in patients with multiple sclerosis, often co-occurring. Most patients experienced at least one clinically significant symptom within the year after diagnosis, indicating a significant impact on patients. Symptom severity showed fluctuations at the individual level, highlighting the need for timely screening and treatment.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Psychology, Multidisciplinary
Lindsey M. Knowles, Anne Arewasikporn, Anna L. Kratz, Aaron P. Turner, Kevin N. Alschuler, Dawn M. Ehde
Summary: This study found that early reduction in depressive symptoms may contribute to improvements in fatigue and pain interference for individuals with multiple sclerosis. Additionally, reducing fatigue impact early may help improve depressive symptoms. However, early reduction in pain interference was not strongly associated with reductions in fatigue impact or depressive symptoms.
ANNALS OF BEHAVIORAL MEDICINE
(2021)
Article
Psychology, Clinical
Carla Sanchis-Segura, Alvaro Javier Cruz-Gomez, Sonia Felix Esbri, Alba Sebastian Tirado, Peter A. Arnett, Cristina Forn
Summary: This study translated and tested the Spanish version of the Chicago Multiscale Depression Inventory (CMDI) to assess depression in persons with Multiple Sclerosis (PwMS). The results showed that the CMDI had good validity in the Spanish population and depression symptoms in PwMS were related to the clinical course of the disease and cognitive performance. Therefore, good assessment and multidisciplinary treatment of depression in PwMS are highly important.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Article
Clinical Neurology
Masaaki Niino, Shoko Fukumoto, Tatsusada Okuno, Nobuo Sanjo, Hikoaki Fukaura, Masahiro Mori, Takashi Ohashi, Hideyuki Takeuchi, Yuko Shimizu, Juichi Fujimori, Izumi Kawachi, Jun-ichi Kira, Eri Takahashi, Yusei Miyazaki, Nobuhiro Mifune
Summary: The study revealed a significant association between cognitive impairment and health-related quality of life (HRQOL) and depression in Japanese patients with MS, while no correlation was found with fatigue.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Psychology, Multidisciplinary
C. Guillemin, E. Lommers, G. Delrue, E. Gester, P. Maquet, F. Collette
Summary: Cognitive impairments are frequent in patients with Multiple Sclerosis (MS), but the influence of MS-related symptoms on cognitive status is not clear. Fatigue is the only factor that affects cognitive abilities in MS patients, and there is an association between depression and cognition.
PSYCHOLOGICA BELGICA
(2022)
Article
Psychology, Clinical
Anna L. Kratz, Kevin N. Alschuler, David A. Williams, Dawn M. Ehde
Summary: The study describes the development of a web-based multisymptom self-management program with stakeholders with multiple sclerosis. Results from a pilot trial showed a clinically significant positive impact on symptoms in a proportion of participants.
REHABILITATION PSYCHOLOGY
(2021)
Article
Clinical Neurology
Curtis Wojcik, Michael Jaworski, Michael G. Dwyer, Margaret Youngs, Mahmut Unverdi, Bianca Weinstock-Guttman, Ralph H. B. Benedict
Summary: This study investigated neuropsychological changes in MS patients with work gains and found significant improvement in the Symbol Digit Modalities Test. Benchmarks for clinically meaningful improvement on the test were found to be similar to those established for clinically meaningful decline.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Review
Clinical Neurology
Fraser S. Brown, Stella A. Glasmacher, Daniel Taylor, Ruth Jenkins, Siddharthan Chandran, David Gillespie, Peter Foley
Summary: This study conducted a systematic review on the relationship between pain and cognitive function in adults with multiple sclerosis. From 11 studies, it was found that there is a negative correlation between pain severity and cognitive performance. However, further research is limited due to study design and lack of evidence in other cognitive domains. Future studies should better establish this relationship and delineate the neurological substrate underpinning it.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Review
Clinical Neurology
Pavithra A. Thomas, Gregory T. Carter, Charles H. Bombardier
Summary: The current research on the effect of cannabis upon pain intensity in spinal cord injury (SCI) pain presents mixed findings due to variability in methodology, indicating insufficient evidence to draw reliable conclusions. Specific limitations in past studies are identified, highlighting the need for standardized dosing paradigms, modes of use, and trial durations in future research.
JOURNAL OF SPINAL CORD MEDICINE
(2022)
Article
Rehabilitation
Paul B. Perrin, Daniel W. Klyce, Lauren B. Fisher, Shannon B. Juengst, Flora M. Hammond, Kelli W. Gary, Janet P. Niemeier, Thomas F. Bergquist, Charles H. Bombardier, Amanda R. Rabinowitz, Ross D. Zafonte, Amy K. Wagner
Summary: Through a long-term longitudinal study, complex relationships and influences among suicidal ideation, depressive symptoms, and functional independence in TBI patients were discovered. Depressive symptoms had a significant impact on suicidal ideation, while functional independence also had a notable effect on depressive symptoms.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Clinical Neurology
Thomas R. Valentine, Kevin N. Alschuler, Dawn M. Ehde, Anna L. Kratz
Summary: The study found that pain, fatigue, depression, and anxiety are common in patients with multiple sclerosis, often co-occurring. Most patients experienced at least one clinically significant symptom within the year after diagnosis, indicating a significant impact on patients. Symptom severity showed fluctuations at the individual level, highlighting the need for timely screening and treatment.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Health Care Sciences & Services
Megan Miller, Rhonda Williams, Kathleen Pagulayan, Jason Barber, Dawn M. Ehde, Jeanne Hoffman
Summary: This study investigated the sleep patterns in Veterans with both traumatic brain injury (TBI) and chronic pain. The results showed that more severe insomnia symptoms were associated with higher depression and PTSD symptoms, as well as slower processing speed. Improving sleep quality in this population may be crucial for improving outcomes following TBI.
DISABILITY AND HEALTH JOURNAL
(2022)
Article
Rehabilitation
Therese M. O'Neil-Pirozzi, Shanti M. Pinto, Mitch Sevigny, Flora M. Hammond, Shannon B. Juengst, Charles H. Bombardier
Summary: This study aimed to identify correlates of life satisfaction 10 years after moderate to severe traumatic brain injury (TBI) using an extreme phenotyping approach. The results revealed that independent functioning, disability level, community participation, employment status, and depressive and anxiety symptoms were associated with extremely high life satisfaction. Non-Hispanic Black individuals had lower rates of extremely high life satisfaction compared to Non-Hispanic White individuals. The relationships between life satisfaction and independent functioning, disability, and participation were weaker among Non-Hispanic Black individuals.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Clinical Neurology
Kevin N. Alschuler, Daniel Whibley, Anna L. Kratz, Mark P. Jensen, Annette Wundes, Gloria von Geldern, Peiqing Qian, Charles H. Bombardier, Dawn M. Ehde
Summary: The study found that in the first year post-MS/CIS diagnosis, the average QOL was high and stable, with only a few variables predicting baseline QOL and changes over time. This suggests that early assessment of certain factors can help predict current and future QOL outcomes for patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Anesthesiology
Rhonda M. Williams, Melissa A. Day, Dawn M. Ehde, Aaron P. Turner, Marcia A. Ciol, Kevin J. Gertz, David Patterson, Shahin Hakimian, Pradeep Suri, Mark P. Jensen
Summary: This study compares the effectiveness of hypnosis training, mindfulness meditation, and active education control in treating chronic pain. The results show that all three interventions provide benefits in improving pain and other related factors. The benefits of hypnosis and mindfulness meditation last longer, while the improvements associated with active education gradually diminish.
Article
Psychology, Clinical
Sherri L. LaVela, Ibuola Kale, Elizabeth Burkhart, Charles H. Bombardier
Summary: This article qualitatively explores strategies to help individuals with spinal cord injuries (SCI) deal with grief and loss. Health care providers offer insights on relational and task-oriented strategies that can reduce suffering and promote healing. Regular screening, coordinated care, support services, and patient education are recommended. Overall, the findings provide guidance for health care providers in addressing grief and loss among individuals with SCI.
REHABILITATION PSYCHOLOGY
(2022)
Article
Rehabilitation
Dawn Neumann, Shannon B. Juengst, Charles H. Bombardier, Jacob A. Finn, Shannon R. Miles, Yue Zhang, Richard Kennedy, Amanda R. Rabinowitz, Amber Thomas, Laura E. Dreer
Summary: This study aimed to determine anxiety trajectories and predictors up to 10 years after traumatic brain injury (TBI). The results showed that factors such as race, insurance, pre-injury mental health treatment, multiple TBIs with loss of consciousness, violent injury, and years post-TBI were associated with higher levels of anxiety. Three different anxiety trajectories were identified, with the high-increasing and high-decreasing groups having consistently mild or higher anxiety scores throughout the 10-year period.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Rehabilitation
Sheryl Katta-Charles, Leah M. Adams, Nancy D. Chiaravalloti, Flora M. Hammond, Paul B. Perrin, Amanda R. Rabinowitz, Umesh M. Venkatesan, Alan H. Weintraub, Charles H. Bombardier
Summary: The study aimed to investigate the prevalence, severity, and correlates of depression, anxiety, and suicidal ideation in individuals with traumatic brain injury (TBI) before and during the COVID-19 pandemic. The findings showed no significant differences in depression, anxiety, or suicidal ideation before vs during the pandemic, and the predictors of mental health outcomes remained similar. The results suggest a general resilience and are consistent with recent studies in the general population, indicating only temporary increases in psychological distress associated with the pandemic. Although not worsened, depression, anxiety, and suicidal ideation are still prevalent and require focused treatment and research efforts.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Neurosciences
Gavin Sanders, Lisa J. J. Rapport, Jenny H. H. Marwitz, Thomas A. A. Novack, William Walker, Candace Tefertiller, Thomas K. K. Watanabe, Richard Kennedy, Yelena Goldin, Thomas Bergquist, Laura E. E. Dreer, Charles H. H. Bombardier, Yue Zhang
Summary: This study examined considerations and perceived barriers to return to driving among adults with traumatic brain injury (TBI) who were not driving, and explored their association with psychosocial outcomes. Results showed that social barriers were the most prominent, while physical barriers were the least endorsed. Gender and race differences were found in both theoretical considerations and barriers to driving. Disability level moderated the relationship between barriers and depression and life satisfaction.
Article
Medicine, General & Internal
Sherri L. LaVela, Robert W. Motl, Beverly Gonzalez, Elizabeth Tarlov, Keith Aguina, Charles H. Bombardier
Summary: This study aims to investigate the impact of the Caring Connections intervention on loneliness and perceived social isolation in individuals with spinal cord injuries and disorders (SCI/D), as well as the satisfaction and areas for improvement of the intervention.
Article
Psychology, Clinical
Tracy M. Anastas, Aaron P. Turner, Erica J. J. Ho, Melissa A. Day, Dawn M. Ehde, Mark P. Jensen, Rhonda M. Williams
Summary: This study validates the value of adding an open label phase after a clinical trial of pain treatments through the analysis of participant characteristics and potential benefits. The results show that a substantial portion of study participants chose to participate in the open label phase and reported it to be beneficial. Analyzing data from an open label phase can provide insights into important aspects of patient experience, barriers to and facilitators of care, and treatment preferences.
REHABILITATION PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Aaron P. Turner, Karlyn A. Edwards, Mark P. Jensen, Dawn M. Ehde, Melissa A. Day, Rhonda M. Williams
Summary: This study examined the impact of three behavioral interventions on substance use among chronic pain patients. The results showed that mindfulness meditation and hypnosis significantly reduced cannabis use, but had no significant effect on tobacco or alcohol use.
REHABILITATION PSYCHOLOGY
(2023)
Article
Clinical Neurology
Kara Link, Lindsey M. Knowles, Kevin N. Alschuler, Dawn M. Ehde
Summary: This study examined the prevalence and characteristics of cannabis use for pain management among adults with multiple sclerosis (MS) and chronic pain. Results showed that 27% of participants used cannabis, with the most common route of administration being oil/tincture. Cannabis users were younger and had higher levels of pain intensity, pain interference, and neuropathic pain.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
