Article
Physiology
QiFeng Liu, ShaSha Li, LiXia Yu, XiaoYa Yin, Xi Liu, JianMing Ye, GuoYuan Lu
Summary: This study investigates the role of the CCL5/p-STAT3/DNMT1 axis in the epigenetic regulation of Klotho expression in chronic kidney disease (CKD). The findings suggest potential therapeutic possibilities for reversing Klotho suppression in CKD.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Dermatology
Yuyao Zhang, Kefan Liu, Juehua Cheng, Chenyu Zhou, Mengna Zhang, Yuan Fan
Summary: Oral lichen planus (OLP) is a chronic inflammatory disease mediated by T cells, with CD4(+)T cell infiltration playing a crucial role in its pathogenesis. This study explores the immune activation and biological functions of OLP fibroblasts on CD4(+)T cells. The findings show that OLP fibroblasts are immunologically activated, leading to CD4(+)T cell infiltration in OLP. They promote cell proliferation and migration while inhibiting cell apoptosis.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Chen Xu, Wen Su
Summary: This study found that hyperforin suppressed IL-13-induced nasal epithelial cell inflammation and barrier damage by targeting BCL6/p38 MAPK/CCL11. These findings provide promising therapeutic targets for allergic rhinitis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Oncology
Yongjian Dong, Shuhui Gao, Xuefang Zhang, Jing Kou, Jing Liu, Ting Ye, Han Shen
Summary: Recent studies have shown that dendritic cell-activated CIK (DC-CIK) cells exhibit enhanced antitumor activity compared to unstimulated CIK cells. It has been found that dendritic cells can secrete CCL17 and CCL22 to increase the expression of CCR4 on CIK cells, thereby enhancing their migratory capacity and tumor-killing efficacy.
Article
Pharmacology & Pharmacy
Shuang Li, Dawei Zou, Zhaoqian Liu
Summary: This study evaluated the predictive value of 16 CXCLs in ovarian cancer patients. The overexpression of CXCL genes in ovarian cancer tissues was observed. Patients were classified into three distinct CXCL subtypes based on their expression patterns. High CXCL scores were associated with better survival outcomes, increased immune cell infiltration, and higher expression of PD-L1/CTLA4.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carmela Nardelli, Ilaria Granata, Marcella Nunziato, Mario Setaro, Fortunata Carbone, Claudio Zulli, Vincenzo Pilone, Ettore Domenico Capoluongo, Giovanni Domenico De Palma, Francesco Corcione, Giuseppe Matarese, Francesco Salvatore, Lucia Sacchetti
Summary: Research shows significant differences in intestinal microbiomes between CRC patients and healthy controls, with Fusobacterium nucleatum potentially serving as a link between obesity and increased CRC risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wenhao Xu, Yuhao Wu, Wangrui Liu, Aihetaimujiang Anwaier, Xi Tian, Jiaqi Su, Haineng Huang, Gaomeng Wei, Yuanyuan Qu, Hailiang Zhang, Dingwei Ye
Summary: This study first revealed the predictive value of chemokine CCL5 in the progression and tumor microenvironment of ccRCC. Different prognostic clusters and immune phenotypes associated with CCL5 expression were identified, providing new strategies for the treatment of ccRCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Jiapei Huang, Lan Yi, Xiaoxiao Yang, Qi Zheng, Jun Zhong, Sen Ye, Xican Li, Hui Li, Dongfeng Chen, Caixia Li
Summary: The transplantation of NSCs combined with ethyl stearate can improve the motor behavioral performance of PD rats by promoting NSCs migration and differentiation into dopaminergic neurons through CCL5/CCR5 signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Boel De Paepe
Summary: Extensive diagnostic delays and deferred treatment significantly impact the quality of life for idiopathic inflammatory myopathy patients. In-depth subtyping of patients is necessary for appropriate disease management, requiring specialized evaluation of clinical and pathological features. Blood-based disease biomarkers, such as circulating cytokines, can offer complementary information for diagnosis, therapeutic response, and prognosis, potentially reducing the need for invasive muscle biopsies.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Shi Tang, Bao Su, Tao Tao, Weiping Yan, Rongrong Zhang, Xinyue Qin, Jinzhou Feng
Summary: RGMa regulates the expression of CCL5 in multiple sclerosis (MS) through the BMP signaling pathway. Inhibition of RGMa delays disease progression, alleviates symptoms, and downregulates CCL5 expression. These findings contribute to a better understanding of the role of RGMa in blood-brain barrier permeability in MS.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Oncology
Xiangjun Sun, Zhijie Chen
Summary: This study showed that primary CAFs isolated from NSCLC patients express and secrete high levels of CCL5, which can promote cisplatin resistance by upregulating HOTAIR expression in tumor cells, thereby interfering with cisplatin-induced apoptosis.
Article
Dermatology
Kenta Nakamura, Atsuko Ashida, Yukiko Kiniwa, Ryuhei Okuyama
Summary: This study found that CCL5 and CXCL12 in blood may serve as biomarkers to predict the therapeutic effect of anti-PD-1 therapy in patients with advanced malignant melanoma. Patients with lower levels of CCL5 and CXCL12 had more TILs and better disease-specific survival rates, indicating these chemokines could be useful predictors for treatment outcomes.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Physics, Atomic, Molecular & Chemical
Mengqi Chai, Christian Bleiholder
Summary: Ion mobility spectrometry-mass spectrometry can characterize structures of transient protein assemblies and isoforms, with a common observation of protein compaction during measurement, indicating structural changes. The challenge lies in identifying which aspects of the solution structure are preserved in the ion mobility measurement.
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2021)
Article
Medicine, Research & Experimental
Jie Lin, Ya Xu, Peiwen Guo, Yu-Jie Chen, Jiru Zhou, Min Xia, Binbin Tan, Xin Liu, Hua Feng, Yujie Chen
Summary: Due to metabolic disequilibrium and immune suppression, intracerebral hemorrhage patients are prone to infections. The intrinsic mechanisms underlying the effects of infection-related peripheral inflammation after ICH remain unclear.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Rheumatology
Eun Jeong Won, Hui-Ju Kim, Yu Jeong Lee, Moon-Ju Kim, Hae-In Lee, Hyun Hee Jang, Seong Hoon Kim, Ji-Hyoun Kang, Ki-Jeong Park, Seung Cheol Shim, Sungsin Jo, Tae-Hwan Kim, Tae-Jong Kim
Summary: This study aims to examine the effectiveness of CCL20 inhibition in treating inflammation in AS. The results show that CCL20 affects the migration of Th17 cells and that the CCL20 inhibitor can reduce joint inflammation in AS patients. Therefore, targeting CCL20 inhibition could be a novel therapeutic approach for AS treatment.
Review
Allergy
S. Mattoli
CLINICAL AND EXPERIMENTAL ALLERGY
(2015)
Review
Biochemistry & Molecular Biology
Sabrina Mattoli
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2015)
Article
Cell & Tissue Engineering
Marek Barczyk, Matthias Schmidt, Sabrina Mattoli
STEM CELL REVIEWS AND REPORTS
(2015)
Article
Cell & Tissue Engineering
Marek Barczyk, Matthias Schmidt, Sabrina Mattoli
STEM CELL REVIEWS AND REPORTS
(2015)
Article
Biochemistry & Molecular Biology
Mirko Isgro, Lorenza Bianchetti, Maurizio A. Marini, Sabrina Mattoli
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2013)
Article
Immunology
A. Bellini, M. A. Marini, L. Bianchetti, M. Barczyk, M. Schmidt, S. Mattoli
MUCOSAL IMMUNOLOGY
(2012)
Editorial Material
Infectious Diseases
Sabrina Mattoli
Summary: Emergency use authorization for COVID-19 vaccines has been issued in various countries, with the possibility of more approvals in the future. While mass vaccination may be achievable in some Western countries by the end of 2021, challenges such as insufficient supplies, unequal access, and lack of community engagement may hinder global vaccination coverage within 2-3 years. One potential strategy to address this gap is integrating improved non-pharmaceutical measures and authorized pharmaceutical interventions to reduce hospitalizations and deaths during anticipated infection peaks in the coming months.
INFECTIOUS DISEASES AND THERAPY
(2021)
Review
Medicine, Research & Experimental
Sabrina Mattoli, Matthias Schmidt
Summary: Serious respiratory virus infections like influenza and COVID-19 are associated with a dysregulated immune response and systemic inflammation. Current treatments that target immunological/inflammatory dysfunction have shown some success, but the need for mechanical ventilation and the risk of death remain high. There is a need for new therapies to improve outcomes for hospitalized patients with severe respiratory virus infections who do not respond to current treatments.
ADVANCES IN THERAPY
(2023)
Article
Medicine, General & Internal
Lorenza Bianchetti, Mirko Isgro, Maurizio A. Marini, Alberto Bellini, Matthias Schmidt, Sabrina Mattoli
