Editorial Material
Medicine, General & Internal
Kostantinos Kostopanagiotou, Mace M. Schuurmans, Ilhan Inci, Rene Hage
Summary: There are two distinct phenotypes in COVID-19 related end stage lung disease, namely COVID-19 related acute respiratory distress syndrome (CARDS) and post-COVID pulmonary fibrosis (PCPF). The CARDS phenotype has a worse prognosis compared to the PCPF phenotype, which evolves without ARDS picture. Further studies are needed to define the optimal treatment options for these two phenotypes, including anti-fibrotic drugs or lung transplantation.
ANNALS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ana Carolina Guerta Salina, Leticia de Aquino Penteado, Naiara Naiana Dejani, Ludmilla Silva-Pereira, Breno Vilas Boas Raimundo, Gabriel Ferranti Correa, Karen Cristina Oliveira, Leandra Naira Zambelli Ramalho, Medeton Mahoussi Michael Boko, Vania L. D. Bonato, C. Henrique Serezani, Alexandra Ivo Medeiros
Summary: The removal of dead cells through efferocytosis is crucial for resolving infections and preserving tissues. The efferocytosis of non-infected apoptotic cells promotes the production of anti-inflammatory macrophages, while the impact of efferocytosis of infected apoptotic cells on macrophage activation remains unknown.
Article
Microbiology
Nicholas D. D. Walter, Jackie P. P. Ernest, Christian Dide-Agossou, Allison A. A. Bauman, Michelle E. E. Ramey, Karen Rossmassler, Lisa M. M. Massoudi, Samantha Pauly, Reem Al Mubarak, Martin I. I. Voskuil, Firat Kaya, Jansy P. P. Sarathy, Matthew D. D. Zimmerman, Veronique Dartois, Brendan K. K. Podell, Radojka M. M. Savic, Gregory T. T. Robertson
Summary: Tuberculosis lung lesions are complex and harbor heterogeneous microenvironments that influence antibiotic effectiveness. Major strides have been made recently in understanding drug pharmacokinetics in pulmonary lesions, but the bacterial phenotypes that arise under these conditions and their contribution to drug tolerance are poorly understood.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Cell Biology
Katia Corano Scheri, Yi-Wen Hsieh, Eunji Jeong, Amani A. Fawzi
Summary: The progression to fibrosis in retinopathy of prematurity and other ischemic retinopathies is a clinical and surgical challenge. In this study, a limited hyperoxia induced retinopathy model was used to evaluate the progression of fibrosis, angiogenesis, and inflammation in mice at different time points.
Article
Medicine, Research & Experimental
David P. Nichols, Sarah J. Morgan, Michelle Skalland, Anh T. Vo, Jill M. Van Dalfsen, Sachinkumar B. P. Singh, Wendy Ni, Lucas R. Hoffman, Kailee McGeer, Sonya L. Heltshe, John P. Clancy, Steven M. Rowe, Peter Jorth, Pradeep K. Singh
Summary: In this study, the effect of the newest CFTR modulator, ETI, on CF lung infections was investigated in 236 CF patients. The results showed that ETI treatment led to significant reductions in densities of drug-resistant pathogens in sputum, but most participants still remained infected with the pathogens present before the treatment. Treatment increased bacterial diversity in sputum, but this change was mainly due to the decrease in CF pathogens rather than other bacteria.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Cell Biology
Poojitha Rajasekar, Jamie Patel, Rachel L. Clifford
Summary: Fibroblasts are essential in connective tissue for tissue structure and immune functions. DNA methylation plays a role in cellular phenotypes and cellular memory. Lung fibroblast populations are heterogeneous, with various mesenchymal populations identified in health and lung disease.
Article
Medicine, Research & Experimental
Izabela Borek, Anna Birnhuber, Norbert F. Voelkel, Leigh M. Marsh, Grazyna Kwapiszewska
Summary: The role of pulmonary vasculature in the development and progression of acute and chronic lung diseases, such as ARDS, PF, and COPD, has been frequently overlooked. However, there is increasing evidence that the vascular endothelium plays an active role in these diseases. This review outlines the current knowledge and future research directions regarding the pulmonary vasculature and hopes to facilitate the development of mechanism-based therapies.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Li Zhao, Wenjing Ye, Yingfeng Zhu, Fangfang Chen, Qian Wang, Xiaoxi Lv, Yinghui Hua, Zunguo Du, Xiaoxia Zhu, Yiyun Yu, Hejian Zou, Lei Liu, Yu Xue
Summary: This study found altered macrophage polarization in different stages of gouty inflammation. In acute gout, macrophages were polarized into M1 at an early stage and into M2 at later stages, while in chronic gout, macrophages were mainly polarized towards M2. The number of M1 increased with the progression of inflammation. An early increase of M2 was also observed, which might be generated directly from M0.
LABORATORY INVESTIGATION
(2022)
Review
Immunology
Fei Hou, Kun Xiao, Li Tang, Lixin Xie
Summary: Different types of lung macrophages play diverse roles and possess unique characteristics in lung diseases. Understanding the similarities and differences among these macrophages is crucial for the study of lung diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Joao Moura, Raquel Samoes, Marcio Cardoso, Ana Paula Sousa, Joana Damasio, Antonio Marinho, Paula Carneiro, Esmeralda Neves, Ana Martins Silva, Ernestina Santos
Summary: Anti-CASPR2-associated neurological disorders can manifest with isolated atypical phenotypes, a slowly progressive clinical course, and normal CSF or imaging findings.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Allergy
Sophia Bjorkander, Susanna Klevebro, Natalia Hernandez-Pacheco, Maura Kere, Sandra Ekstrom, Maria Sparreman Mikus, Marianne van Hage, Anna James, Inger Kull, Anna Bergstrom, Jenny Mjosberg, Christopher Andrew Tibbitt, Erik Melen
Summary: This study aimed to explore inflammation-related plasma biomarkers in lean and overweight/obese asthmatics. The results showed that 41 plasma proteins were associated with lean and/or overweight/obese asthma, and most of the proteins associated with overweight/obese asthma were also associated with overweight/obesity among non-asthmatics, indicating distinct plasma protein phenotypes in lean and overweight/obese asthmatics.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Review
Respiratory System
Anne Trappe, Seamas C. Donnelly, Paul McNally, Judith A. Coppinger
Summary: Extracellular vesicles (EVs) play crucial roles in chronic lung diseases as mediators of intercellular communication and potential biomarkers and drug carriers. Research indicates that EVs are key players in inflammatory processes, offering new avenues for therapies and pathological investigations in a range of lung diseases.
Article
Physiology
Rebecca Berggren-Nylund, Martin Ryde, Anna Lofdahl, Arturo Ibanez-Fonseca, Monica Karedal, Gunilla Westergren-Thorsson, Ellen Tufvesson, Anna-Karin Larsson-Callerfelt
Summary: This study investigated the effect of hypoxia combined with profibrotic stimuli on human lung epithelial cells and its correlation to pathogenesis. The results showed that hypoxia downregulated genes related to fibrosis, mitochondrial stress, oxidative stress, apoptosis, and inflammation. It also resulted in changes in cell viability and metabolic activity. These findings suggest that hypoxia may play a role in the development of chronic lung disorders.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xia Guo, Christudas Sunil, Guoqing Qian
Summary: Obesity-induced inflammation mediators contribute to respiratory complications and lung fibrosis. The association between obesity and lung fibrosis has been identified, with critical inflammatory mediators playing a significant role in this process.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Yu Mikami, Barbara R. Grubb, Troy D. Rogers, Hong Dang, Takanori Asakura, Pradeep Kota, Rodney C. Gilmore, Kenichi Okuda, Lisa C. Morton, Ling Sun, Gang Chen, Jason A. Wykoff, Camille Ehre, Juan Vilar, Catharina van Heusden, Alessandra Livraghi-Butrico, Martina Gentzsch, Brian Button, M. Jackson Stutts, Scott H. Randell, Wanda K. O'Neal, Richard C. Boucher
Summary: Unlike solid organs, human airway epithelia rely on inspired air rather than the vasculature for oxygen supply. Chronic hypoxia in the airway epithelia plays a central role in the pathogenesis of persistent mucus accumulation and airway wall damage in muco-obstructive lung diseases (MOLDs). Chronic hypoxia leads to glycolytic metabolic state, increased MUC5B mucin production, and up-regulation of ENaC subunits, resulting in hyperconcentrated mucus and perpetuated obstruction. Transcriptional changes in airway wall remodeling, destruction, and angiogenesis are also observed in chronically hypoxic airway epithelia.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Guoying Yu, Argyris Tzouvelekis, Rong Wang, Jose D. Herazo-Maya, Gabriel H. Ibarra, Anup Srivastava, Joao Pedro Werneck de Castro, Giuseppe DeIuliis, Farida Ahangari, Tony Woolard, Nachelle Aurelien, Rafael Arrojo e Drigo, Ye Gan, Morven Graham, Xinran Liu, Robert J. Homer, Thomas S. Scanlan, Praveen Mannam, Patty J. Lee, Erica L. Herzog, Antonio C. Bianco, Naftali Kaminski
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hur, Lindsey M. Prescher, Judith L. Meadows, Steven E. Pfau, Robert J. Homer, George Tellides, James J. Yun
ANNALS OF THORACIC SURGERY
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Kelly Brown, Robert Homer, Marina Baine, Justin D. Blasberg
ANNALS OF THORACIC SURGERY
(2019)
Editorial Material
Medicine, Research & Experimental
Benjamin L. Mazer, Robert J. Homer, David L. Rimm
LABORATORY INVESTIGATION
(2019)
Article
Multidisciplinary Sciences
Eriko Kudo, Eric Song, Laura J. Yockey, Tasfia Rakib, Patrick W. Wong, Robert J. Homer, Akiko Iwasaki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Oncology
Deborah Ayeni, Braden Miller, Alexandra Kuhlmann, Ping-Chih Ho, Camila Robles-Oteiza, Mmaserame Gaefele, Stellar Levy, Fernando J. de Miguel, Curtis Perry, Tianxia Guan, Gerald Krystal, William Lockwood, Daniel Zelterman, Robert Homer, Zongzhi Liu, Susan Kaech, Katerina Politi
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Oncology
Jessie Torgersen, Tamar H. Taddei, Lesley S. Park, Dena M. Carbonari, Michael J. Kallan, Kisha Mitchell Richards, Xuchen Zhang, Darshana Jhala, Norbert Br Au, Robert Homer, Kathryn D'Addeo, Rajni Mehta, Melissa Skanderson, Farah Kidwai-Khan, Amy C. Justice, Vincent Lo Re
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Pathology
Marina K. Baine, John H. Sinard, Guoping Cai, Robert J. Homer
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2020)
Article
Immunology
Benjamin Israelow, Eric Song, Tianyang Mao, Peiwen Lu, Amit Meir, Feimei Liu, Mia Madel Alfajaro, Jin Wei, Huiping Dong, Robert J. Homer, Aaron Ring, Craig B. Wilen, Akiko Iwasaki
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Ruoyi Jiang, Kenneth B. Hoehn, Casey S. Lee, Minh C. Pham, Robert J. Homer, Frank C. Detterbeck, Inmaculada Aban, Leslie Jacobson, Angela Vincent, Richard J. Nowak, Henry J. Kaminski, Steven H. Kleinstein, Kevin C. O'Connor
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Tianyang Mao, Benjamin Israelow, Mario A. Pena-Hernandez, Alexandra Suberi, Liqun Zhou, Sophia Luyten, Melanie Reschke, Huiping Dong, Robert J. Homer, W. Mark Saltzman, Akiko Iwasaki
Summary: This study developed a vaccine strategy called prime and spike, which activates mucosal immune memory within the respiratory tract and induces strong immune responses. It enhances both systemic and local immunity against SARS-CoV-2, and provides full protection against lethal infection in partially immune mice.
Article
Multidisciplinary Sciences
Ilianna Barbayianni, Paraskevi Kanellopoulou, Dionysios Fanidis, Dimitris Nastos, Eleftheria-Dimitra Ntouskou, Apostolos Galaris, Vaggelis Harokopos, Pantelis Hatzis, Eliza Tsitoura, Robert Homer, Naftali Kaminski, Katerina M. Antoniou, Bruno Crestani, Argyrios Tzouvelekis, Vassilis Aidinis
Summary: This study found that the formation of podosomes in lung fibroblasts is closely associated with extracellular matrix invasion in patients with idiopathic pulmonary fibrosis and mouse models. Targeting podosome formation or organization may be a potential therapeutic option for pulmonary fibrosis.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
John E. McDonough, Farida Ahangari, Qin Li, Siddhartha Jain, Stijn E. Verleden, Jose Herazo-Maya, Milica Vukmirovic, Giuseppe DeIuliis, Argyrios Tzouvelekis, Naoya Tanabe, Fanny Chu, Xiting Yan, Johny Verschakelen, Robert J. Homer, Dimitris Manatakis, Junke Zhang, Jun Ding, Karen Maes, Laurens De Sadeleer, Robin Vos, Arne Neyrinck, Panayiotis Benos, Ziv Bar-Joseph, Dean Tantin, James C. Hogg, Bart M. Vanaudenaerde, Wim A. Wuyts, Naftali Kaminski
Meeting Abstract
Critical Care Medicine
M. Vukmirovic, A. Fabre, X. Yan, G. Deluliis, T. Woolard, B. Hu, A. Mihaljinec, R. Homer, J. H. Maya, F. Ahangari, D. Smart, F. Conforti, B. Marshall, A. Alzetani, D. E. Davies, L. Richeldi, N. Kaminski, M. Jones
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Critical Care Medicine
Z. Chen, S. Oh, P. Fang, Q. Li, F. Zhang, H. Tang, R. Homer, X. Zhang, N. Kaminski, T. Zheng, Z. Zhu
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)