Review
Chemistry, Multidisciplinary
Zhiqiang Luo, Lingyu Sun, Feika Bian, Yu Wang, Yunru Yu, Zhuxiao Gu, Yuanjin Zhao
Summary: Erythrocytes, with their unique morphology and cellular composition, have inspired the development of various artificial biomaterials that have broad prospects in biomedical applications. This comprehensive review covers the fabrication and applications of erythrocyte-inspired functional materials, highlighting the synthesis strategies of particles with erythrocyte-inspired morphologies and discussing their practical biomedical applications. The future possibilities of advanced erythrocyte-inspired biomaterials are also explored, with the aim of inspiring researchers to develop novel biomaterials and accelerate their progress towards clinical biomedical applications.
Review
Biotechnology & Applied Microbiology
Nour Fatema, Ruben Michael Ceballos, Chenguang Fan
Summary: This review highlights the advances and future prospects of cellulose as a biomaterial. It focuses on the applications of nanofibrillated, nanocrystalline, and bacterial cellulose as biomaterials in the field of biomedicine.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Multidisciplinary Sciences
Rajkamal Balu, Naba K. Dutta, Ankit K. Dutta, Namita Roy Choudhury
Summary: Intrinsically disordered proteins, such as the native elastic insect protein Resilin, have brought about a significant shift in the structure-function paradigm of proteins. Advances in computational techniques, polypeptide synthesis methods, and modular protein engineering have led to the development of novel resilin-like polypeptides with applications in various fields. The encoding of responsive behavior in amino acid sequence level remains a mystery, but the potential for future research lies in the design and development of new modular RLP-based biomaterials with programmable structure, properties, and functions. Resilin-mimetics have emerged as a biomaterial with versatile potential applications, and further exploration and mimicry of natural materials are ongoing.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Applied
Yaling Deng, Amin Shavandi, Oseweuba Valentine Okoro, Lei Nie
Summary: This article reviews the use of click chemistry to modify alginate, enhancing its physical and chemical properties for various applications. Click chemistry can be employed to modify the mechanical strength and biochemical properties of alginate-based materials. The future perspectives of alginates modified with click chemistry are also discussed.
CARBOHYDRATE POLYMERS
(2021)
Review
Materials Science, Multidisciplinary
Ayda Afshar, Merve Gultekinoglu, Mohan Edirisinghe
Summary: This article discusses the importance and utilization of binary polymer systems in biomedical applications. It focuses on the applications of nano-carrier and fiber as biomaterials and their potential for dual and sequential drug delivery. The article also explores the methods of creating binary polymer systems using spinning processes and the effects of different polymer materials.
INTERNATIONAL MATERIALS REVIEWS
(2023)
Article
Green & Sustainable Science & Technology
Gopika Selvakumar, Iyappan Kuttalam, Sankari Mukundan, Suguna Lonchin
Summary: Fish discards are thrown into the sea during fishing activities, resulting in loss of valuable nutrients and negatively impacting marine habitats. This study aims to extract value-added components from discarded fish skin, such as collagen, for waste utilization and a cleaner ecosystem. The extracted collagen showed high biocompatibility and potential for biomedical applications.
JOURNAL OF CLEANER PRODUCTION
(2021)
Review
Materials Science, Multidisciplinary
Zhiyu Zhou, Wentao Wang, Jianmin Wang, Hongshui Wang, Yi Xia, Wei Zhang, Yuxiao Lai, Xiao Lin, Yongcan Huang, Xuenong Zou, Martin J. Stoddart, Zhen Li, Wei Tian, Shaoyu Liu, Xinbao Wu, Manman Gao, Junhong Li, Lei Yang, Dafu Chen
Summary: Tissue engineering is a milestone in the developmental history of life science, but tissue-engineered biomaterials have not been widely used clinically. To overcome these challenges, a new approach has been proposed, focusing on the construction of organoid structures and function-oriented design.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Review
Polymer Science
Bankole Oladapo, S. Abolfazl Zahedi, Francis T. Omigbodun
Summary: This review focuses on 3D printing of calcium hydroxyapatite (cHAp) as a composite on poly-ether-ether-ketone (PEEK) scaffolds, highlighting the interactions between PEEK/cHAp interfaces and the biocompatibility of the materials. It discusses the application of cHAp scaffolds in bone tissue engineering and the development of multifunctional cHAp-based systems for advanced therapies.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
Yumei Wang, Feng Wang, Hui Zhang, Bing Yu, Hailin Cong, Youqing Shen
Summary: BCI is a tough problem caused by bacterial infections in biomaterial centers, attracting high attention in recent years. Research on antibacterial material surfaces has focused on reducing bacterial adhesion and inhibiting biofilm formation. These surfaces can be categorized into three primary types: antiadhesion-based, release-based, and contact-based antibacterial material surfaces.
APPLIED MATERIALS TODAY
(2021)
Review
Chemistry, Multidisciplinary
Shubhrima Ghosh, Razi Ahmad, Md. Zeyaullah, Sunil Kumar Khare
Summary: Nanomaterials have diverse applications in biology, medicine, electronics, and agriculture. Biological synthesis methods can overcome limitations of chemical and physical methods, and microbial nanoparticles play a significant role in biomedical applications but face challenges such as biocompatibility and stability.
FRONTIERS IN CHEMISTRY
(2021)
Review
Materials Science, Multidisciplinary
Yahya Bozkurt, Elif Karayel
Summary: 3D printing technology, a miracle manufacturing method widely used in the medical field in recent years, is applied in surgery, pharmaceutical industry, disease modeling, development of customized implants and prostheses, organ printing, vet medicine, and tissue engineering applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Review
Biotechnology & Applied Microbiology
Daniela Matias de C. Bittencourt, Paula Oliveira, Valquiria Alice Michalczechen-Lacerda, Gracia Maria Soares Rosinha, Justin A. Jones, Elibio L. Rech
Summary: This review discusses the extraordinary mechanical properties of spider silks and the advancements in synthetic biology for designing and producing spidroins that mimic the structure and properties of spider silks. Scientists can explore various non-natural morphologies using spidroins, and their biocompatibility and biodegradability make them ideal for biomedical applications and drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Mai Bay Stie, Kleopatra Kalouta, Valeria Vetri, Vito Fodera
Summary: Protein-based materials are widely used in biomedical fields due to their biocompatibility, biodegradability, and versatility. This review provides an overview of the current scientific knowledge on protein-based materials and reviews selected preclinical and clinical studies, focusing on non-invasive and minimally invasive strategies for topical application.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Physical
D. R. N. Correa, C. R. Grandini, L. A. Rocha, J. P. Proenca, L. Sottovia, N. C. Cruz, E. C. Rangel, T. Hanawa
Summary: This study evaluated the effect of temperature on various properties of Ti-15Zr-xMo alloys, including morphology, crystal structure, chemical composition, roughness, wettability, microhardness, and corrosion resistance. The results showed that optimizing the thermal oxidation treatment at specific temperatures and chemical compositions could lead to alloys with favorable surface properties, which could broaden their biomedical applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Multidisciplinary
Daekeun Kim, Dayoon Kang, Donghwan Kim, Jinah Jang
Summary: Engineered tissues and organs that mimic actual organs have great potential in advancing medicine and pharmacology, but current tissue-engineering techniques face challenges in creating clinically relevant constructs. Three-dimensional bioprinting technology is expected to enable the creation of large-scale functional organs for various applications. This article discusses key considerations and recent advances in volumetric bioprinting, addressing the donor organ shortage and lack of reliable in vitro models.
Article
Clinical Neurology
Jiwon Kim, Hee Jeong Jang, Dawid Schellingerhout, Su-Kyoung Lee, Ha Kim, Young Dae Kim, Kyung-Yul Lee, Hye-Yeon Choi, Han-Jin Cho, Seong-Soo Jang, Sangmin Jeon, Ick Chan Kwon, Kwangmeyung Kim, Wi-Sun Ryu, Matthias Nahrendorf, Seungbum Choi, Dong-Eog Kim
Summary: The study found that short-term cessation of dabigatran therapy can lead to a rebound prothrombotic state, increasing thrombus volume. This effect can be prevented by single-dose aspirin pretreatment, and cessation of dabigatran increases platelet aggregability for 2 days after drug cessation, which can be significantly attenuated by single-dose aspirin pretreatment.
ANNALS OF NEUROLOGY
(2021)
Article
Biochemical Research Methods
Seungho Lim, Woojun Kim, Sukyung Song, Man Kyu Shim, Hong Yeol Yoon, Byung-Soo Kim, Ick Chan Kwon, Kwangmeyung Kim
Summary: The development of BCN-AuNPs allows for enhanced cellular uptake of nanoparticles through bioorthogonal click chemistry on metabolically engineered stem cells.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Han Young Kim, Sang Hoon Um, Yejin Sung, Man Kyu Shim, Suah Yang, Jooho Park, Eun Sun Kim, Kwangmeyung Kim, Ick Chan Kwon, Ju Hee Ryu
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Chemistry, Multidisciplinary
Woojun Kim, Hong Yeol Yoon, Seungho Lim, Patrick S. Stayton, In-San Kim, Kwangmeyung Kim, Ick Chan Kwon
Summary: The non-invasive tracking of T-cells using bioorthogonal click chemistry can predict and induce therapeutic responses in cell therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Gyeong Taek Lim, Dong Gil You, Hwa Seung Han, Hansang Lee, Sol Shin, Byeong Hoon Oh, E. K. Pramod Kumar, Wooram Um, Chan Ho Kim, Seungsu Han, Sangho Lee, Seungho Lim, Hong Yeol Yoon, Kwangmeyung Kim, Ick Chan Kwon, Dong-Gyu Jo, Yong Woo Cho, Jae Hyung Park
Summary: This study successfully prepared surface-edited EVs using bioorthogonal copper-free click chemistry and metabolic glycoengineering, which effectively accumulated in target tissues in animal models, primarily due to prolonged circulation in the bloodstream and active targeting mechanism.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Chemistry, Multidisciplinary
Gijung Kwak, Hyosuk Kim, Jooho Park, Eun Hye Kim, Hochung Jang, Geonhee Han, Sun Young Wang, Yoosoo Yang, Ick Chan Kwon, Sun Hwa Kim
Summary: MI-Anti-miRNAs, a carrier-free delivery system, piggyback onto albumin in vivo and effectively target and silence disease-associated miRNAs, showing superior antitumor activity in both solid and metastatic tumors.
Review
Biochemistry & Molecular Biology
Hee Sook Hwang, Hyosuk Kim, Geonhee Han, Jong Won Lee, Kwangmeyung Kim, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim
Summary: Extracellular vesicles play an important role in inflammatory diseases, and can be engineered to target specific cells, making them promising nanoparticles for personalized therapeutic carriers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Min Ju Kim, Hyosuk Kim, Xueliang Gao, Ju Hee Ryu, Yoosoo Yang, Ick Chan Kwon, Thomas M. Roberts, Sun Hwa Kim
Summary: A multi-targeting siRNA delivery system was proposed for PI3K-targeted anticancer therapy, effectively inhibiting the PI3K signaling pathway in PTEN-deficient cancer cells, leading to delays in cell proliferation and migration.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Correction
Chemistry, Multidisciplinary
Min Ju Kim, Hyosuk Kim, Xueliang Gao, Ju Hee Ryu, Yoosoo Yang, Ick Chan Kwon, Thomas M. Roberts, Sun Hwa Kim
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Eun Hye Kim, Jongwon Lee, Gijung Kwak, Hochung Jang, Hyosuk Kim, Haeun Cho, Yeongji Jang, Jiwoong Choi, Sung Gil Chi, Kwangmeyung Kim, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim
Summary: This study developed a dual-targeting drug delivery system (Pep-21) that can inhibit miR-21 activity in both cancer cells and tumor-associated macrophages (TAMs). The study found that Pep-21 treatment reduced tumor cell migration, reprogrammed immunosuppressive TAMs into immunostimulatory macrophages, and restrained tumor progression.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Hyosuk Kim, Byeong-Wook Song, Soon-Jung Park, Seong Woo Choi, Hanbyeol Moon, Ki-Chul Hwang, Sun-Woong Kang, Sung-Hwan Moon, Yoosoo Yang, Ick Chan Kwon, Sun Hwa Kim
Summary: This study proposes an extracellular vesicle (EV)-guided, nonviral, direct lineage conversion strategy to enhance the transdifferentiation of fibroblasts to induced cardiomyocyte-like cells (iCMs). The resulting iCMs show typical cardiac features and have gene expression profiles similar to cardiomyocytes. This method achieves a high conversion efficiency (>60%) and establishes a more accessible platform for generating specialized somatic cells through direct lineage conversion.
Article
Engineering, Biomedical
Hyosuk Kim, Hyun-Ju Park, Hyo Won Chang, Ji Hyun Back, Su Jin Lee, Yae Eun Park, Eun Hye Kim, Yeonsun Hong, Gijung Kwak, Ick Chan Kwon, Ji Eun Lee, Yoon Se Lee, Sang Yoon Kim, Yoosoo Yang, Sun Hwa Kim
Summary: The highly immunosuppressive tumor microenvironment with protumoral immune cells accelerates malignant transformation and treatment resistance. Tumor-associated macrophages (TAMs), as the predominant immune cells in tumors, play a crucial role in regulating the immunosuppressive tumor microenvironment. This study explores an exosome-guided direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type macrophages, potentially enhancing antitumor immunity.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jangwook Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee
Summary: A new anticancer strategy exploiting abnormal cancer cell metabolism is reported. An antiglycolytic amphiphilic polymer is synthesized and regulates glucose metabolism to inhibit tumor growth. This strategy highlights the necessity for safe and effective cancer treatment without conventional drugs.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Ashita Nair, Kaila Javius-Jones, Jason Bugno, Michael J. Poellmann, Narsimha Mamidi, In-San Kim, Ick Chan Kwon, Heejoo Hong, Seungpyo Hong
Summary: Nanoscale drug delivery systems combining natural exosomes and synthetic dendrimers have been developed to improve the selectivity and reduce the toxicity of cancer treatment. These hybrid nanoparticles exhibit advantageous biological properties and have shown enhanced delivery and downregulation of gene and protein targets in cancer cells.
CHEMISTRY OF MATERIALS
(2023)
Article
Materials Science, Biomaterials
Sanghyo Park, Hyungkyu Park, Chaewon Park, Wan Su Yun, Soonjae Hwang, Hong Yeol Yoon, Ick Chan Kwon, Kwangmeyung Kim, Jaehong Key
Summary: A simple method was developed to enhance the delivery efficiency of doxorubicin in a lung metastasis model by manipulating the size, shape, loading content, and biodegradability of the drug delivery system. The system exhibited high drug release and delivered doxorubicin to lung cancer cells with minimal off-target effects, showing comparable anticancer efficacy to the free drug.
BIOMATERIALS SCIENCE
(2022)
