Article
Geriatrics & Gerontology
Sara Becker, Susanne Solbrig, Katja Michaelis, Bettina Faust, Kathrin Brockmann, Inga Liepelt-Scarfone
Summary: This study aims to examine the agreement between self- and informant-reported activities of daily living (ADL) deficits in Parkinson's Disease (PD) patients and analyze factors influencing ADL ratings. The results showed moderate agreement between patients and informants on some aspects of ADL, but lower agreement on others. These ratings were associated with patient cognitive status and other characteristics. Therefore, in addition to patient and informant reports, objective measures are needed to accurately assess ADL deficits in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Rheumatology
Aoi Nagano, Masaki Takeuchi, Nobuyuki Horita, Takeshi Teshigawara, Tatsukata Kawagoe, Yuki Mizuki, Akira Meguro, Hiroto Nakano, Yohei Kirino, Kaoru Takase-Minegishi, Ryusuke Yoshimi, Michiko Kurosawa, Takeshi Fukumoto, Mitsuhiro Takeno, Takeshi Kaneko, Nobuhisa Mizuki
Summary: This study found that ocular lesions, neurological manifestations, and arthritis affect the activities of daily living (ADL) in patients with Behcet's disease. Patients with ocular lesions or neurological manifestations are more likely to require physical assistance.
Article
Clinical Neurology
Linda S. Deal, David A. Andrae, Daniela E. Myers, Nathan Johnson, Brandon Foster, Christopher J. Evans
Summary: This research aimed to evaluate the structure, scoring, consistency, reliability, and validity of a new patient-reported outcomes instrument called PD-AID, which assesses the clinical benefit of Parkinson's disease treatment from the patient's perspective. The study found that PD-AID demonstrated good reliability and validity characteristics, producing psychometrically sound scores.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Xuedan Lv, Min Chu, Yang Liu, Donglai Jing, Li Liu, Yue Cui, Yihao Wang, Deming Jiang, Weiqun Song, Caishui Yang, Liyong Wu
Summary: This study aimed to identify the impact of brain regions associated with activities of daily living (ADL) in PCA patients. The results showed that PCA patients had lower total ADL, BADL, and IADL scores, which were associated with hypometabolism in bilateral parietal lobes. These findings have potential implications for the application of noninvasive neuromodulatory interventions.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Tomohiko Nagano, Tatsuyuki Kakuma, Yuichi Umezu, Takashi Yanagawa
Summary: This study explored the relationship between nutritional status and activities of daily living in patients with Parkinson's disease. Results showed that poor nutritional status was significantly associated with a decline in activities of daily living. These findings could help in developing nutritional intervention programs to improve daily living activities for Parkinson's disease patients.
Article
Geriatrics & Gerontology
Marine Dufournet, Claire Moutet, Sarah Achi, Floriane Delphin-Combe, Pierre Krolak-Salmon, Virginie Dauphinot
Summary: The corrected IADL score showed excellent agreement with the usual version based on the ICC. This correction could improve clinical practice by providing a more accurate description of patients' real clinical state and benefit research on evaluating patients' functional abilities.
Article
Clinical Neurology
Sara Becker, Claire Pauly, Michael Lawton, Geraldine Hipp, Francesca Bowring, Patricia Sulzer, Michele Hu, Rejko Krueger, Thomas Gasser, Inga Liepelt-Scarfone
Summary: The study suggests that self-reported ADL impairments assessed by the FAQ are related to the severity of cognitive impairment in PD, showing moderate specificity in differentiating cognitive status in PD patients.
NEUROLOGICAL SCIENCES
(2022)
Article
Health Care Sciences & Services
Patricia Sanchez-Herrera-Baeza, M. Pilar Rodriguez-Perez, Gemma Fernandez-Gomez, Nerea Bustamante-Palomo, Sergio Serrada-Tejeda, Paula Obeso-Benitez, Matilde Morales-Cabezas, Rosa M. Martinez-Piedrola, Marta Perez-de-Heredia-Torres
Summary: This study aimed to examine the impact of one year of lockdown and social distancing measures due to the COVID-19 pandemic on Activities of Daily Living (ADLs) in patients with Parkinson's disease, as well as the association between daily performance and tasks requiring manipulative dexterity. A total of 126 participants were recruited from patient associations in Spain, and data were collected through telephone interviews. The findings demonstrate a significant decline in almost all assessed ADLs, and a moderate correlation between dependence in ADLs and difficulty in performing activities that require dexterity. These results highlight the specific needs of these patients in rehabilitation treatment.
Article
Clinical Neurology
Sara Becker, Merle Bode, Kathrin Brockmann, Thomas Gasser, Katja Michaelis, Susanne Solbrig, Hans-Christoph Nuerk, Claudia Schulte, Walter Maetzler, Milan Zimmermann, Daniela Berg, Inga Liepelt-Scarfone
Summary: This study evaluated the phenotype associated with cognitive IADL impairment and its predictive value for defining a high-risk group for PD dementia.
Article
Clinical Neurology
Cristian Sirbu, Brian K. K. Saxby, Cynthia W. W. McNamara, Linda S. S. Deal
Summary: The PD-AID is a patient-reported outcome instrument used to assess the clinical benefit of PD treatment. A study was conducted on 93 patients with moderate to advanced PD, using multilevel factor analysis. The study found that the Morning and Evening PD-AID items had high reliability, with most variability being due to between-individual variability.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Sujin Jang, Katya Numbers, Ben Chun Pan Lam, Perminder S. Sachdev, Henry Brodaty, Simone Reppermund
Summary: The study examined the differences between informant-reported and performance-based measures of instrumental activities of daily living (IADL) and assessed the predictive value of performance-based IADL measures in identifying individuals at risk of developing dementia. The findings showed that performance-based IADL measures can predict dementia progression over a 4-year period, providing additional information beyond informant reports. These measures are promising tools for identifying individuals at greater risk of dementia.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Rehabilitation
Barbara M. Doucet, Ingrid Franc
Summary: Evidence Connection articles are provided by the American Occupational Therapy Association's Evidence-Based Practice Program to offer guidance and support to occupational therapy practitioners in translating research findings into practical strategies. This particular article focuses on interventions for adults with Parkinson's disease to improve their ability in activities of daily living. It includes a case study and discusses evaluation tools and intervention strategies to address specific needs and limitations.
AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
(2023)
Article
Clinical Neurology
Jinse Park, Hojin Choi, Jea-Won Jang, Jae-Sung Lim, YoungSoon Yang, Chan-Nyoung Lee, Kee Hyung Park
Summary: The SOC-ADL is a valid and reliable tool for differentiating dementia from mild cognitive impairment based on an assessment of activities of daily living. The scores are strongly correlated with other dementia assessment tools and can be used for screening in elderly individuals.
JOURNAL OF CLINICAL NEUROLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Sierra M. Sergio D., Daniel E. Garcia A., Sophia Otalora, Maria Camila Arias-Castro, Alejandro Gomez-Rodas, Marcela Munera, Carlos A. Cifuentes
Summary: This study evaluated the AGoRA Smart Walker in older adults and found that those with Parkinson's disease showed significant improvements in lower limb strength tests. The Timed Up and Go Test (TUGT) also indicated significant differences in torque among participants.
FRONTIERS IN NEUROROBOTICS
(2021)
Article
Clinical Neurology
Vuk Milosevic, Marina Malobabic, Ivana Stojanovic, Jelena Basic
Summary: The aim of this study was to analyze the validity and reliability of the Serbian translation of the short version of A-IADL-Q in a population of memory clinic patients. The results showed that the Serbian version of A-IADL-Q had good internal consistency and test-retest reliability, and it could effectively assess the daily living activities of patients with dementia and mild cognitive impairment.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Review
Clinical Neurology
Daniel J. van Wamelen, Pablo Martinez-Martin, Daniel Weintraub, Anette Schrag, Angelo Antonini, Cristian Falup-Pecurariu, Per Odin, Kallol Ray Chaudhuri
Summary: The NMSS, developed in 2007, is the first instrument for comprehensively assessing a range of non-motor symptoms in Parkinson's disease. Over the past 13 years, it has been extensively validated and utilized in over 100 clinical studies, showing strong correlations with health-related quality of life measures. The scale has proven capable of detecting longitudinal changes in non-motor symptoms and has become a key outcome measure in several randomized clinical trials.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Valtteri Kaasinen, Filip Scheperjans, Mikko Karppa, Jaana Korpela, Anna Bruck, Jussi O. T. Sipila, Juho Joutsa, Juha Jarvela, Johanna Eerola-Rautio, Mika H. Martikainen, Katja Airaksinen, Glenn T. Stebbins, Pablo Martinez-Martin, Christopher G. Goetz, Jeffrey Lin, Sheng Luo, Eero Pekkonen
Summary: The study validated the Finnish version of UDysRS and identified subtle differences compared to the reference standard, possibly related to sample composition or disease status.
EUROPEAN NEUROLOGY
(2021)
Article
Clinical Neurology
Anna Sauerbier, Philipp Loehrer, Stefanie T. Jost, Shania Heil, Jan N. Petry-Schmelzer, Johanna Herberg, Pia Bachon, Salima Aloui, Alexandra Gronostay, Lisa Klingelhoefer, J. Carlos Baldermann, Daniel Huys, Christopher Nimsky, Michael T. Barbe, Gereon R. Fink, Pablo Martinez-Martin, K. Ray Chaudhuri, Veerle Visser-Vandewalle, Lars Timmermann, Daniel Weintraub, Haidar S. Dafsari
Summary: This study explores the effects of subthalamic nucleus-deep brain stimulation on impulsive and compulsive behaviours in patients with Parkinson's disease. Results show that patients with higher preoperative impulsive and compulsive behaviours severity and lower dopamine agonist doses have better outcomes, while those with more severe baseline attention/memory deficits may have worse outcomes. Comprehensive assessments of non-motor and motor symptoms are needed for patients undergoing STN-DBS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Michel J. Grothe, Miguel A. Labrador-Espinosa, Silvia Jesus, Daniel Macias-Garcia, Astrid Adarmes-Gomez, Fatima Carrillo, Elena Iglesias Camacho, Pablo Franco-Rosado, Florinda Roldan Lora, Juan Francisco Martin-Rodriguez, Miquel Aguilar Barbera, Pau Pastor, Sonia Escalante Arroyo, Berta Solano Vila, Anna Cots Foraster, Javier Ruiz Martinez, Francisco Carrillo Padilla, Mercedes Pueyo Morlans, Isabel Gonzalez Aramburu, Jon Infante Ceberio, Jorge Hernandez Vara, Oriol de Fabregues-Boixar, Teresa de Deus Fonticoba, Berta Pascual-Sedano, Jaime Kulisevsky, Pablo Martinez-Martin, Diego Santos-Garcia, Pablo Mir
Summary: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Irene A. Malaty, Pablo Martinez-Martin, K. Ray Chaudhuri, Per Odin, Matej Skorvanek, Joohi Jimenez-Shahed, Michael J. Soileau, Susanna Lindvall, Josefa Domingos, Sarah Jones, Ali Alobaidi, Yash J. Jalundhwala, Prasanna L. Kandukuri, Koray Onuk, Lars Bergmann, Samira Femia, Michelle Y. Lee, Jack Wright, Angelo Antonini
Summary: The 5-2-1 screening criteria has demonstrated potential as an objective tool for identifying patients with advanced Parkinson's disease (APD), who face greater clinical, humanistic, and healthcare resource utilization burden. By accurately identifying these patients, the 5-2-1 criteria can aid in timely treatment optimization for patients with suboptimal medication control.
Article
Rehabilitation
Ghorban Taghizadeh, Pablo Martinez-Martin, Sayed Amir Hasan Habibi, Sepideh Goudarzi, Mahsa Meimandi, Arian Dehmiyani, Zahra Nodehi, Siavash Rostami, Naeeme Haji Alizadeh, Maryam Mehdizadeh
Summary: This study aimed to evaluate the psychometric properties of the Brief Pain Inventory (BPI) in patients with PD, and found satisfactory internal consistency and test-retest reliability. The BPI showed acceptable diagnostic accuracy for discriminating different pain levels and between PD patients and non-PD controls.
DISABILITY AND REHABILITATION
(2022)
Article
Clinical Neurology
Federic Sampedro, Saul Martinez-Horta, Andrea Horta-Barba, Michel J. Grothe, Miguel A. Labrador-Espinosa, Silvia Jesus, Astrid Adarmes-Gomez, Fatima Carrillo, Arnau Puig-Davi, Florinda Roldan Lora, Miquel Aguilar Barbera, Pau Pastor, Sonia Escalante Arroyo, Berta Solano Vila, Anna Cots Foraster, Javier Ruiz Martinez, Francisco Carrillo Padilla, Mercedes Pueyo Morlans, Isabel Gonzalez Aramburu, Jon Infante Ceberio, Jorge Hernandez Vara, Oriol de Fabregues-Boixar, Teresa de Deus Fonticoba, Asuncion Avila, Juan Carlos Martinez-Castrillo, Helena Bejr-Kasem, Antonia Campolongo, Berta Pascual-Sedano, Pablo Martinez-Martin, Diego Santos-Garcia, Pablo Mir, Jaime Kulisevsky
Summary: This study found that blood homocysteine levels were increased in Parkinson's disease patients and were associated with cognitive performance and structural damage in the cerebral cortex.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Priya Jagota, Prachaya Srivanitchapoom, Sitthi Petchrutchatachart, Surat Singmaneesakulchai, Apichart Pisarnpong, Praween Lolekha, Suwanna Setthawatcharawanich, Parnsiri Chairangsaris, Natlada Limotai, Pawut Mekawichai, Pattamon Panyakaew, Onanong Phokaewvarangkul, Jirada Sringean, Yuvadee Pitakpatapee, Nancy LaPelle, Pablo Martinez-Martin, Xuehan Ren, Sheng Luo, Glenn T. Stebbins, Christopher G. Goetz, Roongroj Bhidayasiri
Summary: This study aims to validate the Thai translation of the Movement Disorder Society-sponsored revision of the Uni-fied Parkinson's Disease Rating Scale (MDS-UPDRS). The results showed that the Thai version was validated in clinical testing, and the overall factor structure was consistent with the English version.
JOURNAL OF MOVEMENT DISORDERS
(2022)
Review
Clinical Neurology
Michelle H. S. Tosin, Beatriz Guitton R. B. de Oliveira, Christopher G. Goetz, Donald Morisky, Victor McConvey, Matej Skorvanek, Anette Schrag, Pablo Martinez-Martin, Glenn T. Stebbins
Summary: This study critically reviewed the measurement properties of rating scales used to assess medication adherence in Parkinson's disease (PD) and made recommendations. Several scales were suggested for use, but further work is needed to resolve the issues or develop a new scale that meets all criteria.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Pablo Martinez-Martin, Matej Skorvanek, Tove Henriksen, Susanna Lindvall, Josefa Domingos, Ali Alobaidi, Prasanna L. L. Kandukuri, Vivek S. S. Chaudhari, Apeksha B. B. Patel, Juan Carlos Parra, James Pike, Angelo Antonini
Summary: This study examines the impact of advanced Parkinson's disease (APD) on caregiver burden, quality of life (QoL), and health status. The results show that caregivers of people with APD experience a greater burden, are less satisfied with treatment, and spend more time caregiving.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Valtteri Kaasinen, Sheng Luo, Pablo Martinez-Martin, Christopher G. G. Goetz, Glenn T. T. Stebbins
Summary: This study compared patient and clinician evaluations of levodopa-induced dyskinesia (LID) severity across multiple cultures in patients with Parkinson's disease (PD). The results showed that language and cultural differences influence the subjective perception of LID, which is important to consider in multinational clinical trials on dyskinesia assessment.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Jenny M. M. Norlin, Klas Kellerborg, Ulf Persson, Daniel Oudin Astrom, Peter Hagell, Pablo Martinez-Martin, Per Odin
Summary: This study found an association between the Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD) and health-related quality of life assessments. The findings suggest that CISI-PD could be used as a basis for defining health states in future health economic models and as outcomes in managed entry agreements.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Stefanie Jost, Marie-Ann Kaldenbach, Angelo Antonini, Pablo Martinez-Martin, Lars Timmermann, Per Odin, Regina Katzenschlager, Rupam Borgohain, Alfonso Fasano, Fabrizio Stocchi, Nobutaka Hattori, Prashanth Lingappa Kukkle, Mayela Rodriguez-Violante, Cristian Falup-Pecurariu, Sebastian Schade, Jan Niklas Petry-Schmelzer, Vinod Metta, Daniel Weintraub, Guenther J. Deuschl, Alberto J. Espay, Eng-King Tan, Roongroj Bhidayasiri, Victor S. C. Fung, Francisco Cardoso, Claudia Trenkwalder, Peter Jenner, K. S. Ray Chaudhuri, Haidar Dafsari
Summary: This study reviewed the investigations on drug therapy for Parkinson's disease since 2010 and proposed a new drug conversion formula. These conversion formulas can help us compare drug regimens across different clinical trials. The results are important for studying the pharmacological efficacy of Parkinson's disease treatments as well as other non-pharmacological interventions.
MOVEMENT DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
D. Santos Garcia, T. De Deus Fonticoba, C. Cores, E. Suarez Castro, J. Hernandez Vara, S. Jesus, P. Mir Rivera, M. Cosgaya, M. Marti, P. Pastor, I. Cabo Lopez, M. Seijo, I. Legarda, B. Vives, N. Caballol, J. Ruiz Martinez, I. Croitoru, E. Cubo, J. Miranda, G. Alonso Losada, C. Labandeira, N. Lopez Ariztegui, M. Morales Casado, I. Gonzalez Aramburu, J. Infante
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Jorge U. Manez-Miro, Francisco Vivancos-Matellano, John B. Wetmore, Pablo Martinez-Martin
Summary: The study developed a questionnaire (OPTIMIPARK) to assess the dopaminergic status of Parkinson's disease patients and assist clinicians in adjusting treatment. Preliminary results showed promising feasibility and agreement with clinical criteria, suggesting OPTIMIPARK may be a useful tool in clinical decision-making for PD patients.
REVISTA DE NEUROLOGIA
(2021)