Article
Clinical Neurology
Javier Riancho, Manuel Delgado-Alvarado
Summary: This study observed 15 patients with asymmetric arm swing and provided a new clinical clue to evaluate the risk of subjacent parkinsonism.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Arnaud Delval, Nacim Betrouni, Celine Tard, David Devos, Kathy Dujardin, Luc Defebvre, Jordan Labidi, Caroline Moreau
Summary: By analyzing the combination of gait parameters and clinical characteristics, a predictive model was developed to distinguish between fallers and non-fallers in Parkinson's disease patients, showing high accuracy rates.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Beata Lindholm, Christina Brogardh, Per Odin, Peter Hagell
Summary: The study identified predictors for falls/near falls in Parkinson’s disease, including history of falls, abnormal tandem gait, and lower MMSE scores. These factors not only affect the fall risk in the short term but also in the long term among patients with PD.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xinxin Ma, Shuhua Li, Bodi Zheng, Lei Hu, Huijing Liu, Zheng Wang, Zhaoxia Wang, Haibo Chen, Wen Su
Summary: This study investigated retinal structure changes in patients with Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and controls. The results showed that spectral domain optical coherence tomography (SD-OCT) can be used for differential diagnosis and progression evaluation of parkinsonian syndrome. PD and atypical parkinsonism were found to correlate with specific patterns of retina alterations, and OCT parameters were negatively correlated with disease duration in all three conditions.
Article
Clinical Neurology
Young Hee Sung, Suk Yun Kang
Summary: The present study investigated the characteristics of pain in Parkinson's disease (PD) and other parkinsonian disorders. The results suggest that pain can be a pre-motor symptom in PD, multiple system atrophy (MSA), and vascular parkinsonism (VP), but not in progressive supranuclear palsy (PSP). The study also found that the location of pain differed among the different disorders.
NEUROLOGICAL SCIENCES
(2022)
Article
Chemistry, Analytical
Marco Ghislieri, Valentina Agostini, Laura Rizzi, Marco Knaflitz, Michele Lanotte
Summary: Finding objective biomarkers to evaluate gait in Parkinson's Disease (PD) is crucial. One study utilized foot-switch signals analyzed through Statistical Gait Analysis (SGA) to identify atypical gait cycles in PD patients, characterized by a forefoot strike instead of a normal heel strike. The increase in atypical cycles was significantly correlated with the motor clinical score UPDRS-III, highlighting the importance of these cycles as a valid biomarker for subtle gait dysfunctions in PD patients.
Article
Clinical Neurology
Helio A. G. Teive, Paulina Cunha, Matheus Gomes Ferreira, Carlos Henrique F. Camargo, Joao Carlos P. Limongi, Egberto Reis Barbosa, Olivier Walusinski, Yves Agid
Summary: The paragraph discusses the description of "bégaiement de la mise en route du mouvement" phenomenon in patients with Parkinson's disease by Raymond Garcin, a neurology professor in Paris, France, and his Brazilian assistant, Professor Roberto Melaragno in 1948, which was one of the first descriptions of freezing of gait (FOG) in the world.
NEUROLOGICAL SCIENCES
(2021)
Article
Chemistry, Analytical
Hayslenne A. G. O. Araujo, Suhaila M. Smaili, Rosie Morris, Lisa Graham, Julia Das, Claire McDonald, Richard Walker, Samuel Stuart, Rodrigo Vitorio
Summary: Although the multifactorial nature of falls in Parkinson's disease (PD) is well described, optimal assessment for the identification of fallers remains unclear. Thus, we aimed to identify clinical and objective gait measures that best discriminate fallers from non-fallers in PD, with suggestions of optimal cutoff scores.
Article
Clinical Neurology
Dijana Nuic, Sjors van de Weijer, Saoussen Cherif, Anna Skrzatek, Eline Zeeboer, Claire Olivier, Jean-Christophe Corvol, Pierre Foulon, Jenica Z. Pastor, Gregoire Mercier, Brian Lau, Bastiaan R. Bloem, Nienke M. De Vries, Marie-Laure Welter
Summary: This study aimed to evaluate the efficacy of a home-based training system using a tailored exergame for patients with Parkinson's disease (PD) to improve gait and balance disorders. The results showed that home-based training using a tailored exergame can be performed safely by PD patients and could potentially improve gait and balance disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Lakshmi Pillai, Kunal Shah, Aliyah Glover, Tuhin Virmani
Summary: This study found that turning is a common trigger for freezing episodes in patients with Parkinson's disease (PD), which can lead to falls and fractures and decreased quality of life. The study also found increased foot-strike contact variability during turning and abnormal spatiotemporal gait measures in PD patients with Freezing of Gait (FOG). Developing targeted therapies to address these issues could help decrease episodes of freezing of gait.
Article
Geriatrics & Gerontology
Cinzia Tiloca, Stefano Goldwurm, Narghes Calcagno, Federico Verde, Silvia Peverelli, Daniela Calini, Anna Lena Zecchinelli, Davide Sangalli, Antonia Ratti, Gianni Pezzoli, Vincenzo Silani, Nicola Ticozzi
Summary: This study provides further insight into the clinical phenotypic heterogeneity associated with TARDBP mutations, extending beyond ALS and FTD diseases to include PD and atypical parkinsonism. However, the mutational frequency is low and varies considerably in different Caucasian populations.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Geriatrics & Gerontology
Nadeeka N. Dissanayaka, Elana J. Forbes, Kate Perepezko, Albert F. G. Leentjens, Roseanne D. Dobkin, Kathy Dujardin, Gregory M. Pontone
Summary: Anxiety in Parkinson's disease has atypical presentations that are common, clinically relevant, and diverse in nature. Better understanding of these presentations is needed to improve recognition, advance therapeutic development, and optimize quality of life in PD.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Clinical Neurology
Hanieh Agharazi, Elizabeth C. Hardin, Katherine Flannery, Sinem Balta Beylergil, Angela Noecker, Camilla Kilbane, Stewart A. Factor, Cameron McIntyre, Aasef G. Shaikh
Summary: We investigated the impact of conflicting visual and non-visual information on gait abnormalities and explored how subthalamic deep brain stimulation (STN DBS) affects gait dysfunction in Parkinson's disease (PD). By using a motion capture system in immersive virtual reality, we measured the lower limb kinematics during treadmill walking. Our findings showed that the mismatch between optic-flow velocity and treadmill walking speed did not consistently alter gait parameters in PD. However, STN DBS improved PD gait pattern by modifying stride length and step height.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Sport Sciences
Antonio Henrique Leal-Nascimento, Edson Soares da Silva, Ana Paula Janner Zanardi, Andre Ivaniski-Mello, Elren Passos-Monteiro, Flavia Gomes Martinez, Alberito Rodrigo de Carvalho, Rafael Reimann Baptista, Leonardo Alexandre Peyre-Tartaruga
Summary: In healthy adults, Nordic walking increases external mechanical energy fluctuations, while in people with Parkinson's disease, it leads to better pendulum-like energy recovery. Despite similar external mechanical work, those with Parkinson's disease show greater energy fluctuations and altered stride characteristics when using Nordic walking poles.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Liling Delila, Ouada Nebie, Nhi Thao Ngoc Le, Lassina Barro, Ming-Li Chou, Yu-Wen Wu, Naoto Watanabe, Masayasu Takahara, Luc Buee, David Blum, David Devos, Thierry Burnouf
Summary: This study evaluated the virus removal properties of a nanofiltration process on human platelet lysates (HPL) and found that it effectively reduced viral and procoagulant risks while preserving the neuroprotective and anti-inflammatory properties of HPL.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Felix Marchand, Caroline Moreau, Gregory Kuchcinski, Vincent Huin, Luc Defebvre, David Devos
Summary: This study assessed the efficacy of conservative iron chelation with deferiprone in patients with neuroferritinopathy. The results showed that deferiprone treatment led to improvement in patients' conditions, and early initiation of treatment was associated with better outcomes. This study suggests that conservative iron chelation should be further examined as a potential treatment for neuroferritinopathy.
MOVEMENT DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Hind Bouchaoui, Laura Mahoney-Sanchez, Guillaume Garcon, Olivier Berdeaux, Laurent Y. Alleman, David Devos, James A. Duce, Jean-Christophe Devedjian
Summary: Ferroptosis, an iron-dependent regulated cell death triggered by high lipid peroxide levels, has been implicated in neurodegenerative diseases like Parkinson's disease (PD). The exact pathways and conditions leading to the death of dopaminergic neurons in PD remain unknown. This study shows that altering the PUFA composition in dopaminergic neuron membranes can determine susceptibility to ferroptosis, and cotreatment with iron promotes lipid peroxidation and cell death. Inhibition of specific enzymes involved in the lipid peroxidation pathway could be potential targets for neuroprotective strategies in PD.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Clinical Neurology
Carin Janz, Jonathan Timpka, Matthias Loehle, Alexander Bremer, Florin Gandor, Georg Ebersbach, Alexander Storch, Per Odin
Summary: The study aimed to investigate the effect of structured training on motor fluctuations in improving agreement between observer and patient assessments and daily motor state times. The results showed that structured training did not significantly improve the agreement between observers and HD ratings or the reliability of daily motor state times.
ACTA NEUROLOGICA SCANDINAVICA
(2023)
Article
Clinical Neurology
E. Mutez, M. Swiderski, D. Devos, C. Moreau, G. Baille, A. Degardin, G. Ryckewaert, N. Carriere, A. Kreisler, C. Simonin, N. Rouaix, M. Tir, P. Krystkowiak, N. Ramdane, M. Genin, B. Sablonniere, L. Defebvre, V. Huin
Summary: The aim of this study was to establish the effectiveness of MLPA as a primary screening test and propose clinical criteria for genetic diagnostic tests for suspected Mendelian Parkinson's disease. The study found that North African ancestry, female sex, and younger age at onset were significantly associated with a positive test result. Therefore, based on the retrospective analysis, further diagnostic criteria were proposed. This study highlights the importance of MLPA testing for Parkinson's cases with a family history.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Stefan Mainka, Maximilian Lauermann, Georg Ebersbach
Summary: Asymmetry of arm swing is a characteristic of normal physiological gait, but patients with Parkinson's disease (PWPD) may experience a one-sided reduction in arm swing as an early symptom. This study compared arm swing differences between healthy subjects (HS) and mildly-to-moderately impaired PWPD at various walking speeds. The results showed that PWPD had reduced arm swing compared to HS during normal, fast, and very fast walking. The coordination of arm swing was also reduced in PWPD during very slow and normal walking. These findings suggest that reduced one-sided arm swing can be an early sign of parkinsonian gait disturbance.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Correction
Clinical Neurology
Stefan Mainka, Maximilian Lauermann, Georg Ebersbach
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
M. Khamaysa, M. Lefort, M. Pelegrini-Issac, A. Lackmy-Vallee, A. Preuilh, D. Devos, A. -S. Rolland, C. Desnuelle, M. Chupin, V. Marchand-Pauvert, G. Querin, Pierre-Francois Pradat
Summary: This study aimed to evaluate the predictive value of cervical spinal cord MRI parameters for motor capacity in ALS compared to clinical prognostic factors. Structural MRI measurements were significantly correlated with the ALSFRS-R score and its sub-scores. Multiple linear regression models combining spinal multimodal MRI and clinical factors could predict motor capacity in ALS.
JOURNAL OF NEUROLOGY
(2023)
Article
Cell Biology
Alice Capuz, Sylvain Osien, Melodie Anne Karnoub, Soulaimane Aboulouard, Estelle Laurent, Etienne Coyaud, Antonella Raffo-Romero, Marie Duhamel, Amelie Bonnefond, Mehdi Derhourhi, Marco Trerotola, Ikram El Yazidi-Belkoura, David Devos, Monika Zilkova, Firas Kobeissy, Fabien Vanden Abeele, Isabelle Fournier, Dasa Cizkova, Franck Rodet, Michel Salzet
Summary: Using various omics analyses, we discovered that newborn rat astrocytes produce neural immunoglobulin chains with similarities to aberrant immunoglobulins found in cancers. The complete enzymatic V(D)J recombination complex was also found in astrocytes. In addition, we identified different immunoglobulin chains in adult rat astrocytes and primary astrocytes from human fetus. These neural IgGs play a role in astrocyte fate and interact with specific targets.
CELL DEATH & DISEASE
(2023)
Article
Clinical Neurology
Teodor Angelov, Teodora Chamova, Slavena Atemin, Tihomir Todorov, Slavko Ormandzhiev, Ivan Tourtourikov, Albena Todorova, David Devos, Ivailo Tournev
Summary: This study reports a novel variant in the PFN1 gene related to amyotrophic lateral sclerosis (ALS), discovered through whole exome sequencing and targeted analysis of ALS-related genes. The study describes a pedigree involving 3 generations and 4 affected individuals, of which 3 carry the newly identified heterozygous variant: c.92T > G (p.Val31Gly). Segregation analysis in the family reveals the variant was inherited from the affected mother and also present in the affected aunt.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Clara Virbel-Fleischman, Flavien Mousin, Shuo Liu, Sebastien Hardy, Jean-Christophe Corvol, Isabelle Benatru, David Bendetowicz, Matthieu Bereau, Valerie Cochen De Cock, Sophie Drapier, Solene Frismand, Caroline Giordana, David Devos, Yann Retory, David Grabli
Summary: Body-worn sensors can provide valuable information for the management of Parkinson's disease and support treatment decisions based on objective monitoring. This study found a correlation between monitoring results and treatment adaptations, suggesting the potential for automated treatment modifications based on sensor recordings.
NPJ PARKINSONS DISEASE
(2023)
Article
Cell Biology
Alice Capuz, Sylvain Osien, Tristan Cardon, Melodie Anne Karnoub, Soulaimane Aboulouard, Antonella Raffo-Romero, Marie Duhamel, Dasa Cizkova, Marco Trerotola, David Devos, Firas Kobeissy, Fabien van den Abelle, Amelie Bonnefond, Isabelle Fournier, Franck Rodet, Michel Salzet
Summary: The dogma of one gene, one protein is outdated as cells use alternative splicing, alternative translation initiation sites, and alternative termination sites to generate multiple protein isoforms. Recent studies have shown that some non-coding RNAs can actually be translated into proteins. This article presents a longitudinal proteomic study on rat spinal cord injury (SCI) and identifies a plethora of newly predicted protein hits. Among these proteins, one with high homology to immunoglobulin Kappa variable light chains, named Heimdall, is expressed in astrocytes and may play a role in regulating their fate.
CELL DEATH & DISEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gregory Kuchcinski, Lucas Patin, Renaud Lopes, Melanie Leroy, Xavier Delbeuck, Adeline Rollin-Sillaire, Thibaud Lebouvier, Yi Wang, Pascal Spincemaille, Thomas Tourdias, Lotfi Hacein-Bey, David Devos, Florence Pasquier, Xavier Leclerc, Jean-Pierre Pruvo, Sebastien Verclytte
Summary: This study aimed to investigate the brain iron distribution patterns in subtypes of early-onset Alzheimer's disease (EOAD) using quantitative susceptibility mapping (QSM). The results showed that EOAD patients had higher QSM values in deep gray nuclei and limbic structures compared to controls. Among EOAD subtypes, HpSp(MRI) had the highest QSM values in deep gray nuclei, while LPMRI had the highest QSM values in limbic structures. Iron overload in deep gray nuclei could help identify patients with atypical presentation of Alzheimer's disease.
EUROPEAN RADIOLOGY
(2023)
Article
Health Policy & Services
Sabine Bayen, Marc Bayen, Caroline Moreau, Luc Defebvre, David Devos, Nassir Messaadi
Summary: The study revealed discrepancies between patients' needs for person-centered care coordination and the actual services provided by healthcare professionals, who were more competitive rather than collaborative. Patients tended to expect their Family Physician to coordinate the different healthcare professionals instead of assigning a central role to any of them.
INTERNATIONAL JOURNAL OF HEALTHCARE MANAGEMENT
(2022)
