Article
Neurosciences
E. R. Sabidussi, S. Klein, B. Jeurissen, D. H. J. Poot
Summary: Diffusion weighted MRI is essential for patient screening and diagnosis. However, current deep learning methods for quantifying diffusion parameters lack generalization, requiring retraining for each new scan. In this study, we propose dtiRIM, a deep learning method for Diffusion Tensor Imaging with superior generalization due to its ability to solve inverse problems and promote data consistency using the diffusion tensor model. Results show that dtiRIM produces high-quality tensor estimates, comparable or better than existing methods, with low dependency on tissue properties and scanning parameters. Furthermore, a single dtiRIM model can be used for diverse datasets without significant loss in quality, making it a groundbreaking solution for DTI analysis.
Review
Clinical Neurology
Nandakumar Nagaraja
Summary: DWI is a widely used imaging technique for evaluating patients with stroke, but it has potential pitfalls to be recognized, such as false negative results and ischemic stroke mimics that may occur during interpretation. Advanced diffusion imaging techniques like Diffusion Kurtosis Imaging and Diffusion Tensor Imaging are being studied to evaluate ischemic core.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Daryoush Shahbazi-Gahrouei, Fahimeh Aminolroayaei, Hamide Nematollahi, Mohammad Ghaderian, Sogand Shahbazi Gahrouei
Summary: This article reviews the characteristics of new MRI methods and discusses recent findings on breast cancer diagnosis. The findings suggest that diffusion-weighted imaging and diffusion tensor imaging can improve the specificity and accuracy of breast cancer diagnosis, leading to better treatment outcomes.
Article
Neurosciences
Dongrong Xu, Guojun Xu, Zhiyong Zhao, M. Elizabeth Sublette, Jeffrey M. Miller, J. John Mann
Summary: Research on major depressive disorder patients showed differences in network indices based on disease duration and subgroups, with certain brain regions displaying varying clustering coefficients in short and long-term disease subgroups. Network resilience analysis indicated that the MDDS group had more randomized networks compared to healthy controls.
HUMAN BRAIN MAPPING
(2021)
Article
Peripheral Vascular Disease
John P. Laporte, Mary E. Faulkner, Zhaoyuan Gong, Mohammad A. B. S. Akhonda, Luigi Ferrucci, Josephine M. Egan, Mustapha Bouhrara
Summary: This study found a direct association between hypertension and cerebral myelin content, showing that individuals with hypertension have lower myelin content and more impaired brain microstructure. These findings are important for further investigating the relationship between hypertension and brain myelin.
Article
Clinical Neurology
Justin K. Zhang, Dinal Jayasekera, Chunyu Song, Jacob K. Greenberg, Saad Javeed, Christopher F. Dibble, Jacob Blum, Peng Sun, Sheng-Kwei Song, Wilson Z. Ray
Summary: This study evaluated the utility of diffusion basis spectrum imaging (DBSI) in cervical spondylotic myelopathy (CSM) and found that DBSI can serve as a biomarker of CSM disease severity. The results showed that DBSI provides detailed data on white matter tract integrity and offers novel insights into the pathology of CSM.
Article
Mathematics, Applied
Charlan Dellon da Silva Alves, Paulo Roberto Oliveira, Ronaldo Malheiros Gregorio
Summary: This paper presents an edge-preserving and tensor filtering method for diffusion tensor images, using L-alpha Riemannian centers of mass attached to edge information to prevent smoothing of image edges during the filtering process. The method covers both the standard case of the Riemannian weighted mean filter and the Riemannian weighted median filter in a single filter for alpha in the range [1, 2]. The theoretical result on the continuity of the L-alpha Riemannian centers of mass is claimed to establish the well-posedness of the proposed adaptive Riemannian filter.
APPLIED MATHEMATICS AND COMPUTATION
(2021)
Article
Clinical Neurology
Letizia Squarcina, Susanna Lucini Paioni, Marcella Bellani, Maria Gloria Rossetti, Josselin Houenou, Mircea Polosan, Mary L. Phillips, Michele Wessa, Paolo Brambilla
Summary: In this study, the state of white matter structures in bipolar disorder patients was investigated using TBSS and FD analyses. The results showed diffusion abnormalities primarily located in the temporo-parietal network, while no significant differences were found in the morphological complexity of white matter structures. Individual patients showed localized significant deviations in fractal dimension values.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Biochemistry & Molecular Biology
Samuel David, Priya Jhelum, Fari Ryan, Suh Young Jeong, Antje Kroner
Summary: This review examines the mechanisms that control cellular iron homeostasis, the dysregulation of these mechanisms in neurological disorders, and recent research on how iron-induced tissue damage occurs via ferroptosis.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
John O. Onukwufor, Robert T. Dirksen, Andrew P. Wojtovich
Summary: Alzheimer's disease is a neurodegenerative disease characterized by neuronal dysfunction and memory and cognitive decline. Iron dysregulation and iron-dependent cell death are associated with AD. Targeting ferroptosis, a specific form of cell death, may be a potential therapeutic intervention for AD.
Review
Neurosciences
Sharmila Sagnier, Igor Sibon
Summary: The developments in human brain stroke imaging over the last two decades have brought about new MRI biomarkers that play a crucial role in the acute management and prediction of poststroke outcome. Along with stroke location, the analysis of brain parenchyma has highlighted the importance of prestroke cerebral status. Additionally, the analysis of normal-appearing brain parenchyma provides new biomarkers and targets for therapeutic follow-up.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simin Liu, Changhua Wan, Haosen Li, Weiwei Chen, Chu Pan
Summary: This study explored the feasibility of using diffusion tensor imaging (DTI) to evaluate the functional changes in the lateral pterygoid muscle (LPM) in patients with temporomandibular joint disorders (TMDs). The results showed that diffusion parameters in the LPM varied among different groups of TMD patients, indicating the potential of using these parameters as indicators for assessing the severity of LPM hyperfunction at different stages of TMD.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daneshwari Kalage, Pankaj Gupta, Ajay Gulati, Thakur Deen Yadav, Vikas Gupta, Lileswar Kaman, Ritambhra Nada, Harjeet Singh, Santosh Irrinki, Parikshaa Gupta, Chandan Das, Usha Dutta, Manavjit Sandhu
Summary: Objective: To investigate the diagnostic performance of a multiparametric MRI protocol in the characterization of gallbladder wall thickening. Methods: Consecutive adults with gallbladder wall thickening were evaluated using multiparametric MRI, and the association of MRI parameters with malignant gallbladder wall thickening was analyzed. Results: The quantitative MRI parameters were significantly associated with malignant gallbladder wall thickening, and the multiparametric MRI showed higher sensitivity than conventional MRI for diagnosing malignant gallbladder wall thickening. Conclusion: Multiparametric MRI improved the diagnostic performance for differentiating benign and malignant gallbladder wall thickening.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Pratheek S. Bobba, Clara F. Weber, Adrian Mak, Ali Mozayan, Ajay Malhotra, Kevin N. Sheth, Sarah N. Taylor, Arastoo Vossough, Patricia Ellen Grant, Dustin Scheinost, Robert Todd Constable, Laura R. Ment, Seyedmehdi Payabvash
Summary: In this study, the researchers characterized the age-related changes in diffusion metrics in neonatal brains. They found a rapid decrease in diffusivity metrics in cerebral/cerebellar white matter and vermis within the first few weeks of neonatal age, likely due to myelination. Prematurity and low gestational age at birth may also result in lasting delay in myelination of the corpus callosum and cellularity of the cerebral cortex.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felipe S. Furtado, Nathaniel D. Mercaldo, Thomas Vahle, Thomas Benkert, William R. Bradley, Lisa Ratanaprasatporn, Ravi Teja Seethamraju, Mukesh G. Harisinghani, Susanna Lee, Krista Suarez-Weiss, Lale Umutlu, Ciprian Catana, Kelsey L. Pomykala, Liran Domachevsky, Hanna Bernstine, David Groshar, Bruse R. Rosen, Onofrio Antonio Catalano
Summary: This study compared standard (STD-DWI) single-shot echo-planar imaging DWI and simultaneous multislice (SMS) DWI during whole-body positron emission tomography (PET)/MRI in terms of acquisition time, image quality, and lesion detection. The results showed that SMS-DWI shortened the acquisition time and maintained or improved the diagnostic yield in most anatomical regions. Therefore, SMS-DWI has important clinical application prospects in cancer staging and restaging.
EUROPEAN RADIOLOGY
(2023)