Article
Oncology
Kimberly C. Paul, Steve Horvath, Irish Del Rosario, Jeff M. Bronstein, Beate Ritz
Summary: This study found that PD patients had increased levels of DNAm biomarker for tibia-lead, suggesting that chronic and long-term lead exposure tracked via DNAm may contribute to the pathogenesis of PD.
CLINICAL EPIGENETICS
(2021)
Review
Geriatrics & Gerontology
Juan Huang, Xingxing Yuan, Lin Chen, Binbin Hu, Lijuan Jiang, Ting Shi, Hui Wang, Wei Huang
Summary: Cognitive impairment in Parkinson's disease worsens prognosis and causes burdens for caregivers and economic consequences. Subjective cognitive decline (SCD) has been regarded as an at-risk state for mild cognitive impairment (MCI) and a prodromal stage for dementia in Alzheimer's disease (AD). However, there is a lack of consensus on the definition and evaluation of SCD in Parkinson's disease (PD). This review found an association between PD-SCD and objective cognitive function, suggesting the importance of establishing a guideline for defining and evaluating SCD in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Yifei Gan, Hutao Xie, Guofan Qin, Delong Wu, Ming Shan, Tianqi Hu, Zixiao Yin, Qi An, Ruoyu Ma, Shu Wang, Quan Zhang, Guanyu Zhu, Jianguo Zhang
Summary: This study found that Parkinson's disease (PD) patients with freezing of gait (FOG) showed poorer cognitive performance, particularly in global cognition, frontal lobe function, executive function, attention, and working memory. There was cognitive heterogeneity within the FOG patients, and executive function was significantly correlated with FOG severity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ruihan Zhu, Yunjing Li, Lina Chen, Yingqing Wang, Guoen Cai, Xiaochun Chen, Qinyong Ye, Ying Chen
Summary: The total burden of cerebral small vessel disease (CSVD) is closely related to cognitive impairment in Parkinson's disease (PD). CSVD burden and enlarged perivascular spaces are independent risk factors for cognitive impairment in PD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Geriatrics & Gerontology
Rwei-Ling Yu, Ruey-Meei Wu
Summary: Mild cognitive impairment (MCI) is a common non-motor symptom in patients with Parkinson's disease (PD), but lacks consistent diagnostic criteria. Different types of cognitive impairments have different progression rates. This review provides an overview of the diagnostic criteria for PD-MCI and the heterogeneity of patients' cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Environmental Sciences
Bei-Jing Cheng, Jie Sheng, Hong-Li Wang, Yuan Wang, Hong-Juan Cao, Xiu-De Li, Ting-Ting Zhou, Xiang-Long Meng, Huan-Huan Nie, Su-Fang Wang, Dong-Mei Zhang, Gui-Mei Chen, Fang-Biao Tao, Lin-Sheng Yang
Summary: This study aimed to explore the associations between lead (Pb), arsenic (As), and cadmium (Cd) exposure and cognitive function, as well as the moderating effects of selenium (Se), zinc (Zn), and copper (Cu). The results showed that Cd and Pb were negatively associated with cognitive function, while Se exhibited a positive association. Furthermore, Se attenuated the negative effects of Pb or the As, Cd, and Pb mixture on cognitive function. Further prospective studies are needed to confirm these findings.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, General & Internal
I. Daria Bogdan, D. L. Marinus Oterdoom, Teus van Laar, Rients B. Huitema, Vincent J. Odekerken, Judith A. Boel, Rob M. A. de Bie, J. Marc C. van Dijk
Summary: This study investigated the impact of unintentional high-frequency NBM-DBS on cognitive function in Parkinson's disease patients. The results showed that unintentional high-frequency NBM-DBS did not lead to significant cognitive decline. Further research is needed to determine the therapeutic role of NBM-DBS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Yi Qu, Qi-Xiong Qin, Dan-Lei Wang, Jiang-Ting Li, Jing-Wei Zhao, Ke An, Jing-Yi Li, Zhi-Juan Mao, Zhe Min, Yong-Jie Xiong, Zheng Xue
Summary: The study found an association between kidney function and cognitive impairment in Parkinson's disease patients. Decreased kidney function predicted a higher risk of cognitive decline and larger progression of cognitive decline. These findings suggest that kidney function may serve as an indicator to monitor cognitive impairment in Parkinson's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Andrea M. Loftus, Natalie Gasson, Nicole Lopez, Michelle Sellner, Carly Reid, Naomi Cocks, Blake J. Lawrence
Summary: This study found that different proxies of cognitive reserve have varying effects on executive function and memory in patients with Parkinson's disease, with years of education potentially beneficial for verbal fluency and immediate recall.
Article
Psychiatry
Hai-Yang Wang, Lu Ren, Tao Li, Lanlan Pu, Xiaofeng Huang, Song Wang, Chunli Song, Zhanhua Liang
Summary: This study explored the impact of anxiety on cognitive function and brain activity in informal Parkinson's disease (PD) caregivers. The results showed that, compared to non-caregivers, informal PD caregivers had no significant differences in most cognitive domains but performed better in attentional function and had higher levels of anxiety. The brain activity results revealed that anxiety negatively affected activation in the prefrontal regions during a verbal fluency task and connectivity within and between neural networks during the resting state. These findings suggest that despite normal or better cognitive function, informal PD caregivers have impaired brain function, and this impairment is related to anxiety.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Mingjian Li, Xiaoxue Shi, Jianjun Ma, Wenhua Sun, Zhidong Wang, Dongsheng Li, Jinhua Zheng, Zhenxiang Zhao, Qi Gu, Siyuan Chen
Summary: This study found that the plasma ARSA levels were associated with cognitive function in PD patients. Lower ARSA levels and higher alpha-syn levels were related to cognitive impairment in PD patients.
NEUROLOGICAL SCIENCES
(2022)
Article
Biology
Paolo Solla, Carla Masala, Tommaso Ercoli, Claudia Frau, Caterina Bagella, Ilenia Pinna, Francesco Loy, Giovanni Defazio
Summary: Olfactory and cognitive disorders are important non-motor symptoms in Parkinson's disease. The association between specific cognitive domains and olfactory impairment in Parkinson's disease patients has not been clearly established. This study aimed to evaluate the relationship between olfactory dysfunction and specific cognitive domains in patients compared to controls. The data suggested a significant association between olfactory dysfunction and deficit in executive functions.
Review
Geriatrics & Gerontology
Xiang Liu, Huiyu Liu, Zicai Liu, Jinzhu Rao, Jing Wang, Pu Wang, Xiaoqian Gong, Youliang Wen
Summary: This systematic review included 21 tDCS studies with a total of 736 participants and found that tDCS seemed to improve the cognitive performance of patients with PD, but there was insufficient evidence of improvement in motor function. Future research should focus on determining the tDCS parameters that are most beneficial for functional recovery in PD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychiatry
Galit Weinstein, Miri Lutski, Lital Keinan-Boker, Uri Goldbourt, David Tanne
Summary: Exposure to Holocaust conditions may be associated with poorer cognitive function and greater cognitive decline in elderly male adults with coronary heart disease.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Ganqiang Liu, Chunming Ni, Jiamin Zhan, Weimin Li, Junfeng Luo, Zhixiang Liao, Joseph J. Locascio, Wenbiao Xian, Ling Chen, Zhong Pei, Jean-Christophe Corvol, Jodi Maple-Grodem, Meghan C. Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Albert Y. Hung, Michael A. Schwarzschild, Michael T. Hayes, Anne-Marie Wills, Bernard Ravina, Ira Shoulson, Pille Taba, Sulev Koks, Thomas G. Beach, Florence Cormier-Dequaire, Guido Alves, Ole-Bjorn Tysnes, Joel S. Perlmutter, Peter Heutink, Jacobus J. van Hilten, Roger A. Barker, Caroline H. Williams-Gray, Clemens R. Scherzer
Summary: The study shows that specific mitochondrial haplogroups are associated with the progression of cognitive decline in patients with Parkinson's disease, but not with the progression of motor impairment. This finding suggests that mitochondrial haplotypes may be a useful tool for stratifying patients based on their risk of cognitive decline.
Article
Biochemistry & Molecular Biology
Jonathan A. Heiss, Kasey J. Brennan, Andrea A. Baccarelli, Martha M. Tellez-Rojo, Guadalupe Estrada-Gutierrez, Robert O. Wright, Allan C. Just
Letter
Dermatology
A. Mehdizadeh, A. Alavi, V. Piguet, G. Sibbald, L. Vernich, M. Marchand, L. Rosella, H. Hu, A. Laporte, M. Bashash
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Article
Endocrinology & Metabolism
Yun Liu, Adrienne S. Ettinger, Martha Tellez-Rojo, Brisa N. Sanchez, Zhenzhen Zhang, Alejandra Cantoral, Howard Hu, Karen E. Peterson
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Environmental Sciences
Elena Colicino, Allan Just, Marianthi-Anna Kioumourtzoglou, Pantel Vokonas, Andres Cardenas, David Sparrow, Marc Weisskopf, Linda H. Nie, Howard Hu, Joel D. Schwartz, Robert O. Wright, Andrea A. Baccarelli
Summary: Research has developed minimally invasive biomarkers reflecting individual cumulative lead exposure using blood DNA methylation profiles, which have been validated and shown promising results in the study participants.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Environmental Sciences
Yun Liu, Martha Tellez-Rojo, Brisa N. Sanchez, Adrienne S. Ettinger, Citlalli Osorio-Yanez, Maritsa Solano, Howard Hu, Karen E. Peterson
ENVIRONMENT INTERNATIONAL
(2020)
Article
Nutrition & Dietetics
Diana C. Soria-Contreras, Belem Trejo-Valdivia, Alejandra Cantoral, Maria Luisa Pizano-Zarate, Andrea A. Baccarelli, Allan C. Just, Elena Colicino, Andrea L. Deierlein, Robert O. Wright, Emily Oken, Martha Maria Tellez-Rojo, Ruy Lopez-Ridaura
Article
Environmental Sciences
Yuri Levin-Schwartz, Chris Gennings, Birgit Claus Henn, Brent A. Coull, Donatella Placidi, Roberto Lucchini, Donald R. Smith, Robert O. Wright
ENVIRONMENTAL RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Juan F. Yepes, Jayme McCormick-Norris, LaQuia A. Vinson, George J. Eckert, Howard Hu, Yue Wu, Erica C. Jansen, Karen E. Peterson, Martha M. Tellez-Rojo, Esperanza Angeles Martinez Mier
JOURNAL OF PUBLIC HEALTH DENTISTRY
(2020)
Editorial Material
Public, Environmental & Occupational Health
Kate Causey, Katrin Burkart, Gwen Collman, Howard Hu, Michael Brauer, Stephanie J. London
Article
Environmental Sciences
Sung Kyun Park, Coralynn Sack, Matti J. Siren, Howard Hu
ENVIRONMENTAL HEALTH PERSPECTIVES
(2020)
Article
Dentistry, Oral Surgery & Medicine
Alejandra Cantoral, Teresa Munoz-Rocha, Lynda Luna-Villa, Andres Mantilla-Rodriguez, Jose L. Urena-Cirett, Gina A. Castiblanco, Maritsa Solano, Howard Hu, Karen E. Peterson, Martha M. Tellez-Rojo, E. Angeles Martinez-Mier
Summary: The study indicated that higher fluoride intake through foods and beverages is associated with lower dental caries experience among adolescents, even at levels below the average intake recommendation. In contrast, higher total carbohydrate intake and the frequency of intake of sugary foods were associated with a higher dental caries experience, with no apparent threshold for the effects.
Article
Biochemistry & Molecular Biology
Gina A. Castiblanco-Rubio, Teresa Munoz-Rocha, Martha M. Tellez-Rojo, Adrienne S. Ettinger, Adriana Mercado-Garcia, Karen E. Peterson, Howard Hu, Alejandra Cantoral, E. Angeles Martinez-Mier
Summary: This study found that there was no significant difference in urinary fluoride (UF) levels between pregnancy and one year postpartum, but UF levels increased every 10 gestational weeks during pregnancy. Different dietary influences on UF levels were identified in each state, with calcium supplements decreasing UF only during pregnancy and table salt use increasing UF only at one-year postpartum.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Letter
Respiratory System
Howard Hu
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2020)
Article
Respiratory System
Howard Hu
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2020)
Article
Urology & Nephrology
John Danziger, Laura E. Dodge, Howard Hu, Kenneth J. Mukamal
Summary: The study found that CKD is associated with higher blood lead levels, especially among Black individuals, while simultaneously leading to lower urinary lead levels. This suggests that CKD may heighten susceptibility to heavy metal exposure by reducing elimination.