Article
Green & Sustainable Science & Technology
Daniel Horn, Matthias Gross, Maria Pfeiffer, Marco Sonnberger
Summary: This article discusses the impact of the sociotechnical context on the depletability of near-surface geothermal energy and emphasizes the importance of minimizing side effects such as cold plumes. Using Germany as an example, the article explores how cold plumes and interferences from neighboring ground source heat pumps challenge existing regulatory frameworks, necessitating negotiations between different knowledge sets. This highlights the uncertainty of geothermal energy operations and the pressing need for continuous negotiations on sustainable extraction modes.
Review
Biochemistry & Molecular Biology
Thomas J. Foutz, Michael Wong
Summary: This review discusses the clinical use and mechanisms of action of Responsive Neural Stimulation and Deep Brain Stimulation in the treatment of epilepsy, as well as recent advances and challenges. It also presents a rational approach to device selection based on current mechanistic understanding, clinical evidence, and device features.
BIOMEDICAL JOURNAL
(2022)
Article
Neurosciences
Pietro Zeppa, Marco Fraccalvieri, Chiara Fronda, Enrico Lo Bue, Laura Rizzi, Virginia Caliendo, Michele Maria Lanotte
Summary: Skin erosion is a common complication of deep brain stimulation (DBS), which can be managed conservatively or with invasive surgical techniques. In some cases, a flap can be used to cover the implant, but removal of the implant may still be necessary, leading to worsening of symptoms. The treatment of skin erosion requires careful consideration.
Article
Biodiversity Conservation
James Desaegher, Annie Ouin, David Sheeren
Summary: This study aimed to determine the upper limit of the scale of effect for wild bee species. The results showed a significant positive relationship between bee foraging distance and their scale of effect. An index lambda was introduced to estimate the distance beyond which landscape composition has negligible effects on bee abundances. The lambda index can be used to determine the minimum distance between sampling sites before setting up an experiment and the maximum buffer size required in multi-scale analysis to detect the scale of effect.
Review
Neurosciences
Michael Schulder, Akash Mishra, Antonios Mammis, Andres Horn, Alexandre Boutet, Patric Blomstedt, Stephan Chabardes, Oliver Flouty, Andres M. Lozano, Joseph S. Neimat, Francisco Ponce, Philip A. A. Starr, Joachim K. K. Krauss, Marwan Hariz, Jin Woo Chang
Summary: Background: Deep brain stimulation (DBS) is widely used in the treatment of movement disorders, psychiatric disorders, epilepsy, and pain. Surgery for DBS implantation has advanced our understanding of human physiology and led to improvements in DBS technology. This article provides an overview of the role of structural MR imaging and new imaging techniques in visualizing brain targets, as well as the tools and techniques used for targeting and implanting electrodes. The article also discusses the use of functional and connectivity imaging, the pros and cons of different surgical approaches, and the technical aspects of novel electrode designs.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2023)
Article
Acoustics
Martin Snehota, Jaromir Vachutka, Ladislav Dolezal, Klara Balazova, Marketa Trneckova, Hana Kolarova
Summary: In this study, it was found that sonicated samples placed in sonication vessels in the far field are actually exposed to a near field pattern due to the interaction between ultrasound and the well of culture plates. The variability of local acoustic intensity can reach up to several hundreds of percent, and it is recommended to control this phenomenon in future studies.
Review
Neurosciences
Yucan Chen, Zhengde Wei, Huixing Gou, Haiyi Liu, Li Gao, Xiaosong He, Xiaochu Zhang
Summary: Recent advances in brain-inspired AI have shown a tipping point in the collaboration between neuroscience and AI, with AI models achieving remarkable performance without relying heavily on neuroscience. However, recent research on the neurobiological explainability of AI models suggests that these accurate models may align with the computational processes in the brain, despite being developed without explicit references to neuroscience. This perspective highlights the need for a practical framework to evaluate the brain-likeness of AI models and pave the way for further improvements.
FRONTIERS IN NEUROSCIENCE
(2022)
Editorial Material
Hematology
Charles T. Quinn
Summary: In this study, Abdullahi et al provide evidence that fixed low- and moderate-dose daily hydroxyurea regimens can be effective in preventing secondary stroke for patients with sickle cell anemia living in low-resource settings, as an alternative to chronic transfusion therapy.
Editorial Material
Hematology
Christine L. Kempton
Summary: The study evaluated prophylactic factor replacement therapy in patients with hemophilia A by targeting two distinct factor VIII trough levels, aiming to prevent bleeding episodes.
Article
Behavioral Sciences
Marta Berthold-Lindstedt, Jan Johansson, Jan Ygge, Kristian Borg
Summary: This study found a high frequency of oculomotor dysfunctions and visual symptoms in patients with acquired brain injury. Combining symptom assessment and vision examination is necessary to capture visual function issues effectively.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Tim Denison, Martha J. Morrell
Summary: Neuromodulation devices are expected to have expanded applications by 2035 due to advances in understanding neuroanatomical networks and stimulation mechanisms. These devices allow for flexible and targeted stimulation, with various treatment options. However, ethical and economic considerations need to be addressed to ensure widespread access to these technologies.
Article
Multidisciplinary Sciences
Michael Rosenblum, Arkady Pikovsky, Andrea A. Kuehn, Johannes L. Busch
Summary: The computation of instantaneous phase and amplitude using the Hilbert Transform is a powerful tool in data analysis, however, it is not suitable for causal estimation due to the requirement of knowledge of past and future signals. Real-time estimation of phase and amplitude is important in various fields, such as neuroscience. Three causal algorithms that do not rely on the Hilbert Transform but utilize synchronization and resonance were discussed and compared in this study, with their performance tested on synthetic data and accelerometer tremor measurements as well as Parkinsonian patient's brain activity.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Education & Educational Research
Rachel H. Ellaway
Summary: In this editorial, the Editor-in-Chief delves into the question of 'how much is enough?' in health professions education and research, and analyzes the potential implications of different answers to this perpetual question.
ADVANCES IN HEALTH SCIENCES EDUCATION
(2023)
Article
Clinical Neurology
Roxanne Lofredi, Ute Scheller, Aurika Mindermann, Lucia K. Feldmann, Joachim K. Krauss, Assel Saryyeva, Gerd-Helge Schneider, Andrea A. Kuehn
Summary: This study observed that movement speed gradually increased after cessation of pallidal stimulation in dystonia patients. The association between movement slowness and beta oscillations indicates symptom-specific oscillatory patterns in the motor circuit, which has implications for improving deep brain stimulation therapy.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Roxanne Lofredi, Ute Scheller, Aurika Mindermann, Lucia K. Feldmann, Joachim K. Krauss, Assel Saryyeva, Gerd-Helge Schneider, Andrea A. Kuehn
Summary: Pallidal deep brain stimulation (DBS) can alleviate symptoms in dystonia patients, but it may also cause movement slowness. This study found that after the cessation of pallidal stimulation, the movement speed of dystonia patients increased over time. The beta oscillations in the pallidum were found to be associated with the variance in movement speed.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Jorge Guridi, Manuel Alegre
MOVEMENT DISORDERS
(2017)
Article
Clinical Neurology
Ivan Cordon, Maria Jesus Nicolas, Sandra Arrieta, Manuel Alegre, Julio Artieda, Miguel Valencia
Article
Biotechnology & Applied Microbiology
Irantzu Serrano-Mendioroz, Ana Sampedro, Manuel Alegre, Rafael Enriquez de Salamanca, Pedro Berraondo, Antonio Fontanellas
HUMAN GENE THERAPY
(2018)
Article
Biochemistry & Molecular Biology
Lei Jiang, Pedro Berraondo, Daniel Jerico, Lin T. Guey, Ana Sampedro, Andrea Frassetto, Kerry E. Benenato, Kristine Burke, Eva Santamaria, Manuel Alegre, Alvaro Pejenaute, Mayur Kalariya, William Butcher, Ji-Sun Park, Xuling Zhu, Staci Sabnis, E. Sathyajith Kumarasinghe, Timothy Salerno, Matthew Kenney, Christine M. Lukacs, Matias A. Avila, Paolo G. V. Martini, Antonio Fontanellas
Letter
Ophthalmology
Guillermo M. Besne, Manuel Alegre, Adam Podhorski, Nieves Diez
ACTA OPHTHALMOLOGICA
(2020)
Article
Cell Biology
Karol M. Cordoba, Irantzu Serrano-Mendioroz, Daniel Jerico, Maria Merino, Lei Jiang, Ana Sampedro, Manuel Alegre, Fernando Corrales, Maria J. Garrido, Paolo G. Martini, Jose Luis Lanciego, Jesus Prieto, Pedro Berraondo, Antonio Fontanellas
Summary: The administration of a recombinant protein, rhApoAI-PBGD, is shown to enhance hepatic enzymatic activity and protect against acute attacks of AIP.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Environmental Sciences
William D. Moscoso-Barrera, Elena Urrestarazu, Manuel Alegre, Alejandro Horrillo-Maysonnial, Luis Fernando Urrea, Luis Mauricio Agudelo-Otalora, Luis F. Giraldo-Cadavid, Secundino Fernandez, Javier Burguete
Summary: This study focuses on the development of a simple and autonomous processing system for detecting obstructive sleep apnea. The system analyzes polysomnography signals and shows good estimation of awake/sleep states and apneas/hypopneas, making it suitable for possible OSA treatments.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Meeting Abstract
Clinical Neurology
M. Carmona-Abellan, D. Moreno, M. Alegre, J. Guridi, R. Luquin
MOVEMENT DISORDERS
(2018)
Meeting Abstract
Clinical Neurology
M. Carmona-Abellan, G. de Ulibarri, J. Guridi, P. Clavero, M. Alegre, R. Luquin-Piudo
MOVEMENT DISORDERS
(2018)
Meeting Abstract
Clinical Neurology
M. Carmona-Abellan, O. Parras, R. Valenti, J. Guridi, M. Alegre, R. Luquin-Piudo
MOVEMENT DISORDERS
(2018)
Meeting Abstract
Gastroenterology & Hepatology
Herbert L. Bonkovsky, D. Montgomery Bissell, Paolo Ventura, Robert J. Desnick, Manisha Balwani, David Rees, Ulrich Stoelzel, John Phillips, Raili Kauppinen, Janneke Langendonk, Jean Charles Deybach, Charles Park, Hetanshi Naik, Karl E. Anderson, Mike Badminton, Penelope Stein, Elisabeth Minder, Jerzy Windyga, Pavel Martasek, Maria Domenica Cappellini, Eliane Sardh, Pauline Harper, Sverre Sandberg, Aasne Karine Aarsand, Manuel Alegre, Aneta Veselinova Ivanova, Amy Chan, William Querbes, Craig Penz, Amy Simon
Review
Clinical Neurology
Maite Garriz-Luis, Rocio Sanchez-Carpintero, Manuel Alegre, Sonia Tejada
REVISTA DE NEUROLOGIA
(2018)
Article
Otorhinolaryngology
Peter Baptista, Octavio Garaycochea, Laura Alvarez-Gomez, Juan Alcalde, Manuel Alegre, Elena Urrestarazu
ACTA OTORRINOLARINGOLOGICA ESPANOLA
(2018)
Meeting Abstract
Clinical Neurology
M. M. Carmona-Abellan, M. Valencia, J. Guridi, R. Luquin, J. Artieda, M. Alegre
MOVEMENT DISORDERS
(2017)
Article
Anesthesiology
Antonio Martinez-Simon, Manuel Alegre, Cristina Honorato-Cia, Jorge M. Nunez-Cordoba, Elena Cacho-Asenjo, Inaki F. Troconiz, Mar Carmona-Abellan, Miguel Valencia, Jorge Guridi
