Journal
MOVEMENT DISORDERS
Volume 25, Issue 10, Pages 1496-1498Publisher
WILEY-LISS
DOI: 10.1002/mds.23155
Keywords
Parkinson's disease; pallidotomy; dyskinesia
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Funding
- Canadian Institutes of Health Research
- Dystonia Medical Research Foundation
- Michael J. Fox Foundation
- National Parkinson Foundation
- Ontario Problem Gambling Research Centre
- Parkinson's Disease Foundation
- Taro
- GSK
- UCB
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Unilateral pallidotomy has been effectively used to treat parkinsonism and reduce levodopa induced dyskinesia (LID). We sought to determine the long-term effects of pallidotomy on LID in 10 patients who had initial benefit from pallidotomy but went on to require DBS surgery for symptom progression. The Dyskinesia Rating Scale (DRS) was used to rate and quantify LID in a blinded fashion. Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID. (C) 2010 Movement Disorder Society
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