Article
Geriatrics & Gerontology
Hiromi Sano, Atsushi Nambu
Summary: ZNS is an anticonvulsant drug that has beneficial effects on Parkinson's disease and its side effect, L-DOPA-induced dyskinesia, but can also have adverse effects.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Zhihua Liu, Aijuan Yan, Jiahao Zhao, Shuyuan Yang, Lu Song, Zhenguo Liu
Summary: The study revealed the important role of p75NTR in patients with Parkinson's disease and suggested it as a new target for managing L-dopa-induced dyskinesia.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H. H. Greig, Jin Jung, Ho- Choi, Lars Olson, Barry J. J. Hoffer, Kuan-Yin Tseng
Summary: This study evaluated the efficacy of PT320 on L-DOPA-induced dyskinetic behaviors and neurochemistry in a progressive Parkinson's disease MitoPark mouse model. The results showed that early administration of PT320 significantly reduced the severity of L-DOPA-induced abnormal involuntary movements, particularly in excessive standing and abnormal paw movements. However, late administration of PT320 did not improve any L-DOPA-induced dyskinesia measurements. Furthermore, early treatment with PT320 increased both tonic and phasic release of dopamine in striatal slices, indicating its potential role in alleviating L-DOPA-induced dyskinesia in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kathryn Lanza, Christopher Bishop
Summary: Parkinson's Disease (PD) and long-term L-DOPA treatment induce plasticity that contributes to L-DOPA-induced dyskinesia (LID), with the dopamine D3 receptor (D3R) emerging as a promising target in LID management due to its upregulation in LID. D3R undergoes dynamic changes in both PD and LID, and recent genetic and pharmacologic tools have helped clarify its role in LID.
Article
Neurosciences
Edgar Pena, Tareq M. Mohammad, Fedaa Almohammed, Tahani AlOtaibi, Shahpar Nahrir, Sheraz Khan, Vahe Poghosyan, Matthew D. Johnson, Jawad A. Bajwa
Summary: Clinical responses to dopamine replacement therapy for individuals with Parkinson's disease (PD) are unpredictable, but changes in MDS-UPDRS motor factor scores and motor cortical magnetoencephalography (MEG) may provide clues for predicting clinical differences. Subject-specific machine learning approaches based on neuroimaging data offer tools to improve prediction of therapeutic outcomes for PD.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jose A. Pineda-Pardo, Alvaro Sanchez-Ferro, Mariana H. G. Monje, Nicola Pavese, Jose A. Obeso
Summary: The striatal dopaminergic deficit in Parkinson's disease follows a somatotopically related pattern, with an upper-limb onset and progression to other regions of the striatum. The denervation of the putamen was confirmed in both hemispheres and corresponding hemibodies. The findings suggest a precise somatotopic onset of nigrostriatal denervation in Parkinson's disease.
Article
Neurosciences
Monika Jampolska, Kryspin Andrzejewski, Pawel M. Boguszewski, Katarzyna Kaczynska
Summary: Parkinson's disease affects movement control and can also impair respiration, leading to chronic hypoxia and hypercapnia. In this study, we investigated the respiratory response in a PD model and found that baseline ventilation was reduced, but restored with L-DOPA supplementation. This highlights the potential of dopamine supplementation in improving respiratory function in PD.
Article
Neurosciences
Waijiao Cai, Kazumasa Wakamatsu, Fabio A. Zucca, Qing Wang, Kai Yang, Niyaz Mohamadzadehonarvar, Pranay Srivastava, Hitomi Tanaka, Gabriel Holly, Luigi Casella, Shosuke Ito, Luigi Zecca, Xiqun Chen
Summary: By studying samples of substantia nigra from patients with Parkinson's disease, we found increased ratios of pheomelanin to dopamine in the melanin content, as well as reduced levels of eumelanins derived from both DOPA and dopamine. Additionally, an increase in pheomelanin relative to dopamine pheomelanin was observed in Parkinson's disease. These findings provide insights into the roles of pheomelanin and eumelanin in the pathophysiology of Parkinson's disease.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Geriatrics & Gerontology
Shuyuan Yang, Ying Wan, Na Wu, Lu Song, Zhihua Liu, Jiahao Zhao, Ying Liu, Zhenguo Liu, Jing Gan
Summary: The study shows that L-dopa can restore circadian rhythm disturbances in PD rats by regulating the D1R-ERK1/2-mTOR pathway, improving irregular fluctuations in blood pressure and temperature.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Carissa A. Hansen, Douglas R. Miller, Stephanie Annarumma, Carley T. Rusch, Adolfo Ramirez-Zamora, Habibeh Khoshbouei
Summary: This manuscript provides a comprehensive review of treatment protocols, absorption, distribution, and drug/food interactions related to L-DOPA-induced dyskinesia, and discusses current strategies and future directions.
JOURNAL OF NEUROLOGY
(2022)
Article
Chemistry, Analytical
Francesco Asci, Giorgio Vivacqua, Alessandro Zampogna, Valentina D'Onofrio, Adolfo Mazzeo, Antonio Suppa
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the aggregation of alpha-synuclein and the loss of dopaminergic neurons. The diagnosis and management of PD currently rely on clinical procedures, highlighting the need for innovative biomarkers. Miniaturized electrochemical sensors have emerged as a promising tool for PD management, allowing the detection of specific biological molecules through wearable devices.
Article
Biochemistry & Molecular Biology
Bassam Felipe Mogharbel, Marco Andre Cardoso, Ana Carolina Irioda, Priscila Elias Ferreira Stricker, Robson Camilotti Slompo, Julia Maurer Appel, Nathalia Barth de Oliveira, Maiara Carolina Perussolo, Claudia Sayuri Sacaki, Nadia Nascimento da Rosa, Dilcele Silva Moreira Dziedzic, Christophe Travelet, Sami Halila, Redouane Borsali, Katherine Athayde Teixeira de Carvalho
Summary: This study describes the development of nanoparticles capable of delivering L-DOPA and curcumin across the blood-brain barrier. The nanoparticles exhibited good biocompatibility and blood compatibility, making them potential formulations for brain delivery of these drugs.
Article
Clinical Neurology
Andrea Guerra, Francesco Asci, Alessandro Zampogna, Valentina D'Onofrio, Antonio Suppa, Giovanni Fabbrini, Alfredo Berardelli
Summary: The study demonstrates that long-term treatment with safinamide benefits SICF and M1 plasticity in PD patients, potentially preventing worsening of LID severity over time.
Article
Agronomy
Shucheng Duan, Soon Jae Kwon, You Jin Lim, Chan Saem Gil, Chengwu Jin, Seok Hyun Eom
Summary: L-dopa-rich faba tissues are a potential source for pharmaceutical purposes, mainly accumulating in germinating sprouts and flowers, while having lower contents in leaves and pods.
Article
Immunology
Can Cui, Yingying Han, Hongxia Li, Hongxiang Yu, Bei Zhang, Gang Li
Summary: The study demonstrated that CUR has a protective effect on PD by modulating the gut microbiota-metabolite axis. Specific families of bacteria, such as Lactobacillaceae and Aerococcaceae, along with key metabolites like tyrosine and dopamine, play a significant role in CUR-induced neuroprotection in PD mice. These findings provide important insights into the pathogenesis and potential treatment of Parkinson's disease.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Alexandra Sammartino-Arbour, Ariane Dufour, Valerie Frenette, Marie-France Forget, Marie-Andree Bruneau, Simon Ducharme, Richard Camicioli, Quoc Dinh Nguyen, Philippe Desmarais
Summary: The onset of neuropsychiatric symptoms in older adults may indicate the early signs of neurodegenerative disorders. The relationship between somatic symptoms and related disorders (SSRD) and the subsequent development of neurodegenerative disorders is still uncertain. This study critically reviewed studies exploring the association between SSRD and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Fronto-temporal dementia, and Lewy body dementia.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Nabeela Nathoo, Myrlene Gee, Krista Nelles, Jacqueline Burt, Hongfu Sun, Peter Seres, Alan H. Wilman, Christian Beaulieu, Fang Ba, Richard Camicioli
Summary: This study found that susceptibilities in basal ganglia and extra-basal ganglia structures are related to qualitative measures of gait impairment and freezing of gait in Parkinson's disease.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Letter
Clinical Neurology
Nikolai Gil D. Reyes, Daniel G. Di Luca, Vanda McNiven, Anthony E. Lang
Summary: GNB1 encephalopathy is a rare neuro-developmental syndrome caused by pathogenic variants in the GNB1 gene. It is characterized by global developmental delay and co-occurrence of movement disorders, with dystonia being the most common. Other rare phenomenologies include myoclonus, tics, chorea, ataxia, and oculomotor abnormalities. This case report presents a unique phenotype of GNB1 encephalopathy caused by a de novo mutation in exon 11, with symptoms of dystonia, myoclonus, and vertical supranuclear gaze palsy.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neuroimaging
Hannes Almgren, Alexandru Hanganu, Milton Camacho, Mekale Kibreab, Richard Camicioli, Zahinoor Ismail, Nils D. Forkert, Oury Monchi
Summary: Brain atrophy in Parkinson's disease varies in different brain regions, even in the early stage. This study examines the relationship between cortical curvature and thickness in PD diagnosis, motor symptoms, and cognitive performance. The findings indicate an interaction effect between motor symptoms and age, as well as the impact of diagnosis and rigidity on the curvature-thickness association in patients with longer disease durations.
NEUROIMAGE-CLINICAL
(2023)
Letter
Clinical Neurology
Daniel G. Di Luca, Dilinuer Wubuli, Vanda McNiven, Anthony E. Lang
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Geriatrics & Gerontology
Breni Sharma, Meng Wang, Cheryl R. McCreary, Richard Camicioli, Eric E. Smith
Summary: This study reviewed and analyzed the literature on the associations of cerebral small vessel disease (CSVD) with gait impairment and falls. The findings suggest that the severity of CSVD is associated with gait impairment, history of falls, and future falls risk. Therefore, preventing CSVD should be included in a comprehensive public health strategy to improve mobility and reduce the risk of falls in older adults.
Article
Clinical Neurology
Meng Wang, Tolulope T. Sajobi, David B. Hogan, Aravind Ganesh, Dallas P. Seitz, Thierry Chekouo, Nils D. Forkert, Michael J. Borrie, Richard Camicioli, Ging-Yuek Robin Hsiung, Mario Masellis, Paige Moorhouse, Maria Carmela Tartaglia, Zahinoor Ismail, Eric E. Smith
Summary: This study assesses experts' beliefs on important predictors of developing dementia in persons with mild cognitive impairment (MCI). Age, CSF analysis, FDG-PET findings, hippocampal atrophy, MoCA (or MMSE) score, parkinsonism, apathy, psychosis, informant report of cognitive symptoms, and global atrophy were identified as the ten most important predictors.
ALZHEIMERS & DEMENTIA
(2023)
Article
Health Care Sciences & Services
Meng Wang, Thierry Chekouo, Zahinoor Ismail, Nils D. Forkert, David B. Hogan, Aravind Ganesh, Richard Camicioli, Dallas Seitz, Michael J. Borrie, Ging-Yuek Robin Hsiung, Mario Masellis, Paige Moorhouse, Carmela Tartaglia, Eric E. Smith, Tolulope T. Sajobi
Summary: The study aimed to develop and validate a Bayesian risk prediction model combining research cohort data and expert knowledge to predict dementia progression in people with mild cognitive impairment (MCI). The results showed that adding expert knowledge did not improve the accuracy of the model in predicting dementia progression.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Editorial Material
Clinical Neurology
Nikolai Gil D. Reyes, Anthony E. Lang
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Seyedeh Narges Tabatabaee, Sajjad Effat Nejad, Ali Nikkhah, Narges Hashemi, Afagh Alavi, Anthony E. E. Lang, Mohammad Rohani, Maziar Emamikhah
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Geriatrics & Gerontology
Linzy Bohn, Peggy McFall, Myrlene Gee, Ronald B. Postuma, Roger A. Dixon, Richard Camicioli
Summary: This study examined the predictive validity and characteristics of the eight-item Montreal Parkinson Risk of Dementia Scale (MoPaRDS) in a geriatric PD cohort. The results showed that the MoPaRDS can reliably discriminate PD patients with incipient dementia from those without dementia.
CANADIAN GERIATRICS JOURNAL
(2023)
Article
Clinical Neurology
Inaara M. Ebrahim, Maryam Ghahremani, Richard Camicioli, Eric E. Smith, Zahinoor Ismail
Summary: Affective dysregulation in older adults without dementia is associated with a higher risk of developing dementia and should be considered in clinical assessments.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Computer Science, Information Systems
Raissa Souza, Matthias Wilms, Milton Camacho, G. Bruce Pike, Richard Camicioli, Oury Monchi, Nils D. Forkert
Summary: This study investigates the ability of deep learning models to classify originating site locations directly from MRI scans. The results show that DL models can achieve an accuracy of 85% in classifying sites using T1-weighted and intensity-harmonized T1-weighted scans, while the accuracy drops to 54% when using log-Jacobian deformation maps.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Review
Clinical Neurology
Richard Camicioli, Meg E. Morris, Frederico Pieruccini-Faria, Manuel Montero-Odasso, Surim Son, David Buzaglo, Jeffrey M. Hausdorff, Alice Nieuwboer
Summary: This article investigates the gaps in falls prevention for people with Parkinson's disease (PD) and highlights the need for further research on recommended exercises, as well as considering risk factors such as freezing of gait, reduced gait speed, and prior history of falls. It suggests that multimodal and multi-domain interventions may be beneficial and emphasizes the importance of engaging patients, families, and healthcare professionals in falls education. Rating: 8/10.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Iris Lin, Laura Armengou-Garcia, Sanskriti Sasikumar, Greg Kuhlman, Susan H. Fox, Anthony E. Lang, Alberto J. Espay
Summary: Speech-induced craniofacial myoclonus with stuttering-like dysarthria and speech arrests is a disabling iatrogenic complication in Parkinson's disease that resolves upon amantadine discontinuation. Four of the patients with renal insufficiency were identified as a risk factor.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)