Review
Medicine, General & Internal
Yueqin Ding, Zhifeng Chen, Yanling Lu
Summary: Vitamin A supplementation is beneficial for the prophylaxis of bronchopulmonary dysplasia in premature infants, but no significant differences were found in the incidence of other complications such as retinopathy of prematurity, necrotizing enterocolitis, intraventricular hemorrhage, sepsis, and mortality. Further studies on administration approaches and dosages are warranted.
Article
Pediatrics
Zoe Freislich, Benjamin Stoecklin, Naomi Hemy, J. Jane Pillow, Graham L. L. Hall, Andrew C. C. Wilson, Shannon J. J. Simpson
Summary: Preterm infants continue to have attenuated ventilatory response to hypoxia at 12-15 months corrected postnatal age, especially in males. Predictive factors affect the magnitude of the blunted ventilatory response.
FRONTIERS IN PEDIATRICS
(2022)
Article
Physiology
Kai Foerster, Hanna Marchi, Sophia Stoecklen, Olaf Dietrich, Harald Ehrhardt, Mark O. Welipultz, Andreas W. Flemmer, Benjamin Schubert, A. Marcus Mall, Birgit Ertl-Wagner, Anne Hillgendroff
Summary: This study developed a novel scoring system using MRI to assess lung structural changes in neonatal chronic lung disease. It showed high reproducibility and disease specificity, and has the potential to be used as a quantifiable endpoint in clinical trials and disease monitoring.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Respiratory System
Xiaoling Wang, Yan Ma, Shenghui Wang, Wenbin Dong, Xiaoping Lei
Summary: This study investigated the association between bronchopulmonary dysplasia (BPD) and platelet parameters in very premature infants. The results showed that abnormal platelet parameters were observed in BPD infants, and a platelet count ≤ 177*10(9)/L was a potential risk factor for the development of BPD in very premature infants.
BMC PULMONARY MEDICINE
(2022)
Article
Pediatrics
Yi Zheng, Qi Wu, Shuping Han
Summary: This meta-analysis found that inhaled nitric oxide (iNO) can significantly reduce the incidence of bronchopulmonary dysplasia (BPD) in premature infants. However, it may increase the risk of necrotizing enterocolitis (NEC). There were no significant differences in the incidence of in-hospital mortality and adverse events between the overall iNO group and control.
Article
Nutrition & Dietetics
Sophie Laborie, Maxime Bonjour, Justine Bacchetta, Mathilde Mauras, Marine Butin
Summary: Low 25-hydroxyvitamin D (25(OH)D) levels in preterm infants is a risk factor for bronchopulmonary dysplasia (BPD), but increased supplementation does not have a beneficial effect. This study shows that 25(OH)D levels >= 120 nmol/L are not significantly associated with BPD or death.
Article
Pediatrics
Melania E. Ebrahimi, Michelle Romijn, Roos J. S. Vliegenthart, Douwe H. Visser, Anton H. van Kaam, Wes Onland
Summary: This study found that the need for mechanical ventilation and the duration of mechanical ventilation during late-onset sepsis are independently associated with an increased risk of preterm infants developing bronchopulmonary dysplasia.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Joseph Mariduena, Maya Ramagopal, Mark Hiatt, Shakuntala Chandra, Robert Laumbach, Thomas Hegyi
Summary: This study examined the relationship between VEGF levels in tracheal and gastric samples of premature infants and the development of BPD, finding that BPD infants had lower levels of T-VEGF on day 3, likely due to decreased expression in the lungs of less mature infants, and that lower VEGF levels were associated with lower respiratory support indices.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ying Dong, Stefano Rivetti, Arun Lingampally, Sabine Tacke, Baktybek Kojonazarov, Saverio Bellusci, Harald Ehrhardt
Summary: Intra-amniotic infection (IAI) is a major cause of preterm birth and can have both positive and negative effects on premature lung development. Animal models are essential for studying the pathogenesis of bronchopulmonary dysplasia (BPD), as the intra-amniotic cavity is inaccessible during pregnancies. Imbalanced inflammation, regulated by lung immune cells such as macrophages, may lead to abnormal lung development, while excessive suppression of inflammation can also cause lung injury. Effective strategies for preventing and treating BPD are currently scarce.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Erik A. Jensen, Robin K. Whyte, Barbara Schmidt, Dirk Bassler, Nestor E. Vain, Robin S. Roberts
Summary: This study found that early development of prolonged intermittent hypoxemia in premature infants, beginning in the first week after birth, was associated with an increased risk of severe bronchopulmonary dysplasia.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Masato Ito, Shin Kato, Makoto Saito, Naoyuki Miyahara, Hirokazu Arai, Fumihiko Namba, Erika Ota, Hidehiko Nakanishi
Summary: This scoping review aimed to screen available evidence regarding perinatal risk factors associated with the development and severity of bronchopulmonary dysplasia (BPD). The results identified several risk factors for BPD, including male sex, maternal hypertensive disorders of pregnancy, low gestational age, small-for-gestational-age birth weight, and mechanical ventilation. Rating: 8 out of 10.
Article
Pediatrics
Wen-Jue Soong, Pei-Chen Tsao, Chia-Feng Yang, Yu-Sheng Lee, Chien-Heng Lin, Chieh-Ho Chen
Summary: This study aimed to determine the efficacy of flexible endoscopy (FE) in assessing and changing the clinical management of infants with severe bronchopulmonary dysplasia (sBPD). The results showed that FE with non-invasive ventilation (FE-NIV) is a safe and valuable technique for direct and dynamic visual measurement of the aeroesophageal tract (AET) in sBPD infants, leading to changes in management.
FRONTIERS IN PEDIATRICS
(2022)
Article
Genetics & Heredity
Dan Dai, Huiyao Chen, Xinran Dong, Jinglong Chen, Mei Mei, Yulan Lu, Lin Yang, Bingbing Wu, Yun Cao, Jin Wang, Wenhao Zhou, Liling Qian
Summary: Genetic factors play a role in susceptibility to bronchopulmonary dysplasia (BPD). The predictive model developed in this study, combining BPD-RGS with basic clinical risk factors, accurately stratifies BPD risk in premature infants.
FRONTIERS IN GENETICS
(2021)
Article
Pediatrics
Marilena Savoia, Francesca Rech Morassutti, Luigi Castriotta, Daisy Pavoni, Peter M. Mourani, Paola Freschi, Luigi Cattarossi, Antonio Tonutti
Summary: This study evaluated the feasibility of using neonatologist-performed echocardiography for follow-up of preterm infants with moderate/severe bronchopulmonary dysplasia (BPD) and described the course of pulmonary hypertension (PH) in these infants. NPE follow-up was found to be safe for infants with BPD, aiding in early detection of mild PH.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Seong Hee Oh, Hyun-Jeong Do, Ji Sook Park, Jae Young Cho, Chan-Hoo Park
Summary: Red cell distribution width (RDW) is a useful marker for assessing the severity and prognosis of various diseases in adults. This study investigated the RDW values of preterm infants and evaluated its predictive ability for bronchopulmonary dysplasia (BPD). The results showed no correlation between RDW and the development of BPD.
Review
Pediatrics
Lucinda J. Weaver, Colm P. Travers, Namasivayam Ambalavanan, David Askenazi
Summary: This article discusses the impact of excessive fluid accumulation on neonates and its related pathophysiology, and provides clinical recommendations for monitoring, prevention, and treatment of fluid overload.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Jeremy M. Loberger, Ryan M. Jones, Adeline S. Phillips, Jeremy A. Ruhlmann, A. K. M. Fazlur Rahman, Namasivayam Ambalavanan, Priya Prabhakaran
Summary: This study aimed to evaluate the relationship between endotracheal secretions and pediatric extubation failure, and found that the evaluation of secretion character by bedside nurses was independently associated with extubation failure. A model combining other key factors showed good discrimination for predicting extubation outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Jean Lowe, Janell F. Fuller, Allison G. Dempsey, Barbara Do, Carla M. Bann, Abhik Das, Kathryn E. Gustafson, Betty R. Vohr, Susan R. Hintz, Kristi L. Watterberg
Summary: This study found that a blunted cortisol awakening response is associated with memory and attention problems in preterm children. This has implications for stress reactivity and learning problems in preterm children.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Amelia E. Freeman, Kent A. Willis, Luhua Qiao, Ahmed S. Abdelgawad, Brian Halloran, Gabriel Rezonzew, Zoha Nizami, Nancy Wenger, Amit Gaggar, Namasivayam Ambalavanan, Trent E. Tipple, Charitharth Lal
Summary: Bronchopulmonary dysplasia (BPD) is a common lung disease in premature infants caused by hyperoxia exposure and microbial dysbiosis. This study reveals that airway dysbiosis impairs Nrf2-dependent antioxidant function, leading to a more severe phenotype of BPD. Furthermore, supporting colonization with Lactobacillus species to enhance Nrf2-mediated antioxidant activity can improve dysbiotic-augmented lung injury.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Critical Care Medicine
Samuel J. Gentle, Colm P. Travers, Matthew Clark, Waldemar A. Carlo, Namasivayam Ambalavanan
Summary: In extremely preterm infants on respiratory support on postnatal day 28, the presence and longer duration of patent ductus arteriosus (PDA) were associated with the development of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Samuel J. Gentle, Colm P. Travers, Arie Nakhmani, Premananda Indic, Waldemar A. Carlo, Namasivayam Ambalavanan
Summary: Early identification of infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) is crucial due to the higher risk of death. We investigated the intermittent hypoxemia (IH) patterns in infants with BPD-PH and compared them with infants with BPD alone. Our findings showed that infants with BPD-PH had longer duration of hypoxemic events, which was associated with both the diagnosis of BPD-PH and death in these infants.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Engineering, Biomedical
Pravinkumar G. Kandhare, Namasivayam Ambalavanan, Colm P. Travers, Waldemar A. Carlo, Nikolay M. Sirakov, Arie Nakhmani
Summary: Prediction of biomedical signal changes is useful for clinical applications, but evaluation and applicability of prediction tools depend on specific clinical contexts. This study proposes a novel method to evaluate and compare vital sign predictors and validates it for rare events scenarios. Experimental results show that simple statistical predictors can outperform state-of-the-art deep learning architectures for low-dimensional signals.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Pediatrics
Jane E. Brumbaugh, Betty R. Vohr, Edward F. Bell, Carla M. Bann, Colm P. Travers, Elisabeth C. Mcgowan, Heidi M. Harmon, Waldemar A. Carlo, Andrea F. Duncan, Susan R. Hintz
Summary: This study aims to analyze the relationship between social determinants of health (SDOH) and outcomes for extremely preterm infants. The results showed that infants born to mothers with public/no insurance had older postmenstrual age (PMA) at discharge and were more likely to be readmitted. Children exposed to multiple risk-associated SDOH at birth had higher rates of neurodevelopmental impairment (NDI) and death postdischarge compared to those not exposed.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Vivek V. Shukla, A. K. M. Fazlur Rahman, Xuejun Shen, Allison Black, Nitin Arora, C. Vivek Lal, Edward F. Bell, Arie Nakhmani, Chengcui Zhang, Namasivayam Ambalavanan, Waldemar A. Carlo
Summary: The study evaluated the association between the COVID-19 pandemic and stillbirth and neonatal mortality rates. The findings showed that the neonatal mortality rate decreased during the pandemic periods compared to the baseline period, while the stillbirth rate did not significantly change.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Pravitha Ramanand, Premananda Indic, Colm P. Travers, Namasivayam Ambalavanan
Summary: This study aimed to investigate oxygenation patterns during two types of oxygen supplementation in preterm infants and assess their performance in hypoxemia risk screening during NICU monitoring. The findings showed that oxygen saturation had higher volatility and complexity during digitally-set servo-controlled oxygen environment supplementation. Additionally, variability measures of oxygen saturation exhibited early prognostic value in discriminating infants at higher risk of hypoxemic events. Multivariate models with two features showed good performance in risk stratification.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, Research & Experimental
Bianca M. . Vamesu, Teodora Nicola, Rui Li, Snehashis Hazra, Sadis Matalon, Naftali Kaminski, Namasivayam Ambalavanan, Jegen Kandasamy
Summary: Mitochondrial dysfunction at birth is associated with the development of bronchopulmonary dysplasia (BPD) in extremely low-birth weight (ELBW) infants. Nebulized thyroid hormone (TH) has shown potential to improve mitochondrial function and reduce pulmonary fibrosis in adult animals. This study investigated the effects of intranasal T3 on neonatal lung injury and mitochondrial dysfunction in newborn mice, as well as its impact on lung fibroblasts and mesenchymal stem cells from ELBW infants. The results demonstrated that inhaled T3 attenuated hyperoxia-induced lung injury and improved mitochondrial function in mice, suggesting that TH supplementation might be a valuable therapeutic strategy for BPD.
Article
Medicine, General & Internal
Samuel J. Gentle, Matthew A. Rysavy, Lei Li, Matthew M. Laughon, Ravim. Patel, Erik A. Jensen, Susan Hintz, Namasivayam Ambalavanan, Waldemar A. Carlo, Kristi Watterberg
Summary: In extremely preterm infants, the use of hydrocortisone does not reduce the risk of bronchopulmonary dysplasia or death, nor does it increase the risk of neurodevelopmental impairment or death.
Article
Pediatrics
Debra E. Weese-Mayer, Juliann M. Di Fiore, Douglas E. Lake, Anna Maria Hibbs, Nelson Claure, Jiaxing Qiu, Namasivayam Ambalavanan, Eduardo Bancalari, James S. Kemp, Amanda M. Zimmet, John L. Carroll, Richard J. Martin, Katy N. Krahn, Aaron Hamvas, Sarah J. Ratcliffe, Narayanan Krishnamurthi, Premananda Indic, Alaleh Dormishian, Phyllis A. Dennery, J. Randall Moorman
Summary: The study found that cardioventilatory events peak during the first month of life in extremely preterm infants, but the trajectory afterwards depends on the type of event, race, sex, and use of mechanical ventilation. Apnea, periodic breathing, and intermittent hypoxemia events rose from day 3 of life then fell to near-resolution by 8-12 weeks of age. Apnea and intermittent hypoxemia were inversely correlated with gestational age, while periodic breathing was positively correlated with gestational age.
PEDIATRIC RESEARCH
(2023)
Article
Microbiology
Ahmed Abdelgawad, Teodora Nicola, Isaac Martin, Brian A. Halloran, Kosuke Tanaka, Comfort Y. Adegboye, Pankaj Jain, Changchun Ren, Charitharth V. Lal, Namasivayam Ambalavanan, Amy E. O'Connell, Tamas Jilling, Kent A. Willis
Summary: This study identifies a gut-lung axis driven by intestinal AMP expression and mediated by the intestinal microbiota that is linked to lung injury in newborns. These findings support that intestinal AMPs modulate lung injury and repair.
Article
Psychiatry
Carla M. Bann, Katherine C. Okoniewski, Leslie Clarke, Deanne Wilson-Costello, Stephanie Merhar, Sara DeMauro, Scott Lorch, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Catherine Limperopoulos, Brenda Poindexter, Jonathan M. Davis, Michele Walsh, Jamie Newman
Summary: This study found that perceived stigma in healthcare settings during pregnancy is associated with psychological distress in the postpartum period. Individuals who reported stigma had higher levels of depression, anxiety, and anger, and lower levels of well-being. They were also more likely to experience food insecurity, adverse childhood experiences, and abuse during pregnancy, and had less emotional support.
ARCHIVES OF WOMENS MENTAL HEALTH
(2023)