Article
Otorhinolaryngology
Bedia Samanci, Erdi Sahin, Comert Sen, Yavuz Samanci, Mine Sezgin, Serkan Emekli, Elif Kocasoy Orhan, Kadir Serkan Orhan, Betul Baykan
Summary: Cluster headache patients show significant impairment in olfactory function compared to healthy controls. In CH patients, threshold scores were significantly lower during in-bout periods compared to out-of-bout periods, and CH patients with left-sided headache had significantly lower discrimination scores than those with right-sided headache.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Neurosciences
Fengjiao Chen, Wei Liu, Penglai Liu, Zhen Wang, You Zhou, Xingyu Liu, Anan Li
Summary: The aggregation of alpha-synuclein in the olfactory bulb can impair odor detection and perception in mice, as well as increase the activity of M/Ts cells. This study provides direct evidence of the impact of alpha-synuclein aggregates on olfactory dysfunction in Parkinson's disease and reveals the neural circuit mechanisms involved.
NPJ PARKINSONS DISEASE
(2021)
Article
Neurosciences
Paolo Solla, Qian Wang, Claudia Frau, Valentina Floris, Francesco Loy, Leonardo Antonio Sechi, Carla Masala
Summary: The study aimed to determine whether olfactory impairment and other clinical characteristics can predict higher scores on the RBD screening questionnaire (RBDSQ) in PD patients. The severity of olfactory impairment was found to be closely correlated with RBD symptoms, and the study confirmed the presence of gender differences in RBD in PD patients.
Article
Environmental Sciences
Ingrid A. Ekstrom, Debora Rizzuto, Giulia Grande, Tom Bellander, Erika J. Laukka
Summary: The study found that older adults exposed to air pollutants such as PM2.5 and NOx have a faster decline in olfactory ability, suggesting a potential association between air pollution and olfactory decline.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Neurosciences
Behzad Iravani, Artin Arshamian, Martin Schaefer, Per Svenningsson, Johan N. Lundstrom
Summary: Olfactory dysfunction is a common non-motor symptom of Parkinson's disease, potentially serving as an early biomarker for the condition. By using the non-invasive electrobulbogram method, researchers were able to identify EBG components that could differentiate PD patients from controls with high sensitivity and specificity, and were also related to various PD characteristics. This study suggests the potential of EBG as a tool for experimental PD assessments, aiding in diagnosis, and possibly developing into an early biomarker for PD.
NPJ PARKINSONS DISEASE
(2021)
Review
Neurosciences
Thomas Koeglsperger, Svenja-Lotta Rumpf, Patricia Schliesser, Felix L. Struebing, Matthias Brendel, Johannes Levin, Claudia Trenkwalder, Guenter U. Hoeglinger, Jochen Herms
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons. Previous studies have identified cellular and molecular changes that occur before the appearance of Lewy bodies (LBs) in these neurons. Understanding these early pathological events may help in the development of therapeutic and diagnostic strategies for PD.
MOLECULAR NEURODEGENERATION
(2023)
Article
Clinical Neurology
Stephen Joza, Michele T. Hu, Ki-Young Jung, Dieter Kunz, Ambra Stefani, Petr Dusek, Michele Terzaghi, Dario Arnaldi, Aleksandar Videnovic, Mya C. Schiess, Wiebke Hermann, Jee-Young Lee, Luigi Ferini-Strambi, Simon J. G. Lewis, Laurene Leclair-Visonneau, Wolfgang H. Oertel, Elena Antelmi, Friederike Sixel-Doering, Valerie Cochen De Cock, Claudio Liguori, Jun Liu, Federica Provini, Monica Puligheddu, Alessandra Nicoletti, Claudio L. A. Bassetti, Jitka Buskova, Yves Dauvilliers, Raffaele Ferri, Jacques Y. Montplaisir, Michael Lawton, Han-Joon Kim, Frederik Bes, Birgit Hoegl, Karel Sonka, Giuseppe Fiamingo, Pietro Mattioli, Maria Lorena Lavadia, Jessika Suescun, Kyung Ah Woo, Sara Marelli, Kaylena Ehgoetz Martens, Annette Janzen, Giuseppe Plazzi, Brit Mollenhauer, Mariana Fernandes, Yuanyuan Li, Pietro Cortelli, Michela Figorilli, Calogero Edoardo Cicero, Carolin Schaefer, Lily Guiraud, Giuseppe Lanza, Jean-Francois Gagnon, Jun-Sang Sunwoo, Abubaker Ibrahim, Nicola Girtler, Claudia Trenkwalder, Luca Baldelli, Amelie Pelletier, Ronald B. Postuma
Summary: The synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, have a long prodromal period with progressive subclinical symptoms. Idiopathic REM sleep behavior disorder is an early predictor of these diseases and provides an opportunity for intervention with neuroprotective therapy.
Article
Neurosciences
A. Kuzkina, J. Roessle, A. Seger, C. Panzer, A. Kohl, V. Maltese, T. Musacchio, S. J. Blaschke, G. Tamgueney, S. Kaulitz, K. Rak, A. Scherzad, P. H. Zimmermann, J. P. Klussmann, S. Hackenberg, J. Volkmann, C. Sommer, M. Sommerauer, K. Doppler
Summary: Seed amplification assays (SAA) are commonly used to detect alpha-synuclein aggregates in synucleinopathies. However, the sensitivity of SAA in the olfactory epithelium is lower compared to CSF or skin, which may be due to the inhibitory effect of the nasal brushing matrix. The distribution of misfolded alpha-synuclein is not uniform, with a higher deposition in iRBD patients and a subgroup of PD patients showing detection only in the olfactory epithelium.
NPJ PARKINSONS DISEASE
(2023)
Article
Behavioral Sciences
Cecilia Tremblay, Johannes Frasnelli
Summary: The research focused on the impact of Parkinson's disease on the trigeminal system and the interaction between olfactory and trigeminal systems, proposing a model for distinguishing between PD-related OD and NPOD. While these patterns of chemosensory impairment still need confirmation in prodromal PD, appropriate chemosensory tests may eventually aid in developing diagnostic tools to identify individuals at risk for PD.
Article
Clinical Neurology
Paulo Bugalho, Marta Magrico, Luisa Alves, Claudia Borbinha
Summary: Sleep disorders are closely related to cognitive decline in Parkinson's disease and Dementia with Lewy Bodies. In PD patients, Rapid Eye Movement Behavior Disorder (RBD) diagnosis and tonic excessive muscular tone are significantly associated with cognitive deterioration. This suggests that specific features of sleep disorders may have predictive value in understanding disease progression.
Article
Clinical Neurology
Fardin Nabizadeh, Kasra Pirahesh, Elham Khalili
Summary: This study investigates the relationship between olfactory dysfunction and motor and non-motor symptoms in different subtypes of Parkinson's disease. The findings show a significant correlation between olfactory dysfunction and declined motor functions in the tremor dominant subtype, as well as significant correlations with attention processing and executive function in healthy controls. However, no significant association was observed in the postural instability and gait difficulty subtype. The study suggests that olfactory dysfunction may be an early biomarker in the tremor dominant subtype, but not in other subtypes.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Fardin Nabizadeh, Fatemeh Sodeifian, Kasra Pirahesh
Summary: This study found different associations between olfactory dysfunction and striatal dopaminergic neuronal loss among three motor subtypes of Parkinson's disease.
NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jonas K. Olofsson, Fredrik Ekesten, Steven Nordin
Summary: Parosmia, a distorted smell sensation, is a common outcome of respiratory virus infections. This study found that parosmia experiences are prevalent in the population and can persist for some individuals for several years, but they are mostly benign and do not significantly impact quality of life.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Xing-Yang Liu, Ke Wang, Xian-Hua Deng, Yi-Hua Wei, Rui Guo, Sui-Feng Liu, Yi-Fan Zhu, Jia-Jun Zhong, Jing-Yuan Zheng, Meng-Dan Wang, Qiu-Hong Ye, Jian-Quan He, Kai-Hang Guo, Jun-Rong Zhu, Shu-Qiong Huang, Ze-Xu Chen, Chong-Shan Lv, Lei Wen
Summary: Olfactory dysfunction is an early non-motor symptom of Parkinson's disease (PD). Alpha-synuclein plays a key role in the pathology of the olfactory pathway in early PD. However, the local neural microcircuit mechanisms underlying olfactory dysfunction between the olfactory epithelium and olfactory bulb in early PD are still unknown.
CELL AND BIOSCIENCE
(2023)
Article
Clinical Neurology
Jessie S. Gibson, Joseph L. Flanigan, James T. Patrie, W. Alex Dalrymple, Madaline B. Harrison
Summary: In this study, predictors of anxiety symptoms over a 3-year period in a clinic-based Parkinson's disease cohort were identified. It was found that symptoms of REM sleep behavior disorder (RBD) and dysautonomia were independent predictors of anxiety symptoms, while cognitive impairment was not. These findings provide insights for further research and treatment of anxiety symptoms in Parkinson's disease.
NEUROLOGICAL SCIENCES
(2023)
Article
Obstetrics & Gynecology
Takashi Tanaka, Yoshitomo Kobori, Kazutaka Terai, Yasuyuki Inoue, Akiyoshi Osaka, Naoki Yoshikawa, Yukihito Shimomura, Keisuke Suzuki, Tetsuji Minami, Toshiyuki Iwahata, Shin Onota, Atsushi Yamamoto, Kouhei Sugimoto, Hiroshi Okada
Summary: Varicocele is a common cause of male infertility, and it has been found to be associated with increased sperm DNA fragmentation index. This study assessed the effects of varicocele on seminal oxidation-reduction potential and sperm DNA fragmentation index in both fertile and infertile men. The findings showed that infertile men with varicocele had higher seminal oxidation-reduction potential and sperm DNA fragmentation index compared to fertile controls.
Article
Clinical Neurology
Mai Hamaguchi, Hiroaki Fujita, Tomonari Suzuki, Keisuke Suzuki
Summary: This article reports a case of a patient with NMOSD who presented with refractory nausea, vomiting, and sick sinus syndrome (SSS) as the initial manifestation. Clinicians should be aware of the possibility that medullary lesions in NMOSD can cause SSS as the initial manifestation, as SSS is a life-threatening complication.
Article
Geriatrics & Gerontology
Kyoko Numahata, Tomoyuki Miyamoto, Yasuhisa Akaiwa, Masayuki Miyamoto
Summary: This study found that easy Z-score imaging system-specific volume-of-interest analysis (SVA) can predict the short-term development of neurodegenerative dementia in patients with idiopathic rapid eye movement sleep behavior disorder (IRBD). This has important implications for clinical trials of disease-modifying therapies.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Hidehiro Takekawa, Daisuke Tsukui, Saro Kobayasi, Keisuke Suzuki, Hirotoshi Hamaguchi
Summary: Carotid artery ultrasonography is a useful tool in the emergency room for diagnosing and managing stroke, providing valuable information within a short time period.
JOURNAL OF MEDICAL ULTRASONICS
(2022)
Article
Clinical Neurology
Tomoyuki Miyamoto, Yasuhisa Akaiwa, Kyoko Numahata, Kenta Yoshizawa, Toshimi Sairenchi, Masayuki Miyamoto
Summary: This study found that right-handed IRBD patients have asymmetric nigrostriatal dopaminergic function, with a faster rate of decline in the left striatum compared to the right striatum. This asymmetry may be associated with the early pathological process of Parkinson's disease or dementia with Lewy bodies.
PARKINSONISM & RELATED DISORDERS
(2022)
Letter
Clinical Neurology
Tomoko Komagamine, Takashi Kanbayashi, Keisuke Suzuki, Koichi Hirata, Seiji Nishino
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Clinical Neurology
Taku Hatano, Osamu Kano, Renpei Sengoku, Asako Yoritaka, Keisuke Suzuki, Noriko Nishikawa, Yohei Mukai, Kyoichi Nomura, Norihito Yoshida, Morinobu Seki, Miho Kawabe Matsukawa, Hiroo Terashi, Katsuo Kimura, Jun Tashiro, Shigeki Hirano, Hidetomo Murakami, Hideto Joki, Tsuyoshi Uchiyama, Hideki Shimura, Kotaro Ogaki, Jiro Fukae, Yoshio Tsuboi, Kazushi Takahashi, Toshimasa Yamamoto, Naotake Yanagisawa, Hiroshi Nagayama
Summary: The ISTRA ADJUST PD study aims to evaluate the effect of adjunctive istradefylline on levodopa dosage titration in PD patients. The study plans to recruit 100 evaluable patients for efficacy analysis by February 2022, with the goal of determining whether istradefylline can reduce the cumulative additional dose of levodopa-containing medications in PD patients experiencing the wearing-off phenomenon and lower the risk of levodopa-associated complications.
Article
Clinical Neurology
Tomoyuki Miyamoto, Masayuki Miyamoto
Summary: This study found that anosmia in patients with isolated REM sleep behavior disorder (IRBD) predicts a higher short-term risk of transition to Lewy body disease (LBD). Although it cannot distinguish between Parkinson's disease (PD) and dementia with Lewy bodies (DLB), anosmia can serve as a marker of prodromal LBD.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Review
Clinical Neurology
Keisuke Suzuki, Shiho Suzuki, Tomohiko Shiina, Saro Kobayashi, Koichi Hirata
Summary: This article reviewed the association between central sensitization (CS) and migraine, emphasizing the role of CS in the pathogenesis of chronic migraine. The importance of appropriate screening and management of CS in improving the quality of life for migraine patients was highlighted.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Clinical Neurology
Masayuki Miyamoto, Tomoyuki Miyamoto
Summary: This study found that among IRBD patients with reduced cardiac MIBG accumulation, a MoCA-J score of <26 and a low sub-item score for delayed recall predicted short-term progression to probable DLB.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Keisuke Suzuki, Shiho Suzuki, Tomohiko Shiina, Muneto Tatsumoto, Hiroaki Fujita, Yasuo Haruyama, Koichi Hirata
Summary: Real-world study confirms the effectiveness and safety of CGRP mAbs in reducing migraine days in patients.
Article
Clinical Neurology
Keisuke Suzuki, Shiho Suzuki, Tomohiko Shiina, Yasuo Haruyama, Hiroaki Fujita, Kei Funakoshi, Koichi Hirata
Summary: This study retrospectively assessed the effect of galcanezumab in the first week after administration and found that it had a significant effect. The number of weekly migraine days and monthly migraine days significantly improved after 1-3 months of treatment. Additionally, the response rate at week 1 could predict the response rate at 3 months.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Tomoko Komagamine, Reika Aoki-Kawabata, Mai Hamaguchi, Keisuke Suzuki, Norito Kokubun
Summary: This study found that the maximum diameter of the interscalene gap was significantly larger in CIDP patients compared to patients with cervical spondylosis. It suggests that conventional cervical spine MRI can be used as a screening tool for nerve hypertrophy in CIDP.
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Keisuke Suzuki, Madoka Okamura, Yasuo Haruyama, Shiho Suzuki, Tomohiko Shiina, Gen Kobashi, Koichi Hirata
Summary: This study assessed the frequency of multiple chemical sensitivity (MCS) and its related factors in patients with migraine and found that 20% of patients with migraine had MCS. The results suggest a possible association of MCS with central sensitization and hypersensitivity-related symptoms in patients with migraine.
JOURNAL OF OCCUPATIONAL HEALTH
(2022)
