Review
Clinical Neurology
Stephen Tisch, Kishore Raj Kumar
Summary: GPi DBS is an effective intervention for refractory dystonia, with factors such as disease duration and subtype influencing outcomes. Other factors affecting variability in results include body distribution, pattern of dystonia, and DBS-related factors. Different monogenic forms of dystonia may respond differently to DBS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Suzhen Lin, Yimei Shu, Chencheng Zhang, Lingbing Wang, Peng Huang, Yixin Pan, Jianqing Ding, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study compared the effectiveness of targeting the globus pallidus internus (GPi) and the subthalamic nucleus (STN) in patients with isolated dystonia. The results showed that STN-DBS had superior effects at 1 month, 1 year, and 3 years, while GPi-DBS was better for axis symptoms, particularly for trunk involvement. STN-DBS was also more effective for symptoms involving the eyes and generalized dystonia, and required less electrical energy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Xue Wang, Shanshan Mei, Zichen Tian, Lin Wang, Guiliang Hao, Xin Zhu, Wei Mao, Jianyu Li
Summary: Dopa-responsive dystonia (DRD) is a movement disorder with genetic and clinical heterogeneity, characterized by a dramatic response to levodopa. This study presents the clinical outcome of pallidal stimulation in a DRD patient who had a poor response to levodopa. The results show that pallidal stimulation leads to promising clinical outcomes for levodopa-resistant DRD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Surgery
Marek Balaz, Jiri Buril, Tereza Jurkova, Eva Koritakova, Dusan Hrabovsky, Jonas Kunst, Petra Bartova, Jan Chrastina
Summary: This study aims to compare the preplanned trajectories for deep brain stimulation (DBS) with the final trajectories selected after electrophysiological monitoring, and to discuss the factors responsible for the differences. The results showed significant differences between the preplanned and final trajectories, but no predictors for these differences were identified. There was also no association between the anatomical-electrophysiological differences and clinical outcome.
FRONTIERS IN SURGERY
(2023)
Article
Clinical Neurology
Wentao Zheng, Gaoquan Lv, Yunwei Lu, Jiayu Liu, Qingpei Hao, Hu Ding, Yezu Liu, Ruen Liu
Summary: Bilateral globus pallidus internus deep brain stimulation (GPi-DBS) is a safe and effective treatment approach for Meige syndrome, improving motor function and quality of life without cognitive and mood side effects.
Article
Neurosciences
Shiro Horisawa, Kotaro Kohara, Masato Murakami, Atsushi Fukui, Takakazu Kawamata, Takaomi Taira
Summary: The Forel field has potential for the treatment of cervical dystonia, Parkinson's disease, and dystonia. Recent studies have shown promising results for the efficacy of FF-DBS in treating dystonia.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Suzhen Lin, Lingbing Wang, Yimei Shu, Shunyu Guo, Tao Wang, Hongxia Li, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: Bilateral STN-DBS plus unilateral PVP may be an effective rescue procedure for patients with isolated dystonia who experienced suboptimal movement improvement following GPi-DBS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Chun-Hwei Tai, Sheng-Che Chou, Chin-Hsien Lin, Wang-Tso Lee, Ruey-Meei Wu, Sheng-Hong Tseng
Summary: Patients with isolated dystonia, either monogenic or idiopathic, tend to respond better to GPi DBS compared to those with acquired dystonia. Selection of patients based on dystonia etiology, accurate placement of DBS leads in GPi targets, and proper stimulation programming are crucial for achieving better long-term outcomes.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Kantharuby Tambirajoo, Luciano Furlanetti, Michael Samuel, Keyoumars Ashkan
Summary: Adult-onset dystonic syndromes presenting with dystonic opisthotonus are rare, and often refractory to medical management. In this study, three patients showed rapid and sustained clinical improvement of symptoms following GPi-DBS, with the ability to resume daily activities and reintegrate into society. Thorough investigation and tailored management are necessary for this highly disabling condition with varying etiologies.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Biology
Hiroshi Koyama, Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Taku Matsuda, Koji Fujita, Yuishin Izumi, Ryuji Kaji, Satoshi Goto, Yasushi Takagi
Summary: The study assessed the outcomes of 12 patients with TD who underwent GPi DBS, with an average BFMDRS improvement rate of 75.6% at 1 month postoperatively and 78.0% in the long term. Two patients responded poorly to DBS, which was attributed to longer duration from TD onset to surgery and older age at surgery.
Article
Neurosciences
Takashi Asahi, Kiyonobu Ikeda, Jiro Yamamoto, Hiroyuki Tsubono, Yuko Muro, Shuji Sato
Summary: Limited studies have been conducted on stereotactic and functional neurosurgery for lingual dystonia. This case report demonstrates the effectiveness of bilateral GPi-DBS in improving symptoms of primary lingual dystonia. Placing the directional part of the lead in the GPi bottom has shown to enhance stimulation effects.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2021)
Article
Clinical Neurology
Yijie Lai, Naying He, Hongjiang Wei, Lifu Deng, Haiyan Zhou, Jun Li, Marcus Kaiser, Chencheng Zhang, Dianyou Li, Bomin Sun
Summary: This study investigated patient-specific functional connectivity related to globus pallidus internus (GPi) deep brain stimulation (DBS) outcome in Parkinson disease (PD) and established connectivity models for outcome prediction. The results showed that patient-specific functional connectivity seeding from the VTA-GPi intersection could help in GPi DBS outcome prediction.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Cecile Delorme, Emmanuel Roze, Carine Karachi, Marie Vidailhet, Elodie Hainque
Summary: This case study documented a 44-year-old patient with a wide phenotypic spectrum of generalized dystonia associated with TUBB4A gene mutations. After undergoing bipallidal deep brain stimulation surgery, a significant reduction in dystonia severity was observed, particularly in the cervical and facial regions.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Sait Ozturk, Yasin Temel, Dursun Aygun, Ersoy Kocabicak
Summary: GPi-DBS shows favorable long-term efficacy and safety in treating patients with secondary dystonia, while STN appears to be a promising stimulation target for patients with secondary dystonia. Further studies with larger patient cohorts, longer follow-up periods, and more homogeneous patients are needed to determine the optimal DBS target for secondary dystonias.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Joshua K. Wong, Janine Melo Lobo Jofili Lopes, Wei Hu, Anson Wang, Ka Loong Kelvin Au, Tamara Stiep, Jessica Frey, Jon B. Toledo, Robert S. Raike, Michael S. Okun, Leonardo Almeida
Summary: This study compares the safety and tolerability of active recharge biphasic DBS (bDBS) with conventional clinical DBS (clinDBS) in patients with primary dystonia. Results show that bDBS is safe and well-tolerated in all 10 subjects, with greater immediate improvement compared to clinDBS after 4 hours of stimulation.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Medicine, General & Internal
Annika Danielsson, Miryam Carecchio, Laura Cif, Anne Koy, Jean-Pierre Lin, Goran Solders, Luigi Romito, Katja Lohmann, Barbara Garavaglia, Chiara Reale, Giovanna Zorzi, Nardo Nardocci, Philippe Coubes, Victoria Gonzalez, Agathe Roubertie, Gwenaelle Collod-Beroud, Goran Lind, Kristina Tedroff
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Clinical Neurology
Rocio N. Villar-Quiles, Maja von Der Hagen, Corinne Metay, Victoria Gonzalez, Sandra Donkervoort, Enrico Bertini, Claudia Castiglioni, Denys Chaigne, Jaume Colomer, Maria Luz Cuadrado, Marianne de Visser, Isabelle Desguerre, Bruno Eymard, Nathalie Goemans, Angela Kaindl, Emmanuelle Lagrue, Jurg Lutschg, Edoardo Malfatti, Michele Mayer, Luciano Merlini, David Orlikowski, Ulrike Reuner, Mustafa A. Salih, Beate Schlotter-Weigel, Mechthild Stoetter, Volker Straub, Haluk Topaloglu, J. Andoni Urtizberea, Anneke van der Kooi, Ekkehard Wilichowski, Norma B. Romero, Michel Fardeau, Carsten G. Bonnemann, Brigitte Estournet, Pascale Richard, Susana Quijano-Roy, Ulrike Schara, Ana Ferreiro
Article
Clinical Neurology
Emily Sanrey, Valerie Macioce, Victoria Gonzalez, Laura Cif, Fabienne Cyprien, Emilie Chan Seng, Philippe Coubes, Gaetan Poulen
Summary: HD is a neurodegenerative disorder associated with motor, psychiatric and cognitive deterioration. This study found that GPi continuous electrical neuromodulation had a positive impact on global cognitive function in HD patients, maintaining stability during the first 3 years of treatment despite disease progression.
JOURNAL OF NEUROLOGY
(2021)
Letter
Clinical Neurology
Marion Tailland, Victoria Gonzalez, Pauline Prin, Clarisse Carra-Dalliere, Xavier Ayrignac, Pierre Labauge
REVUE NEUROLOGIQUE
(2021)
Article
Clinical Neurology
Thomas Klopstock, Aleksandar Videnovic, Almut Turid Bischoff, Cecilia Bonnet, Laura Cif, Cynthia Comella, Marta Correa-Vela, Maria L. Escolar, Jamie L. Fraser, Victoria Gonzalez, Neal Hermanowicz, Robert Jech, Hyder A. Jinnah, Tomasz Kmiec, Anthony Lang, Maria J. Marti, Saadet Mercimek-Andrews, Migvis Monduy, Graeme A. M. Nimmo, Belen Perez-Duenas, Helle Cecilie Viekilde Pfeiffer, Lluis Planellas, Emmanuel Roze, Nivedita Thakur, Laura Tochen, Nora Vanegas-Arroyave, Giovanna Zorzi, Colleen Burns, Feriandas Greblikas
Summary: The study investigated the effect of fosmetpantotenate replacement therapy on PKAN symptoms and disease progression, showing that while treatment with fosmetpantotenate was safe, it did not improve function in patients with PKAN.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Jasper E. Visser, Adam C. Cotton, David J. Schretlen, Jocelyne Bloch, Kristina Tedroff, Gaston Schechtmann, Diana Radu Djurfeldt, Victoria Gonzalez, Laura Cif, Hyder A. Jinnah
Summary: Although DBS may be effective in treating LND, further research is needed to understand the reasons for variability in response and the unusually high rates of adverse events before recommending DBS for these patients.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Letter
Clinical Neurology
Marianthi Breza, Jennifer Hirst, Viorica Chelban, Guillaume Banneau, Laurene Tissier, Bophara Kol, Thomas Bourinaris, Samia A. Said, Yann Pereon, Anna Heinzmann, Rabab Debs, Raul Juntas-Morales, Victoria G. Martinez, Jean P. Camdessanche, Clarisse Scherer-Gagou, Jean-Medard Zola, Alkyoni Athanasiou-Fragkouli, Stephanie Efthymiou, George Vavougios, Georgios Velonakis, Maria Stamelou, John Tzartos, Constantin Potagas, Thomas Zambelis, Caterina Mariotti, Craig Blackstone, Jana Vandrovcova, Theodoros Mavridis, Chrisoula Kartanou, Leonidas Stefanis, Nicholas Wood, Georgia Karadima, Eric LeGuern, Georgios Koutsis, Henry Houlden, Giovanni Stevanin
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Marta Correa-Vela, Joao Carvalho, Julia Ferrero-Turrion, Ana Cazurro-Gutierrez, Maria Vanegas, Victoria Gonzalez, Ramiro Alvarez, Anna Marce-Grau, Antonio Moreno, Alfons Macaya-Ruiz, Belen Perez-Duenas
Summary: This study aims to evaluate early dystonic features in children and adolescents with SGCE-myoclonus-dystonia. The study found that these patients show recognizable dystonic patterns and sensory tricks, which can lead to early diagnosis and timely treatment.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Marc Rodrigo-Gisbert, Arnau Llaurado, Andres Baucells, Cristina Auger, Victoria Gonzalez
Summary: We report a case of an 82-year-old woman with subacute altered mental status, oculomotor disturbances, and ataxia. The examination revealed bilateral ptosis, complete horizontal ophthalmoplegia, limited vertical eye movements during upgaze, and prominent truncal ataxia. MRI showed mild hyperintensity in the posterior brainstem extending to the upper cervical cord without gadolinium enhancement. This case highlights the importance of comprehensive differential diagnosis and screening for malignancy in patients with subacute brainstem encephalitis, in case of negative initial workup.
Editorial Material
Clinical Neurology
Andreu Vilaseca, Elena Martinez-Saez, Victoria Gonzalez, Cristina Auger, Laura Naranjo, Raquel Ruiz-Garcia
Summary: Paraneoplastic cerebellar degeneration (PCD) has been observed in a small number of patients with melanoma and specific neuronal antibodies (Yo and CARPVIII).
Article
Clinical Neurology
Laura Cif, Diane Demailly, Jean-Pierre Lin, Katy E. Barwick, Mario Sa, Lucia Abela, Sony Malhotra, Wui K. Chong, Dora Steel, Alba Sanchis-Juan, Adeline Ngoh, Natalie Trump, Esther Meyer, Xavier Vasques, Julia Rankin, Meredith W. Allain, Carolyn D. Applegate, Sanaz Attaripour Isfahani, Julien Baleine, Bettina Balint, Jennifer A. Bassetti, Emma L. Baple, Kailash P. Bhatia, Catherine Blanchet, Lydie Burglen, Gilles Cambonie, Emilie Chan Seng, Sandra Chantot Bastaraud, Fabienne Cyprien, Christine Coubes, Vincent D'Hardemare, Asif Doja, Nathalie Dorison, Diane Doummar, Marisela E. Dy-Hollins, Ellyn Farrelly, David R. Fitzpatrick, Conor Fearon, Elizabeth L. Fieg, Brent L. Fogel, Eva B. Forman, Rachel G. Fox, William A. Gahl, Serena Galosi, Victoria Gonzalez, Tracey D. Graves, Allison Gregory, Mark Hallett, Harutomo Hasegawa, Susan J. Hayflick, Ada Hamosh, Marie Hully, Sandra Jansen, Suh Young Jeong, Joel B. Krier, Sidney Krystal, Kishore R. Kumar, Chloe Laurencin, Hane Lee, Gaetan Lesca, Laurence Lion Francois, Timothy Lynch, Neil Mahant, Julian A. Martinez-Agosto, Christophe Milesi, Kelly A. Mills, Michel Mondain, Hugo Morales-Briceno, John R. Ostergaard, Swasti Pal, Juan C. Pallais, Frederique Pavillard, Pierre-Francois Perrigault, Andrea K. Petersen, Gustavo Polo, Gaetan Poulen, Tuula Rinne, Thomas Roujeau, Caleb Rogers, Agathe Roubertie, Michelle Sahagian, Elise Schaefer, Laila Selim, Richard Selway, Nutan Sharma, Rebecca Signer, Ariane G. Soldatos, David A. Stevenson, Fiona Stewart, Michel Tchan, Ishwar C. Verma, Bert B. A. de Vries, Jenny L. Wilson, Derek A. Wong, Raghda Zaitoun, Dolly Zhen, Anna Znaczko, Russell C. Dale, Claudio M. de Gusmao, Jennifer Friedman, Victor S. C. Fung, Mary D. King, Shekeeb S. Mohammad, Luis Rohena, Jeff L. Waugh, Camilo Toro, F. Lucy Raymond, Maya Topf, Philippe Coubes, Kathleen M. Gorman, Manju A. Kurian
Meeting Abstract
Clinical Neurology
P. Prin, V. Gonzalez, L. Cif, F. Cyprien, E. Sanrey, E. Chan Seng, G. Poulen, E. Le Bars, A. Coget, N. Leboucq, N. Menjot de Champfleur, P. Coubes
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Meeting Abstract
Clinical Neurology
V. Gonzalez, L. Cif, F. Cyprien, E. Chan Seng, E. Sanrey, S. Biskup, N. Leboucq, O. Dereure, D. Doummar, P. Coubes
EUROPEAN JOURNAL OF NEUROLOGY
(2019)
Meeting Abstract
Clinical Neurology
M. Vanegas, E. Timmers, F. Hamami, S. Boesch, W. Vandenberghe, O. Burgazlieva, M. Moller, L. Hjermind, M. Vidailhet, A. Meneret, T. Baumer, S. Siegert, T. Gasser, L. Schoels, J. Molnar, A. Capuano, F. Nicita, G. Zorzi, A. Albanese, A. Federico, E. Lohmann, J. Guk, M. Willemsen, N. Wolf, M. Dec-Cwiek, D. Neubauer, D. Flisar, V. Gonzalez, A. Darling, M. Marti, H. Houlden, C. Reinhard, A. Weissbach, M. Tijssen, B. Perez-Duenas
MOVEMENT DISORDERS
(2021)
Meeting Abstract
Clinical Neurology
M. Correa-Vela, J. Carvalho, M. Vanegas, A. Cazurro-Gutierrez, V. Gonzalez, R. Alvarez, A. Marce-Grau, A. Moreno, A. Macaya, B. Perez-Duenas
MOVEMENT DISORDERS
(2021)