Journal
MOVEMENT DISORDERS
Volume 24, Issue 10, Pages 1524-1530Publisher
WILEY
DOI: 10.1002/mds.22593
Keywords
Gaucher; glucocerebrosidase; parkinsonism; Parkinson's disease; Lewy body dementia
Categories
Funding
- Genzyme
Ask authors/readers for more resources
Parkinsonism has been described in patients with Gaucher's disease (GD). We reviewed the 10 cases of patients with both parkinsonism and GD recorded in the French national GD registry, as well as 49 previously published cases. Relative to the general population, parkinsonism in GD patients (1) was more frequent, (2) occurred at an earlier age, (3) responded less well to levodopa, and (4) was more frequently associated with signs of cortical dysfunction. Enzyme replacement therapy (ERT) and substrate reduction therapy (SRT) were ineffective on GD-associated parkinsonism, suggesting that parkinsonism itself is not an indication for ERT or SRT in this setting. (C) 2009 Movement Disorder Society
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available