Journal
MOVEMENT DISORDERS
Volume 23, Issue 9, Pages 1307-1312Publisher
WILEY-LISS
DOI: 10.1002/mds.22029
Keywords
Parkinson's disease; structural equation modeling; dimensionality; Motor Section of the UPDRS
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This study aims to investigate the structure of the motor symptoms of Parkinson's disease (PD), as measured by the Motor Section of the Unified Parkinson's Disease Rating Scale (UPDRS). The dimensionality of the Motor Section of the UPDRS was studied using structural equation modeling. The UPDRS measures were obtained from 405 patients with PD [237 men (39 off, 170 on, 28 unknown) and 168 women (21 off, 140 on, 7 unknown)]. The ordinal character of UPDRS scores and sample size substantiated the use of robust diagonally weighted least squares model estimation. It was shown that the Motor Section of the UPDRS incorporates five main latent symptom factors (rigidity, tremor, bradykinesia of the extremities, axial/gait bradykinesia, speech/hypomimia) plus two additional factors for laterality, which account for asymmetry of tremor, rigidity and bradykinesia of the extremities. Tremor seems to be an independent symptom factor of PD. Other latent variables are substantially correlated. (C) 2008 Movement Disorder Society.
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