Review
Biochemistry & Molecular Biology
Alexandru Cosmin Pantazi, Mustafa Ali Kassim Kassim, Wassan Nori, Liliana Ana Tuta, Cristina Maria Mihai, Tatiana Chisnoiu, Adriana Luminita Balasa, Larisia Mihai, Ancuta Lupu, Corina Elena Frecus, Vasile Valeriu Lupu, Sergiu Ioachim Chirila, Anca Gabriela Badescu, Laurentiu-Tony Hangan, Simona Claudia Cambrea
Summary: The gut microbiota plays a vital role in kidney disease, and interventions targeting the gut microbiota show promising results. Challenges remain in terms of patient variability and safety concerns. Further research is needed to understand the mechanisms and validate personalized interventions through clinical trials.
Article
Immunology
Robson E. Silva, Eliziaria C. Santos, Patricia B. Justino, Margarida P. Santos, Giovane Galdino, Reggiani Goncalves, Romulo D. Novaes
Summary: The relationship between dialysis adequacy and circulating levels of inflammatory mediators was investigated, showing that low Kt/V results and creatinine accumulation may serve as potential indicators of systemic inflammatory stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takeo Koshida, Tomohito Gohda, Takuya Sugimoto, Takashi Asahara, Rin Asao, Isao Ohsawa, Hiromichi Gotoh, Maki Murakoshi, Yusuke Suzuki, Yuichiro Yamashiro
Summary: The composition of the gut microbiome differs between patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) and those with normal renal function (NRF). This difference is associated with altered levels of stool organic acids, systemic inflammation, and accumulation of uremic toxins (UTs). Furthermore, the levels of UTs, inflammatory markers, and stool organic acids differ significantly between patients with NRF and those undergoing HD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Paula C. Silveira-Silva, Robson E. Silva, Eliziaria C. Santos, Patricia B. I. Justino, Margarida P. Santos, Reggiani Goncalves, Romulo D. Novaes
Summary: Controlling systemic proinflammatory and prooxidant effectors is crucial for reducing cardiovascular risk and mortality in patients with end-stage renal disease (ESRD). However, monitoring these processes is challenging due to limited understanding of their determinants and predictors. This study investigated the relationship between advanced glycosylation end products (AGE) and proinflammatory and prooxidant effectors in ESRD patients undergoing hemodialysis (HD). The results showed that AGE accumulation was associated with elevated proinflammatory and prooxidant markers, suggesting that monitoring AGE levels may help predict systemic inflammatory stress and the balance between oxidant and antioxidant status in ESRD patients.
Review
Medicine, General & Internal
An-Yu Cheng, Lai-San Wong
Summary: Uremic pruritus is a common condition in patients with chronic kidney disease or end-stage renal disease, and its diagnosis requires careful evaluation to exclude other causes. The underlying pathophysiology of uremic pruritus is still unclear and may involve multiple factors.
Article
Biochemistry & Molecular Biology
Kuo-Hua Lee, Yuan-Chia Chu, Ming-Tsun Tsai, Wei-Cheng Tseng, Yao-Ping Lin, Shuo-Ming Ou, Der-Cherng Tarng
Summary: This study used machine learning to predict the risk of end-stage renal disease (ESRD) in sepsis survivors. The researchers found that estimated glomerular filtration rates, hemoglobin, and proteinuria were important predictors of ESRD development.
Article
Biochemistry & Molecular Biology
Mahmoud M. Zakaria, Safaa A. Derbala, Ayman E. Salem, Amgad E. EL-Agroudy, Fatma M. El-Tantawy
Summary: The study found that ESRD patients have a significantly lower number of T-cell subsets compared to CKD patients, which is related to a higher degree of apoptosis in these cells.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Pharmacology & Pharmacy
Zoe M. Lipman, Gil Yosipovitch
Summary: DFK, a kappa opioid receptor agonist, shows promising results in effectively and safely reducing uremic pruritus in hemodialysis patients. Its intravenous formulation provides rapid and safe itch reduction without many side effects associated with other opioids, making it a potential candidate for CKD-aP treatment.
EXPERT OPINION ON PHARMACOTHERAPY
(2021)
Article
Infectious Diseases
Jose Molto, Fredzzia Graterol, Adrian Curran, Natalia Ramos, Arkaitz Imaz, Diego Sandoval, Francisco Perez, Lucia Bailon, Saye Khoo, Laura Else, Roger Paredes
Summary: This study evaluated the effect of haemodialysis on doravirine concentrations in people living with HIV (PLWH) undergoing routine haemodialysis. The results showed that despite moderate removal of doravirine by haemodialysis, trough doravirine concentrations in plasma after the haemodialysis sessions remained in excess of the protein-binding-adjusted EC50 (5 ng/mL). Therefore, doravirine dosage adjustments are unnecessary in PLWH undergoing intermittent haemodialysis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Dermatology
Gil Yosipovitch, Ahmed Awad, Robert H. Spencer, Catherine Munera, Frederique Menzaghi
Summary: This study evaluated the efficacy and safety of difelikefalin in reducing itch in patients with non-dialysis-dependent chronic kidney disease and those undergoing hemodialysis. The results showed that difelikefalin significantly reduced itch intensity and improved itch-related quality of life in these patients.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Endocrinology & Metabolism
Rodolfo J. Galindo, Francisco J. Pasquel, Priyathama Vellanki, Cesar Zambrano, Bonnie Albury, Citlalli Perez-Guzman, Zheng Ziduo, Guillermo E. Umpierrez
Summary: This study revealed significant metabolic differences among DKA patients with different levels of renal function, with beta-hydroxybutyrate levels potentially assisting in confirming the diagnosis of DKA in ESKD patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Zaipul I. Md Dom, Eiichiro Satake, Jan Skupien, Bozena Krolewski, Kristina O'Neil, Jill A. Willency, Simon T. Dillon, Jonathan M. Wilson, Hiroki Kobayashi, Katsuhito Ihara, Towia A. Libermann, Marlon Pragnell, Kevin L. Duffin, Andrzej S. Krolewski
Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yinghui Wang, Lu Gao
Summary: Chronic kidney disease and cardiac insufficiency often co-exist, especially in uremic patients on hemodialysis. Impaired renal function is often indicative of poor prognosis in patients with cardiac insufficiency. Inflammation plays a significant role in the development of cardiovascular complications in patients with chronic kidney disease and is indicative of prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Lorry Aitkens, Jennifer L. Waller, Stephanie L. Baer, Azeem Mohammed, Sarah Tran, Budder Siddiqui, Sandeep Padala, Lufei Young, Mufaddal Kheda, Wendy B. Bollag
Summary: This study found that psoriasis is protective against pneumonia in patients with end-stage renal disease, with other factors such as the Charlson Comorbidity Index (CCI) and tobacco use being more strongly associated with increased risk for pneumonia.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Editorial Material
Peripheral Vascular Disease
Joao Pedro Teixeira, Sara A. Combs, Jonathan G. Owen
Summary: This case describes a hemodialysis patient who developed unexplained thrombosis of an arteriovenous fistula during a symptomatic COVID-19 infection, requiring multiple treatments and ultimately a tunneled dialysis catheter. The recurrence of thromboses was speculated to be related to the hypercoagulable state of severe COVID-19, highlighting the importance for interventionalists to consider this when planning access interventions for patients with symptomatic COVID-19.
JOURNAL OF VASCULAR ACCESS
(2022)
Article
Biochemistry & Molecular Biology
J. Pedro Teixeira, Sharon Barone, Kamyar Zahedi, Manoocher Soleimani
Summary: This article discusses the epidemiology of kidney disease in COVID-19 and its association with poor outcomes. It also presents emerging data on long-term renal impairment caused by COVID-19 and delves into the ongoing debate about whether AKI in COVID-19 is mediated by direct viral injury. Furthermore, it explores the molecular pathogenesis of SARS-CoV-2 infection and proposes novel therapeutic targets for COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Michelle Shieh, Julie A. Giannini, Sara A. Combs, Saeed K. Shaffi, Nidia C. Messias, J. Pedro Teixeira
Summary: Acute kidney injury is a common complication of COVID-19, with PGNMID being a rare glomerular disease associated with this viral infection. Treatment with anti-plasma cell therapy may be effective in managing COVID-19-associated PGNMID.
Article
Medicine, Research & Experimental
Douglas J. Perkins, Alexandra Yingling, Qiuying Cheng, Amber Castillo, Janae Martinez, Steven B. Bradfute, Shuguang Leng, Jeremy Edwards, Yan Guo, Gregory Mertz, Michelle Harkins, Mark Unruh, Anthony Worsham, Christophe G. Lambert, J. Pedro Teixeira, Phillip Seidenberg, Jens Langsjoen, Kristan Schneider, Ivy Hurwitz
Summary: Epidemiological data in the United States show health disparities in COVID-19 infection, hospitalization, and mortality based on race/ethnicity. This study found that there is a strong relationship between SARS-CoV-2 viral loads and severe COVID-19, particularly in the American Indian or Alaska Native population.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Urology & Nephrology
J. Pedro Teixeira, Kirby P. Mayer, Benjamin R. Griff, Naomi George, Nathaniel Jenkins, C. Anil Pal, Felipe Gonzalez-Seguel, Javier A. Neyra
Summary: Acute kidney injury (AKI) and intensive care unit-acquired weakness (ICU-AW) are two common complications of critical illness that have recently been found to have a relationship with each other. This review examines the epidemiology and pathophysiological mechanisms linking AKI and ICU-AW, and discusses interventions to mitigate the risk of ICU-AW in patients with AKI. The conclusion suggests the need for further studies to better understand the relationship between AKI, AKI-KRT, and ICU-AW, and to test interventions to improve the long-term functional status and quality of life of AKI survivors.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Review
Urology & Nephrology
J. Pedro Teixeira, Javier A. Neyra, Ashita Tolwani
Summary: AKI, a common complication of critical illness, can be treated with continuous KRT, a form of dialysis. However, there is considerable variation in the application of continuous KRT due to a lack of standardization. This article provides an overview of the therapy, recent clinical trials, and outcome studies, emphasizing the importance of multidisciplinary collaboration and quality assurance programs.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Engineering, Biomedical
Erik Kraai, J. Pedro Teixeira, Ishan A. Patel, Trenton C. Wray, Jessica A. Mitchell, Naomi George, Ashley Kamm, Justin Henson, Aibek Mirrhakimov, Sundeep Guliani, Isaac Tawil, Todd Dettmer, Jonathan Marinaro
Summary: This study retrospectively analyzed the development, implementation, and outcomes of an intensivist-led adult extracorporeal life support (ECLS) program at the University of New Mexico Hospital. The results showed that the intensivist-led ECLS program was successful, with a survival rate comparable to the literature, reaching 56% in the non-ECPR V-A group and 66.7% in the COVID-19-negative V-V group.
Editorial Material
Urology & Nephrology
J. Pedro Teixeira, Ashita J. Tolwani
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Wesley H. Self, Matthew S. Shotwell, Kevin W. Gibbs, Marjolein de Wit, D. Clark Files, Michelle Harkins, Kristin M. Hudock, Lisa H. Merck, Ari Moskowitz, Krystle D. Apodaca, Aaron Barksdale, Basmah Safdar, Ali Javaheri, Jeffrey M. Sturek, Harry Schrager, Nicole Iovine, Brian Tiffany, Ivor S. Douglas, Joseph Levitt, Laurence W. Busse, Adit A. Ginde, Samuel M. Brown, David N. Hager, Katherine Boyle, Abhijit Duggal, Akram Khan, Michael Lanspa, Peter Chen, Michael Puskarich, Derek Vonderhaar, Lokesh Venkateshaiah, Nina Gentile, Yves Rosenberg, James Troendle, Amanda J. Bistran-Hall, Josh DeClercq, Robert Lavieri, Meghan Morrison Joly, Michael Orr, Jill Pulley, Toddw. Rice, Jonathan S. Schildcrout, Matthew W. Semler, Li Wang, Gordon R. Bernard, Sean P. Collins
Summary: Two randomized clinical trials found that RAS modulation (TXA-127 or TRV-027) did not improve oxygen-free days or outcomes in adults with severe COVID-19.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
J. Pedro Teixeira, Benjamin R. Griffin, Chaitanya Anil Pal, Felipe Gonzalez-Seguel, Nathanial Jenkins, Beth M. Jones, Yuri Yoshida, Naomi George, Hayley Puffer Israel, Lama Ghazi, Javier A. Neyra, Kirby P. Mayer
Summary: Acute kidney injury requiring renal replacement therapy (AKI- RRT) is common in the ICU and is associated with significant morbidity and mortality. The impact of AKI- RRT on skeletal muscle mass and function during and following critical illness remains unknown.
Article
Medicine, Research & Experimental
Daniel Q. Huang, Veeral Ajmera, Christian Tomaszewski, Andrew LaFree, Ricki Bettencourt, Wesley K. Thompson, Davey M. Smith, Atul Malhotra, Ravindra L. Mehta, Vaishal Tolia, Jeffrey Yin, Paul A. Insel, Stone Leachman, Jinho Jung, Summer Collier, Lisa Richards, Kristin Woods, Maral Amangurbanova, Archana Bhatt, Xinlian Zhang, Oana M. Penciu, Stuart Zarich, Tamrat Retta, Michelle S. Harkins, J. Pedro Teixeira, Brian Chinnock, Netanya S. Utay, Jordan E. Lake, Rohit Loomba
Summary: This study evaluated the efficacy of the ACE inhibitor ramipril in the treatment of COVID-19 through a clinical trial on patients with the virus. The results showed that ramipril was not significantly different from placebo in improving or worsening clinical outcomes of COVID-19, but it appeared to be safe in non-critically ill patients.
ADVANCES IN THERAPY
(2023)
Article
Urology & Nephrology
J. Pedro Teixeira, Lisa Saa, Kevin A. A. Kaucher, Ruben D. D. Villanueva, Michelle Shieh, Crystal R. R. Baca, Brittany Harmon, Zanna J. J. Owen, Ismael Mendez Majalca, Darren W. W. Schmidt, Namita Singh, Saeed K. K. Shaffi, Zhi Q. Q. Xu, Thomas Roha, Jessica A. A. Mitchell, Sevag Demirjian, Christos P. P. Argyropoulos
Summary: This study reports the emergency implementation and outcomes of locally produced continuous kidney replacement therapy (CKRT) dialysate during the COVID-19 pandemic. By utilizing intermittent hemodialysis machines, hemodialysis concentrate, sterile parenteral nutrition bags, and 3D printed biocompatible connectors, 22 patients were successfully treated. Analysis of limited sample size showed that the locally produced dialysate had appropriate electrolyte composition, endotoxin levels, and no bacterial contamination. No catheter-associated bloodstream infections occurred within 7 days of exposure to the locally produced dialysate.
Article
Anesthesiology
J. Pedro Teixeira, Lance M. Larson, Kristin M. Schmid, Keith Azevedo, Erik Kraai
INTERNATIONAL ANESTHESIOLOGY CLINICS
(2023)
Letter
Medicine, General & Internal
Olivier C. Manintveld, Stefan Roest, Yannick J. H. J. Taverne
Summary: In the study by Suverein et al., the use of extracorporeal cardiopulmonary resuscitation (CPR) in patients with refractory out-of-hospital cardiac arrest was examined. The results showed similar survival rates with a favorable neurologic outcome between extracorporeal CPR and conventional CPR. This raises questions about the role of extracorporeal CPR as an adjunct to conventional CPR.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ivy Hurwitz, Alexandra V. Yingling, Teah Amirkabirian, Amber Castillo, Jehanzaeb J. Khan, Alexandra Do, Dominic K. Lundquist, October Barnes, Christophe G. Lambert, Annabeth Fieck, Gregory Mertz, Clinton Onyango, Samuel B. Anyona, J. Pedro Teixeira, Michelle Harkins, Mark Unruh, Qiuying Cheng, Shuguang Leng, Philip Seidenberg, Anthony Worsham, Jens O. Langsjoen, Kristan A. Schneider, Douglas J. Perkins
Summary: Epidemiological data in the United States show health disparities in COVID-19 infection, hospitalization, and mortality among different racial/ethnic groups. This study conducted at the University of New Mexico Hospital found that American Indian or Alaska Native (AI/AN) populations had a higher risk of severe COVID-19 and death compared to other racial/ethnic groups, even when adjusting for symptom onset and comorbid conditions.