Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 37, Issue 3, Pages 251-259Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-015-0475-7
Keywords
CD8(+) T cells; CD4(+) T cells; Cytotoxicity; Dendritic cells; Immunotherapy; Immunopathology; Leishmania; Macrophages; MHC class I; Phagolysosome; Th1 cells and vaccine
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Funding
- NIH [AI106842, AI088650]
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CD8(+) T lymphocytes are components of the adaptive immune response and play an important role in protection against many viral and bacterial infections. However, their role in parasitic infections is less well understood. In leishmaniasis, a disease caused by intracellular protozoan parasites of the genus Leishmania, CD8(+) T cells have been shown to be protective. However, increasing evidence indicates that CD8(+) T cells may also exacerbate disease. In this review, we will describe the situations where CD8(+) T cells are either good or bad for the outcome of the infection and attempt to reconcile the dual role played by CD8(+) T cells in cutaneous leishmaniasis.
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