Vasculopathy in scleroderma

A possible contribution of endothelial CCN1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis

(2015) Ryosuke Saigusa et al.   EXPERIMENTAL DERMATOLOGY

Fibrosis, Vascular Activation, and Immune Abnormalities Resembling Systemic Sclerosis in Bleomycin-Treated Fli-1-Haploinsufficient Mice

(2015) Takashi Taniguchi et al.   Arthritis & Rheumatology

Pericytes as targets in hereditary hemorrhagic telangiectasia

(2015) Jérémy Thalgott et al.   Frontiers in Genetics

Rituximab for refractory digital infarcts and ulcers in systemic sclerosis

(2014) Chiew-Gek Khor et al.   CLINICAL RHEUMATOLOGY

Successful experience of rituximab therapy for systemic sclerosis-associated interstitial lung disease with concomitant systemic lupus erythematosus

(2014) Hayakazu Sumida et al.   JOURNAL OF DERMATOLOGY

Dual endothelin receptor antagonism with bosentan reverses established vascular remodeling and dysfunctional angiogenesis in diabetic rats: Relevance to glycemic control

(2014) Mohammed Abdelsaid et al.   LIFE SCIENCES

Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene

(2014) Yohei Ichimura et al.   Modern Rheumatology

Dermal mast cell density in fingers reflects severity of skin sclerosis in systemic sclerosis

(2014) Sonosuke Yukawa et al.   Modern Rheumatology

The role of genetics and epigenetics in the pathogenesis of systemic sclerosis

(2014) Jasper C. A. Broen et al.   Nature Reviews Rheumatology

Correction: Capillary Regeneration in Scleroderma: Stem Cell Therapy Reverses Phenotype?

(2014) Jo N. Fleming et al.   PLoS One

Increased frequency of Th17 cells in systemic sclerosis is related to disease activity and collagen overproduction

(2014) Xiaoqin Yang et al.   ARTHRITIS RESEARCH & THERAPY

Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis

(2014) Shinji Noda et al.   Nature Communications

Transcriptional Regulation of Endothelial Cell and Vascular Development

(2013) Changwon Park et al.   CIRCULATION RESEARCH

Clinical correlation of brachial artery flow-mediated dilation in patients with systemic sclerosis

(2013) Takehiro Takahashi et al.   Modern Rheumatology

Targeting the endothelin axis in scleroderma renal crisis: rationale and feasibility

(2013) H. Penn et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis

(2013) S. Noda et al.   RHEUMATOLOGY

Toll-Like Receptor 4 Signaling Augments Transforming Growth Factor-β Responses

(2012) Swati Bhattacharyya et al.   AMERICAN JOURNAL OF PATHOLOGY

Bosentan fosters microvascular de-remodelling in systemic sclerosis

(2012) S. Guiducci et al.   CLINICAL RHEUMATOLOGY

Impaired IL-17 Signaling Pathway Contributes to the Increased Collagen Expression in Scleroderma Fibroblasts

(2012) T. Nakashima et al.   JOURNAL OF IMMUNOLOGY

Longterm Effects of Endothelin Receptor Antagonism on Microvascular Damage Evaluated by Nailfold Capillaroscopic Analysis in Systemic Sclerosis

(2012) M. CUTOLO et al.   JOURNAL OF RHEUMATOLOGY

Treatment of Systemic Sclerosis-Associated Calcinosis: A Case Report of Rituximab-Induced Regression of CREST-Related Calcinosis and Review of the Literature

(2012) Dimitrios Daoussis et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro

(2011) Zhaodong Li et al.   ARTHRITIS AND RHEUMATISM

CCN1/CYR61: the very model of a modern matricellular protein

(2011) Lester F. Lau   CELLULAR AND MOLECULAR LIFE SCIENCES

Imatinib mesylate for the treatment of pulmonary arterial hypertension

(2011) Henrik ten Freyhaus et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Ulnar artery occlusion is predictive of digital ulcers in SSc: a duplex sonography study

(2011) M. Frerix et al.   RHEUMATOLOGY

Angiogenesis and Vasculopathy in Systemic Sclerosis: Evolving Concepts

(2011) Bradley J. Rabquer et al.   Current Rheumatology Reports

Endothelial Fli1 Deficiency Impairs Vascular Homeostasis

(2010) Yoshihide Asano et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-endothelial cell antibodies in systemic sclerosis

(2010) C Mihai et al.   ANNALS OF THE RHEUMATIC DISEASES

Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial

(2010) M. Matucci-Cerinic et al.   ANNALS OF THE RHEUMATIC DISEASES

Endothelial function and hemodynamics in systemic sclerosis

(2010) Pascal Rossi et al.   CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

Future treatments in systemic sclerosis

(2010) Yoshihide ASANO   JOURNAL OF DERMATOLOGY

Cell Adhesion Molecules Regulate Fibrotic Process via Th1/Th2/Th17 Cell Balance in a Bleomycin-Induced Scleroderma Model

(2010) A. Yoshizaki et al.   JOURNAL OF IMMUNOLOGY

Endothelial progenitor cells: Quo Vadis?

(2010) Matthew R. Richardson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Brachial Artery Endothelial-dependent Flow-mediated Dilation Identifies Early-stage Endothelial Dysfunction in Systemic Sclerosis and Correlates with Nailfold Microvascular Impairment

(2010) D. ROLLANDO et al.   JOURNAL OF RHEUMATOLOGY

Therapeutic options for systemic sclerosis related interstitial lung diseases

(2010) Luc Mouthon et al.   RESPIRATORY MEDICINE

Mobilization of endothelial progenitor cells by intravenous cyclophosphamide in patients with systemic sclerosis

(2010) Y. Furuya et al.   RHEUMATOLOGY

Angiopoietins-1 and -2 are differentially expressed in the sera of patients with systemic sclerosis: high angiopoietin-2 levels are associated with greater severity and higher activity of the disease

(2010) Małgorzata Michalska-Jakubus et al.   RHEUMATOLOGY

Enhanced angiogenic potency of monocytic endothelial progenitor cells in patients with systemic sclerosis

(2010) Yukie Yamaguchi et al.   ARTHRITIS RESEARCH & THERAPY

Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis

(2010) Nobuyo Higashi-Kuwata et al.   ARTHRITIS RESEARCH & THERAPY

Endothelial–Mesenchymal Transition as a Novel Mechanism for Generating Myofibroblasts during Diabetic Nephropathy

(2009) Akane Kizu et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial-Myofibroblast Transition Contributes to the Early Development of Diabetic Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice

(2009) Jinhua Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial–Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis

(2009) Naozumi Hashimoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Arterial gene transfer of the TGF-β signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF

(2009) Rishi Kundi et al.   CARDIOVASCULAR RESEARCH

Significant improvement of right ventricular function by imatinib mesylate in scleroderma-associated pulmonary arterial hypertension

(2009) Henrik ten Freyhaus et al.   Clinical Research in Cardiology

Phosphorylation of Fli1 at Threonine 312 by Protein Kinase C   Promotes Its Interaction with p300/CREB-Binding Protein-Associated Factor and Subsequent Acetylation in Response to Transforming Growth Factor  

(2009) Y. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cyclophosphamide treatment improves microvessel damage in systemic sclerosis

(2008) Paola Caramaschi et al.   CLINICAL RHEUMATOLOGY

The impact of systemic sclerosis on arterial wall stiffness parameters and endothelial function

(2008) Alma Cypienė et al.   CLINICAL RHEUMATOLOGY

Imatinib for the treatment of refractory, diffuse systemic sclerosis

(2008) P. P. Sfikakis et al.   RHEUMATOLOGY

Autocrine TGF-β signaling in the pathogenesis of systemic sclerosis

(2007) Hironobu Ihn   JOURNAL OF DERMATOLOGICAL SCIENCE