Journal
SEMINARS IN IMMUNOLOGY
Volume 27, Issue 2, Pages 119-124Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2015.03.012
Keywords
Dendritic cells; Pathogens; Immune evasion; Tolerance
Categories
Funding
- European Commission
- Italian Ministry of Health
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Dendritic cells (DCs) are specialized antigen presenting cells (APC) that are fundamental to initiate both immunity and tolerance. DCs play a 'sentinel' role to protect our body from potential pathogens and induce tolerogenic responses toward harmless antigens. The flexibility of DCs or macrophages to adapt to the environment and to respond accordingly can be hijacked by pathogens for their own interest to transform a potentially immunogenic APC into a tolerogenic cell with clear consequences in pathogen clearance. While these immune evasion mechanisms can be detrimental for the host, they can highlight important molecular pathways in DCs necessary for their function. In this review we will mention several mechanisms employed by pathogens to evade DC patrolling function. (C) 2015 Elsevier Ltd. All rights reserved.
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