Review
Chemistry, Medicinal
Jiao Qu, Qianqian Liu, Guoquan You, Ling Ye, Yiguang Jin, Lingdong Kong, Wenjie Guo, Qiang Xu, Yang Sun
Summary: Andrographolide, a natural lactone with a range of pharmacological actions in traditional Chinese medicine, shows promising potential in treating inflammatory diseases and cancers. Its effects have been studied extensively in preclinical use and clinical trials, highlighting advancements in both disease categories.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Luis A. Constantino-Jonapa, Yoshua Espinoza-Palacios, Alma R. Escalona-Montano, Paulina Hernandez-Ruiz, Luis M. Amezcua-Guerra, Amedeo Amedei, Maria M. Aguirre-Garcia
Summary: Trimethylamine N-oxide (TMAO) is associated with increased incidence of cardiovascular diseases and is affected by factors such as diet, drugs, age, and hormones. Recent studies have shown that gut dysbiosis is a new approach for understanding various inflammatory diseases. Diabetic and obese patients have increased levels of TMAO, which is directly correlated with cardiovascular diseases.
Article
Pharmacology & Pharmacy
Roman Drai, Tatiana L. Karonova, Alexander Y. Mayorov, Igor E. Makarenko, Artem R. Dorotenko, Viktoria S. Kulesh, Vladislav V. Kovalik, Alena T. Andreeva
Summary: This clinical trial compared the pharmacokinetics and pharmacodynamics of GP40071 and NovoRapid Penfill in a hyperinsulinemic euglycemic clamp. The results demonstrated the bioequivalence, similar pharmacokinetics and pharmacodynamics, and comparable safety profiles of GP40071 and NovoRapid Penfill.
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2022)
Article
Chemistry, Multidisciplinary
Jungyoon Ohn, Mingyu Jang, Bo Mi Kang, Huisuk Yang, Jin Tae Hong, Kyu Han Kim, Ohsang Kwon, Hyungil Jung
Summary: The newly designed candle flame-shaped TA-loaded dissolving microneedles can effectively treat chronic inflammatory skin diseases, reduce patient pain, and are favored by dermatologists.
Review
Chemistry, Analytical
Isidro Badillo-Ramirez, Yojana J. P. Carreon, Claudia Rodriguez-Almazan, Claudia M. Medina-Duran, Selene R. Islas, Jose M. Saniger
Summary: This article introduces the recent advances and potential of graphene derivative materials (GDMs) in developing biosensors. These materials have excellent properties and play an important role in the simple, accurate, and sensitive detection of biomarkers. Through electrochemical and optical sensing methods, these materials can be integrated into robust, wearable, remote, and smart biosensor devices for the detection of biomarkers for chronic inflammatory diseases.
Article
Medicine, Research & Experimental
Ran Jin, Chidozie Nduka, Delphine Courmier, Hannah Knight, Rachael Meadows, James Piercy, J. R. F. Cummings, Waldemar Radziszewski
Summary: The use of ABP 501 biosimilar in the treatment of inflammatory bowel disease has shown positive outcomes and high satisfaction among patients.
ADVANCES IN THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Santina Venuto, Anna Rita Daniela Coda, Ruperto Gonzalez-Perez, Onofrio Laselva, Doron Tolomeo, Clelia Tiziana Storlazzi, Arcangelo Liso, Massimo Conese
Summary: The lung is an important organ for gas exchange and immune response. The insulin-like growth factor (IGF) system and its binding proteins (IGFBPs) play a role in the development of the lung as well as the pathogenesis of respiratory diseases and lung tumors. Among the IGFBPs, IGFBP-6 has emerged as a mediator of airway inflammation and tumor suppression in lung tumors. This review focuses on the multiple roles of IGFBP-6 in respiratory diseases, including its function in inflammation, fibrosis, and different types of lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Anna Torun, Anna Hupalowska, Piotr Trzonkowski, Jaroslaw Kierkus, Beata Pyrzynska
Summary: The incidence and prevalence of chronic inflammatory disorders are increasing in the pediatric population, with recent research highlighting the importance of interactions between altered intestinal microbiome and the immune system in disease pathogenesis. Therapies for these disorders mainly focus on symptom management, with sustained improvement being difficult to achieve due to challenges like changing physiology and susceptibility to adverse medication effects in children. New therapeutic approaches targeting the gut microbiota and immune system hold promise for inducing long-lasting remission and improving the quality of life for pediatric patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Maartje M. M. van de Meeberg, Renske C. F. Hebing, Michael T. T. Nurmohamed, Herma H. H. Fidder, Martijn W. W. Heymans, Gerd Bouma, Marjolein S. S. de Bruin-Weller, Janneke Tekstra, Bart van den Bemt, Robert de Jonge, Maja Bulatovic Calasan
Summary: This study investigates the relationship between MTX-PG concentration and disease activity in RA, JIA, and psoriasis. Higher concentrations of MTX-PG are significantly associated with lower disease activity. These findings are important for the implementation of TDM in the treatment of various IMIDs.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Rheumatology
Jerome Avouac, Rodolphe Cougnaud Murail, Claire Goulvestre, Sophie Dumas, Anna Molto, Corinne Miceli-Richard, Ornella Conort, Frederic Batteux, Yannick Allanore
Summary: This study aimed to investigate the risk of immunogenicity of GP2013 in patients with chronic inflammatory rheumatic disorders. The results showed a low risk of immunogenicity with GP2013, and switching to GP2013 did not increase the risk. However, patients with high antibody levels may experience reduced treatment efficacy.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Review
Immunology
Hanae Miyazawa, Taizo Wada
Summary: This review discusses recent findings in inflammatory diseases associated with chronic excess of serum IL-18 and describes the clinical and therapeutic relevance of understanding the pathology of this group of diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Geriatrics & Gerontology
Shun Liu, Weihua Nong, Lin Ji, Xiuhong Zhuge, Huimei Wei, Min Luo, Leguang Zhou, Shenghua Chen, Shun Zhang, Xiaocan Lei, Hua Huang
Summary: Inflammation and telomeres are involved in a feedback regulatory loop, where inflammation increases telomere attrition and telomere components participate in regulating the inflammatory response. The specific mechanism behind this feedback loop is not fully understood.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Pharmacology & Pharmacy
Vardhipathi Sravana Swathi, Shrishti Saroha, Jai Prakash, Shashi Bhushan
Summary: The study in India found that the age group of 40-80 years is at high risk for NSAIDs-induced CKD, with a majority being male and most cases caused by diclofenac. About 79% of the cases were serious, requiring hospitalization for further treatment, and NSAIDs were discontinued in 86% of the cases.
INDIAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jerko Stambuk, Frano Vuckovic, Sinisa Habazin, Maja Hanic, Mislav Novokmet, Susanna Nikolaus, Florian Tran, Stefan Schreiber, Andre Franke, Philip Rosenstiel, Gordan Lauc, Konrad Aden, Marija Pezer
Summary: Immunosuppressants and biologicals impact the glycosylation of serum immunoglobulin G (IgG) in patients with chronic inflammatory diseases (CID). The study reveals a decrease in IgG glycosylation in CID patients, while an increase in glycosylation is observed in patients undergoing therapy and in remission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Yi Xing, Xun Sun, Yiming Dou, Min Wang, Yanmei Zhao, Qiang Yang, Yanhong Zhao
Summary: Extracellular vesicles (EVs) act as natural nanocarriers and intercellular messengers, playing a crucial role in cell communication, while macrophage-derived EVs may have significant implications in the development of chronic inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Walter P. Maksymowych, Nele Herregods, Nisha Varma, Arthur B. Meyers, Jennifer Stimec, Andrea S. Doria, Nikolay Tzaribachev, Tarimobo M. Otobo, Marion A. van Rossum, Joel Paschke, Stephanie Wichuk, Robert G. Lambert
Summary: This study aimed to investigate whether systematic calibration improves the scoring proficiency of JAMRIS-SIJ and whether contrast-enhancement enhances its performance. The results showed that calibrated readers achieved greater reliability in scoring specific inflammatory and structural lesions. Sensitivity and reliability for scoring inflammatory lesions were higher on fluid-sensitive sequences compared to contrast-enhanced sequences. Therefore, systematic calibration should be implemented before using JAMRIS-SIJ in clinical trials, and it is unlikely that contrast-enhanced MRI will improve the performance of this method.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
L. van Ouwerkerk, S. A. Bergstra, T. D. Maarseveen, T. W. J. Huizinga, R. Knevel, C. F. Allaart
Summary: This study evaluated whether the initial use of glucocorticoid (GC) bridging in RA patients leads to a higher probability of long-term GC and bDMARD use. The results showed that patients who initially started GC had a higher risk of later GC use, but the risk of bDMARD use was not significantly increased.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu
Summary: This study assessed the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. The results showed that in women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation and arrhythmias, but the cardiovascular risk in men with osteoporosis is uncertain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)