4.2 Article

Synthesis of 8-oxoprotoberberines using acid-mediated cyclization or the Heck reaction

Journal

MONATSHEFTE FUR CHEMIE
Volume 143, Issue 5, Pages 825-830

Publisher

SPRINGER WIEN
DOI: 10.1007/s00706-011-0656-6

Keywords

8-Oxoprotoberberines; Acid-mediated; Cyclization; Heck reaction

Funding

  1. Chinese National Science & Technology Major Project Key New Drug Creation and Manufacturing Program [2009ZX09301-001, 2009ZX09102-022]
  2. National Natural Science Foundation of China [30925040, 90713046, 30772638, U0633008]
  3. CAS Foundation [KSCX2-YW-R-168, KSCX2-YW-R-179]
  4. Shanghai Commission of Science and Technology [08DZ2291300, 09DZ2291200, 09431902100]
  5. National Hi-Tech Research and Development Program Grant of China [2007AA09Z402, 2007AA02Z147, 2008AA02Z105]

Ask authors/readers for more resources

A facile method of synthesizing 8-oxoprotoberberines is described from 6-benzoyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbaldehyde via acid-mediated cyclization or from 2-(2-iodophenethyl)isoquinolin-1(2H)-one via the Heck reaction. The present method offers several advantages, such as good yields and a simple procedure.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.2
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available