Article
Immunology
Lingtong Huang, Xueling Fang, Xuan Zhang, Weifang Wu, Hangping Yao, Qiang Fang
Summary: The study confirmed the expression of the RON receptor in BMDCs, showing that inhibiting RON affects the ubiquitination levels of MHC II and CD86, leading to decreased levels of these molecules and reducing the ability of DCs to promote T cell proliferation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Sun Kyung Kim, Jintaek Im, Eun Byeol Ko, Dongwook Lee, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun Han
Summary: This study investigated the role of lipoteichoic acid (LTA) in the activation of human dendritic cells (DCs) stimulated with Streptococcus gordonii. The results showed that LTA interferes with bacteria-induced DC maturation, suggesting its potential role in immune evasion.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jun-Ho Lee, So-Yeon Choi, Soo-Yeoun Park, Nam-Chul Jung, Kyung-Eun Noh, Ji-Hee Nam, Ji-Soo Oh, Hyun-Ji Choi, Ji-Su Jang, Ji-Young Yoo, Jie-Young Song, Han Geuk Seo, Dae-Seog Lim
Summary: The study investigated the biological effects of Enpp2 on dendritic cells (DCs) and found that Enpp2 is essential for the migration capacity of mature DCs (mDCs) to lymph nodes, enhancing our understanding of DC biology. Regulating Enpp2 may improve DC migration to lymph nodes, thereby enhancing the effectiveness of cancer vaccines based on DCs.
Review
Immunology
Madison R. R. Smith, Lisa R. Forbes Satter, Alexander Vargas-Hernandez
Summary: The STAT5 proteins play important roles in immune regulation and hematopoietic cell development. Specific mutations in STAT5B have been identified and associated with immune dysregulation and malignant transformation. Inactivating mutations result in growth impairment, recurrent infections, and immune dysregulation, while gain of function mutations cause dysregulated allergic inflammation. These rare mutations provide a disease model for studying the biological mechanisms of STAT5 and have implications for therapy using Jak inhibitors in autoimmune and malignant disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hei Jung Kim, Joanna Bandola-Simon, Satoshi Ishido, Nathan W. Wong, Vishal N. Koparde, Maggie Cam, Paul A. Roche
Summary: Ubiquitination plays a crucial role in regulating MHC-II turnover on dendritic cells, impacting their ability to activate CD4 T cells and secrete IL-12. While MHC-II ubiquitination mutants exhibit functional defects, these can be reversed by activating DCs with LPS.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Polymer Science
Cuifang Wu, Lijing Teng, Caiyuan Wang, Tianbao Qian, Zuquan Hu, Zhu Zeng
Summary: This review first summarizes the gelation mechanisms of hydrogels, followed by highlighting the significant effects of developing hydrogels on DC function and discussing potential molecular mechanisms. Finally, persisting questions and future perspectives are presented.
Review
Immunology
Xinyu Liu, Yuanheng Li, Xiaoying Jiang, Yu'en Deng, Chuanwei Ma, Qiongfang Yu, Dian Gao
Summary: Long non-coding RNAs (LncRNAs) modulate immune function by regulating gene expression or protein function, affecting the maturity, differentiation and activation of immune cells, as well as cytokine release and immune phenotype. They play a critical role in dendritic cells (DCs) and their cell phenotype and immune function. Factors such as tumors, inflammation, autoimmune disease, viral infection, and age can impact LncRNAs in DCs and alter their function and behavior. This review provides a better understanding of the multiple effects of LncRNAs on cell function in DCs.
CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Weiya Zhang, Yuan Liu, Hong Zhang
Summary: The extracellular matrix plays a crucial role in tissue development and muscle fiber environment, providing structural support and influencing physiological functions. The review provides an in-depth overview of ECM structure, components, its role in skeletal muscle development, and applications in biomedical engineering.
CELL AND BIOSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Ane Goikolea-Vives, Helen B. Stolp
Summary: Neurodevelopmental disorders can result from a complex interplay of genetic variation and environmental factors, leading to overlapping mechanisms of cellular injury and dysfunction. Disrupted neuronal arborisation and synapse formation are common features in these conditions, primarily affecting the cortex and hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yanan Tong, Guoxiu Lu, Zhiguo Wang, Shanhu Hao, Guoxu Zhang, Hongwu Sun
Summary: In this study, a new dendritic cell (DC) vaccine was developed to improve the efficacy of colorectal cancer (CRC) immunotherapy. The vaccine utilized a plant-derived adjuvant called tubeimuside I (TBI) to enhance the immune response and inhibit F. nucleatum infection. Encapsulating TBI in a nanoemulsion significantly improved drug efficacy and reduced dosage and administration times.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Kyu-Won Lee, Judy Wai Ping Yam, Xiaowen Mao
Summary: In the era of cancer immunotherapy, immune checkpoint blockades (ICBs) and adoptive cell transfer therapies (ACTs) have limitations. Dendritic cell (DC)-based vaccines are suggested as a new cancer immunotherapy regimen that can address these limitations. Different types of innovative DC vaccines are under investigation, which are expected to provide breakthroughs in cancer immunotherapy.
Review
Medicine, General & Internal
Cheng Yan, Haojie Wu, Xianchun Fang, Junji He, Feng Zhu
Summary: Platelets, as anucleate blood components, play a crucial role in regulating hemostasis and thrombosis. They not only participate in hemostasis but also have the ability to influence innate and adaptive immune responses. This review summarizes platelet development and their functions in hemostasis, as well as the interactions between platelet products and innate or adaptive immune cells. Understanding the exact mechanisms underlying these effects will contribute to the further application of platelet transfusion.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Martina Musella, Andrea Guarracino, Nicoletta Manduca, Claudia Galassi, Eliana Ruggiero, Alessia Potenza, Ester Maccafeo, Gwenola Manic, Luca Mattiello, Sara Soliman Abdel Rehim, Michele Signore, Marco Pietrosanto, Manuela Helmer-Citterich, Matteo Pallocca, Maurizio Fanciulli, Tiziana Bruno, Francesca De Nicola, Giacomo Corleone, Anna Di Benedetto, Cristiana Ercolani, Edoardo Pescarmona, Laura Pizzuti, Francesco Guidi, Francesca Sperati, Sara Vitale, Daniele Macchia, Massimo Spada, Giovanna Schiavoni, Fabrizio Mattei, Adele De Ninno, Luca Businaro, Valeria Lucarini, Laura Bracci, Eleonora Arico, Giovanna Ziccheddu, Francesco Facchiano, Stefania Rossi, Massimo Sanchez, Alessandra Boe, Mauro Biffoni, Ruggero De Maria, Ilio Vitale, Antonella Sistigu
Summary: The study demonstrates that type I interferons can promote the formation of cancer stem cells by upregulating the chromatin remodeling factor KDM1B. Inhibition of KDM1B could potentially prevent stem cell expansion and increase the long-term benefit of therapy.
Review
Immunology
Grzegorz Krzak, Cory M. Willis, Jayden A. Smith, Stefano Pluchino, Luca Peruzzotti-Jametti
Summary: The rapidly evolving field of immunometabolism has highlighted the key signaling roles of metabolites in cellular communication, with recent evidence focusing on the succinate-SUCNR1 axis as a crucial regulator of tissue homeostasis. Succinate signaling through SUCNR1 guides diverse immune cell responses, which are influenced by tissue and context. This research explores cellular pathways regulated by the succinate-SUCNR1 axis and its impact on myeloid cell function, aiming to identify new therapeutic targets for addressing detrimental myeloid cell responses in tissues, including those in the persistently inflamed central nervous system (CNS).
TRENDS IN IMMUNOLOGY
(2021)
Article
Immunology
Shinji Morisaki, Hideya Onishi, Takafumi Morisaki, Makoto Kubo, Masayo Umebayashi, Hiroto Tanaka, Norihiro Koya, Shinichiro Nakagawa, Kenta Tsujimura, Sachiko Yoshimura, Poh Yin Yew, Kazuma Kiyotani, Yusuke Nakamura, Masafumi Nakamura, Takanari Kitazono, Takashi Morisaki
Summary: Through analysis of four patients, we found that intranodal vaccination with hybrid neoantigen-pulsed DCs successfully induced a strong immune response and provided insight into the mechanisms of action, suggesting future directions in neoantigen vaccine design.
FRONTIERS IN IMMUNOLOGY
(2023)