Article
Cell & Tissue Engineering
Tao Li, Kelsey L. Conroy, Amy M. Kim, Julian Halmai, Kewa Gao, Emily Moreno, Aijun Wang, Anthony G. Passerini, Jan A. Nolta, Ping Zhou
Summary: Human induced pluripotent stem cells (hiPSCs) have great potential as a source of vascular cells for therapy and as a model for studying vascular cell differentiation and functionality. This study found that the MEF2C transcription factor was significantly upregulated during the differentiation of vascular progenitors and endothelial cells (ECs) from hiPSCs. Vascular endothelial growth factors (VEGF) induced MEF2C expression in endothelial lineage cells, and this upregulation was dependent on extracellular signal regulated kinase (ERK). Knockdown of MEF2C reduced the migration and tube formation capacity of hiPSC-derived ECs. The study also identified TNF-related apoptosis inducing ligand (TRAIL) and transmembrane protein 100 (TMEM100) as novel targets of MEF2C. These findings highlight the importance of MEF2C in regulating human EC functions and suggest its potential as a therapeutic target for vascular malfunction-associated diseases.
Article
Biochemistry & Molecular Biology
Min Choi, Seung Min Lee, Jin Woo Lee, Inki Kim, Chan-Gi Pack, Chang Hoon Ha
Summary: This study investigated the correlation between yeast-derived 13-glucan and HDAC5 in human umbilical vein endothelial cells (HUVECs), revealing that 13-glucan induces angiogenesis through HDAC5. The study showed that 13-glucan stimulates HDAC5 phosphorylation, leading to its translocation from the nucleus to the cytoplasm. This translocation mediates the transcriptional activation of MEF2 and the expression of MEF2-dependent genes involved in angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, Research & Experimental
Anastasia Chilla, Cecilia Anceschi, Elena Frediani, Francesca Scavone, Tommaso Del Rosso, Giuseppe Pelagio, Antonio Tufaro, Giuseppe De Palma, Mario Del Rosso, Gabriella Fibbi, Paola Chiarugi, Anna Laurenzana, Francesca Margheri
Summary: Studies have found that inhibitors of matrix metalloproteinase (MMPs) as anti-tumoral drugs have been disappointing. Recent research shows that endothelial cells and endothelial colony forming cells (ECFCs) can switch invasion modes and perform amoeboid angiogenesis in the absence of protease activity. TIMP1, TIMP2, and TIMP3 have been identified as high-powered protease inhibitors that can induce amoeboid invasion of ECFCs, while Marimastat promotes ECFC invasion and tubular formation. It is important to consider the amoeboid mechanism of invasion in developing new cancer drugs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
F. Fahmideh, N. Marchesi, L. I. M. Campagnoli, L. Landini, C. Caramella, A. Barbieri, S. Govoni, A. Pascale
Summary: Diabetic retinopathy is one of the most common complications of diabetes, and current pharmacological approaches are limited. This study found that a molecular cascade triggered by hyperglycemia can be blocked to prevent the increase of VEGF in the retina, providing a new pharmacological option for preventing the development of diabetic retinopathy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yanfen Cui, Hui Liu, Zhaosong Wang, He Zhang, Jianfei Tian, Zhiyong Wang, Weijie Song, Hui Guo, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Fei Zhang, Ruifang Niu
Summary: High fructose intake is associated with increased risk of multiple cancers. Fructose can enhance the biological function of vascular endothelial cells (VECs) and promote angiogenesis by activating the Akt and Src signaling pathways. It can also upregulate production of reactive oxygen species (ROS) in colorectal cancer cells, indirectly enhancing the function of VECs. These findings have been validated in clinical colorectal cancer tissues and mouse models.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Rahul Mallick, Erika Gurzeler, Pyry I. Toivanen, Tiina Nieminen, Seppo Yla-Herttuala
Summary: VEGF-B186R127S induces vascular growth in mouse heart by recruiting EPCs. It is a novel therapeutic agent for cardiac therapeutic angiogenesis to rescue myocardial tissue after an ischemic insult.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Genetics & Heredity
Shu Yan, Ji Hu, Jia Li, Pengchao Wang, Yilong Wang, Zhaohui Wang
Summary: PRMT4 is upregulated in ischemic muscles and promotes angiogenesis. It regulates VEGF expression by interacting with YB1. Knockdown of YB1 attenuates PRMT4-mediated angiogenic effects in vitro.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Cell Biology
Aikaterini Gatsiou, Kateryna Sopova, Alexandros Tselepis, Konstantinos Stellos
Summary: Platelets are immune cells known for their haemostatic properties and play a key role in vascular regeneration and angiogenesis by releasing growth factors. The IL-17A/IL-17RA axis selectively induces the release of pro-angiogenic factors from platelets, affecting endothelial cells and driving them towards a pro-angiogenic state.
Article
Oncology
YanJie Lu, HanZheng Zhao, Ying Liu, YanZhen Zuo, Qian Xu, Lei Liu, XiaoMin Li, HongBin Zhu, Ying Zhang, Shuling Zhang, XiangYang Zhao, YuHong Li
Summary: Chronic stress can exacerbate tumor angiogenesis, primarily through elevating stress-related hormone levels and causing behavioral changes in individuals. Utilizing isoprenaline as an agonist of beta 2-adrenergic receptor, the study demonstrated the molecular mechanisms of stress in tumor angiogenesis both in vivo and in vitro. Isoprenaline promotes VEGF autocrine in HUVECs, up-regulating plexinA1 and VEGFR2 levels, leading to activation of the JAK2-STAT3 signaling pathway essential for angiogenesis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Biochemistry & Molecular Biology
Yaqian Wang, Fangfang Chen, Yuan Zhang, Xiangyu Zheng, Shiyan Liu, Meijuan Tang, Ziling Wang, Pan Wang, Yongping Bao, Dan Li
Summary: Sulforaphane (SFN) was found to promote migration and tube formation of HUVECs under hypoxic conditions, while alleviating hypoxia-induced proliferation retardation. Additionally, SFN protected against hypoxia-induced mitochondrial injury and regulated angiogenesis via modulation of Nrf2 and mitochondrial dynamics.
Article
Neurosciences
Wen Zeng, Qiaoling Lei, Jiao Ma, Shuqiang Gao, Rong Ju
Summary: This study investigated the biological effects of EPC-derived MVs on BMECs, showing that EPC-MVs can enhance BMEC viability, proliferation, migration, and tube formation. These results suggest the proangiogenic effect of EPC-derived MVs on BMECs, which holds potential applications in cell-free therapy for brain injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Polymer Science
Ana C. Manjua, Joaquim M. S. Cabral, Frederico Castelo Ferreira, Carla A. M. Portugal
Summary: This work demonstrates the ability to remotely control the paracrine performance of MSCs in secreting VEGF-A by modulation of an external magnetic field. Higher magnetic field intensity is associated with increased cell death and poor angiogenic effect. Dynamic magnetic field and higher frequency stimulation improve the angiogenic performance of endothelial cells.
Article
Engineering, Biomedical
Ping Wu, Zan Tong, Lihua Luo, Yanan Zhao, Feixiang Chen, Yinping Li, Celine Huselstein, Qifa Ye, Qingsong Ye, Yun Chen
Summary: The combination of VEGF and Schwann cells in peripheral nerve repair shows promising results in promoting nerve regeneration. The HSPS conduits loaded with VEGF-A overexpressing Schwann cells demonstrate high durability and efficiency in repairing nerve tissue, making them a potential new avenue for nerve tissue engineering.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Yi-Fan Chou, Yu-Hsuan Lan, Jun-Han Hsiao, Chiao-Yun Chen, Pei-Yu Chou, Ming-Jyh Sheu
Summary: Curcumin and demethoxycurcumin demonstrated antiangiogenic activity via the inhibition of endoglin/Smad1 signaling. Combination treatment with curcuminoids and semaxanib is expected to reverse semaxanib resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)