Article
Toxicology
Min-Sung Kang, Sung-Hwan Kim, Mi-Jin Yang, Hyeon-Young Kim, In-Hyeon Kim, Jeong Won Kang, Hye-Sook Choi, Seung-Woo Jin, Eun-Jung Park
Summary: This study investigated the pathological and immune changes after instillation of polyhexamethylene guanidine phosphate (PHMG-P) in mice lungs, and found that cell death, pathological lesions, and inflammatory response may play important roles in PHMG-P-induced lung fibrosis.
TOXICOLOGY LETTERS
(2022)
Article
Environmental Sciences
Jun Woo Kim, Mi Ho Jeong, Hyeong Tae Yu, Yong Joo Park, Hyung Sik Kim, Kyu Hyuck Chung
Summary: Polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, causes lung diseases and fibrosis. This study found that small extracellular vesicles (sEVs) from bronchoalveolar lavage fluid (BALF) of PHMG-p-exposed mice can activate naive macrophages and aggravate fibrogenesis through proteins such as fibrinogen.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Seri Choi, Sunkyung Choi, Yeongsoo Choi, Namjoon Cho, Seung-Yeon Kim, Chang Hyun Lee, Han-Jin Park, Won Keun Oh, Kee K. Kim, Eun-Mi Kim
Summary: The study investigated the impact of PHMG-p on human lung tissue models under oxidative stress and viral infection, revealing that PHMG-p induced SG formation and severe lung toxicity. Evaluation of toxicity under stressful conditions is crucial for accurately predicting the potential effects of chemicals on the respiratory tract.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Minjeong Kim, Sumin Hur, Kwang H. Kim, Yejin Cho, Keunyoung Kim, Ha Ryong Kim, Ki Taek Nam, Kyung-Min Lim
Summary: This study developed a new mouse model of liver fibrosis using PHMG-p, which induced liver fibrosis in multiple regions and affected key genes and pathways associated with human liver fibrosis. The model provides a new tool for studying the pathophysiology of liver fibrosis and establishing effective treatment strategies.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Environmental Sciences
Hyo-Seon Yang, Mijin Yang, Mihyun Kang, Bumseok Kim, Kyuhong Lee
Summary: Humidifier disinfectant (HD) is a causative agent of atypical lung injury reported in South Korea in 2011. Limited research has been conducted on the association between reported diseases and HD exposure, as well as the progression of diseases caused by HD exposure. In this study, the effects of HD inhalation on rats were investigated.
Article
Chemistry, Physical
Qiuhu Lin, Lili Wu, Wei Hu, Xiaodong Wan, Zhongkui Wu, Chaocan Zhang
Summary: In this study, the PVDF micropore membrane was surface modified with PHMG coating and TA immobilization, resulting in excellent antifouling and antibacterial properties.
SURFACES AND INTERFACES
(2022)
Article
Cell Biology
Arnoldo Cambronero-Urena, Sunkyung Choi, Seri Choi, Kee K. Kim, Eun-Mi Kim
Summary: This study aimed to confirm the effects of certain substances on cell behavior. SG formation was not observed after treatments with the substances, and there was no change in the phosphorylation of the translation initiation factor eIF2 alpha. These findings could help determine the biological hazards of these materials.
ANIMAL CELLS AND SYSTEMS
(2021)
Article
Biochemistry & Molecular Biology
Jeongah Song, Kyung-Jin Jung, Mi-Jin Yang, Woojin Kim, Byoung-Seok Lee, Seong-Kyu Choe, Seong-Jin Kim, Jeong-Ho Hwang
Summary: This study investigated the cause of fatal lung injury caused by inhaled polyhexamethylene guanidine phosphate (PHMG-P) and demonstrated that the disruption of membrane integrity through ionic interaction is the initiating event of PHMG-P toxicity. Fibrotic changes in the lungs and increased production of inflammatory cytokines were detected only in the group that received intratracheal instillation of PHMG-P.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jong-Hwan Woo, Ki Cheon Kim, Hyeon-Young Kim, In-Hyeon Kim, Sung-Hwan Kim, Kyuhong Lee
Summary: This study compared the pulmonary toxicity of PHMG in different rat strains and found that F344 and SD rats had higher mortality rates compared to Wistar rats. Body weight decreased in all rat strains after PHMG instillation but gradually recovered. Lung weights increased in all rat strains after dose-dependent PHMG instillation. Histopathological analysis revealed inflammation and cell infiltration in all PHMG-instilled rat strains. Eosinophilic infiltration was only observed in SD and Wistar rats. TGF-beta 1-positive cells were present in the lung tissues of all rat strains, while IL-5-positive cells were only found in SD and Wistar rats. These results could assist in selecting experimental species for inhalation toxicity studies.
MOLECULAR & CELLULAR TOXICOLOGY
(2022)
Review
Respiratory System
Marya Ghazipura, Manoj J. Mammen, Derrick D. Herman, Stephanie M. Hon, Brittany D. Bissell, Madalina Macrea, Fayez Kheir, Yet H. Khor, Shandra L. Knight, Ganesh Raghu, Kevin C. Wilson, Tanzib Hossain
Summary: The study found that the use of nintedanib in patients with progressive pulmonary fibrosis significantly reduced disease progression but led to an increase in gastrointestinal side effects. Different subtypes of ILD showed varying responses to nintedanib, and the quality of evidence for these effects ranged from very low to moderate.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Paolo Cameli, Valerio Alonzi, Miriana d'Alessandro, Laura Bergantini, Elena Pordon, Marco Guerrieri, Rosa Metella Refini, Piersante Sestini, Elena Bargagli
Summary: This study aimed to investigate the effectiveness and safety of nintedanib in reducing functional disease progression in patients with IPF and PF-ILD. The results showed that nintedanib significantly reduced the decline rate of FVC in IPF and PF-ILD patients, but had no significant impact on FPF patients. Survival analysis revealed that gender and impaired lung function influenced the survival of patients.
Article
Chemistry, Analytical
Ju Kyung Lee, Han Na Suh, Sung Hoon Yoon, Kyu Hong Lee, Sae Young Ahn, Hyung Jin Kim, Sang Hee Kim
Summary: This study developed a one-step monitoring method for NADH using electrocatalytic reaction and successfully applied it to cell viability monitoring in cell culture supernatants.
Article
Biochemistry & Molecular Biology
Wen-Kuang Yu, Wei-Chih Chen, Vincent Yi-Fong Su, Hsiao-Chin Shen, Huai-Hsuan Wu, Hao Chen, Kuang-Yao Yang
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease, and pulmonary endothelial cells may generate pulmonary fibroblasts through endothelial mesenchymal transition (EndoMT), leading to pulmonary fibrosis. The tyrosine kinase receptor inhibitor, nintedanib, has been found to ameliorate bleomycin-induced pulmonary fibrosis and suppress EndoMT in vivo and in vitro models. These findings contribute to a better understanding of the mechanism and signaling pathway of EndoMT, and provide new insights for developing more effective drugs for IPF treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
S. Park, J. Y. Park, J. H. Nahm, G. Kim, Y. L. Cho, W. J. Kang, J. Key
Summary: This study prepared nintedanib-loaded poly (lactic-co-glycolic acid)-based discoidal polymeric particles (Nib-PLGA-DPPs) for the treatment of idiopathic pulmonary fibrosis (IPF). The Nib-PLGA-DPPs showed improved therapeutic efficacy in reducing fibrosis and inflammation compared to nintedanib alone.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Medicine, General & Internal
Donato Lacedonia, Michele Correale, Lucia Tricarico, Giulia Scioscia, Silvia Romana Stornelli, Filomena Simone, Massimo Casparrini, Natale Daniele Brunetti, Maria Pia Foschino Barbaro
Summary: IPF is a chronic progressive disease that leads to respiratory failure and death within years, particularly poor in patients with PH. Severity of PH is associated with reduction of DLCO value and increase of the GAP index. Echocardiographic stratification may be useful in predicting prognosis and determining specific treatments.
INTERNAL AND EMERGENCY MEDICINE
(2022)