Journal
MOLECULES
Volume 19, Issue 5, Pages 6009-6030Publisher
MDPI
DOI: 10.3390/molecules19056009
Keywords
organoantimony(V); organobismuth(V); carboxylate; crystal structure; cytotoxicity; antileishmanial; antibacterial
Funding
- TWAS-CNPq (The World Academy of Sciences-Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- INCT-INOFAR
- INCT-NANOBIOFAR
- CNPq
- FAPEMIG
- CAPES
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Two novel organoantimony(V) and two organobismuth(V) complexes of the type ML2 were synthesized, with L = acetylsalicylic acid (HL1) or 3-acetoxybenzoic acid (HL2) and M = triphenylantimony(V) (M1) or triphenylbismuth(V) (M2). Complexes, [M1(L1)(2)] (1), [M1(L2)(2)]center dot CHCl3 (2), [M2(L1)(2)], (3) and [M2(L2)(2)] (4), were characterized by elemental analysis, IR and NMR. Crystal structures of triphenylantimony(V) dicarboxylate complexes 1 and 2 were determined by single crystal X-ray diffraction. Structural analyses revealed that 1 and 2 adopt five-coordinated extremely distorted trigonal bipyramidal geometries, binding with three phenyl groups in the equatorial position and two deprotonated organic ligands (L) in the axial sites. The metal complexes, their metal salts and ligands were evaluated in vitro for their activities against Leishmania infantum and amazonensis promastigotes and Staphylococcus aureus and Pseudomonas aeruginosa bacteria. Both the metal complexes showed antileishmanial and antibacterial activities but the bismuth complexes were the most active. Intriguingly, complexation of organobismuth(V) salt reduced its activity against Leishmania, but increased it against bacteria. In vitro cytotoxic test of these complexes against murine macrophages showed that antimony(V) complexes were the least toxic. Considering the selectivity indexes, organoantimony(V) complexes emerge as the most promising antileishmanial agents and organobismuth(V) complex 3 as the best antibacterial agent.
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