Article
Cell Biology
Akira Takaguri, Rena Ishizaka, Shota Maki, Kumi Satoh
Summary: This study reveals the important role of TRIB2 in VSMC proliferation, which is upregulated following vascular injury and PDGF-BB stimulation. The expression of TRIB2 is mediated by ROS/ERK/EGR-1 pathways and plays a critical role in VSMC proliferation via modulation of ERK activity.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Joo-Hui Han, Hyun-Soo Park, Do-Hyung Lee, Jun-Hwan Jo, Kyung-Sun Heo, Chang-Seon Myung
Summary: The study suggests that PDGF-BB-induced VSMC autophagy is mainly regulated by Erk1/2, independent of the mTOR pathway. Targeting autophagy modulation may be a potential therapeutic strategy for addressing abnormal VSMC proliferation and migration.
Article
Chemistry, Multidisciplinary
Moon Young Jun, Rajendra Karki, Keshav Raj Paudel, Nisha Panth, Hari Prasad Devkota, Dong-Wook Kim
Summary: Liensinine showed significant anti-oxidative activity by inhibiting serum lipid peroxidation and reducing NO generation in macrophage cells. It also suppressed proliferation and enzymatic activity in vascular smooth muscle cells as well as expression of inflammatory markers. These findings suggest the potential preventive effect of liensinine on vascular inflammation.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Ae-Rang Hwang, Hee-Jung Lee, Suji Kim, Seong-Hee Park, Chang-Hoon Woo
Summary: Inhibition of phosphorylated p90RSK with specific inhibitors, such as FMK or BI-D1870, can suppress PDGF-BB-induced migration and proliferation of vascular smooth muscle cells (VSMCs), reduce phenotypic changes and extracellular matrix accumulation in VSMCs. It can also affect VSMC proliferation by regulating the expression of cyclin D1 and cyclin-dependent kinase-4, and inhibit the decrease of Cdk inhibitor p27 expression induced by PDGF-BB, thereby inhibiting VSMC proliferation in the G0/G1 phase. The use of phosphorylated p90RSK inhibitors can attenuate the PDGF-BB-induced phenotypic switch and neointimal hyperplasia in VSMCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jingyu Wang, Xiaoyan Hu, Xinxin Hu, Fuhua Gao, Mei Li, Ying Cui, Xiaoqing Wei, Yuanhua Qin, Chenghong Zhang, Ying Zhao, Ying Gao
Summary: Atherosclerosis, a chronic inflammatory disease and leading cause of death worldwide, has been linked to dysregulation of microRNAs (miRNAs). In this study, miR-520c-3p was found to reduce atherosclerotic plaque size and collagen content, and inhibit proliferation and migration of VSMCs by targeting RelA/p65, indicating a potential therapeutic strategy for atherosclerosis.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Wenli Hao, Yongkang Gan, Ying Yue, Fang Liu, Tian Liang, Ying Cao, Hongmei Cui
Summary: The study investigated the influence of Forsythoside A on PDGF-BB-induced VSMC proliferation, migration and phenotypic switch, demonstrating that Forsythoside A can effectively inhibit these processes.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Liu-Yi Lu, Ni Pan, Ze-Han Huang, Jing-Song Wang, Yong-Bo Tang, Hong-Shuo Sun, Hui Han, Han-Yan Yang, Jun-Zhen Zhu, Yong-Yuan Guan, Bin Zhang, Dong-Zhi Li, Guan-Lei Wang
Summary: This study found that CFTR attenuates neointimal formation by suppressing the cell signaling pathway stimulated by PDGF-BB, indicating that CFTR plays an important negative regulatory role in vascular remodeling.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Gang Xing, Dahong Li, Anthony Yiu-Ho Woo, Zhengxing Zhi, Lei Ji, Ruijuan Xing, Hailiang Lv, Bin He, Hui An, Haiyan Zhao, Bin Lin, Li Pan, Maosheng Cheng
Summary: Asthma patients in resource-poor countries face difficulties in accessing basic asthma medications, which are mostly inhalants. This study focuses on creating oral antiasthmatic drugs with high beta 2/beta 1-selectivity, potentially reducing treatment costs. Compound 1a was identified as the lead compound and showed remarkable beta 2-selectivity and good oral bioavailability. It holds great potential for drug development as an oral antiasthmatic agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ming Cai, Ziqing Wang, Thi Thu Trang Luu, Dakai Zhang, Brian Finke, Jingquan He, Li Wei Rachel Tay, Gilbert Di Paolo, Guangwei Du
Summary: Phospholipase D1 plays a critical role in neointima formation, mediating VSMC proliferation signal by promoting the production of reactive oxygen species (ROS).
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Pharmacology & Pharmacy
Weikang Zhang, Yuhang Gong, Xiaohang Zheng, Jianxin Qiu, Ting Jiang, Lihua Chen, Fangying Lu, Xinhui Wu, Fengmin Cheng, Zhenghua Hong
Summary: PDGF-BB promotes extracellular matrix synthesis of NPCs and inhibits pyroptosis, participating in the inhibition of IDD through regulating the MAPK signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Xingkai Hao, Xiuying Yang, Shan Zou, Xudong Cao
Summary: A sandwich enzyme-linked dendrimer-aptamer assay (ELDAA) was developed to improve the detection performances of a traditional enzyme-linked immunosorbent assay (ELISA) using glass-bottom 96-micro-well plates. Poly(amidoamine) (PAMAM) dendrimers were immobilized onto the microwell surfaces and aptamers against human platelet-derived growth factor BB (PDGF-BB) were conjugated onto the surfaces via the immobilized PAMAM dendrimer templates. The ELDAA demonstrated a broader linear detection range and a lower limit of detection compared to the standard ELISA.
APPLIED SURFACE SCIENCE
(2023)
Article
Neurosciences
Huan Chen, Yan Teng, Xingmin Chen, Zhihao Liu, Fan Geng, Yanzhuo Liu, Haisong Jiang, Ziyan Wang, Lu Yang
Summary: The study demonstrated that PDGF-BB directly regulates the expression of TH by activating downstream Akt/ERK/CREB signaling pathways, which may enhance the therapeutic potential of PDGF-BB in Parkinson's disease.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Jian-Zhi Zhao, Qi-Yao Li, Jia-Jie Lin, Li-Yun Yang, Mei-Yang Du, Yu Wang, Ke-Xin Liu, Ze-An Jiang, Huan-Huan Li, Si-Fan Wang, Bo Sun, Shi-Qing Mu, Bin Li, Kun Liu, Miao Gong, Shao-Guang Sun
Summary: This study explored the potential of tsRNAs in human aortic smooth muscle cell (HASMC) proliferation and found that during HASMC proliferation, the expression levels of many tsRNAs are altered. AS-tDR-000067 and AS-tDR-000076 act as new factors promoting VSMC proliferation.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Cardiac & Cardiovascular Systems
Jia-Jie Lin, Wei Chen, Miao Gong, Xin Xu, Mei-Yang Du, Si-Fan Wang, Li-Yun Yang, Yu Wang, Ke-Xin Liu, Peng Kong, Bin Li, Kun Liu, Yi-Ming Li, Li-Hua Dong, Shao-Guang Sun
Summary: The research identified multiple lncRNAs involved in regulating VSMC proliferation, with HIF1A-AS2 promoting HASMC proliferation through the miR-30e-5p/CCND2 mRNA axis. These findings reveal potential pathways for treating VSMC proliferative diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yan Qi, Xiuying Liang, Haijing Guan, Jingwen Sun, Wenjuan Yao
Summary: This study revealed that PDGF-BB promotes RhoGDI1 stability via the PDGF receptor, affecting VSMC phenotypic transformation. Additionally, RhoGDI1 promotes the interaction between RhoGDI1 and Cdc42, as well as the activation of Cdc42, thereby influencing VSMC phenotypic transformation and neointima formation.
Article
Biochemical Research Methods
Junke Song, Wen Zhang, Jialin Sun, Xue Zhang, Xiaona Xu, Li Zhang, Zhangying Feng, Guanhua Du
BIOMEDICAL CHROMATOGRAPHY
(2016)
Article
Hematology
Lan Sun, Yongyi Bai, Rui Zhao, Tao Sun, Ruihua Cao, Fuyu Wang, Guorong He, Wen Zhang, Ying Chen, Ping Ye, Guanhua Du
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2016)
Review
Pharmacology & Pharmacy
Ying Zhao, Xin Mu, Guanhua Du
PHARMACOLOGY & THERAPEUTICS
(2016)
Review
Pharmacology & Pharmacy
Guanhua Du, Lan Sun, Rui Zhao, Lida Du, Junke Song, Li Zhang, Guorong He, Yongxiang Zhang, Juntian Zhang
PHARMACOLOGY & THERAPEUTICS
(2016)
Article
Multidisciplinary Sciences
Guifen Qiang, Hyerim Whang Kong, Difeng Fang, Maximilian McCann, Xiuying Yang, Guanhua Du, Matthias Bluher, Jinfang Zhu, Chong Wee Liew
NATURE COMMUNICATIONS
(2016)
Article
Oncology
Jinhua Wang, Li Li, Shiwei Liu, Ying Zhao, Lin Wang, Guanhua Du
Article
Oncology
Jie Yi, Ran Gao, Yu Chen, Zhuo Yang, Pei Han, Hui Zhang, Yaling Dou, Wenjing Liu, Wengong Wang, Guanhua Du, Yingchun Xu, Jinhua Wang
Article
Oncology
Jinhua Wang, Yali Xu, Li Li, Lin Wang, Ru Yao, Qiang Sun, Guanhua Du
Article
Plant Sciences
Shengqian Yang, Ziru Yu, Lin Wang, Tianyi Yuan, Xue Wang, Xue Zhang, Jinhua Wang, Yang Lv, Guanhua Du
JOURNAL OF ETHNOPHARMACOLOGY
(2017)
Article
Chemistry, Analytical
Dezhi Yang, LingTai Jiao, Baoxi Zhang, Guanhua Du, Yang Lu
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2017)
Article
Chemistry, Analytical
Jiajia Cui, Yuetao Liu, Yinghuan Hu, Jiayu Tong, Aiping Li, Tingli Qu, Xuemei Qin, Guanhua Du
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2017)
Article
Chemistry, Medicinal
Dezhi Yang, Ningbo Gong, Li Zhang, Yang Lu, Guanhua Du
JOURNAL OF PHARMACEUTICAL SCIENCES
(2017)
Article
Pharmacology & Pharmacy
Yihuang Lin, Yu Yan, Huifang Zhang, Yucai Chen, Yangyang He, Shoubao Wang, Lianhua Fang, Yang Lv, Guanhua Du
ACTA PHARMACEUTICA SINICA B
(2017)
Article
Pharmacology & Pharmacy
Tianyi Yuan, Huifang Zhang, Yucai Chen, Xiaozhen Jiao, Ping Xie, Lianhua Fang, Guanhua Du
CURRENT VASCULAR PHARMACOLOGY
(2017)
Article
Biochemical Research Methods
Yu Yan, Huifang Zhang, Zhihui Zhang, Junke Song, Yucai Chen, Xiaobo Wang, Yangyang He, Hailin Qin, Lianhua Fang, Guanhua Du
BIOMEDICAL CHROMATOGRAPHY
(2017)