Journal
MOLECULES
Volume 19, Issue 4, Pages 4548-4559Publisher
MDPI
DOI: 10.3390/molecules19044548
Keywords
Datura metel L.; withanolides; dmetelins; NO inhibition
Funding
- Outstanding Young Scientists Program of Heilongjiang Province [JC201105]
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Four new withanolides named dmetelins A-D (compounds 1-4), along with the known compound 7 alpha,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC50 values of 17.8, 11.6, 14.9, 33.3 and 28.6 mu M, respectively.
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