Stimulation of Natural Killer T Cells by Glycolipids

Cutting Edge: Nonglycosidic CD1d Lipid Ligands Activate Human and Murine Invariant NKT Cells

(2014) J. D. Silk et al.   JOURNAL OF IMMUNOLOGY

Natural Killer T cell obsession with self-antigens

(2013) Laurent Gapin et al.   CURRENT OPINION IN IMMUNOLOGY

Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity

(2013) Lee A Albacker et al.   NATURE MEDICINE

Synthesis of Fungal Glycolipid Asperamide B and Investigation of Its Ability to Stimulate Natural Killer T Cells

(2013) Vinod Chaudhary et al.   ORGANIC LETTERS

Design and synthesis of new KRN7000 analogues

(2013) Man Sun et al.   TETRAHEDRON

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile

(2012) Tetsuya Toba et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New CD1d agonists: Synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides

(2012) Peter J. Jervis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Sphingolipids with an ω-Esterified Long Acyl Chain, Ceramide Components of the Human Epidermis

(2012) Takuya TASHIRO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

(2012) Peter J. Jervis et al.   CARBOHYDRATE RESEARCH

Species-Specific Activity of Glycolipid Ligands for Invariant NKT Cells

(2012) Emma M. Dangerfield et al.   CHEMBIOCHEM

Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor

(2012) Jacinto López-Sagaseta et al.   EMBO JOURNAL

CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells

(2012) Joseph P. Sanderson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Turned on by danger: activation of CD1d-restricted invariant natural killer T cells

(2012) Victoria Lawson   IMMUNOLOGY

Globosides but Not Isoglobosides Can Impact the Development of Invariant NKT Cells and Their Interaction with Dendritic Cells

(2012) S. Porubsky et al.   JOURNAL OF IMMUNOLOGY

Structural and Functional Characterization of a Novel Nonglycosidic Type I NKT Agonist with Immunomodulatory Properties

(2012) J. Kerzerho et al.   JOURNAL OF IMMUNOLOGY

3-Fluoro- and 3,3-Difluoro-3,4-dideoxy-KRN7000 Analogues as New Potent Immunostimulator Agents: Total Synthesis and Biological Evaluation in Human Invariant Natural Killer T Cells and Mice

(2012) Julie Hunault et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus

(2012) Federica Facciotti et al.   NATURE IMMUNOLOGY

An improved synthesis of dansylated α-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells

(2011) Janice M.H. Cheng et al.   CARBOHYDRATE RESEARCH

Activation of natural killer T cells by α-carba-GalCer (RCAI-56), a novel synthetic glycolipid ligand, suppresses murine collagen-induced arthritis

(2011) Y. Yoshiga et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide

(2011) Andrew E. Hogan et al.   CLINICAL IMMUNOLOGY

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

(2011) Sandrine Aspeslagh et al.   EMBO JOURNAL

NKT TCR Recognition of CD1d- -C-Galactosylceramide

(2011) O. Patel et al.   JOURNAL OF IMMUNOLOGY

iNKT cells in microbial immunity: recognition of microbial glycolipids

(2011) Yuki Kinjo et al.   MICROBIOLOGY AND IMMUNOLOGY

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

(2011) Patrick J Brennan et al.   NATURE IMMUNOLOGY

Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria

(2011) Yuki Kinjo et al.   NATURE IMMUNOLOGY

Synthesis of a Novel α-Galactosyl Ceramide Haptenated-Lipid Antigen, a Useful Tool in Demonstrating the Involvement ofiNKT Cells in the Production of Antilipid Antibodies

(2010) Natacha Veerapen et al.   BIOCONJUGATE CHEMISTRY

Introduction of aromatic group on 4′-OH of α-GalCer manipulated NKT cell cytokine production

(2010) Wenpeng Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological activity of ester and ether analogues of α-galactosylceramide (KRN7000)

(2010) Masao Shiozaki et al.   CARBOHYDRATE RESEARCH

Clinical experience with α-galactosylceramide (KRN7000) in patients with advanced cancer and chronic hepatitis B/C infection

(2010) Famke L. Schneiders et al.   CLINICAL IMMUNOLOGY

Synthetic iNKT cell-agonists as vaccine adjuvants—finding the balance

(2010) Vincenzo Cerundolo et al.   CURRENT OPINION IN IMMUNOLOGY

Induction of Th1-biased cytokine production by  -carba-GalCer, a neoglycolipid ligand for NKT cells

(2010) T. Tashiro et al.   INTERNATIONAL IMMUNOLOGY

Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity

(2010) Ya-Jen Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

Diverse Endogenous Antigens for Mouse NKT Cells: Self-Antigens That Are Not Glycosphingolipids

(2010) B. Pei et al.   JOURNAL OF IMMUNOLOGY

α-Galactosylceramide Analogs with Weak Agonist Activity for Human iNKT Cells Define New Candidate Anti-Inflammatory Agents

(2010) Gabriel Bricard et al.   PLoS One

Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant

(2010) X. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An α-GalCer analogue with branched acyl chain enhances protective immune responses in a nasal influenza vaccine

(2010) Yoon-Sook Lee et al.   VACCINE

Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH

(2009) Geetha Velmourougane et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of 3″- and 4″-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000

(2009) Ravinder Raju et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Roles of 3′ and 4′ Hydroxy Groups in α-Galactosylceramide Stimulation of Invariant Natural Killer T Cells

(2009) Chengfeng Xia et al.   ChemMedChem

Aminocyclitol-Substituted Phytoceramides and their Effects on iNKT Cell Stimulation

(2009) Youssef Harrak et al.   ChemMedChem

The Synthesis and in vivo Evaluation of 2′,2′-Difluoro KRN7000

(2009) Leo Leung et al.   ChemMedChem

Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 and Vβ7 Semi-invariant NKT T Cell Receptors

(2009) Daniel G. Pellicci et al.   IMMUNITY

Identification of C-glycoside analogues that display a potent biological activity against murine and human invariant natural killer T cells

(2009) Xiangming Li et al.   IMMUNOLOGY

Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by Vα14 i NKT Cells

(2009) Barbara A. Sullivan et al.   JOURNAL OF IMMUNOLOGY

Early Recycling Compartment Trafficking of CD1a Is Essential for Its Intersection and Presentation of Lipid Antigens

(2009) M. Cernadas et al.   JOURNAL OF IMMUNOLOGY

Structural Evaluation of Potent NKT Cell Agonists: Implications for Design of Novel Stimulatory Ligands

(2009) André Schiefner et al.   JOURNAL OF MOLECULAR BIOLOGY

Determination of Cellular Lipids Bound to Human CD1d Molecules

(2009) Daryl Cox et al.   PLoS One

Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells

(2009) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen recognition by CD1d-restricted NKT T cell receptors

(2009) Dale I. Godfrey et al.   SEMINARS IN IMMUNOLOGY

Facile synthesis of biotin-labelled α-galactosylceramide as antigen for invariant natural killer T cells

(2009) Chengfeng Xia et al.   TETRAHEDRON

Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine

(2009) Sarah A. Kopecky-Bromberg et al.   VACCINE

Recognition of Lyso-Phospholipids by Human Natural Killer T Lymphocytes

(2009) Lisa M. Fox et al.   PLOS BIOLOGY

Natural Killer T Cells Activated by a Lipopeptidophosphoglycan from Entamoeba histolytica Are Critically Important To Control Amebic Liver Abscess

(2009) Hannelore Lotter et al.   PLoS Pathogens

RCAI-17, 22, 24–26, 29, 31, 34–36, 38–40, and 88, the analogs of KRN7000 with a sulfonamide linkage: Their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines

(2008) Takuya Tashiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties

(2008) Yang Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand

(2008) Jeong-Ju Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

α-S-GalCer: Synthesis and evaluation for iNKT cell stimulation

(2008) Marisa L. Blauvelt et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer

(2008) D. H. Chang et al.   BLOOD

Natural Sphingomonas Glycolipids Vary Greatly in Their Ability to Activate Natural Killer T Cells

(2008) Yuki Kinjo et al.   CHEMISTRY & BIOLOGY

Synthesis and in vitro Evaluation of α‐GalCer Epimers

(2008) Matthias Trappeniers et al.   ChemMedChem

CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune system

(2008) Jennifer L Matsuda et al.   CURRENT OPINION IN IMMUNOLOGY

Synthesis of α-Galactosyl Ceramide (KRN7000) and Analogues Thereof via a Common Precursor and Their Preliminary Biological Assessment

(2008) Mario Michieletti et al.   JOURNAL OF ORGANIC CHEMISTRY

6′-Derivatised α-GalCer Analogues Capable of Inducing Strong CD1d-Mediated Th1-Biased NKT Cell Responses in Mice

(2008) Matthias Trappeniers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000

(2008) Leo Leung et al.   ORGANIC LETTERS

The First Synthesis of a Thioglycoside Analogue of the Immunostimulant KRN7000

(2008) Ravindra T. Dere et al.   ORGANIC LETTERS

Asthma Is Inversely Associated with Helicobacter pylori Status in an Urban Population

(2008) Joan Reibman et al.   PLoS One

Humans Lack iGb3 Due to the Absence of Functional iGb3-Synthase: Implications for NKT Cell Development and Transplantation

(2008) Dale Christiansen et al.   PLOS BIOLOGY

Glycolipids as immunostimulating agents

(2007) Douglass Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY